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Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease

World Journal of Gastroenterology 2011年第27期17卷 3235-3241页

作者： hubert mnnikes Robert C Heading Holger Schmitt hubert Doerfler Department of medicine Martin-Luther HospitalAcademic Teaching Hospital of CharitéUniversitts-medizin14193 BerlinGermany Edinburgh EH10 7ARScotlandUnited Kingdom Nycomed GmbH 78467 ConstanceGermany Nycomed International management GmbH 8152 ZurichSwitzerland

AIm: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. mETHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P minal com- plaints" symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD.

关键词： Pantoprazole ReQuestTm Clinical practice Irritable bowel syndrome Gastroesophageal reflux disease

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megacolon in adulthood after surgical treatment of Hirschsprung's disease in early childhood

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World Journal of Gastroenterology 2005年第36期11卷 5742-5745页

作者： Christoph R.Werner Gisela Stoltenburg-Didinger Henning Weidemann Christoph Benckert marco Schmidtmann Ivo R.van der Voort Viola Andresen Burghard F.Klapp Peter Neuhaus Bertram Wiedenmann hubert mnnikes Department of medicine Division of Hepatology and Gastroenterology Charite Campus Virchow-Klinikum Universitatsmedizin Berlin Augustenburger Platz 1 13353 Berlin Germany Department of Neuropathology Charité Campus Virchow-Klinikum Universittsmedizin Berlin Augustenburger Platz 1 13353 Berlin Germany Department of General Visceral and Transplantation Surgery Charité Campus Virchow-Klinikum Universittsmedizin Berlin Augustenburger Platz 1 13353 Berlin Germany Department of medicine Division of Psychosomatic medicine and Psychotherapy Charité Campus Virchow-Klinikum Universittsmedizin Berlin Augustenburger Platz 1 13353 Berlin Germany Department of medicine Division of Hepatology and Gastroenterology Charité Campus Virchow-Klinikum Universittsmedizin Berlin Augustenburger Platz 113353 Berlin Germany

Hirschsprung＇s disease （HD） is a disorder associated with congenital malformation of the enteric nervous system with segmental aganglionosis. Prevailing therapy includes a resection of the affected part of the bowel, However, patients often do not obtain complete functional improvement after surgical treatment. We present the case of a 25-year-old woman who had surgical treatment of lid in early childhood. After that procedure she had clinical features of constipation for years in the end, passing of stool once a week, requiring laxatives and enemas. We diagnosed an incomplete resection of the aganglionic bowel via rectal biopsy and resected the remaining aganglionic segment. Two months after surgery the patient＇s bowel function improved to a frequency of 1-4 stools per day. We conclude that regular follow-up is required to identify lid patients with persistent alterations of bowel function after surgery. In patients presenting with constipation, recognition of a remaining aganglionic segment or other alterations of the enteric nervous system should be aimed at in an early stage. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Hirschsprung's disease megacolon Surgicaltreatment Constipation

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Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

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World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller miriam Goebel-Stengel hubert mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn m Quigley Gregory Sayuk magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler Department of General Internal medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany Department of Human molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany Department of Human molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research Dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain Department of Clinical and Experimental medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium Department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham Digestive Diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany Department of medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany Division of microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland medicine in Digestive Disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIm To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression Anxiety Somatization

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Direct Pointwise Comparison of FE Predictions to StereoDIC measurements:Developments and Validation Using Double Edge-Notched Tensile Specimen

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Computer modeling in Engineering & Sciences 2024年第8期140卷 1263-1298页

作者： Troy myers michael A.Sutton hubert Schreier Alistair Tofts Sreehari Rajan Kattil Department of mechanical Engineering University of South CarolinaColumbiaSC29208USA Correlated Solutions Incorporated 121 Dutchman BlvdColumbiaSC29063USA

To compare finite element analysis(FEA)predictions and stereovision digital image correlation(StereoDIC)strain measurements at the same spatial positions throughout a region of interest,a field comparison procedure is *** procedure includes(a)conversion of the finite element data into a triangular mesh,(b)selection of a common coordinate system,(c)determination of the rigid body transformation to place both measurements and FEA data in the same system and(d)interpolation of the FEA nodal information to the same spatial locations as the StereoDIC measurements using barycentric *** an aluminum Al-6061 double edge notched tensile specimen,FEA results are obtained using both the von mises isotropic yield criterion and Hill’s quadratic anisotropic yield criterion,with the unknown Hill model parameters determined using full-field specimen strain measurements for the nominally plane stress *** Hill’s quadratic anisotropic yield criterion,the point-by-point comparison of experimentally based full-field strains and stresses to finite element predictions are shown to be in excellent agreement,confirming the effectiveness of the field comparison process.

