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Bone Morphogenic Protein 9(BMP9)/Growth Differentiation Factor 2(GDF2)modulates mouse adult hippocampal neurogenesis by regulating the survival of early neural progenitors

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Genes & Diseases 2023年第4期10卷 1175-1179页

作者： Mary Rose Rogers Wei Zeng Xian Zhang Ruidong Li Qiang Wei Yuhan Kong Piao Zhao Guozhi Zhao Yonghui Wang Jiamin Zhong Yi Zhu Rex C.Haydon hue H.Luu Russell R.Reid Daniel A.Peterson Michael J.Lee Tong-Chuan He Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Graduate Program Committee on Genetics Genomics and System BiologyThe University of ChicagoChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Neurology The Second Affiliated Hospital of Jianghan UniversityWuhanHubei 430000China Department of Orthopaedic Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Clinical Laboratory Medicine Rehabilitation MedicineOrthopaedic Surgery and UrologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Endocrinology Shanghai Jiao-Tong University School of MedicineShanghai 200000China Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopaedic Surgery Beijing HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Center for Stem Cell and Regenerative Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

Adult neurogenesis occurs in two specialized regions of the mammalian brain,the subventricular zone(SVZ)and the subgranular zone(SGZ)of the dentate gyrus(DG).^(1)Adult hippocampal neural stem cells(NSCs),referred to as Type 1 cells represented by radial glia-like cells(RGLs),generate Type 2 cells that are divided into Type 2a and Type 2 b subpopulations,the latter of which give rise to Type 3 cells(neuroblasts).

关键词： neural progenitor ventricular

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Software Application of the New Algorithm for Restoration of Faded Photographs and Maps in Geology

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Management Studies 2017年第1期5卷 57-66页

作者： Le Thanh hue Hanoi University of Mining and Geology Hanoi Vietnam

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Doppler Ultrasound Abnormalities of the Lower Limbs in Patients with Diabetic Foot at the Yopougon University Hospital in Ivory Coast

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Open Journal of Endocrine and Metabolic Diseases 2022年第5期12卷 113-121页

作者： Kossi Kodjo Mamadou Mansour Diallo Alpha Mamadou Diallo Koffi Pierre Dago Adelaide hue Assita Yao Abodo Jacko Adrien Lokrou Department of Endocrinology and Diabetes Yopougon University Hospital Abidjan Ivory Coast Department of Internal Medicine and Endocrinology Sylvanus Olympio University Hospital of Lomé Faculty of Health Sciences University of Lomé Lomé Togo Department of Endocrinology Diabetology Donka Hospital University Hospital of Conakry Conakry Guinea

Background: Diabetic foot is a frequent complication of diabetes, of multifactorial origin, associating nervous and/or circulatory disorders to which infection is often added. Its care is multidisciplinary and requires coordination between different actors. In this context, arterial doppler ultrasound is essential in the diagnosis of diabetic arteriopathy and participates in therapeutic decision-making. The aim of this study was to describe the abnormalities found on Doppler ultrasonography of patients hospitalized for the diabetic foot in the Ivory Coast. Methods: We conducted a retrospective descriptive study including 235 patients hospitalized for the diabetic foot in the Endocrinology department of the Yopougon University Hospital from February 2002 to December 2015. All records of patients who performed arterial Doppler ultrasound of the lower limbs were selected and the various abnormalities were described. Results: The sex ratio (M/F) was 1.1 (124 men to 111 women). The predominant age group was 61.2 years. Type 2 diabetes was found in 97.4% of cases. The average evolution of diabetes was 8.9 years with extremes of 1 and 32 years. Wet gangrene was the most common type of lesion found in 75.8% of cases. On ultrasonography, 98.7% of the patients had an arterial abnormality of the lower limbs. It was bilateral in 62.2% of cases, dominated by atheromatous overloads and mediacalcosis in 46.4% and 43.8% of cases, respectively. Arterial stenosis was lesions hemodynamically found in 76.3% of cases and arterial occlusions in 32.7% of cases. The amputation rate was 72.7%. Conclusion: This study shows the high frequency of arterial abnormalities in patients with the diabetic foot with a predominantly distal involvement. Arterial Doppler ultrasound of the lower limbs remains an essential tool in the care of diabetic foot. This easily accessible, non-invasive examination has a key role in therapeutic decision-making.

