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Effects of direct aging treatment on microstructure,mechanical properties and residual stress of selective laser melted AlSi10Mg alloy

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Journal of Materials Science & Technology 2023年第8期139卷 198-209页

作者： huaping tang Chaofeng Gao Yong Zhang Nannan Zhang Chuan Lei Yunjie Bi Ping tang Jeremy Heng Rao Institute of Advanced Additive Manufacturing Ji Hua LaboratoryFoshan 528200China Department of Materials Science and Engineering Monash UniversityClaytonVIC 3800Australia National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China Hunan Farsoon High-Tech Co. LtdChangsha 410000China

Direct aging treatment is an important post-processing procedure,yet little research has been done on how it balances the mechanical properties and the stress removal for selective laser melted(SLMed)AlSi10Mg ***,we proposed a typical direct aging treatment on SLMed AlSi10Mg alloys,and studied the effects on their microstructure,properties and residual stress *** results indi-cate that the as-built microstructure is mainly composed of fine cellularα-Al and reticulated Si phases,and some pre-existing precipitates and dislocations are found in these *** direct aging treatment promotes the precipitation of nano-scaled Si phases and preserves a network-like Si ***,the strength of the peak-aged alloy increases while the ductility *** the aging temperature in-creases from 160 to 200℃,aging hardening behavior was accelerated *** at 160℃ for 4-9 h removes 32.0%-43.0%of the residual stress,which is attributed to the decomposition of the su-persaturatedα-Al matrix,the precipitation of the nano-Si phase and the exposure of low-angle grain boundaries(LAGBs).Considering the overal alloy performance obtained,over-aging at 160℃ for 4 h is the optimized heat treatment *** this condition,the yield strength(YS),ultimate tensile strength(UTS)and elongation(EL)of the alloy in the transverse and longitudinal direction are 309.5 MPa,464.4 MPa and 8.3%and 286.4 MPa,464.9 MPa and 5.1%,respectively.

关键词： Selective laser melting AlSi10Mg alloys Direct aging treatment Residual stress removal

Prototype of multi-filament electron curtain accelerator

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Nuclear Science and Techniques 2013年第B12期24卷 1-4页

作者： LI Guohua tang huaping LIU Jinsheng ZHANG Huayi LIU Yaohong ZHANG Dongsheng HE Yu LI Jian GUAN Weiqiang Division of Accelerator Technology Nuctech Co. Ltd Beijing 100084 China Department of Engineering Physics Tsinghua University Beijing 100084 China

In this paper, we present a prototype of electron curtain accelerator with 200 kV high voltage and an average beam current around 20 mA with beam width about 600 mm. Several physical and mechanical design of this facility is discussed in detail thoroughly, in conjunction with 3D software modeling and simulation. And some efforts to modulate cathode structure have been done to improve the electron beam uniformity effectively. © 2013, Science Press. All rights reserved.

关键词：电子帘加速器原型机械设计软件建模阴极结构高电压均匀性电子束

Multivariate relationships between microstructure evolution and strengthening mechanisms in laser powder bed fusion of Al-Mn-Sc alloy:towards improved fatigue performance

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Light(Advanced Manufacturing) 2024年第1期5卷 3-18页

作者： huaping tang Chaofeng Gao Shiheng Zhang Xiaojing Xiong Sheng Cao Xiaopeng Wu Yunjie Bi Jeremy Heng Rao Institute of Advanced Additive Manufacturing Ji Hua LaboratoryFoshanGuangdong528200China Department of Mechanical Engineering College of EngineeringShantou UniversityShantouGuangdong515063China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China