关键词： StereoDIC spatial co-registration data transformation finite element simulations point-wise comparison of measurements and FEA predictions double edge notch specimen model validation

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Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Lessons learned from single-balloon enteroscopy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés-Durán Laurent monino Pierre H Deprez hubert Piessevaux Tom G moreels Department of Gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(SBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. methods: We retrospectively analyzed 106 SBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary SBE-ERCP was performed in 34 patients and pancreatic SBE-ERCP in 17, including 5 with both indications. From a total of 106 SBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 SBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary SBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary SBE-ERCP). mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary SBE-ERCP), without serious adverse events. After SBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using SBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. SBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy Surgically altered anatomy Whipple’s procedure

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macroangiopathic Complications and Associated Factors in Type 2 Diabetics at CNHU-HKm

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Journal of Diabetes mellitus 2024年第1期14卷 13-19页

作者： Annelie Kerekou Hode hubert Dedjan Gaëtan Ayina Endocrinology Metabolism and Nutrition Department CNHU-HKM Cotonou Benin Department of medicine and medical Specialties CHUD-OP Porto-Novo Benin

Nowadays, chronic clinical manifestations of diabetemellitus constitute an important disease and a huge public health issue. Aim: Study the macroangiopathic complications in type 2 diabetics. method: It is a descriptive cross-sectional study with an analytical aim covering the period from January 2019 to December 31, 2021 in the Endocrinology, metabolism and Nutrition clinic of the National Teaching Hospital hubert Koutoukou maga (CNHU-HKm) We thus identified 150 type 2 diabetic patients. Results: The prevalence of macroangiopathy was 60% with 11.3% for stroke, 28.6% for acute coronary syndrom, 4% for cervical macroangiopathy, and 46.97% ± 25.36% for obliterating arteriopathy of the lower limbs (OALL). The mean age of the patients was 57.69 ± 1.77 years with a sex ratio 1. The duration of diabetes progression was greater than 10 years for more than half of the patients 52.6%. The main associated cardiovascular risk factors were arterial high blood pressure (64.7%), family history of diabetes (33.7%), obesity with 20.0%. The death rate was 7.3%. Conclusion: macroangiopathy’s mortality rate of in type 2 diabetics is high. Prevention remains the best treatment and involves screening for factors associated with macroangiopathy.

关键词： Type 2 Diabetes macroangiopathy Coronary Artery Disease Stroke Peripheral Arterial Disease

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Pathological and Clinical Correlation European Union-Thyroid Imaging Reporting and Data System (EU-TIRADS) Classification of Thyroid Nodules in Two University Hospitals in Cotonou

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Open Journal of Endocrine and metabolic Diseases 2024年第2期14卷 15-25页

作者： Annelie Kerekou Hode hubert Dedjan Fréjus Alamou Department of Endocrinology metabolism Nutrition of National University Hospital Center-hubert Koutoukou maga Cotonou Bénin Department of medicine and medical Specialties of the Departemental University Hospital Center of Ouémé/Plateau Porto-Novo Bénin

