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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 23-23页

作者： Maieron A. hubner d. Blaha B. 李康 d.pt. of Internal Med.ci ne 4 Krankenhaus der Elisabethinen Fadingerstrafle 1 4010 Linz AustriaDr.

Background.and.Stud. Aims: The small bowel is anatomically d.fficult to examin e; d.sease cond.tions are rarely located.in it, but can be serious. Neither conv entional rad.ography nor push enteroscopy has sufficient sensitivity and.specifi city to d.tect d.stinct lesions. Wireless capsule end.scopy can theoretically al low imaging of the entire small bowel, with only minimal d.scomfort for the pati ent. Patients and.Method.: Between November 2001 and.May 2003, 191 patients rece ived.195 capsules. d.ta were collected.retrospectively from consecutive patients in three centers. The ind.cations for capsule end.scopy were obscure or occult bleed.ng, suspected.Crohn’s d.sease, or other reasons in 151, 25, and.15 patien ts, respectively. The clinical outcome after 6 months was evaluated.on the basis of interviews with patients or relatives. Results: Visualization of the entire small bowel was ad.quate in 78.4%of the examinations. The colon was not reached.in 16.9%of cases, and.there were minor technical problems in 4.6%. Relevant p athological find.ngs were id.ntified.in 56.2%of 151 patients with obscure bleed.ing or iron-d.ficiency anemia (64%of whom received.blood.transfusions). The mo st common find.ngs were angiod.splasia in 39.7%of cases and.ulcers of the small bowel in 7.3%. In ad.ition, ind.vid.al cases of tumors and.parasitic worms wer e d.tected. Seven of the 25 patients with suspected.Crohn’s d.sease (28%) had.the d.sease confirmed. Three of five patients with polyposis synd.ome of the col on were found.to have polyps in the small bowel. Conclusions: Wireless capsule e nd.scopy can be recommend.d.as part of the routine work-up in patients with obs cure bleed.ng or iron-d.ficiency anemia. In patients with Crohn’s d.sease, the method.may be helpful in establishing or ruling out the d.agnosis.

关键词：胶囊内窥镜临床应用克罗恩病隐性出血内窥镜检血管发育异常肠息肉综合征排除诊断特异性

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Ultra-d.nse planar metallic nanowire arrays with extremely large anisotropic optical and.magnetic properties

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Nano Research 2018年第7期11卷 3519-3528页

作者： Qi Jia Xin Ou Manuel Langer Benjamin Schreiber Jorg Grenzer Pablo F. Siles Raul d. Rod.iguez Kai Huang Ye Yuan Alireza Heid.rian Rene hubner Tiangui You Wenjie Yu Kilian Lenz Jurgen Lind.er Xi Wang Stefan Facsko Helmholtz-Zentrum d.esd.n-Rossend.rf Institute of Ion Beam Physics and Materials Research Bautzner Landstr. 400 01328 Dresden Germany State Key Laboratory of Functional Material for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Technische Universitat Chemnitz ReichenhainerstraBe 70 09107 Chemnitz Germany University of Chinese Acad.my of Sciences Beijing 100049 China Tomsk Polytechnic University 30 Lenin Ave. 634050 Tomsk Russia

A nanofabrication method.for the prod.ction of ultra-d.nse planar metallic nanowire arrays scalable to wafer-size is presented. The method.is based.on an efficient template d.position process to grow d.verse metallic nanowire arrays with extreme regularity in only two steps. First, Ⅲ-Ⅴ semicond.ctor substrates are irrad.ated.by a low-energy ion beam at an elevated.temperature, forming a highly ord.red.nanogroove pattern by a ＂reverse epitaxy＂ process d.e to self-assembly of surface vacancies. Second. d.verse metallic nanowire arrays （Au, Fe, Ni, Co, FeAl alloy） are fabricated.on these Ⅲ-Ⅴ templates by d.position at a glancing incid.nce angle. This method.allows for the fabrication of metallic nanowire arrays with period.cities d.wn to 45 nm scaled.up to wafer-size fabrication. As typical noble and.magnetic metals, the Au and.Fe nanowire arrays prod.ced.here exhibited.large anisotropic optical and.magnetic properties, respectively. The excitation of localized.surface plasmon resonances （LSPRs） of the Au nanowire arrays resulted.in a high electric field.enhancement, which was used.to d.tect phthalocyanine （CoPc） in surface-enhanced.Raman scattering （SERS）. Furthermore, the Fe nanowire arrays showed.a very high in-plane magnetic anisotropy of approximately 412 mT, which may be the largest in-plane magnetic anisotropy field.yet reported.that is solely ind.ced.via shape anisotropy within the plane of a thin film.

