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新生儿缺氧缺血性脑病影响因素分析

中外医学研究 2024年第23期22卷 168-171页

作者：谢毅陈华青王锦陈佳文傅嘉婧福建医科大学附属龙岩第一医院福建龙岩364000

目的:探讨新生儿缺氧缺血性脑病(HIE)影响因素。方法:回顾性选取2014年2月—2022年2月福建医科大学附属龙岩第一医院收治的69例HIE患儿纳入HIE组,同期未发生HIE的84例健康新生儿纳入非HIE组。调查所有新生儿一般资料。对HIE影响因素进... 详细信息

目的:探讨新生儿缺氧缺血性脑病(HIE)影响因素。方法:回顾性选取2014年2月—2022年2月福建医科大学附属龙岩第一医院收治的69例HIE患儿纳入HIE组,同期未发生HIE的84例健康新生儿纳入非HIE组。调查所有新生儿一般资料。对HIE影响因素进行单因素及多因素分析。结果:HIE组妊娠期高血压疾病、妊娠期糖尿病、羊水污染、胎盘早剥、血性羊水、胎膜早破、胎儿宫内窘迫占比均高于非HIE组,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,羊水污染、胎盘早剥、血性羊水、胎膜早破、胎儿宫内窘迫均是HIE的独立危险因素(P<0.05)。结论:新生儿HIE的发生与胎儿宫内窘迫、羊水污染、胎盘早剥、血性羊水、胎膜早破有关。临床应加强孕妇的孕期保健和监护工作,及时进行健康宣教,重视孕妇产前检查,密切关注羊水性状改变,避免胎儿宫内窘迫及新生儿窒息的发生。

关键词：新生儿缺氧缺血性脑病羊水污染胎盘早剥妊娠期糖尿病

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旬阳铅锌矿带地质环境问题现状及治理对策

黄金 2024年第1期45卷 93-98,106页

作者：杨敏杨兵陈华清聂兴信张鑫贺攀阳西安建筑科技大学资源工程学院中国地质调查局西安地质调查中心

旬阳铅锌矿带铅锌矿资源多年粗放式开发,导致地质环境问题逐步显现,主要表现为由采矿活动引发的地质环境污染、矿山土地资源损毁及矿山地质灾害隐患等。对旬阳铅锌矿带环境问题现状进行了详细分析和总结,并提出相应的地质环境治理对策。

关键词：旬阳铅锌矿带矿山地质环境治理对策环境污染地质灾害

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Evolutionary genomics analysis reveals gene expansion and functional diversity of arylalkylamine N-acetyltransferases in the Culicinae subfamily of mosquitoes

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Insect Science 2023年第2期30卷 569-581页

作者： Yu Tang huaqing chen Zhinan Lin Lei Zhang Archana Upadhyay chenghong Liao David J.Merkler Qian Han Laboratory of Tropical Veterinary Medicine and Vector Biology School of Life SciencesHainan UniversityHaikouChina One Health Institute Hainan UniversityHaikouChina Department of Chemistry University of South FloridaTampaFloridaUSA

Arylalkylamine N-acetyltransferase(aaNAT),considered a potential new insecticide target,catalyzes the acetylation of arylalkylamine substrates such as serotonin and dopamine and,hence,mediates diverse functions in ***,the origin of insect aaNATs(iaaNATs)and the evolutionary process that generates multiple aaNATs in mosquitoes remain largely ***,we have analyzed the genomes of 33 species to explore and expand our understanding of the molecular evolution of this gene family in *** show that aaNAT orthologs are present in Bacteria,Cephalochordata,Chondrichthyes,Cnidaria,Crustacea,Mammalia,Placozoa,and Teleoste,as well as those from a number of insects,but are absent in some species of Annelida,Echinozoa,and Mollusca as well as ***,more than 10 aaNATs were detected in the Culicinae subfamily of *** evolutionary analysis of aaNAT/aaNAT-like genes in mosquitoes reveals that tandem duplication events led to gene expansion in the Culicinae subfamily of mosquitoes more than 190 million years *** selection analysis demonstrates that mosquito aaNATs evolved under strongly positive pressures that generated functional diversity following gene duplication ***,this study may provide novel insights into the molecular evolution of the aaNAT family in mosquitoes.

