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中国医院药学杂志 2024年第13期44卷 1481-1485页

作者：湖北省临床药师培训管理中心《湖北省医疗机构住院药学诊查服务技术规范》编写组张玉曹勤不详华中科技大学同济医学院附属协和医院武汉430022 湖北省卫生健康委药政处

医疗机构住院药学诊查服务是由符合资质的药师为保障住院患者用药安全和优化治疗效果提供的药学服务。为加强医疗机构住院药学诊查服务管理,确保药学服务质量,根据相关法律法规和规章制度,《湖北省医疗机构住院药学诊查服务技术规范》... 详细信息

医疗机构住院药学诊查服务是由符合资质的药师为保障住院患者用药安全和优化治疗效果提供的药学服务。为加强医疗机构住院药学诊查服务管理,确保药学服务质量,根据相关法律法规和规章制度,《湖北省医疗机构住院药学诊查服务技术规范》编写组在湖北省临床药师培训管理中心的指导下制定了该规范。该规范适用于湖北省内提供住院药学诊查服务的医疗机构。

关键词：住院药学诊查技术规范药学服务

Fas counterattack in cholangiocarcinoma:a mechanism for immune evasion in human hilar cholangiocarcinomas

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World Journal of Gastroenterology 2001年第6期7卷 860-863页

作者： Zi-Yu Li Sheng-Quan Zou Department of General Surgery of Tongji Hospital,Wuhan,430030,hubei province,China Department of General Surgery of Tongji Hospital Wuhan 430030 Hubei Province China.

AIM: To investigate FasL expression in hilar cholangiocarcinoma tissues and cultured cholangiocarcinoma cells, and to assess its ability to induce apoptosis. METHODS: We studied the expression of FasL by human hilar cholangiocaroinomas tissues by immunohistochemistry, and the QBC939 cholangiocarcinoma cell line by RT-PCR, immunohistochemistry, and Western Blot. TUNEL and flow cytometry were used to detect apoptotic cells. RESULTS: Prevalent expression of FasL was detected in 39 resected hilar cholangiocarcinoma tissues. TUNEL staining disclosed a high level of cell death among lymphocytes infiltrating FasL positive areas of tumor. FasL mRNA and protein expressions in cholangiocarcinoma cells could induce Jurkat cells. CONCLUSION: Hilar cholangiocarcinomas may elude immunological surveillance by inducing, via Fas/FasL system, the apoptosis of activated lymphocytes.

关键词： Immunologic Surveillance Apoptosis Cholangiocarcinoma Culture Techniques Humans Membrane Glycoproteins RNA, Messenger Tumor Cells, Cultured

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安徽合肥滨湖新区租赁住房项目

建筑实践 2024年第3期 88-95页

作者： Anhui province Architectural Design and Research Institute Co., Ltd. 安徽省建筑设计研究总院股份有限公司

项目位于合肥市滨湖新区贵州路与遵义路交叉口,以自由寓、未来苑、天空城为设计主题,强调开放性、公共性,打造配套设施齐全、生活便利的生态住所;充分利用屋面空间,营造追寻自然、健康,及对美好生活向往的空中公园。为避免城市界面过于...

项目位于合肥市滨湖新区贵州路与遵义路交叉口,以自由寓、未来苑、天空城为设计主题,强调开放性、公共性,打造配套设施齐全、生活便利的生态住所;充分利用屋面空间,营造追寻自然、健康,及对美好生活向往的空中公园。为避免城市界面过于封闭呆板,采用两个体量相同、相互错动的居住组团,营造开放、活泼的城市界面;组团内住宅楼围合布置,形成安全、稳定的居住氛围;南北组团紧密联系,内外空间相互协调。配套设施位于两个组团底层,并顺应城市人流方向在西北角设置外街服务带,形成两环—带的布局模式,最大程度对外开放。利用北侧组团2层屋面打造空中跑道,满足健康生活的需求。

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Effects of Cadmium on the Energy Metabolism of Isolated Hepatocytes: Its Relationship with the Nonviability of Isolated Hepatocytes Caused by Cadmium

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Biomedical and Environmental Sciences 1990年第3期3卷 251-261页

作者： LIU RUINING AND LIU YUGU Department of Environmental Toxicology, Tongji Medical University, Wuhan, hubei province, China Department of Environmental Toxicology Tongji Medical University Wuhan Hubei Province China.