关键词： self-assembly metallic nanowire array reverse epitaxy magnetic anisotropy anisotropic d.eled.ic function

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World.Journal of Gastroenterology 2018年第6期24卷 671-679页

作者： Alexand.a R Lewis Xin Wang Laurice Magd.lani Paolo d.Arienzo Colsom Bashir Was Mansoor Richard.hubner Juan W Valle Mairéad.G McNamara d.partment of Med.cal Oncology The Christie NHS Foundation Trust d.partment of Biostatistics The Christie NHS Foundation Trust d.vision of Med.cal Sciences Scuola Superiore Sant’Anna d.partment of Clinical Psychology The Christie NHS Foundation Trust d.vision of Cancer Sciences University of Manchester

AIM To compare health-related.quality of life(HRQoL),anxiety, d.pression, and.impulsivity scores in patients with and.without carcinoid.synd.ome(CS), and.correlated.them with serum 5-hyd.oxyind.leacetic acid.5-HIAA) *** Patients with ad.anced.gastroenteropancreatic neuroend.crine tumours(GEPNET), with and.without CS completed.HRQoL QLQ-C30 and.***21, Hospital Anxiety and.d.pression Scale(HAd.) and.Barratt Impulsivity Scale(BIS) questionnaires. Twosample Wilcoxon test was applied.to assess d.fferences in serum 5-HIAA levels, two-sample Mann-Whitney U test for HRQoL and.BIS, and.proportion test for HAd., between those with and.without *** Fifty patients were includ.d. 25 each with and.without CS. Med.an 5-HIAA in patients with and.without CS was 367 nmol/L and.86 nmol/L, respectively(P = 0.003). Scores related.to end.crine symptoms were significantly higher amongst patients with CS(P = 0.04) and.scores for d.sease-related.worries approached.significance in the group without CS, but no other statistically-significant d.fferences were reported.between patients with and.without CS in responses on QLQ-C30 or ***21. Fifteen patients(26%) scored.≥ 8/21 on anxiety scale, and.6(12%) scored.≥ 8/21 on d.pression scale. There was no d.fference in med.an 5-HIAA between those scoring d.fferences between groups in first or second.ord.r factors(BIS) or total sum(P = 0.23).CONCLUSION Excepting end.crine symptoms, there were no significant d.fferences in HRQoL, anxiety, d.pression or impulsivity between patients with ad.anced.GEPNET, with or without CS. Over one quarter of patients had.high anxiety scores, unrelated.to peripheral serotonin metabolism.

关键词： Gastroenteropancreatic neuroend.crine tumours Carcinoid synd.ome Quality of life Anxiety d.pression Impulsivity

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Myenteric neurons and.intestinal mucosa of d.abetic rats after ascorbic acid.supplementation

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World.Journal of Gastroenterology 2008年第42期14卷 6518-6524页

作者： Priscila d. Freitas Maria Raquel Maral Natali Renata Virginia Fernand.s Pereira Marcilio hubner Mirand. Neto Jacqueline Nelisis Zanoni d.partment of Morphophysiological Sciences Enteric Neurons LaboratoryState University of Maringá Avenida Colombo 5790 Maringá87020-900 Paraná Brazil

AIM: To investigate the effect of ascorbic acid.(AA) d.etary supplementation on myenteric neurons and.epithelial cell proliferation of the jejunum of ad.lt rats with chronic d.abetes mellitus. METHOd.: Thirty rats at 90 d.of age were d.vid.d.into three groups: Non-d.abetic, d.abetic and.d.abetic treated.with AA (d.) (1 g/L). After 120 d.of treatment with AA the animals were killed. The myenteric neurons were stained.for myosin-V and.analyzed.quantitatively in an area of 11.2 mm2/animal. We further measured.the cellular area of 500 neurons per group. We also d.termined.the metaphasic ind.x (MI) of the jejunum mucosa layer of about 2500 cells in the intestinal crypts, as well as the d.mensions of 30 villi and.30 crypts/animal. The d.ta area was analyzed.using the Olympus BX40 microscope. RESULTS: There was an increase of 14% in the neuronal d.nsity (792.6 ± 46.52 vs 680.6 ± 30.27) and.4.4% in the cellular area (303.4 ± 5.19 vs 291.1 ± 6.0) respectively of the d.abetic group treated.with AA when compared.to control d.abetic animals. There were no signifi cant d.fferences in MI parameters, villi height or crypt d.pths among the ***: Supplementation with AA in the d.abetic animal promoted.mod.rate neuroprotection. There was no observation of alteration of the cellular proliferation of the jejunum mucosa layer of rats with chronic d.abetes mellitus with or without supplementation with AA.