Introduction: Since its creation in 2017 by the European community, the EU-TIRADS classification has enjoyed an excellent reputation in several countries around the world. Indeed, several studies conducted in these countries testify to the effectiveness of this tool for the management of nodular thyroid pathology. However, in Benin, the contribution of this classification has not yet been evaluated. It is therefore to overcome this inadequacy that we undertook this study. Objective: Participate in improving the diagnostic and therapeutic management of thyroid nodules at the CNHU HKm in Cotonou and at the CHUZ in Suru-Léré. methods: This is a cross-sectional study with retrospective data collection spread over a period of 3 years 5 months, from January 2019 to may 2022 and carried out jointly in the Endocrinology metabolism Nutrition and ORL-CCF departments of the CNHU HKm of Cotonou and in the ORL-CCF department of the CHUZ of Suru-Léré. The study population consisted of patients who consulted the University Clinic of Endocrinology metabolism Nutrition, the University Clinic of ORL-CCF of the CNHU-HKm and the University Clinic of ORL-CCF of the CHUZ of Suru-Léré for thyroid nodule and who have had surgery. The study data was collected from patients hospitalization records using a survey form. Results: On ultrasound, according to the EU-TIRADS classification, 56.8% of nodules presented a low risk of malignancy (EU-TIRADS 3) compared to respectively 19.8%;23% and 2.5% of nodules with zero (EU-TIRADS 2), intermediate (EU-TIRADS 4) and high (EU-TIRADS 5) risk of malignancy. Regarding the performance of this classification, it is sensitive in 37.5% of cases and has a specificity of 78.5% with a PPV (Positive Predictive Value) and a NPV (Negative Predictive Value) respectively of 6.6 % and 91.6%. Furthermore, the bivariate correlations revealed that the size of the nodule was significantly associated with the malignancy of the nodule (p = 0.014) and the calculated value o

关键词： Thyroid Nodules EU-TIRADS Classification malignancy

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Hypoglycaemiac medicinal Plants Used by Diabetics at CNHU-HKm

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Journal of Diabetes mellitus 2024年第1期14卷 41-48页

作者： Annelie Kerekou Hode hubert Dedjan Léonce Gaba Department of Endocrinology metabolism Nutrition of CNHU-HKm Cotonou Bénin Department of medicine and medical Specialties of the CHUD-OP Porto-Novo Benin

Introduction: Diabetes is a major public health problem. medicinal plants are frequently used either combine with industrial treatment or exclusively, in Africa and particularly in Benin. Our study aims to identify the different medicinal plants used by diabetic patients at the CNHU-HKm. method: we carried out a descriptive and analytical cross-sectional study. It took place at the University Clinic of Endocrinology, metabolism and Nutrition of CNHU-HKm over a of 3 months period from 20th of June to 16th of September, 2022, over diabetic followed-up. Results: One hundred and seventy-three (173) patients were gathered using an anonymous inquiry form. In the study population, the age of the patients varied between 31 and 75 years with an average age of 59 +/− 1.43 years, women represented 59% with a sex ratio (male/female) of 0.69. Sixty-five (65) or 37.6% of the population had used medicinal plants. Among given reasons for using medicinal plants were, mainly the positiveness on a third party. Data analysis outcome twenty-nine species of plants belonging to twenty (20) botanical families, the most represented being the Annonaceae and Fabaceae. The most used species are Phyllanthus amarus (hlenwé in fon), mangifera indica (mangatin in fon), momordica charantia (gninsikin in fon), Combretum micranthum (kinkéliba in fon), and Picralima nitida (ayorkpè in fon). most used parts of the plants are the leaves. The recipes are prepared mainly by infusion and are administered exclusively by mouth. most of the patients who used the hypoglycaemic medicinal plants were satisfied and no adverse effects were reported by them. Conclusion: Hypoglycaemic medicinal plants could be subjected to pharmacognosy and marketed due to their richness in active components, after further toxicological studies.

关键词： Diabetes Hypoglycaemic medicinal Plants Glycemic Imbalance Chronic Complications Benin

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mitogenomic phylogeny,biogeography,and cryptic divergence of the genus Silurus(Siluriformes:Siluridae)

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Zoological Research 2024年第4期45卷 711-723页

作者： Weitao Chen Nicolas hubert Yuefei Li Shuli Zhu Jun Wang Denggao Xiang Shang Gao Chunni Kou Jilong Wang Tai Wang Zhiqiang Liang Junjie Wu Xinhui Li Jie Li Pearl River Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhouGuangdong 510380China China Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province GuangzhouGuangdong 510380China Key Laboratory of Prevention and Control for Aquatic Invasive Alien Species Ministry of Agriculture and Rural AffairsGuangzhouGuangdong 510380China Scientific Observing and Experimental Station of National Fisheries Resources and Environment GuangzhouGuangdong 510380China Institut de Recherche pour le Développement MontpellierUMR 226 ISEM(UM-CNRS-IRD)France State Key Laboratory of Eco-hydraulic in Northwest Arid Region of China Xi’an University of TechnologyXi’anShaanxi 710048China Heilongjiang River Fisheries Research Institute Chinese Academy of Fishery SciencesHarbinHeilongjiang 150076China Gansu Fisheries Research Institute LanzhouGansu 730030China Hunan Fisheries Science Institute ChangshaHunan 410153China Yunnan Institute of Fishery Sciences Research KunmingYunnan 650111China

