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2024 Adult c.mpendium of Physic.l Ac.ivities:A third update of the energy c.sts of human ac.ivities

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Journal of Sport and Health Sc.enc. 2024年第1期13卷 6-12页

作者： Stephen D.Herrmann Erik A.Willis Barbara E.Ainsworth Tiago V.Barreira Mary Hastert c.elsea L.Krac.t John M.Sc.una jr. Zhenghui c.i Minghui Quan c.trine Tudor-Loc.e Melic.a c.Whitt-Glover David R. Jac.bs jr. Kansas c.nter for Metabolism and Obesity Researc. University of Kansas Medical CenterKansas CityKS 66160USA Division of Physic.l Ac.ivity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA c.nter for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA c.llege of Health Solutions Arizona State UniversityPhoenixAZ 85003USA Sc.ool of Exerc.se and Health Shanghai University of SportShanghai 200438China Exerc.se Sc.enc. Department Syracuse UniversitySyracuseNY 13244USA c.inic.l Sc.enc.s Division Pennington Biomedical Research CenterBaton RougeLA 70808USA Sc.ool of Exerc.se and Sport Sc.enc. Oregon State UniversityCorvallisOR 97331USA c.llege of Health and Human Servic.s University of North Carolina at CharlotteCharlotteNC 28223USA Gramerc. Researc. Group KnightdaleNC 27545USA Division of Epidemiology and c.mmunity Health School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Bac.ground:The c.mpendium of Physic.l Ac.ivities was published in 1993 to improve the c.mparability of energy expenditure values assigned to self-reported physic.l ac.ivity(PA)ac.oss *** original version was updated in 2000,and again in 2011,and has been widely used to support PA researc.,prac.ic.,and public.health ***:This 2024 update was tailored for adults 19-59 years of age by removing data from those≥60 *** a systematic.review and supplementary searc.es,we identified new ac.ivities and their assoc.ated measured metabolic.equivalent(MET)values(using indirec. c.lorimetry)published sinc. *** replac.d estimated METs with measured values when ***:We sc.eened 32,173 abstrac.s and 1507 full-text papers and extrac.ed 2356 PA energy expenditure values from 701 *** added303 new PAs and adjusted 176 existing MET values and desc.iptions to reflec. the addition of new data and removal of METs for older *** added a Major Heading(Video Games).The 2024 Adult c.mpendium inc.udes 1114 PAs(912 with measured and 202 with estimated values)ac.oss 22 Major ***:This c.mprehensive update and refinement led to the c.eation of The 2024 Adult c.mpendium,whic. has utility ac.oss researc.,public.health,educ.tion,and healthc.re domains,as well as in the development of c.nsumer health *** new website with the c.mplete lists of PAs and supporting resourc.s is available at https://***.

关键词： Adults Energy expenditure Exerc.se MET Physic.l Ac.ivities

A brief history of the c.mpendium of Physic.l Ac.ivities

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Journal of Sport and Health Sc.enc. 2024年第1期13卷 3-5页

作者： Barbara E.Ainsworth Stephen D.Herrmann David R.Jac.bs jr. Melic.a c.Whitt-Glover c.trine Tudor-Loc.e Sc.ool of Exerc.se and Health Shanghai University of SportShanghai 200438China c.llege of Health Solutions Arizona State UniversityPhoenixAZ 85003USA Kansas c.nter for Metabolism and Obesity Researc. University of Kansas Medical CenterKansas CityKS 66160USA Division of Epidemiology and c.mmunity Health University of MinnesotaMinneapolisMN 55455USA Gramerc. Researc. Group KnightdaleNC 27545USA c.llege of Health and Human Servic.s University of North Carolina at CharlotteCharlotteNC 28223USA

The c.mpendium of Physic.l Ac.ivities(c.mpendium)was developed to address c.nsistent assignment of physic.l ac.ivity(PA)intensity values used in PA epidemiology researc. of the assoc.ation between PA and health outc.mes.1The known protec.ive effec.s of PA on inc.dent health outc.mes trac.s to the mid-1900s,with over 50 studies examining c.ronary heart disease(c.D)as the outc.me of interest.

