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伊立替康在成人和儿童中的ADE信号差异分析

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中国药房 2024年第11期35卷 1369-1373页

作者：李芳杜小换尚翔王文娟周密朱增燕苏州大学附属儿童医院药剂科江苏苏州215002 苏州市广济医院药剂科江苏苏州215003

目的挖掘和分析伊立替康上市后在成人和儿童群体中的药物不良事件(ADE)信号,为临床安全用药提供参考。方法提取美国FDA不良事件报告系统数据库中2004年第1季度至2023年第1季度的伊立替康ADE报告,采用报告比值比法和比例报告比值比法挖... 详细信息

目的挖掘和分析伊立替康上市后在成人和儿童群体中的药物不良事件(ADE)信号,为临床安全用药提供参考。方法提取美国FDA不良事件报告系统数据库中2004年第1季度至2023年第1季度的伊立替康ADE报告,采用报告比值比法和比例报告比值比法挖掘该药的风险信号,分别对患者年龄<18岁(儿童)和≥18岁(成人)的ADE报告及信号进行统计分析。结果共挖掘到8 013份以伊立替康为首要怀疑药物的ADE报告,其中成人与儿童ADE报告分别有7 656、357份,分别挖掘出518、75个ADE信号,主要累及胃肠系统疾病、血液及淋巴系统疾病和全身性疾病及给药部位各种反应等系统器官分类。信号频度排前20位的ADE信号在伊立替康的药品说明书中大部分有记载;周围神经病、口腔黏膜炎、肺栓塞、表皮痣综合征、生殖毒性等是成人中新的ADE信号,而高血压、进展性肿瘤、肿瘤溶解综合征、栓塞等是儿童中新的ADE信号。结论临床应用伊立替康时应警惕说明书未提及的上述新的可疑高风险信号。

关键词：伊立替康药物不良事件 FAERS数据库风险信号儿童

The giant Bayan Obo REE-Nb-Fe deposit,China:Controversy and ore genesis

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Geoscience Frontiers 2016年第3期7卷 335-344页

作者： Hong-Rui Fan Kui-Feng Yang fang-fang Hu shang Liu Kai-Yi Wang Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences

Bayan Obo ore deposit is the largest rare-earth element（REE） resource,and the second largest niobium（Nb） resource in the *** to the complicated element/mineral compositions and involving several geological events,the REE enrichment mechanism and genesis of this giant deposit still remains intense *** deposit is hosted in the massive dolomite,and nearly one hundred carbonatite dykes occur in the vicinity of the *** carbonatite dykes can be divided into three types from early to late：dolomite,co-existing dolomite-calcite and calcite type,corresponding to different evolutionary stages of carbonatite magmatism based on the REE and trace element *** latter always has higher REE *** origin of the ore-hosting dolomite at Bayan Obo has been addressed in various models,ranging from a normal sedimentary carbonate rocks to volcano-sedimentary sequence,and a large carbonatitic *** geochemical evidences show that the coarse-grained dolomite represents a Mesoproterozoic carbonatite pluton and the fine-grained dolomite resulted from the extensive REE mineralization and modification of the coarse-grained *** ore bodies,distributed along an E-W striking belt,occur as large lenses and underwent more intense fluoritization and *** first episode mineralization is characterized by disseminated mineralization in the *** second or main-episode is banded and/or massive mineralization,cut by the third episode consisting of aegirinerich *** dating methods gave different mineralization ages at Bayan Obo,resulting in long and hot *** of available data suggests that the mineralization is rather variable with two peaks at～1400 and 440 *** early mineralization peak closes in time to the intrusion of the carbonatite dykes.A significant thermal event at ca.440 Ma resulted in the formation of late-stage veins with coarse crystals of REE *** involving in the REE-Nb-Fe mineralization at