The effects of cadmium on the energy metabolism of mitochondria were studied with isolated hepatocytes and rat liver mitochondria. It was found that cadmium inhibited the respiration of both isolated hepatocytes and mitochondria and decreased the ATP content of isolated hepatocytes. This inhibition of energy metabolism of mitochondria was highly related to the nonviability of isolated hepatocytes caused by cadmium. The site of electron transport of the mitochondrial respiratory chain blocked by cadmium was located between cytochrome b and flavoproteins. The uncoupling effects of mitochondrial oxidative phosphorylation caused by cadmium may have resulted from changes in the fluidity and permeability of the mitochondrial membrane. (c) 1990 Academic Press. Inc.

关键词： Effects of Cadmium on the Energy Metabolism of Isolated Hepatocytes

Clinical　Observation　on　118　Cases　of　Cervical　Spondylopathy　Treated　by　Catgut　Embedding　Therapy

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中国针灸 1995年第S2期15卷 285-286页

作者： Xu Sanwen Wang Hougen(Ezhou Convalescent Home,hubei province, 436000)

ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｏｎ１１８ＣａｓｅｓｏｆＣｅｒｖｉｃａｌＳｐｏｎｄｙｌｏｐａｔｈｙＴｒｅａｔｅｄｂｙＣａｔｇｕｔＥｍｂｅｄｄｉｎｇＴｈｅｒａｐｙ￥ＸｕＳａｎｗｅｎ；ＷａｎｇＨｏｕｇｅｎ（Ｅｚｈｏ... 详细信息

ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｏｎ１１８ＣａｓｅｓｏｆＣｅｒｖｉｃａｌＳｐｏｎｄｙｌｏｐａｔｈｙＴｒｅａｔｅｄｂｙＣａｔｇｕｔＥｍｂｅｄｄｉｎｇＴｈｅｒａｐｙ￥ＸｕＳａｎｗｅｎ；ＷａｎｇＨｏｕｇｅｎ（ＥｚｈｏｕＣｏｎｖａｌｅｓｃｅｎｔＨｏｍｅ...

关键词： Therapy

Microfossils from the Chert in the Lower Cambrian Shuijingtuo Formation at Miaohe, Zigui, hubei province

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Acta Geologica Sinica(English Edition) 1993年第2期67卷 223-233,246-247页

作者： Yin Chongyu, Yue Zhao, Gao Linzhi Institute of Geology, CAGS, Beijing and Ding Qixiu hubei Geological Institute, hubei Bureau of Geology, Wuhan Institute of Geology CAGS Beijing China

This paper reports for the first time on the microfossils discovered in the black cherts of the basal part of the Lower Cambrian Shuijingtuo Formation at Miaohe village, Zigui County, hubei province, all of which were observed in thin sections. Nine genera, 9 species and 3 indeterminate species (including a new species) are described. According to these microfossils, the conclusion is made that the microfossil zone may be equivalent to the small shelly fossil assemblage zones 2—3 of the Meishucun stage. They have provided another important line of evidence for the correlation of the Sinian-Cambrian boundary strata with those of the adjacent areas.

