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Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process

Neural Regeneration Research 2021年第1期16卷 58-67页

作者： Mariana Toricelli Arthur Antonio Ruiz Pereira Guilherme Souza Abrao Helena Nascimento Malerba Julia Maia hudson sousa buck Tania Araujo Viel Department of Physiological Sciences Santa Casa de Sao Paulo School of Medical SciencesSao PauloBrazil Laboratory of Neurobiology of Aging School of ArtsSciences and HumanitiesUniversidade de São PauloSao PauloBrazil

Aging is a dynamic and progressive process that begins at conception and continues until *** process leads to a decrease in homeostasis and morphological,biochemical and psychological changes,increasing the individual’s vulnerability to various *** growth in the number of aging populations has increased the prevalence of chronic degenerative diseases,impairment of the central nervous system and dementias,such as Alzheimer’s disease,whose main risk factor is age,leading to an increase of the number of individuals who need daily support for life *** theories about aging suggest it is caused by an increase of cellular senescence and reactive oxygen species,which leads to inflammation,oxidation,cell membrane damage and consequently neuronal ***,mitochondrial mutations,which are generated throughout the aging process,can lead to changes in energy production,deficiencies in electron transport and apoptosis induction that can result in decreased ***,increasing cellular senescence and the release of proinflammatory cytokines can cause irreversible damage to neuronal *** reports point to the importance of changing lifestyle by increasing physical exercise,improving nutrition and environmental enrichment to activate neuroprotective defense ***,this review aims to address the latest information about the different mechanisms related to neuroplasticity and neuronal death and to provide strategies that can improve neuroprotection and decrease the neurodegeneration caused by aging and environmental stressors.

关键词： cell senescence cell signaling cholinergic enriched environment long-term potentiation neurodegeneration neurogenesis neuroinflammatory neuronal death neuroprotection neurotophin

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Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new?

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World Journal of Clinical Pediatrics 2024年第1期13卷 7-13页

作者： Alexandra S hudson Ghassan T Wahbeh Hengqi Betty Zheng Department of Pediatrics University of WashingtonSeattleWA 98109United States

Pediatric inflammatory bowel disease(IBD)is a chronic inflammatory disorder,with increasing incidence and prevalence *** have been recent advances in imaging and endoscopic technology for disease diagnosis,treatment,and *** ultrasound,including transabdominal,transperineal,and endoscopic,has been emerging for the assessment of transmural bowel inflammation and disease complications(e.g.,fistula,abscess).Aside from surgery,IBD-related intestinal strictures now have endoscopic treatment options including through-the-scope balloon dilatation,injection,and needle knife stricturotomy and new evaluation tools such as endoscopic functional lumen imaging *** transnasal endoscopy may have a role in patients with upper gastrointestinal Crohn’s disease or those with IBD with new upper gastrointestinal *** to dysplasia screening in pediatric patients with longstanding colonic disease or primary sclerosing cholangitis hold promise with the addition of virtual chromoendoscopy and ongoing research in the field of artificial intelligence-assisted endoscopic *** intelligence and machine learning is a rapidly evolving field,with goals of further personalizing IBD diagnosis and treatment selection as well as *** review summarized these advancements,focusing on pediatric patients with IBD.

关键词： Intestinal ultrasound Endoscopy Inflammatory bowel disease Pediatrics Imaging

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn E.hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven L.Spitalnik Vassilis L.Tzounakas Department of Biochemistry School of MedicineUniversity of Patras26504 PatrasGreece Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA Laboratory of Reliability and Quality Control in Laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA Present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain

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阿拉伯字体设计,探寻神秘的桥梁

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艺术与设计 2024年第2期 20-61页

作者：吉丽 Thames&hudson(图) 不详

全球超过4.4亿人讲阿拉伯语,但阿拉伯国家与其他国家之间的文化差异所带来的认知鸿沟依然存在,固然神秘,但也为全球化浪潮中的文化交融与碰撞带来困难。语言是文化的载体,也是交流的桥梁。当我们尝试跨越这道桥梁,走向一个陌生而又庞大... 详细信息

全球超过4.4亿人讲阿拉伯语,但阿拉伯国家与其他国家之间的文化差异所带来的认知鸿沟依然存在,固然神秘,但也为全球化浪潮中的文化交融与碰撞带来困难。语言是文化的载体,也是交流的桥梁。当我们尝试跨越这道桥梁,走向一个陌生而又庞大的阿拉伯语使用者群体时,理解其背后的历史、宗教、文化细微差别,就显得尤为重要。

关键词：字体设计细微差别阿拉伯语全球化浪潮认知鸿沟文化差异交流的桥梁神秘

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尾矿的特性、灾害及其资源潜力

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金属矿山 2024年第8期 216-227页

作者：王昆张峥 KAREN A.hudson-EDWARDS 杨鹏诸利一杨修志陈志翔山东科技大学能源与矿业工程学院山东青岛266590 埃克塞特大学环境与可持续发展研究所英国康沃尔TR109FE 北京市信息服务工程重点实验室北京100010 北京科技大学土木与资源工程学院北京100083 山东省科技服务发展推进中心山东济南250101

尾矿是矿石磨细选别后残余的固体废弃物,尾矿物理化学特性及尾矿库的常规地表堆存共同导致尾矿库存在较大的安全与环境风险。低品位矿体高强度开采趋势下,我国尾矿年排放量维持在10亿t以上的高位,累计堆存规模超200亿t,细粒尾矿堆存方... 详细信息