The genus Silurus,an important group of catfish,exhibits heterogeneous distribution in Eurasian freshwater *** group includes economically important and endangered species,thereby attracting considerable scientific *** this interest,the lack of a comprehensive phylogenetic framework impedes our understanding of the mechanisms underlying the extensive diversity found within this ***,we analyzed 89 newly sequenced and 20 previously published mitochondrial genomes(mitogenomes)from 13 morphological species to reconstruct the phylogenetic relationships,biogeographic history,and species diversity of *** phylogenetic reconstructions identified eight clades,supported by both maximum-likelihood and Bayesian ***-based species delimitation analyses yielded multiple molecular operational taxonomic units(mOTUs)in several taxa,including the Silurus asotus complex(four mOTUs)and Silurus microdorsalis(two mOTUs),suggesting that species diversity is underestimated in the genus.A reconstructed time-calibrated tree of Silurus species provided an age estimate of the most recent common ancestor of approximately 37.61 million years ago(ma),with divergences among clades within the genus occurring between 11.56 ma and 29.44 ma,and divergences among mOTUs within species occurring between 3.71 ma and 11.56 *** reconstructions suggested that the ancestral area for the genus likely encompassed China and the Korean Peninsula,with multiple inferred dispersal events to Europe and Central and Western Asia between 21.78 ma and 26.67 ma and to Japan between 2.51 ma and 18.42 *** factors such as the Eocene-Oligocene extinction event,onset and intensification of the monsoon system,and glacial cycles associated with sea-level fluctuations have likely played significant roles in shaping the evolutionary history of the genus Silurus.

关键词： maximum likelihood Bayesian inferences Ancestral area estimation Cryptic diversity Dispersal pathways mitogenomes Sea levels

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Prognostic Factors for Diabetic Foot at CNHU-HKm

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Journal of Diabetes mellitus 2024年第1期14卷 20-27页

作者： Annelie Kerekou Hode Alihonou hubert Dedjan Déo-Gratias Gnaho Centre National Hospitalier Universitaire hubert Koutoukou maga Cotonou Benin Centre Hospitalier Universitaire Départemental-Ouémé/Plateau Porto-Novo Porto-Novo Benin

Introduction: Predictions on the prevalence of diabetes mellitus, according to the International Diabetes Federation, indicated 9.3% in 2019 and nearly 10.9% of the general population in 2045. In Benin, the increase in this prevalence, according to the World Health Organization (WHO), is constantly increasing. Diabetic foot is one of its most common complications. The aim of this work was to study the prognostic factors of diabetic foot in the Department of Endocrinology, metabolism and Nutrition of the CNHU-HKm of Cotonou. Patients and method: This is a descriptive and analytical retrospective study of the prognostic factors of diabetic foot over a period of 3 years from January 2019 to December 2021 in patients who have been hospitalized or followed on an outpatient basis for diabetic foot in the Endocrinology, metabolism and Nutrition Department of the CNHU-HKm of Cotonou. Results: A total of 112 patients were included in this study. The average age of the patients was 59.70 ± 2.10 years. A male predominance was noted with a sex ratio (m/F) of 1.7. mixed gangrene and phlegmons were the most common lesions. According to the classification of diabetic feet according to the University of Texas, 59.1% of patients had a 100% risk of amputation. Ten patients died from sepsis (8.9%). The average blood glucose on admission was 2.74 ± 0.23 g/l, reflecting the glycemic imbalance in these patients. There is a statistically significant association between the duration of progression of diabetes, the type of lesion and amputation. Patients whose diabetes has lasted more than 30 years and patients who are not monitored have a greater risk of death. Conclusion: Diabetic patients most often consulted at a late stage, compromising conservative treatment. The duration of diabetes and the type of lesion on admission were the main factors leading to amputation, thus compromising the functional prognosis. As for death, it was mainly linked to irregular monitoring of diabetes and the

关键词： Diabetes Diabetic Foot Prognosis Blood Sugar Imbalence Benin

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