关键词： Diabetes Arterial Doppler Ultrasound Arteriopathy Ivory Coast

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Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance

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Genes & Diseases 2022年第6期9卷 1608-1623页

作者： William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon The Pritzker School of Medicine and the Medical Scientist Training ProgramThe University of Chicago Medical CenterChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Surgery The University of Chicago Medical CenterChicagoIL 60637USA

Cutaneous melanoma is a common cancer and cases have steadily increased since the mid *** some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment *** sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically *** initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory *** represent an alternative to molecular targeted ***,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long *** the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of *** future direction of the field may be to find a molecule that connects all of the ***,noncoding RNAs have been shown to play important roles in melanoma development and *** noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current *** review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool.

关键词： BRAF inhibitors Checkpoint inhibitors Drug resistance Immunotherapy Melanoma Melanoma metastasis Skin cancer Targeted therapy Therapeutic resistance

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Spontaneous Absorption of a Lumbar Epidural Hematoma after Interlaminar Epidural Steroid Injection in a Patient with Spinal Stenosis： Close Observation as a Treatment Strategy

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Chinese Medical Journal 2018年第1期131卷 117-118页

作者： Soo Hyang Kim Yun Joung Han Young Hoon Kim Jae Min Lee Yoo Mi Kim hue Jung Park Department of Anesthesiology and Pain Medicine College of Medicine Seoul St. Mary's Hospital The Catholic University of Korea Seoul 06591 Korea

To the Editor： A lumbar epidural block is used to treat patients with a herniated intervertebral disc, spinal stenosis, or lumbosacral radiculopathy. This approach reduces radicular pain by decreasing inflammation of nerve roots through epidural corticosteroid injection. Patients with moderate-to-severe spinal stenosis who taking various anticoagulant agents have more risk for epidural hematoma.

关键词： Spontaneous Absorption a Lumbar Epidural Hematoma after Interlaminar

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Base-mesocompact Spaces

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Chinese Quarterly Journal of Mathematics 2010年第3期25卷 430-435页

作者： CAO Jin-wen SONG Ji-ping LIU hue Department of Applied Mathematics Chengdu University of Technology Chengdu 610059 China Department of Mathematics Leshan Teachers College Leshan 614004 China

在这份报纸， base-mesocompactness 的符号被介绍，下列结果主要被获得:( 1 )让 X 是 *** X 的一个 F 子集是的 base-mesocompact 和X'正常，当时，X'是相对让的X.( 2 )的 base-mesocompact f : X Y 是印射的 base-mesocompact ，(X... 详细信息

在这份报纸， base-mesocompactness 的符号被介绍，下列结果主要被获得:( 1 )让 X 是 *** X 的一个 F 子集是的 base-mesocompact 和X'正常，当时，X'是相对让的X.( 2 )的 base-mesocompact f : X Y 是印射的 base-mesocompact ，(X)是 X 的常规集的势， w (X)(Y) .If Y 是 base-mesocompact 并且常规，当时， X 是让的base-mesocompact.( 3 ) f : X Y 是与常规领域印射的关上的 lindelof ，常规 *** Y 是 base-mesocompact ，当时， X 是base-mesocompact.( 4 )

关键词： base-mesocompact 印射的 base-paracompact 印射的 base-mesocompact 印射的关上的 lindelof

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汉越俗语对比及教学研究

汉越俗语对比及教学研究

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作者：阮氏秋慧（NGUYEN THI THU hue）辽宁师范大学

学位级别：硕士

俗语是由人民群众在生产或生活中创造出并通过口头流传的定型语句,反映人民从实践总结出来的经验以及对生活的愿望。众所周知,中越两国自古以来在各领域已有着频繁的交往,所以越南语言和文化也受到中国的深刻影响,有许多相同之处,俗语... 详细信息