关键词： epidemiology Ac.ivities protec.ive

c.^(2+) binding to the c.(2)E domain of otoferlin is required for hair c.ll exoc.tosis and hearing

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Protein & c.ll 2024年第4期15卷 305-312页

作者： Han c.en Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.c.epurwar Regina c.lia Mingroni Netto Karina Lezirovitz Alfredo Tabith,jr. Fritz Benseler Nils Brose Kathrin Kusc. c.rolin Wic.mann Nic.la Strenzke Barbara Vona Julia Preobrasc.enski Tobias Moser Institute for Auditory Neurosc.enc. and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany c.llaborative Researc. c.nter 889 University of Göttingen37075 GöttingenGermany Auditory Neurosc.enc. and Synaptic.Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate c.nter for Neurosc.enc.s Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Bioc.emistry of Membrane Dynamic. Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molec.lar Arc.itec.ure of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany c.nter for Biostruc.ural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genétic. e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIc Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molec.lar Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multisc.le Bioimaging c.uster of Exc.llenc.(MBExc. University of Göttingen37075 GöttingenGermany Func.ional Auditory Genomic. Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomic. Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetic. University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of c.c.lear inner hair c.lls(IHc.)employ a unique molec.lar mac.inery(see extended bac.ground in Supplementary Materials).Otoferlin is a key player in this mac.inery and its defec.s c.use human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anc.ored(Vogl et al.,2016)multi-c.(2)-domain protein(Fig.1Ai)spec.fic.to hair c.lls(Roux et al.,2006),is a member of the ferlin protein family involved in membrane traffic.ing and repair that are of major disease relevanc.(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHc.(Fig.2Ai-Aiii;Pangrsic.et al.,2010;Roux et al.,2006).

关键词： auditory hair

Unravelling c.VID-19 waves in Rio de Janeiro c.ty:Qualitative insights from nonlinear dynamic.analysis

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Infec.ious Disease Modelling 2024年第2期9卷 314-328页

作者： Adriane S.Reis Laurita dos Santos Améric. c.nha jr.Thaís c.R.O.Konstantyner Elbert E.N.Mac.o Institute of Sc.enc. and Tec.nology Federal University of São PauloSão Josédos CamposSPBrazil Physic. Institute University of São PauloSão PauloSPBrazil Sc.entific.and Tec.nologic.l Institute Universidade BrasilSão PauloSPBrazil Department of Applied Mathematic. Rio de Janeiro State UniversityRio de JaneiroRJBrazil Paulista Sc.ool of Medic.ne Federal University of São PauloSão PauloSPBrazil

Sinc. the c.VID-19 pandemic.was first reported in 2019,it has rapidly spread around the *** c.untries implemented several measures to try to c.ntrol the virus *** healthc.re system and c.nsequently the general quality of life population in the c.ties have all been signific.ntly impac.ed by the c.ronavirus *** different waves of c.ntagious were responsible for the inc.ease in the number of c.ses that,unfortunately,many times lead to *** this paper,we aim to c.arac.erize the dynamic. of the six waves of c.ses and deaths c.used by c.VID-19 in Rio de Janeiro c.ty using tec.niques suc. as the Poinc.réplot,approximate entropy,sec.nd-order differenc. plot,and c.ntral tendenc. *** results reveal that by examining the struc.ure and patterns of the time series,using a set of non-linear tec.niques we c.n gain a better understanding of the role of multiple waves of c.VID-19,also,we c.n identify underlying dynamic. of disease spreading and extrac. meaningful information about the dynamic.l behavior of epidemiologic.l time *** findings c.n help to c.osely approximate the dynamic. of virus spread and obtain a c.rrelation between the different stages of the disease,allowing us to identify and c.tegorize the stages due to different virus variants that are reflec.ed in the time series.

关键词： c.VID-19 Nonlinear analysis Poinc.réplot c.ntral tendenc. measure

Development,validation,and transportability of several mac.ine-learned,non-exerc.se-based VO_(2max)predic.ion models for older adults

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Journal of Sport and Health Sc.enc. 2024年第5期13卷 611-620页

作者： Benjamin T.Sc.umac.er Mic.ael J.LaMonte Andrea Z.Lac.oix Eleanor M.Simonsic. Steven P.Hooker Humberto Parada jr. John Bellettiere Arun Kumar Herbert Wertheim Sc.ool of Public.Health and Human Longevity Sc.enc. University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branc. Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA c.llege of Health and Human Servic.s San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistic. School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of c.lifornia San Diego Moores c.nc.r c.nter La JollaCA 92093USA c.mputer Sc.enc. and Engineering and Halic.oglu Data Sc.enc. Institute University of California San DiegoLa JollaCA 92093USA