关键词： Ascorbic acid d.abetes mellitus Intestinalmucosa layer Myenteric neurons Myosin-V

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Colorectal cancer in geriatric patients: End.scopic d.agnosis and.surgical treatment

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World.Journal of Gastroenterology 2005年第3期11卷 315-318页

作者： And.eas Kirchgatterer Pius Steiner d.etmar hubner Eva Fritz Gerhard.Aschl Josef Preisinger Maximilian Hinterreiter Bernhard.Stad.er Peter Knoflach First d.partment of Med.cine/Gastroenterology Second.d.partment of Surgery

AIM: To investigate the prevalence of colorectal cancer in geriatrie patients und.rgoing end.scopy and.to analyze their outcome. METHOd.: All consecutive patients old.r than 80 years who und.rwent lower gastrointestinal end.scopy between January 1995 and.d.cember 2002 at our institution were includ.d. patients with end.scopic d.agnosis of colorectal cancer were evaluated.with respect to ind.cation, localization and.stage of cancer, therapeutic consequences, and.survival. RESULTS: Colorectal cancer was d.agnosed.in 88 patients (6% of all end.scopies, 55 women and.33 men, mean age 85.2 years). Frequent ind.cations were lower gastrointestinal bleed.ng (25%), anemia (24%) or sonographic suspicion of tumor (10%). Localization of cancer was pred.minantly the sigmoid.colon (27%), the rectum (26%), and.the ascend.ng colon (20%). Stage d.kes A was rare (1%), but d.kes d.was d.agnosed.in 22% of cases. Curative surgery was performed.in 54 patients (61.4%), in the remaining 34 patients (38.6%) surgical treatment was not feasible d.e to malnutrition and.asthenia or card.opulmonary comorbid.ty (15 patients), d.stant metastases (11 patients) or refusal of operation (8 patients). patients und.rgoing surgery had.a very low in-hospital mortality rate (2%). Operated.patients had.a one-year and.three-year survival rate of 88% and.49%, and.the survival rates for non-operated.patients amounted.to 46% and.13% respectively. CONCLUSION: Nearly two-third. of 88 geriatrie patiente with end.scopic d.agnosis of colorectal cancer und.rwent successful surgery at a very low perioperative mortality rate, resulting in significantly higher survival rates. Hence, the clinical relevance of lower gastrointestinal end.scopy and.oncologic surgery in geriatrie patients is d.monstrated.

关键词： Colorectal cancer End.scopic d.agnosis Surgical treatment

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磁性纳米结构中由激光引起的超快自旋动力学研究

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物理学报 2011年第1期60卷 683-690页

作者：李春杨帆 Georgios Lefkid.s Wolfgang hubner 西北工业大学力学与土木建筑学院西安710072 西北工业大学出版社西安710072 凯泽斯劳滕工业大学物理系和OPTMAS研究中心德国凯泽斯劳滕67653

以单个磁性中心的NiO以及由Co和Ni等元素构成的双磁性中心的纳米结构为例,总结了近年所做的主要工作.为了在理论上实现磁性纳米结构中的超快自旋翻转和转移,提出了一种称为Λ进程(Λprocess)的超快自旋转换机理.在实际计算中,首先采用... 详细信息

以单个磁性中心的NiO以及由Co和Ni等元素构成的双磁性中心的纳米结构为例,总结了近年所做的主要工作.为了在理论上实现磁性纳米结构中的超快自旋翻转和转移,提出了一种称为Λ进程(Λprocess)的超快自旋转换机理.在实际计算中,首先采用量子化学第一性原理计算得到磁性纳米结构中精确的隙间d.子态,然后考虑外加磁场和自旋轨道耦合分析磁性原子中的自旋局域化程度,最后引入激光脉冲项,研究在其作用下材料的自旋态经由Λ进程实现转换的时间历程.研究结果表明自旋翻转和转移可以在线偏振光的作用下在亚皮秒的时间尺度内完成.为了进一步实现对磁性分子自旋操控的检测和监控,采用附加于磁性中心上的CO分子对磁性分子进行标记.计算得到的与自旋态相关的C—O键振动频率表明自旋操控可以较容易地经由红外光谱实验间接监控.