俗语是由人民群众在生产或生活中创造出并通过口头流传的定型语句,反映人民从实践总结出来的经验以及对生活的愿望。众所周知,中越两国自古以来在各领域已有着频繁的交往,所以越南语言和文化也受到中国的深刻影响,有许多相同之处,俗语也不例外。虽然汉越俗语相同之处较多,但对于越南学生,汉语俗语是很难把握的语言现象。因此,本论文通过汉越俗语的对比分析、教材中俗语编写的考察分析以及越南学生汉语俗语使用与偏误的情况调查,分析越南学生在学习和使用汉语俗语过程中所遇到的问题,从而对汉语俗语的学习和教学提出建议。全部论文共八部分,具体是:第一部分:绪论,说明本论文研究背景、研究意义、研究理论、研究方法以及语料来源。第二部分:对前人已研究成果进行综述,包括汉语俗语本体的研究综述、越南语俗语本体的研究综述、汉越俗语对比的研究综述和对外汉语俗语教学的研究综述。第三部分:介绍汉语俗语和越南语俗语的定义、来源和特征。第四部分:对汉语俗语和越南语俗语的句法结构和语义语形进行对比,找出汉越俗语同大异小。第五部分:对《汉语教程》教材中所出现的俗语进行统计、分类以及分析其编写特点,从而指出本教材俗语编写的不足:俗语释义数量不够、释义内容不完善、俗语练习单一和俗语复现率低。第六部分:以《汉语教程》教材中的俗语为调查问卷的语料来源,对越南学生汉语俗语的使用和偏误情况进行调查分析。从问卷调查结果总结出偏误类型,其包括书写偏误、表达偏误、语义偏误和语用偏误。根据调查结果和偏误类型总结偏误的原因,其包括母语负迁移、目的语知识负迁移、学生学习策略的影响和教材中俗语编写的局限。第七部分:根据上述调查研究的结果,针对越南学生的俗语学习、教学和教材中俗语编写提出建议。具体,教师可以运用对比分析方法进行教学,以避免母语负迁移、及时纠正偏误,以避免目的语负迁移、创造实际情景进行教学、利用各种教学资源。越南学生要调整学习方法并采用网络资源来学习汉语俗语。在教材中俗语编写方面,要选编适合学生汉语水平的俗语、完善俗语释义内容以及完善俗语练习。第八部分:结语,对本文研究进行总结,并说明本文的创新之处以及不足之处。

关键词：汉语俗语越南语俗语对比研究汉语俗语教学

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粉煤灰作惰性粒子的镍复合镀层(英文)

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Transactions of Nonferrous Metals Society of China 2013年第8期23卷 2348-2353页

作者： Viet hue NGUYEN Thi Anh Tuyet NGO Hong Hanh PHAM Ngoc Phong NGUYEN Institute of Materials Science

用粉煤灰(FA)作为惰性粒子,电沉积得到复合镀层Ni/FA。粉煤灰的尺寸为3-7μm,主要成分是72%SiO2和25%Al2O3。进行电沉积的工艺条件是瓦兹镀镍液含粉煤灰的浓度为5、20、50 g/L,电流密度为2、4A/dm2,温度为50℃,磁搅拌速度为250 r/min。... 详细信息

用粉煤灰(FA)作为惰性粒子,电沉积得到复合镀层Ni/FA。粉煤灰的尺寸为3-7μm,主要成分是72%SiO2和25%Al2O3。进行电沉积的工艺条件是瓦兹镀镍液含粉煤灰的浓度为5、20、50 g/L,电流密度为2、4A/dm2,温度为50℃,磁搅拌速度为250 r/min。采用扫描电子显微镜(SEM+EDX)、电化学测试和硬度测量来研究复合镀层Ni/FA的形态、成分和性能。镀层中粉煤灰的含量与镀液中粉煤灰的浓度以及相关工艺参数有关。由于镀层中加入了粉煤灰从而使镀层的力学与电化学性能得到改善。复合镀层Ni/FA的硬度达HV430,而纯Ni镀层的硬度只有HV198。电化学测试表明,复合镀层Ni/FA的耐腐蚀比纯镍镀层的高。