尾矿是矿石磨细选别后残余的固体废弃物,尾矿物理化学特性及尾矿库的常规地表堆存共同导致尾矿库存在较大的安全与环境风险。低品位矿体高强度开采趋势下,我国尾矿年排放量维持在10亿t以上的高位,累计堆存规模超200亿t,细粒尾矿堆存方式、潜在灾害防治及综合利用面临新挑战,采选新技术装备及政策利好因素推动尾矿资源潜力亟待释放。因此,以尾矿物理化学特性、排放堆存方法、溃坝灾害、尾矿资源潜力为主线,综述了尾矿物理化学特性、尾矿堆存形式、尾矿溃坝灾害防治等方面的研究进展,系统梳理了尾矿空区充填、尾矿制备材料、尾矿二次利用、超积累植物提取金属元素、尾矿固碳等资源综合利用方法,可为研究者及工业界系统全面地重新审视尾矿废弃物特性、尾矿库灾害防治、矿产可持续开发利用提供启示。

关键词：尾矿库溃坝灾害环境危害尾矿综合利用

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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A system-on-chip microwave photonic processor solves dynamic RF interference in real time with picosecond latency

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Light(Science & Applications) 2024年第1期13卷 91-102页

作者： Weipeng Zhang Joshua C.Lederman Thomas Ferreira de Lima Jiawei Zhang Simon Bilodeau Leila hudson Alexander Tait Bhavin J.Shastri Paul R.Prucnal Department of Electrical and Computer Engineering Princeton UniversityPrinceton08544NJUSA NEC Laboratories America Princeton08540NJUSA Department of Electrical and Computer Engineering Queen’s UniversityKingstonK7L 3N6OntarioCanada Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonK7L 3N6OntarioCanada

Radio-frequency interference is a growing concern as wireless technology advances,with potentially life-threatening consequences like interference between radar altimeters and 5 G cellular *** transceivers mix signals with varying ratios over time,posing challenges for conventional digital signal processing(DSP)due to its high *** challenges will worsen as future wireless technologies adopt higher carrier frequencies and data ***,conventional DSPs,already on the brink of their clock frequency limit,are expected to offer only marginal speed *** paper introduces a photonic processor to address dynamic interference through blind source separation(BSS).Our system-on-chip processor employs a fully integrated photonic signal pathway in the analogue domain,enabling rapid demixing of received mixtures and recovering the signal-of-interest in under 15 *** reduction in latency surpasses electronic counterparts by more than three orders of *** complement the photonic processor,electronic peripherals based on field-programmable gate array(FPGA)assess the effectiveness of demixing and continuously update demixing weights at a rate of up to 305 *** compact setup features precise dithering weight control,impedance-controlled circuit board and optical fibre packaging,suitable for handheld and mobile *** experimentally demonstrate the processor’s ability to suppress transmission errors and maintain signal-to-noise ratios in two scenarios,radar altimeters and mobile *** work pioneers the real-time adaptability of integrated silicon photonics,enabling online learning and weight adjustments,and showcasing practical operational applications for photonic processing.

关键词： processor mixing dynamic

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Potential Linkages Between Social Capital,Flood Risk Perceptions,and Self-Efficacy

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International Journal of Disaster Risk Science 2020年第3期11卷 251-262页

作者： Paul hudson Liselotte Hagedoorn Philip Bubeck Institute of Environmental Science and Geography University of Potsdam14476 PotsdamGermany Institute for Environmental Studies Vrije University1081 HV AmsterdamThe Netherlands

A growing focus is being placed on both individuals and communities to adapt to flooding as part of the Sendai Framework for Disaster Risk Reduction 2015–*** to flooding requires sufficient social capital(linkages between members of society),risk perceptions(understanding of risk),and self-efficacy(selfperceived ability to limit disaster impacts)to be ***,there is limited understanding of how social capital,risk perceptions,and self-efficacy *** seek to explore how social capital interacts with variables known to increase the likelihood of successful *** study these linkages we analyze survey data of 1010 respondents across two communities in Thua Tien-Hue Province in central Vietnam,using ordered probit *** find positive correlations between social capital,risk perceptions,and self-efficacy *** is a partly contrary finding to what was found in previous studies linking these concepts in Europe,which may be a result from the difference in risk *** absence of an overall negative exchange between these factors has positive implications for proactive flood risk adaptation.

关键词： Flood risk Protection motivation theory Risk perceptions Social capital Self-efficacy Vietnam

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Synthesis, Mechanism of Formation and Insecticidal Activity of Novel Fluorinated Organophosphorus Compounds

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Chinese Journal of Chemistry 2002年第12期20卷 1598-1601,1464页

作者：吴军 hudson Harry R. Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 China Division of Chemistry School of Biological and Applied Sciences University of North London London N7 8DB UK

The major products of the interaction between triethyl phosphite and 3-fluoropropanoyl chloride at room temperature are diethyl (E)-1-(3-fluoropropanoyloxy)-3-fluoroprop-1-enylphosphonate (3) and diethyl l-(diethoxyphosphoryl)-3-fluoropropyl phosphate (4). The compounds 3 and 4 were separated by chromatography, and structurally characterized by elemental analysis, NMR spectroscopy (1H, 13C, 19F and 31P) and mass spectrometry. Possible reaction mechanisms are proposed. The major products 3 and 4 were tested for insecticidal activity. 3 gave 100% control of Musca domestica L. and Phaedon cochledriae Fab. at a dose of 20 μg/per insect.

关键词： synthesis reaction mechanism insecticidal activity fluorinated organophosphonate

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