关键词： the Lower Cambrian the Shuijingtuo Formation chert microfossil the Sinian-Cambrian Boundary

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鲍卫忠工作方法的时代价值

人民司法 2024年第4期 21-24页

作者： Party Group of Lincang Intermediate People's Court of Yunnan province 云南省临沧市中级人民法院

2023年12月18日,中共中央宣传部追授鲍卫忠同志“时代楷模”称号。他长期扎根祖国西南边睡,对党忠诚、公正司法,为民族地区繁荣稳定贡献法治力量;他始终珍视民族团结,深入村寨普法释法,依法保护各族群众合法权益,被当地群众亲切地称为... 详细信息

2023年12月18日,中共中央宣传部追授鲍卫忠同志“时代楷模”称号。他长期扎根祖国西南边睡,对党忠诚、公正司法,为民族地区繁荣稳定贡献法治力量;他始终珍视民族团结,深入村寨普法释法,依法保护各族群众合法权益,被当地群众亲切地称为佤山法治“老黄牛”;他严于律已、清正廉洁,彰显了新时代人民法官的政治本色。在24年执法办案和服务群众的司法实践中,鲍卫忠同志积累了丰富的工作经验和方法。鲍卫忠同志的工作方法,集中体现了习近平法治思想人民至上的理论品格与深刻的现实关怀,具有丰富的时代价值。

关键词：习近平法治思想公正司法理论品格中共中央宣传部西南边睡严于律已执法办案现实关怀

Expression and signifi cance of TLR4 and HIF-1α in pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2010年第23期16卷 2881-2888页

作者： Jian-Jun Zhang,He-Shui Wu,Lin Wang,Yuan Tian,Jing-Hui Zhang,Hai-Long Wu Department of Pancreatic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,hubei province,China Department of Pediatrics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,hubei province,China Laboratory of General Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,hubei province,China Department of Pancreatic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China.

AIM:To investigate the expression of toll-like receptor(TLR) 4,nuclear factor-κB(NF-κB) p65 and hypoxiainducible transcription factor 1α(HIF-1α) in pancreatic ductal adenocarcinoma and their clinical ***:The mRNA of TLR4 and HIF-1α were investigated by real-time polymerase chain reaction in 30 cases of pancreatic ductal adenocarcinoma and its adjacent tissues,and expression of TLR4,NF-κB p65 and HIF-1α protein were detected by immunohistochemistry in 65 cases of pancreatic ductal adenocarcinoma tissues and 38 cases of corresponding adjacent *** relationship between TLR4 or HIF-1α and pathologic features,as well as the association between TLR4 and HIF-1α,were also ***-Meier method was used to assess the impact of expression of TLR4 and HIF-1α on survival of patients with pancreatic ***:The relative quantif ication of TLR4 and HIF-1α mRNA in tumor tissues was 0.81±0.10 and 0.87±0.11,respectively,signif icantly higher than that in adjacent tissues(0.81±0.10 vs 0.70±0.16,P=0.002;0.87±0.11 vs 0.68±0.13,P=0.000).The protein expression of TLR4,NF-κB p65 and HIF-1α in tumor tissues was 69.20%,66.15% and 70.80%,respectively,being signif icantly higher than that in adjacent normal tissues(69.20% vs 39.50%,P=0.003;66.15% vs 31.58%,P=0.001;70.80% vs 36.80%,P=0.001).There was no signif icant correlation between TLR4 or HIF-1α expression and the age,gender,tumor location,the degree of tumor differentiation in the patients(P>0.05).However,there was signif icant correlation between the expression of TLR4 or HIF-1α and tumor size,lymph node metastasis,venous invasion and clinical staging(P<0.05).The expression of TLR4 and HIF-1α had a signif icant impact on survival of patients with pancreatic ***:TLR4,NF-κB p65 and HIF-1α are overexpressed in pancreatic adenocarcinoma,TLR4 may be partly involved in up-regulating HIF-1α,and both synergestically promote development of pancreatic adenocarcinoma.

关键词： Pancreatic ductal adenocarcinoma Toll-like receptor 4 Nuclear factor-κB p65 Hypoxia-inducible factor 1

Research on Automated Trust Negotiation in Grid Environment

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Research on Automated Trust Negotiation in Grid Environment