关键词：复合镀层粉煤灰显微观硬度耐腐蚀性惰性粒子

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Dicoumarol Alters Cellular Redox State and Inhibits Nuclear Factor Kappa B to Enhance Arsenic Trioxide-Induced Apoptosis

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Acta Biochimica et Biophysica Sinica 2004年第3期36卷 235-242页

作者： Ya-Wu JING, Jing YI, Yu-Ying CHEN, Qing-Shen HU, Gui-Ying SHI, hue LI, and Xue-Ming TANG* Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China Department of Cell Biology Shanghai Second Medical University

The effects of a number of cytotoxic drugs are influenced by cellular reduction/oxidation (redox) state. In the present study, we attempt to explore if dicoumarol, an inhibitor of NADPH: quinone oxidoreductase (NQO1), alters the cellular redox state and how this alteration affects the redox-related apoptosis. Flow cytometry was used to assess the reactive oxygen species (ROS) level and apoptotic rates of HeLa cells treated with arsenic trioxide (As2O3) alone or in combination with natural anthraquinone emodin and dicoumarol or plus N-acetyl-cysteine. Western blot, immunofluorescence, electrophoretic mobility shift assay and luciferase assay were used to detect Nuclear Factor kappa B (NF-κB) activation. The results showed that dicoumarol synergized with emodin to sensitize HeLa cells to As2O3-induced apoptosis through raising the ROS level. More notably, this enhanced susceptibility was associated with a ROS-mediated inhi- bition of NF-κB activation in which the combinative treatment with dicoumarol prevented NF-κB from binding to target DNA. It was suggested that dicoumarol in combination with anthraquinones might be a novel strategy to expand the chemotherapeutic spectrum of As2O3 by means of interfering the cellular redox state.

关键词： dicoumarol arsenic trioxide reduction/ oxidation state apoptosis NF-κB

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商品市场与金融市场之间的关系 ——来自原油价格,股票市场和汇率的证据

商品市场与金融市场之间的关系 ——来...

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作者： Do hue Linh 上海财经大学

学位级别：硕士

传统上,股票和债券一直在投资者的投资组合中占主导地位,而商品通常出现在工业和消费领域。自2000年代以来,考虑到投资组合多元化带来的收益,投资者可能会将商品与金融资产,例如股票和外汇,一起纳入其金融投资组合中。然而,商品价格飞涨... 详细信息

传统上,股票和债券一直在投资者的投资组合中占主导地位,而商品通常出现在工业和消费领域。自2000年代以来,考虑到投资组合多元化带来的收益,投资者可能会将商品与金融资产,例如股票和外汇,一起纳入其金融投资组合中。然而,商品价格飞涨,加上商品在参与金融活动或金融化之后立即增加的波动性,意味着两个曾经没有关系或关系较弱的市场之间的联系更加紧密和复杂,这动摇了投资组合多元化的信念。因此,本论文旨在研究以原油价格为代表的商品市场与以股票收益率和汇率组成的金融市场之间的关系。通过搜集整理美国能源信息署（EIA）官方网站、上海证券交易所平台和美联储经济数据,得到从1993年12月31日到2020年12月31日的每日样本数据,包括WTI原油价格,上交所综合指数及人民币对美元的汇率。实证结果表明,原油,股票价格和汇率之间的关系确实存在,但取决于不同的时间段。具体而言,在2000年代商品市场金融化之前,原油和股票价格之间的相关关系最不稳定,通常为负,此后则为正。关于原油和汇率之间的相关性,波动仍然存在,但幅度较小。至于股票价格和汇率这两个金融市场因素的相关性,在整个采样时间内,除了从商品市场金融化开始到危机前的2008-2009年期间,该相关性完全为负。

关键词：商品市场金融市场金融化原油股票收益率汇率相关性

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