检索结果-南通市图书馆

Cell polarization in ischemic stroke: molecular mechanisms and advances

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

加减瓜蒌牛蒡汤治疗非哺乳期乳腺炎60例的临床观察

在线全文

学校读者我要写书评

暂无评论

首都食品与医药 2022年第10期29卷 106-108页

作者：袁德汉肖文良唐华中廖淑英广东省东莞市石碣医院广东东莞523290

目的观察加减瓜蒌牛蒡汤治疗非哺乳期乳腺炎的临床效果.方法选取2019年1月-2021年6月东莞市石碣医院收治的60例非哺乳期乳腺炎患者为研究对象.并为非哺乳期乳腺炎患者提供经此院改良后自拟的瓜蒌牛蒡汤方剂口服治疗干预.随访半年,评估... 详细信息

目的观察加减瓜蒌牛蒡汤治疗非哺乳期乳腺炎的临床效果.方法选取2019年1月-2021年6月东莞市石碣医院收治的60例非哺乳期乳腺炎患者为研究对象.并为非哺乳期乳腺炎患者提供经此院改良后自拟的瓜蒌牛蒡汤方剂口服治疗干预.随访半年,评估患者的治疗效果、治愈时间、复发率以及不良反应发生率.结果该组总有效率98.33%,不良反应发生率3.33%,平均治愈时间(7.31±1.22)周.随访6个月,该组复发率1.67%.结论加减瓜蒌牛蒡汤治疗非哺乳期乳腺炎的实际效果显著,能够显著降低患者的痛苦,无需手术切除病灶,复发率低、不良反应发生率少,值得临床推广使用.

关键词：瓜蒌牛蒡汤中药外敷非哺乳期乳腺炎

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Technological Exploration of RRAM Crossbar Array for Matrix-Vector Multiplication

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2016年第1期31卷 3-19页

作者： Lixue Xia Peng Gu Boxun Li Tianqi tang Xiling Yin Wenqin Huangfu Shimeng Yu Yu Cao Yu Wang huazhong Yang Department of Electronic Engineering Tsinghua University Beijing 100084 China Tsinghua National Laboratory for Information Science and Technology (TNList) Tsinghua University Beijing 100084 China School of Electrical Computer and Energy Engineering Arizona State University Arizona 85281 U.S.A.

Matrix-vector multiplication is the key operation for many computationally intensive algorithms. The emerging metal oxide resistive switching random access memory （RRAM） device and RRAM crossbar array have demonstrated a promising hardware realization of the analog matrix-vector multiplication with ultra-high energy efficiency. In this paper, we analyze the impact of both device level and circuit level non-ideal factors, including the nonlinear current-voltage relationship of RRAM devices, the variation of device fabrication and write operation, and the interconnect resistance as well as other crossbar array parameters. On top of that, we propose a technological exploration flow for device parameter configuration to overcome the impact of non-ideal factors and achieve a better trade-off among performance, energy, and reliability for each specific application. Our simulation results of a support vector machine （SVM） and Mixed National Institute of Standards and Technology （MNIST） pattern recognition dataset show that RRAM crossbar array based SVM is robust to input signal fluctuation but sensitive to tunneling gap deviation. A further resistance resolution test presents that a 6-bit RRAM device is able to realize a recognition accuracy around 90%, indicating the physical feasibility of RRAM crossbar array based SVM. In addition, the proposed technological exploration flow is able to achieve 10.98% improvement of recognition accuracy on the MNIST dataset and 26.4% energy savings compared with previous work. Experimental results also show that more than 84.4% power saving can be achieved at the cost of little accuracy reduction.

关键词： resistive switching random access memory (RRAM) machine learning electronic design automation matrixvector multiplication non-ideal factor

A New Buck-Based Configuration AC Chopper Voltage Conditioner

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2001年第2期12卷 36-43页

作者： tang Fuliang, Xiong Youlun & Ma Jianfeng huazhong University of Science and Technology, Wuhan 430074, P. R. China huazhong University of Science and Technology Wuhan 430074 P. R. China

This paper presents a new AC chopper voltage conditioner, which can generate high quality sinusoidal waveforms with adjustable amplitudes. The circuit structure, operation principle, and control mode are analyzed in detail, the system essentially consisting of an equal duty cycle modulation AC voltage buck chopper and a voltage polarity change H-bridge, a full-wave rectifier, to perform tightly closed-loop control of the AC chopper voltage condtioner, a digital controller on a new converter model has been developed. The controller has very well dynamic response. To evaluate the new circuit and proposed control scheme, a 5kW conditioner is developed and the experimental results demonstrate that the system has good performances.