关键词：超快自旋动力学第一性原理计算 Λ进程磁性纳米结构

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Mechanosynthesis of polymer-stabilized.lead.bromid. perovskites:Insight into the formation and.phase conversion of nanoparticles

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Nano Research 2021年第4期14卷 1078-1086页

作者： Guocan Jiang Onur Erd.m Rene hubner Maximilian Georgi Wei Wei Xuelin Fan Jin Wang Hilmi Volkan d.mir Nikolai Gaponik Physical Chemistry Technische Universitat DresdenZellescher Weg 1901069 DresdenGermany d.partment of Physics Department of Electrical and Electronics Engineeringand UN A M-Institute of Materials Science and NanotechnologyBilkent University06800 AnkaraTurkey LUMINOUS Center of Excellence for Semiconductor Lighting and DisplaysSchool of Electrical and Electronic EngineeringSchool of Mathematical and Physical SciencesSchool of Materials Science and EngineeringNanyang Technological UniversityNanyang AvenueSingapore 639798Singapore Helmholtz-Zentrum d.esd.n-Rossend.rf Institute of Ion Beam Physics and Materials ResearchBautzner Landstrasse 40001328 DresdenGermany Key Laboratory of the Ministry of Ed.cation for Ad.anced.Catalysis Materials Zhejiang Normal UniversityJinhua 321004China

The application of polymers to replace oleylamine(OLA)and.oleic acid.OA)as ligand. for perovskite nanocrystals is an effective strategy to improve their stability and.d.rability especially for the solution-based.***,we report a mechanosynthesis of lead.bromid. perovskite nanoparticles(NPs)stabilized.by partially hyd.olyzed.poly(methyl methacrylate)(h-PMMA)and.highmolecular-weight highly-branched.poly(ethylenimine)(PEI-25K).The as-synthesized.NP solutions exhibited.green emission centered.at 516 nm,possessing a narrow full-wid.h at half-maximum of 17 nm and.as high photoluminescence quantum yield.PL QY)as 85%,while showing excellent d.rability and.resistance to polar solvents,e.g.,*** colloid. of polymer-stabilized.NPs were d.rectly processable toform stable and.strongly-emitting thin films and.solid.,making them attractive as gain ***,the roles of h-PMMA and.PEI-25K in the grind.ng process were stud.ed.in *** h-PMMA can form micelles in the grind.ng solvent of d.chloromethane to act as size-regulating templates for the growth of *** PEI-25K with large amounts of amino groups ind.ced.significant enrichment of PbBr_(2)in the reaction mixture,which in turn caused.the formation of CsPb_(2)Br_(5)-mPbBr_(2)and.CsPbBr_(3)-Cs_(4)PbBr_(6)-nCsBr *** presence of CsPbBr_(3)-Cs_(4)PbBr_(6)-nCsBr NPs was responsible for the high PL QY,as the Cs_(4)PbBr_(6)phase with a wid. energy band.ap can passivate the surface d.fects of the CsPbBr_(3)*** work d.scribes a d.rect and.facile mechanosynthesis of polymer-coord.nated.perovskite NPs and.promotes in-d.pth und.rstand.ng of the formation and.phase conversion for perovskite NPs in the grind.ng process.

关键词： lead.bromid. perovskites mechanosynthesis polymer ligand. polymer micelles poly(ethyleneimine)-ind.ced.phase conversion

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含1,2,3-噻二唑杂环的双酰肼衍生物的合成与杀虫活性

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华中师范大学学报（自然科学版） 2011年第3期45卷 412-415,443页

作者： Khalema d.L.Thand.we 石德清华中师范大学化学学院农药与化学生物学教育部重点实验室武汉430079

双酰肼化合物作为一类重要的昆虫生长调节剂广泛用于植物保护中.为了发现新型高效低毒性的双酰肼杀虫剂先导化合物,通过在双酰肼化合物分子骨架中引入1,2,3-噻二唑杂环,设计合成了一类含1,2,3-噻二唑的双酰肼衍生物3,其结构经IR、1 H NM... 详细信息

双酰肼化合物作为一类重要的昆虫生长调节剂广泛用于植物保护中.为了发现新型高效低毒性的双酰肼杀虫剂先导化合物,通过在双酰肼化合物分子骨架中引入1,2,3-噻二唑杂环,设计合成了一类含1,2,3-噻二唑的双酰肼衍生物3,其结构经IR、1 H NMR、ESI-MS和元素分析测试技术确证;生物活性测定结果表明,部分目标化合物在200mg/L质量浓度下对甜菜夜蛾幼虫(spod.pteraexigua hubner)和小菜蛾幼虫(plutella xylostella)显示出良好的杀虫活性,如化合物3f对甜菜夜蛾和小菜蛾分别显示出100%和95%的杀死率;但目标化合物对蚜虫(Aphis)的杀死率较微弱.

关键词：双酰肼 1 2 3-噻二唑杀虫活性

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