关键词： arylalkylamine N-acetyltransferase functional diversity gene duplication molecular evolution mosquito N-acyltransferase

Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene

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Science China(Life Sciences) 2017年第2期60卷 152-157页

作者： Yuting chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu huaqing chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai 200241 China Ecole Normale Supérieure Institut de Biologie de l' Ecole Normale Supérieure Institut National de la Santé et de la Recherche Médicale U1024 Centre National de la Recherche Scientifique Unité Mixte de Recherche 8197 Paris F-75005 France Institute of Biosciences and Technology Department of Molecular and Cellular Medicine Texas A&M University Health Science Center Houston Texas 77030 USA

The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technology to generate Leptin receptor(Lepr) knockout rats on the Sprague Dawley(SD) genetic background. Through direct injection of in vitro transcribed m RNA of TALEN pairs into SD rat zygotes, somatic mutations were induced in two of three resulting pups. One of the founders carrying bi-allelic mutation exhibited early onset of obesity and infertility. The other founder carried a chimeric mutation which was efficiently transmitted to the progenies. Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders. However, no obvious defect was observed in a strain with an in-frame 57 bp deletion in the extracellular domain of Lepr. This suggests the deleted amino acids do not significantly affect Lepr structure and function. This is the first report of generating the Lepr mutant obese rat model in SD strain through a reverse genetic approach. This suggests that TALEN is an efficient and powerful gene editing technology for the generation of disease models.

关键词： TALENs Lepr knockout rat germ-line transmission

Physical Layer Encryption of OFDM-PON Based on Quantum Noise Stream Cipher with Polar Code

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China Communications 2024年第3期21卷 174-188页

作者： Xu Yinbo Gao Mingyi Zhu huaqing chen Bowen Xiang Lian Shen Gangxiang Jiangsu Engineering Research Center of Novel Optical Fiber Technology and Communication Network Suzhou Key Laboratory of Advanced Optical Communication Network Technologythe School of Electronic and Information EngineeringSoochow UniversityNo.1 Shizi StreetSuzhou 215006China

Orthogonal frequency division multiplexing passive optical network(OFDM-PON) has superior anti-dispersion property to operate in the C-band of fiber for increased optical power budget. However,the downlink broadcast exposes the physical layer vulnerable to the threat of illegal eavesdropping. Quantum noise stream cipher(QNSC) is a classic physical layer encryption method and well compatible with the OFDM-PON. Meanwhile, it is indispensable to exploit forward error correction(FEC) to control errors in data transmission. However, when QNSC and FEC are jointly coded, the redundant information becomes heavier and thus the code rate of the transmitted signal will be largely reduced. In this work, we propose a physical layer encryption scheme based on polar-code-assisted QNSC. In order to improve the code rate and security of the transmitted signal, we exploit chaotic sequences to yield the redundant bits and utilize the redundant information of the polar code to generate the higher-order encrypted signal in the QNSC scheme with the operation of the *** experimentally demonstrate the encrypted 16/64-QAM, 16/256-QAM, 16/1024-QAM, 16/4096-QAM QNSC signals transmitted over 30-km standard single mode fiber. For the transmitted 16/4096-QAM QNSC signal, compared with the conventional QNSC method, the proposed method increases the code rate from 0.1 to 0.32 with enhanced security.

关键词： physical layer encryption polar code quantum noise stream cipher

The role of CYP1A1/2 in cholesterol ester accumulation provides a new perspective for the treatment of hypercholesterolemia

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Acta Pharmaceutica Sinica B 2023年第2期13卷 648-661页

作者： Jian Lu Xuyang Shang Bingyi Yao Dongyi Sun Jie Liu Yuanjin Zhang He Wang Jingru Shi huaqing chen Tieliu Shi Mingyao Liu Xin Wang Changning Maternity and Infant Health Hospital and School of Life Sciences Shanghai Key Laboratory of Regulatory BiologyEast China Normal UniversityShanghai 200241China

Cholesterol is an important precursor of many endogenous *** of cholesterol homeostasis can cause many pathological changes,leading to liver and cardiovascular ***1A is widely involved in cholesterol metabolic network,but its exact function has not been fully ***,we aim to explore how CYP1A regulates cholesterol *** data showed that CYP1A1/2 knockout(KO)rats presented cholesterol deposition in blood and *** serum levels of low-density lipoprotein cholesterol,high-density lipoprotein cholesterol and total cholesterol were significantly increased in KO *** studies found that the lipogenesis pathway(LXRa-SREBP1-SCD1)of KO rats was activated,and the key protein of cholesterol ester hydrolysis(CES1)was ***,lansoprazole can significantly alleviate rat hepatic lipid deposition in hypercholesterolemia models by inducing *** findings reveal the role of CYP1A as a potential regulator of cholesterol homeostasis and provide a new perspective for the treatment of hypercholesterolemia.