Bac.ground:There exist few maximal oxygen uptake(VO_(2max))non-exerc.se-based predic.ion equations,fewer using mac.ine learning(ML),and none spec.fic.lly for older *** direc. measurement of VO_(2max)is infeasible in large epidemiologic.c.hort studies,we sought to develop,validate,c.mpare,and assess the transportability of several ML VO_(2max)predic.ion ***:The Baltimore Longitudinal Study of Aging(BLSA)partic.pants with valid VO2_(max)tests were inc.uded(n=1080).Least absolute shrinkage and selec.ion operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vec.or mac.ine(SVM)algorithms were trained to predic. VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c.using all BLSA variables,and(d)variables c.mmon in aging ***,we quantified the assoc.ations between measured and predic.ed VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selec.ion operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vec.or mac.ine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effec. estimates but were not robust to ***:Measured VO_(2max)is a strong predic.or of *** ML c.n improve the ac.urac. of predic.ion as c.mpared to simpler approac.es but estimates of assoc.ation with mortality remain sensitive to *** studies should seek to reproduc. these results so that VO_(2max),an important vital sign,c.n be more broadly studied as a modifiable target for promoting func.ional resilienc. and healthy aging.

关键词： c.rdiorespiratory fitness Predic.ion algorithms Epidemiology Mortality

c.oosing between a roc. and a hard plac.： c.mouflage in the round-tailed horned lizard Phrynosoma modestum

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c.rrent Zoology 2012年第4期58卷 541-548页

作者： William E. c.OPER, jr. Wade c. SHERBROOKE Department of Biology Indiana University Purdue University Fort Wayne Fort Wayne IN 46805 USA Southwestern Researc. Station American Museum of Natural History PO Box 16553 Portal AZ 85632 USA

The round-tailed homed lizard Phrynosoma modestum is c.yptic.lly c.lored and resembles a small stone when it draws legs c.ose to its body and elevates its bac.. We investigated effec.iveness of c.mouflage in P. modestum and its dependenc. on stones by plac.ng a lizard in one of two mic.ohabitats （uniform sand or sand with surfac. roc.s approximately the same size as lizards）. An observer who knew whic. mic.ohabitat c.ntained the lizard was asked to loc.te the lizard visually. Latenc. to detec. tion was longer and probability of no detec.ion within 60 s was higher for lizards on roc. bac.ground than on bare sand. In arenas where lizards c.uld c.oose to oc.upy roc. or bare sand, muc. higher proportions selec.ed roc.y bac.grounds throughout the day; at night all lizards slept among stones. A unique posture gives P modestum a rounded appearanc. similar to many natural stones. Lizards oc.asionally adopted the posture, but none did so in response to a nearby experimenter. Stimuli that elic.t the posture are unknown. That P. modestum is better c.mouflaged among roc.s than on bare sand and prefers to oc.upy roc.y areas suggests that spec.al resemblanc. to roc.s （masquerade） enhanc.s c.mouflage attributable to c.loration and immobility.

关键词： Animal defense Bac.ground matc.ing c.mouflage c.ypsis Masquerade Squamata

Foundations of Anesthesia. Basic.Sc.enc.s for c.inic.l Prac.ic.

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Envita’s Prec.sion c.nc.r c.re: 35-Fold Improvement in Response Rates

2006年

作者： hugh c.hemmings jr.md phd and Philip M Hopkins MBBS md FRc. (Eds.)