The effects of direct aging treatment(at 300℃ for 5 hours)on selective laser melted(SLMed)Al-4.5Mn-1.5Mg-0.9Sc-0.2Zr alloy were investigated in this work,with the microstructure,fatigue behaviors,and fracture characteristics examined to determine the primary cause of fatigue crack *** results revealed that the microstructure of the investigated alloy comprised fine equiaxed and columnar *** aging treatment,a significant number of nano-scaled Al3(Sc,Zr)precipitates were dispersed within the grains,leading to a substantial increase in *** yield strength improved from 431 MPa to 568 MPa,representing an increase of more than 32%,while the fatigue strength improved from 180 MPa to 220 MPa after aging ***,the fracture toughness decreased significantly from 25.1 MPa·√m to 12.3 MPa·√*** results of the fatigue fracture characteristics indicate that the Mn-rich phase and the formation of defects such as pores and poor powder fusion are the sources of fatigue *** direct aging treatment can significantly increase the yield strength,decrease the rate of fatigue crack propagation,and thus improve the fatigue performance,it deteriorates the fracture toughness,and thus shortens the fatigue life of the alloy as well.

关键词： Selective laser melting Al-Mn-Sc alloys High-cycle fatigue

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2751-2777页

作者： Yurong Lai Xiaoyan Chu Li Di Wei Gao Yingying Guo Xingrong Liu Chuang Lu Jialin Mao Hong Shen huaping tang Cindy Q.Xia Lei Zhang Xinxin Ding Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA Department of Pharmacokinetics Pharmacodynamics and Drug MetabolismMerck&Co.Inc.KenilworthNJ 07033USA Pharmacokinetics Dynamics and MetabolismPﬁzer Worldwide Research and DevelopmentGrotonCT 06340USA Eli Lilly and Company IndianapolisIN 46221USA Drug Metabolism and Pharmacokinetics BiogenCambridgeMA 02142USA Drug Metabolism and Pharmacokinetics Accent TherapeuticsInc.LexingtonMA 02421USA Department of Drug Metabolism and Pharmacokinetics GenentechA Member of the Roche GroupSouth San FranciscoCA 94080USA Drug Metabolism and Pharmacokinetics Department Bristol-Myers Squibb CompanyPrincetonNJ 08540USA Bioanalysis and Biomarkers Glaxo Smith KlineKing of the PrussiaPA 19406USA Department of Drug Metabolism and Pharmacokinetics Takeda Pharmaceuticals International Co.CambridgeMA 02139USA Ofﬁce of Research and Standards Ofﬁce of Generic DrugsCDERFDASilver SpringMD 20993USA Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Current afﬁliation:Translational Medicine EMD Serono Research&Development InstituteInc.BillericaMA 01821USA Current afﬁliation:Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA

Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical *** nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological *** progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the *** importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly *** increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME *** this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.

关键词： Drug discovery and development New drug application Biologics license application Pharmacokinetics ADME New modalities Model-informed drug development Micro-physiological systems

Endothelial cells on the proliferation and expression of intercellular adhesion molecule 1 and interleukinβof vascular smooth muscle cells

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Endothelial cells on the proliferation and expression of int...

一种离子交换树脂金属复合材料（IPMC）的力学参数测定

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： wei han huaping tang lixin sun department of respiratory medicine Qingdao municipal hospital

Objective To investigate the influence of activated endothelial cells on the proliferation and secretion of vascular smooth muscle cells. Methods Cultured lung microvascular endothelial cells were treated with or without tumor necrosis factor alpha (TNF-a;10 ng/mL) for 6 h,and the supernatant was collected and *** supernatant with TNF-a was called fluid A,and that without TNF-a was called fluid B.

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来源： cnki会议评论

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高技术通讯 2007年第5期17卷 508-511页

作者：唐运军唐华平殷陈锋中南大学机电工程学院长沙410083

对一种新型的人工肌肉材料——离子交换树脂金属复合材料（IPMC）的力学性能参数进行了测试研究。进行了精密拉伸实验,测定了其弹性模量E和泊松比υ,确定了其本构关系,证实了其具有各向同性特性。测试研究为开展IPMC人工肌肉和其应用研... 详细信息

对一种新型的人工肌肉材料——离子交换树脂金属复合材料（IPMC）的力学性能参数进行了测试研究。进行了精密拉伸实验,测定了其弹性模量E和泊松比υ,确定了其本构关系,证实了其具有各向同性特性。测试研究为开展IPMC人工肌肉和其应用研究提供了参考数据。