关键词： Hyperlipidemia Hypercholesteremia Cholesterol CYP1A Lipidosis LXR CES1 Lansoprazole

GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice

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Science China(Life Sciences) 2018年第6期61卷 675-687页

作者： Roumei Xing Fang Liu Yiqing Yang Xueqin Cui Tongtong Wang Ling Xie Yongliang Zhao Lei Fang Tingfang Yi Biao Zheng Mingyao Liu huaqing chen Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Third Venture Biotechnology Co. Ltd. Institute of Biosciences and Technology Department of Molecular and Cellular Medicine Texas A&M University Health Science Center

GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we investigated the role of GPR54 in T cell and immune tolerance. GPR54 deficiency led to an enlarged thymus, an increased number of thymocytes, and altered thymic micro-architecture starting around puberty, indicating GPR54 function in T-cell development through its regulatory effect on the gonadal system. However, flow cytometry revealed a significant reduction in the peripheral regulatory T cell population and a moderate decrease in CD4 single-positive thymocytes in prepubertal Gpr54^(-/-) mice. These phenotypes were confirmed in chimeric mice with GPR54 deficient bone marrow-derived cells. In addition, we found elevated T cell activation in peripheral and thymic T cells in Gpr54^(-/-) mice. When intact mice were immunized with myelin oligodendrocyte glycoprotein, a more severe experimental autoimmune encephalomyelitis(EAE) developed in the Gpr54^(-/-) mice. Interestingly, aggravated EAE disease was also manifested in castrated and bone marrow chimeric Gpr54^(-/-) mice compared to the respective wild-type control,suggesting a defect in self-tolerance resulting from GPR54 deletion through a mechanism that bypassed sex hormones. These findings demonstrate a novel role for GPR54 in regulating self-tolerant immunity in a sex hormone independent manner.

关键词： GPR54 T cells regulatory T cells experimental autoimmune encephalomyelitis knockout mice

Numerical implementation of suction-dependent resilient modulus constitutive model for subgrade granular material

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Journal of Southeast University(English Edition) 2018年第2期34卷 251-258页

作者： Liao Gongyun chen huaqing Sun Peixiang School of Transportation Southeast UniversityNanjing 210096China

In order to investigate the suction-dependent properties of subgrade granular material and its effect on pavement responses,coupled hydro-mechanical simulations were conducted in Abaqus.A suction-dependent resilient modulus model was integrated into the commercial finite element(FE)code Abaqus by developing a user-defined material(UMAT)*** developed model was validated by triaxial test results under different suction conditions and good agreement was achieved.A three-dimensional(3D)FE pavement model was established and the suction-dependent properties of subgrade granular material was characterized by the developed constitutive ***-mechanical pavement responses subjected to three moisture states and the falling weight deflectometer(FWD)load were *** results reveal that the resilient modulus of subgrade granular material is sensitive to suction and stress states;high groundwater table decreases the overall resilient moduli of subgrade structure due to suction reduction,leading to the increase of the maximum surface deflection,the tensile strain at bottom of the surface layer,compressive strain on top of subgrade,and consequently,deterioration in pavement performance.

关键词： resilient modulus model suction pavement model finite element granular material

OsPPG encodes a pseudouridine-5'-phosphate glycosidase and regulates rice spikelet development

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The Crop Journal 2024年第3期12卷 698-708页

作者： Rui chen Dagang Tian Yarong Lin Jiaqing Huang Qinqin Yang Yupei Li huaqing Liu Shaohua Yang Jingyang chen Shufen Zhou Feng Wang Shubiao Zhang Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of Education/Key Laboratory of Biological Breeding for Fujian and Taiwan CropsMinistry of Agriculture and Rural AffairsFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Key Laboratory of Genetic Engineering for Agriculture Biotechnology Research InstituteFujian Academy of Agricultural SciencesFuzhou 350003FujianChina Institute of Resources Environment and Soil FertilizerFujian Academy of Agricultural SciencesFuzhou 350013FujianChina

Florets are the basic structural units of spikelets,and their morphogenesis determines the yield and quality of rice ***,whether and how pseudouridine-5’-phosphate glycosidase participates in rice spikelet development remains an open *** this study,we identified a novel gene,OsPPG,which encodes a peroxisome-localized pseudouridine-5’-phosphate glycosidase and regulates the development of rice *** mutants exhibited abnormal sterile lemma,lemma,palea,lodicule,stamens,and pistils;male sterility;shorter panicles;and reduced plant *** was found to regulate several OsMADS genes,thereby affecting the morphogenesis of rice ***,metabolomics revealed that the OsPPG gene was involved in the decomposition of pseudouridine via the pyrimidine metabolism pathway and may affect the jasmonic acid signaling *** results suggest that OsPPG is a key regulator of rice spikelet development.

关键词： OsPPG Reproductive regulation Spikelet development Rice