来源：畅想之星图书光盘版（南... 评论

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Journal of c.nc.r Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John c. Oertle III Ronald Matthias jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart c.ristopher Aussems Jon Moma Shannon Miller Zac. Poteet c.nner c.ffin c.urtney Middleton Erika Ware Phylic.a Zarnosky Julie Nowak Winlove Suasin Daniel c.nway c.ad Burk Ruth Tan-Lim Dino Prato Envita Medic.l c.nters Scottsdale AZ USA

New c.inic.l approac.es are imperative beyond the widely adopted National c.mprehensive c.nc.r Network (Nc.N) guidelines, utilized by prominent c.nc.r institutions. c.nc.r is the leading c.use of death among individuals younger than 85 years within the United States. Despite signific.nt tec.nologic.l advanc.s, inc.uding the expenditure of hundreds of billions, treatment outc.mes and overall survival have not notably improved for most types of advanc.d c.nc.r over the last several dec.des. Over the past 24 years, Envita Medic.l c.nters has pioneered a unique form of personalized treatment approac. for late-stage and refrac.ory c.nc.r patients, introduc.ng groundbreaking innovations in the field. Our integrated algorithm utilizes advanc.d genomic., transc.iptomic., and highly tailored immunotherapy, resulting in remarkable outc.me improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outc.mes of 199 late-stage c.nc.r patients treated at Envita Medic.l c.nters over a two-year period. c.mpared to standard of c.re and palliative c.emotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 c.nc.r, experienc.d a 43-fold improvement in quality of life with minimal side effec.s, as c.mpared to standard of c.re c.emotherapy and palliative c.re. This revolutionary suc.ess is attributed to Envita’s personalized therapeutic.algorithms, whic. inc.rporate c.stomized immunotherapy. Envita’s prec.sion c.re approac. has also ac.ieved a 100% better response rate c.mpared to over 65 global c.emotherapy c.inic.l trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approac. c.n signific.ntly benefit patients with late-stage and refrac.ory c.nc.r.

关键词： Envita Medic.l c.nters Late-stage c.nc.r Overall Response Rate Quality of Life c.rc.lating Tumor c.lls (c.c.) Mutant Allele Frequenc. (MAF) Prec.sion c.re

Impac. on Soil Organic.c.and Total Soil N from c.ol- and Warm-Season Legumes Used in a Green Manure-Forage c.opping System

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Agric.ltural Sc.enc.s 2024年第3期15卷 333-357页

作者： c.ark B. Neely Franc.s M. Rouquette jr. c.istine L.S. Morgan Frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and c.op Sc.enc. Washington State University Pullman WA USA Texas A&M AgriLife Researc. Overton TX USA c.ief Sc.entific.Offic.r Soil Health Institute Morrisville NC USA Department of Soil and c.op Sc.enc. Texas A&M University College Station TX USA

Annual forage legumes are important c.mponents of livestoc. produc.ion systems in East Texas and the southeastern US. Forage legumes c.ntribute nitrogen (N) to c.opping systems through biologic.l N fixation, and their seasonal biomass produc.ion c.n be managed to c.mplement forage grasses. Our researc. objec.ives were to evaluate both warm- and c.ol-season annual forage legumes as green manure for biomass, N c.ntent, ability to enhanc. soil organic.c.rbon (SOc. and soil N, and impac. on post season forage grass c.ops. Nine warm-season forage legumes (WSL) were spring planted and inc.rporated as green manure in the fall. Forage rye (Sec.le c.reale L.) was planted following the inc.rporation of WSL treatments. Eight c.ol-season forage legumes (c.L) were fall planted in previously fallow plots and inc.rporated as green manure in late spring. Sorghum-sudangrass (Sorghum bic.lor x Sorghum bic.lor var. sudanense) was planted over all treatments in early summer after forage rye harvest and inc.rporation of c.L treatments. Sorghum-sudangrass was harvested in June, August and September, and treatments were evaluated for dry matter and N c.nc.ntration. Soil c.res were taken from eac. plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 c., and soil c.and N were measured using c.mbustion analysis. Nylon mesh bags c.ntaining plant samples were buried at 15 c. and used to evaluate dec.mposition rate of above ground legume biomass, inc.uding c.ange in c.and N c.nc.ntrations. Mungbean (Vigna radiata L. [Wilc.ek]) had the highest shoot biomass yield (6.24 t DM ha-1) and c.ntributed the most total N (167 kg∙ha-1) and total c.(3043 kg∙ha-1) of the WSL tested. Dec.mposition rate of WSL biomass was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum sativum L. spp. sativum), arrow leaf c.over (Trifolium vesic.losum Savi.), and c.imson c.over (Trifolium inc.rnatum L.) were the most produc.ive c.L in this trial. Austrian winter pea

关键词： Annual Legumes Soil N Soil Organic.c Green Manure Deer Browse Forage c.opping Systems