关键词： Geochemistry Geochronology Carbonatite Dolomite Bayan Obo REE-Nb-Fe deposit

桃核承气汤联合针刺改善气虚血瘀型脑卒中偏瘫患者上肢功能的临床研究

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皖南医学院学报 2024年第3期43卷 249-253页

作者：尚甲甲方运葵孙雪淮南东方医院集团总医院康复医学科安徽淮南2320001

目的:探讨针刺联合桃核承气汤治疗气虚血瘀型急性缺血性脑卒中(AIS)患者上肢功能障碍的临床疗效。方法:选取淮南东方医院集团总医院2020年6月~2022年5月收治的110例气虚血瘀型AIS患者,随机分为观察组(针刺联合桃核承气汤治疗组)和对照组... 详细信息

目的:探讨针刺联合桃核承气汤治疗气虚血瘀型急性缺血性脑卒中(AIS)患者上肢功能障碍的临床疗效。方法:选取淮南东方医院集团总医院2020年6月~2022年5月收治的110例气虚血瘀型AIS患者,随机分为观察组(针刺联合桃核承气汤治疗组)和对照组(针刺治疗组)各55例,疗程21 d。比较两组患者治疗前、治疗第21天及治疗结束第90天Fugl-Meyer评分(FMA)、香港版偏瘫上肢功能测试(FTHUE-HK)评分、改良Barthel指数(MBI)、中医证候积分及血液黏度相关指标,记录治疗期间不良事件发生率。结果:观察组和对照组分别有54、52例患者纳入研究。相较于对照组,观察组患者治疗第21天和治疗结束第90天FMA、FTHUE-HK和MBI评分升高,而中医证候总积分、HCT、FIB和D-Dimer水平下降(P0.05)。结论:针刺联合桃核承气汤内服可明显改善气虚血瘀型AIS患者上肢运动功能,降低中医证候积分,提高AIS患者生活自理能力,其主要机制可能与降低患者血液高凝状态有关。

关键词：气虚血瘀脑卒中桃核承气汤针刺

DBP formation from degradation of DEET and ibuprofen by UV/chlorine process and subsequent post-chlorination

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Journal of Environmental Sciences 2017年第8期29卷 146-154页

作者： Ehsan Aghdam Yingying Xiang Jianliang Sun Chii shang Xin Yang Jingyun fang Department of Civil and Environmental Engineering Hong Kong University of Science and Technology Kowioon Hong Kong China Hong Kong Branch of the Chinese National Engineering Research Center for Control & Treatment of Heavy Metal Pollution Hong Kong University of Science and Technology Kowloon Hong Kong China School of Environmental Science and Engineering Sun Yat-sen University Guangzhou China

The formation of disinfection by-products（DBPs） from the degradation of N,N-diethyl-3-methyl benzoyl amide（DEET） and ibuprofen（IBP） by the ultraviolet irradiation（UV）/chlorine process and subsequent post-chlorination was investigated and compared with the UV/H_2O_2 *** pseudo first-order rate constants of the degradation of DEET and IBP by the UV/chlorine process were 2 and 3.1 times higher than those by the UV/H_2O_2 process, respectively, under the tested conditions. This was due to the significant contributions of both reactive chlorine species U（RCS） and hydroxyl radicals（HO） in the UV/chlorine process. Trichloromethane, 1,1,1-trichloro-2-propanone and dichloroacetic acid were the major known DBPs formed after 90% of both DEET and IBP that were degraded by the UV/chlorine process. Their yields increased by over 50%after subsequent 1-day post-chlorination. The detected DBPs after the degradation of DEET and IBP comprised 13.5% and 19.8% of total organic chlorine（TOCl）, respectively, and the proportions increased to 19.8% and 33.9% after subsequent chlorination, respectively. In comparison to the UV/H_2O_2 process accompanied with post-chlorination, the formation of DBPs and TOCl in the UV/chlorine process together with post-chlorination was 5%–63% higher,Ulikely due to the generation of more DBP precursors from the attack of RCS, in addition to HO.