关键词：人工肌肉离子交换树脂金属复合材料(IPMC) 本构关系

A major vernalization-independent QTL for tiller angle on chromosome arm 2BL in bread wheat

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The Crop Journal 2022年第1期10卷 185-193页

作者： Jiajun Liu Jieguang Zhou huaping tang Yang Tu Yang Mu Lulu Gou Qiantao Jiang Yaxi Liu Guoyue Chen Jirui Wang Pengfei Qi Wei Li Yunfeng Jiang Zehong Yan Houyang Kang Yuming Wei Xiujin Lan Youliang Zheng Jian Ma State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Triticeae Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina College of Agronomy Sichuan Agricultural UniversityChengdu 611130SichuanChina

Tiller angle(TA)strongly influences plant architecture and grain yield in ***,the genetic basis of TA in wheat is largely *** identified three TA-related quantitative trait loci(QTL).One of them was ***-2 B-769,a major QTL localized on chromosome arm 2 ***-2 B-769 was detected in seven environments,explaining 18.1%–51.1%of phenotypic *** developed a linked Kompetitive Allele-Specific Polymerase chain reaction(KASP)marker,KASP-AX-108792274,to further validate this locus in three additional populations in multiple ***-2 B-769 increased TA by up to 24.9%in these *** were significant and positive correlations between TA and flag leaf angle(FLANG).However,TA was not correlated with plant height or anthesis date,suggesting that expression of ***-2 B-769 is independent of *** CS2 B01 G583800,a gene known to be involved in leaf angle regulation,was identified as the most likely candidate gene for ***-2 *** results enrich our understanding of the mechanisms regulating wheat TA at maturity and may support precise mapping and cloning of gene(s)underlying ***-2 B-769.

关键词： Tiller angle QTL detection and validation Candidate genes Expression patterns

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电子辐照灭菌中剂量深度分布的分析

清华大学学报（自然科学版） 2005年第6期45卷 806-809页

作者：刘志弢张化一唐华平清华大学工程物理系北京100084

为研制加速器电子束邮件灭菌安全系统,用MonteCarlo(MCNP)程序模拟计算了4.5MeV电子束辐照复印纸和聚苯乙烯时吸收剂量随深度的变化。计算分析了邮件灭菌中电子束的能量、入射角度、复印纸厚度及上下铝衬底材料等对辐照效果的影响。结... 详细信息

为研制加速器电子束邮件灭菌安全系统,用MonteCarlo(MCNP)程序模拟计算了4.5MeV电子束辐照复印纸和聚苯乙烯时吸收剂量随深度的变化。计算分析了邮件灭菌中电子束的能量、入射角度、复印纸厚度及上下铝衬底材料等对辐照效果的影响。结果表明,受照物质中的吸收剂量呈先增后减的趋势;电子束能量越高,穿透深度越大,吸收剂量峰值变低;入射角度变化,穿透深度不变;衬底材料可提高受照物质上表面的吸收剂量。结果与实验符合,验证了模拟的可信性,也显示出MCNP计算的速度快、效率高、应用灵活等优点。

关键词：直线电子加速器电子辐照灭菌 Monte Carlo程序(MCNP) 剂量深度分布复印纸

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树状多柔体系统动力学递推组集建模法

西南交通大学学报 1999年第3期34卷 284-289页

作者：唐华平孔祥安西南交通大学应用力学与工程系

引入一种描述多柔体系统的随体坐标系，实现了刚体平动、刚体转动与弹性运动的分解，较好地消除了由于刚体大角度转动而产生的刚弹耦合非线性特性。根据约当变分原理，应用递推组集技术，由外层到内层逐层组装系统动力学方程，概括出一... 详细信息

引入一种描述多柔体系统的随体坐标系，实现了刚体平动、刚体转动与弹性运动的分解，较好地消除了由于刚体大角度转动而产生的刚弹耦合非线性特性。根据约当变分原理，应用递推组集技术，由外层到内层逐层组装系统动力学方程，概括出一种树状多柔体系统动力学递推组集建模方法，降低了所需计算机存贮。最后给出一个数值算例。

关键词：动力学组集技术多柔体系统建模法机械系统