关键词： Voltage conditioner Equal duty cycle modulation Power supply.

NMDA and AMPA receptors mediate intracellular calcium increase in rat cortical astrocytes

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第6期25卷 12-18页

作者： Bo HU, Sheng-gang SUN2, E-tang TONGNeurology Department, Union Hospital, Tongji College, huazhong University of Science and Technology, Wuhan 430022, China Neurology Department Union Hospital Tongji College Huazhong University of Science and Technology Wuhan 430022 China

AIM: To study the effect of glutamate on the intracellular calcium signal of pure cultured rat astrocytes and the roleof N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) re-ceptors in the procedure. METHODS: The fluorescence of calcium was measured by Fura-2/AM (F345/F380).RESULTS: L-Glutamate induced [Ca2+]i increase in most of the cells in concentration- and time-dependent *** 50 mmol/L induced the fluorescence increase by almost three to four times, while the effect of AMPA 50mmol/L was just half of that of D-(-)-2-amino-5-phosphonopentanoic acid (D-AP-5; a selective antagonist of theNMDA receptor). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX, a selective antagonist of the AMPA receptor)abolished the effects of NMDA and AMPA, respectively. D-AP-5 and CNQX simultaneously or respectively attenu-ated the effect of L-glutamate at different degrees, but could not abolish it entirely. CONCLUSION: Glutamatemodulated intracellular Ca2+ of pure cultured rat astrocytes through different pathways. The activation of NMDAand AMPA receptors took part in the complex mechanisms.

关键词： glutamate astrocytes NMDA receptors AMPA receptors calcium

THE POWER FLOW AND TRAVELING WAVE APPROACH TO THE VIBRATION ANALYSIS OF BASE-ISOLATED MULTI-STOREY BUILDINGS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 1995年第3期8卷 228-235页

作者： Zhu Hongping tang Jiaxiang (Department of Civil Engineering,huazhong University of Science & Technology,Wuhan 430074,P.R.China) huazhong UNIV SCI & TECHNOL DEPT CIVIL ENGNWUHAN 430074PEOPLES R CHINA

The receptance approach to periodic structure theory is applied to study the wave propagation and vibration power flow into a base-isolated multi-storey building due to horizontal harmonic ground ***-storey buildings and laminated rubber bearings have been modeled as periodic systems in this paper. Although the simplified model considered is quite simple,it is expected that it will bring forth the key differences between continuous and a single freedom *** results indicate that the isolation effectiveness depends on not only the number of storeys of the laminated rubber bearings but also the frequency characteristics of the superstructure.

关键词： wave propagation power flow laminated rubber bearings

Experimental Studies of the Practicability of a New Type Tuned Mass Damper System

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2002年第3期17卷 87-89页

作者：张耀庭 huazhong University of Science and Technology

Based on the principle of Tuned Mass Damper (TMD),the test of a new quake reduction system was *** main structure of the system is connected with the top floor through Laminated Rubber Bearing (LRB) to make up a huge TMD system suspended structure. It was shown from the test that the new TMD quake reduction system can reduce the acceleration of the top floor by more than one quarter if the parameters are chosen *** the good effectiveness and easy availability, this system has the practical value in earth quake engineering.

关键词： suspended top floor tuned mass damper laminated rubber bearing shaking tables test

Research on Nonlinear Dynamic Characteristics ofStructures Supported on Slide-Limited Friction Base Isolation System

在线全文

学校读者我要写书评

暂无评论

Journal of China University of Geosciences 2001年第4期12卷 301-308页

作者： Fan Jian tang Jiaxiang Department of Civil Engineering , huazhong University of Science and Technology , Wuhan 430074 Department of Civil Engineering Huazhong University of Science and Technology Wuhan 430074

This paper presents a new type of base isolation system, i. e. , slide-limited friction (S-LF) base isolation system . Based on this system, the harmonic and subharmonic periodic response of S-LF subjected to harmonic motions is investigated by using Fourier-Galerkin-Newton (FGN) method with Flo-quet theory. The dynamic response of S-LF subjected to earthquake ground motions is calculated with a high order precision direct integration method, and the numerical results are presented in maximum acceleration response spectra of superstructure and maximum sliding displacement response spectrum form. The comparison of isolating effects of S-LF, pure-friction base isolation system (P-F) and resilient-friction base isolation system (R-FBI) shows that the isolating property of S-LF is superior to those of P-F and R-FBI. Finally, by analyzing an engineering example, it is observed that the distribution of the maximum shear between floors and absolute acceleration of S-LF to earthquake ground motion is very different from that of traditional structures.

关键词： base isolation friction slide-limited device precision direct integration method FGN method.