关键词： Pharmaceuticals and personal care products Disinfection by-products UV/chlorine process UV/H2O2 process Chlorination

Influence of genotypes and environmental factors on leaf triterpenoid content and growth of Cyclocarya paliurus

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Journal of Forestry Research 2019年第3期30卷 789-798页

作者： Bo Deng Shengzuo fang Xulan shang Xiangxiang Fu Wanxia Yang College of Forestry Nanjing Forestry University Nanjing 210037People’s Republic of China Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037 People’s Republic of China School of Forestry and Landscape Architecture Anhui Agricultural UniversityHefei 230036 People’s Republic of China

Cyclocarya paliurus, an economically valuable tree species, has traditionally been used as a nutraceutical food or medicine in China. However, limited information is available on its genotype selection and cultivation under a wide range of environmental conditions for growth and targeted health-promoting substances. We studied the effects of genotype and environment, and their interaction on leaf triterpenoid content and tree growth for 12 genotypes of C. paliurus grown at four sites. We quantified the correlation between leaf triterpenoid accumulation and tree growth. The contents of cyclocaric acid B, cyclocarioside I, and arjunolic acid ranged from 0.06 to 3.89, 0 to 3.71, and 0.65 to 8.86 mg g^-1, respectively. Three individual triterpenoids were primarily influenced by genotype (variation ranged from 53.7 to 68.0%), while environment accounted for most of the variation in total triterpenoid content and tree growth (71.3–89.5%). Most tested environmental parameters were significantly correlated to total triterpenoid content, but not to the contents of the individual triterpenoids measured. Growth in tree height and diameter at breast height were significantly negatively correlated with total triterpenoid content but were non-significantly correlated with individual triterpenoid contents. We conclude that genotypic selection, manipulation of environmental conditions, and implementation of appropriate silvicultural operations would be important strategies for increasing the accumulation of health-promoting phytochemicals.

关键词： Cyclocarya paliurus Genotypic selection Interaction Phytochemicals Tree growth

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营养小米糊工艺配方研究

粮食与油脂 2024年第1期37卷 74-78页

作者：陈健鹏刘洋张婉商亚芳冯俊俏马意龙合肥工业大学食品与生物工程学院安徽合肥230601 安徽焦甜香生物科技有限公司安徽宣城242000

以小米为主要原料,通过膨化工艺制备营养小米糊。在单因素试验的基础上,通过正交试验优化小米膨化工艺和营养小米糊工艺配方。结果表明:小米最佳膨化工艺为水分添加量9%(以小米粉质量为基准)、机筒温度150℃、螺杆转速160r/min;营养小... 详细信息

以小米为主要原料,通过膨化工艺制备营养小米糊。在单因素试验的基础上,通过正交试验优化小米膨化工艺和营养小米糊工艺配方。结果表明:小米最佳膨化工艺为水分添加量9%(以小米粉质量为基准)、机筒温度150℃、螺杆转速160r/min;营养小米糊最佳工艺配方为膨化小米粉100g、蔗糖20g、石斛粉15g、山药粉5g、红枣粉15g和党参粉5g。

关键词：营养小米糊膨化工艺配方

夏季高温条件下不同贮运装置对医院“互联网+药品”配送温度的影响

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中国药房 2024年第6期35卷 758-761页

作者：蔡峥尚晨何娜刘芳石伟龙赵喆赵荣生北京大学第三医院药剂科北京100191

目的探索高温环境下适宜的“互联网+药品”配送贮运装置。方法对北京地区夏季高温情况进行调研;回顾性分析2021年7月-2022年6月我院“互联网+药品”配送订单中不同贮藏条件药品所占的比例及其配送范围;通过温控模拟实验及验证实验探究... 详细信息

目的探索高温环境下适宜的“互联网+药品”配送贮运装置。方法对北京地区夏季高温情况进行调研;回顾性分析2021年7月-2022年6月我院“互联网+药品”配送订单中不同贮藏条件药品所占的比例及其配送范围;通过温控模拟实验及验证实验探究夏季高温条件下,适宜北京同城“互联网+药品”配送的药品贮运装置。结果北京市1991-2022年每年6-8月的月平均气温均在25.0℃以上;2021年7月-2022年6月,我院在北京地区“互联网+药品”配送目录中的333种药品中,要求25.0℃以下贮藏的药品共计104种(占比31.23%),这些药品的总配送次数为1058次(占比19.63%);温控模拟实验及验证实验结果显示,“纸箱+泡沫箱+复合铝膜珍珠棉+500g冷冻冰袋×2+气柱袋”次日达配送过程中药品包装内平均最高温度为9.6℃,平均最低温度为2.7℃,总体温度均处于15.0℃以下,可有效保障药品质量。结论在夏季高温条件下,“纸箱+泡沫箱+复合铝膜珍珠棉+500g冷冻冰袋×2+气柱袋”的贮运装置可以满足北京同城配送药品的贮藏温度要求。

关键词：互联网+药品高温北京贮运装置配送温度

Optical polarization response at gold nanosheet edges probed by scanning near-field optical microscopy

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Chinese Physics B 2018年第8期27卷 554-558页

作者： Zhuan-fang Bi Mu Yang Guang-Yi shang Department of Applied Physics Key Laboratory of Mircro-nano Measurement-manipulation and Physics（Ministry of Education）Beihang UniversityBeijing 100191China Beijing Institute of Space Mechanics and Electronics CASTBeijing 100191China

Optical properties of metallic edge-like structures known as knife-edges are a topic of interest and possess potential applications in enhanced Raman scattering, optical trapping, etc. In this work, we investigate the near-field optical polar- ization response at the edge of a triangular gold nanosheet, which is synthesized by a wet chemical method. A homemade scanning near-field optical microscope （SNOM） in collection mode is adopted, which is able to accurately locate its probe at the edge during experiments. An uncoated straight fiber probe is used in the SNOM, because it s611 preserves the prop- erty of light polarization though it has the depolarization to some extent. By comparing near-field intensities at the edge and glass substrate, detected in different polarization directions of incident light, the edge-induced depolarization is found, which is supported by the finite differential time domain （FDTD） simulated results. The depolarized phenomenon in the near-field is similar to that in the far-field.

关键词： nanosheet scanning near-field optical microscopy edge effect depotarization

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基于源头质量控制理念的供应商培育方案

中国质量 2024年第6期 104-109页

作者：陶前林方林陶成松上官孟琦合肥中车轨道交通车辆有限公司

在工业全球化的浪潮下，生产制造型企业面临着愈发严峻的国内外竞争环境，如生产周期缩减、原材料价格上涨、用工成本上升、生产流水线工作量不饱和等诸多问题，制约着产品质量水平的提升，这种对产品质量的影响涉及整个供应链的上下游... 详细信息

在工业全球化的浪潮下，生产制造型企业面临着愈发严峻的国内外竞争环境，如生产周期缩减、原材料价格上涨、用工成本上升、生产流水线工作量不饱和等诸多问题，制约着产品质量水平的提升，这种对产品质量的影响涉及整个供应链的上下游。而作为生产制造型企业，特别是作为终端产品制造的主机厂，除了要面对自身质量控制的压力外，供应商甚至分供方的产品源头质量问题也愈发突出，直接影响产品关键质量指标的实现。因此，此类企业应当利用自身质量管理体系健全、质量控制流程成熟、质量管理手段丰富的优势，帮扶供应商完成其内部的质量管理升级，培育出具有较高质量控制水平的供应商，特别是核心零部件及关键零部件供应商。本文通过对生产制造型企业供应商产品质量问题及其影响进行分析和研究，提出了一套供应商培育方案，用以提升企业供应商质量管理水平，做好从源头质量控制，达到提升最终产品质量的目标。

关键词：产品质量供应商培育源头质量