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*** mycelium inhibits epithelial–mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis

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Frontiers of Medicine 2021年第2期15卷 313-329页

作者： Li Lu Haiyan Zhu Hailin Wang huaping liang Yayi Hou Huan Dou The State Key Laboratory of Pharmaceutical Biotechnology Division of ImmunologyMedical SchoolNanjing UniversityNanjing 210093China Department of Rheumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China State Key Laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDaping HospitalThe Army Medical UniversityChongqing 400042China Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjing 210093China

The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory *** previous studies established the antifibrotic action of Hirsutella sinensis mycelium(HSM)in the *** epithelial–mesenchymal transition(EMT)is involved in the pathogenesis of idiopathic pulmonary *** present study investigates the role of HSM in mediating EMT during the development of pulmonary *** significantly inhibits bleomycin(BLM)-induced pulmonary fibrosis by blocking the *** addition,the expression levels of midkine are increased in the lungs of the BLM-induced *** analysis of the results indicates that the mRNA level of midkine correlated positively with *** markedly abrogates the transforming growth factorβ-induced EMT-like phenotype and behavior in *** activation of midkine related signaling pathway is ameliorated following HSM treatment,whereas this extract also caused an effective attenuation of the induction of EMT(caused by midkine overexpression)in *** further confirm that oral medication of HSM disrupted the midkine pathway in ***,findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM.

关键词： epithelial-mesenchymal transition H.sinensis mycelium midkine pulmonary fibrosis

Assessment of plasma 12(S)-Hydroxyeicosatetraenoic acid as a biomarker to predict mortality in adults with severe trauma

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Burns & Trauma 2020年第1期8卷 148-151页

作者： Liping Yang Qian Cheng Qi Huang huaping liang Yan Luo Department of Laboratory Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Wound Infection and DrugArmy Medical Center(Daping Hospital)Army Medical UniversityChongqing400042China

To the Editor Identification upon admission of a group of patients with severe traumatic injury presenting with a higher risk of death is crucial in designing personalized treatment strategies[1].However,there are as yet limited biomarkers for the prediction of mortality in patients with traumatic injury.12(S)-Hydroxyeicosatetraenoic acid(12(S)-HETE),as a classic metabolite of arachidonic acid,was suggested to be a potential biomarker in brain injury[2]or subarachnoid hemorrhage[3].

关键词： mortality traumatic injury

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BIOCELL 2022年第10期46卷 2291-2301页

作者： FEIFEI TIAN HUAN HU DI WANG HUAN DING QINGJIA CHI huaping liang WENLI ZENG School of Life Science and Engineering Southwest Jiaotong UniversityChengdu610000China Department of Engineering Structure and Mechanics School of ScienceWuhan University of TechnologyWuhan430070China State Key Laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDapingHospitalThe ArmyMedical UniversityChongqing400042China Renmin Hospital of Wuhan University Nursing Department Wuhan430070China

TIME,Immunity,Prognosis,BioinformaticsThis study used transcriptome and epigenetic data to predict the prognosis of immune-related genes(IRGs)Apelin(APLN)in patients with hepatocellular carcinoma(HCC).The TCGA database has gene expression and clinical data for *** DNA methylation 450 k data for HCC was download from the University of California Santa Cruz(UCSC)Xena *** clinical and prognostic analysis of APLN expression,results show that APLN is highly expressed in tumor *** it has an increasing trend with the development of clinical stage and T *** explore the prognostic role of APLN,the Immune-related DNA methylation(DNAm)sites associated with APLN analyzed by *** COX screened the methylation sites that are related to both APLN and *** risk score related to methylation site signature was determined according to their least absolute shrinkage and selection operator(LASSO)*** the patients were divided into high-risk groups and low-risk *** differences in overall survival(OS)were found in the training *** shows that APLN or methylation signature can effectively predict the prognosis of HCC *** summary,APLN may be a diagnostic and prognostic marker for HCC.

关键词： TIME Immunity Prognosis Bioinformatics

Prediction of sepsis in trauma patients

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Burns & Trauma 2014年第3期2卷 106-113页

作者： He Jin Zheng Liu Ya Xiao Xia Fan Jun Yan huaping liang State Key Laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDaping HospitalThe Third Military Medical UniversityChongqingChina

Trauma is one of the leading causes of death worldwide. Approximately 39.5% of deaths occur in the hospital, and the mortality rate of delayed death caused by septic complications is still high. Early prediction of the development of sepsis can help promote early intervention and treatment for patients and contribute to improving patient outcomes. Thus so far, biomarkers, patient demo-graphics and injury characteristics are the main methods used for predicting sepsis in trauma patients. However, studies that verify their predictive value are limited, and the results are still controversial. More work should be conducted to explore more efcient and accurate ways to predict post-traumatic sepsis.

关键词： Sepsis trauma infection prediction

Multifunctional and Sprayable 2D MoS_(2)/Silk Sericin Bio‑Nanocomposite Dressings with Enhanced Photothermal Effect for Infected Wound Healing

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Advanced Fiber Materials 2024年第4期6卷 1074-1091页

作者： Libin Qiu Lian Duan Hongyu Lin Min Wang huaping liang Guilong Peng Xiao Yang Yang Si Shixiong Yi State Key Laboratory of Resource Insects College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715People’s Republic of China Institute for Clean Energy and Advanced Materials School of Materials and EnergySouthwest UniversityChongqing 400715People’s Republic of China State Key Laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDaping HospitalThird Military Medical UniversityChongqing 400042People’s Republic of China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 200051People’s Republic of China

Developing novel antibacterial dressing protecting skin injuries from infection is essential for wound *** this study,sericin,a bio-waste produced during the degumming of silk cocoons,is utilized to exfoliate MoS_(2)layers and improve the dispersity and stability of MoS_(2)nanosheets(MoS_(2)-NSs).Moreover,owing to its ability to promote oxygen permeability and cell growth and its good biocompatibility,MoS_(2)-NS/Sericin maintains its photothermal property under an 808 nm light source for a strong antibacterial activity as well as improves the fibroblast migration,which accelerates wound ***-thermore,the in vitro experiments indicates that MoS_(2)-NS/Sericin can also scavenge reactive oxygen species(ROS)at an inflammatory stage of wound healing and transform classical activated macrophages(M1-type)into alternatively activated macrophages(M2-type),which is beneficial for wound *** on these results observed in vitro,full-thickness skin wound experiments are conducted on rats,and the corresponding results show that MoS_(2)/Sericin under 808 nm irradiation exhibits the best performance in promoting wound ***,MoS_(2)-NS/Sericin exhibits a high potential for bacteria-infected wound healing.

关键词： MoS_(2) Sericin Photothermal therapy Antibacterial Infected wound healing

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战创伤急救与脓毒症预防新策略

战创伤急救与脓毒症预防新策略

创伤／烧伤后T淋巴细胞数量、分布和功能变化及其机制的研究进展

2017第13届中国中西医结合学会灾害医学学术年会与第12届广东省中西医结合学会灾害医学学术年会暨广东省中西医结合学会卫生应急学专业委员会成立大会暨2017灾害医学与急危重症高端论坛中国中西医结合研究灾害医学十年回顾

作者： huaping liang Third Military Medical University State Key Laboratory of TBC

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中华创伤杂志 2015年第12期31卷 1139-1142页

作者：余静严军梁华平第三军医大学大坪医院野战外科研究所第一研究室创伤、烧伤与复合伤国家重点实验室重庆400042

创伤／烧伤可导致机体炎症反应和免疫失衡，甚至引起严重感染和脓毒症。创伤／烧伤所带来的伤道（创面）局部感染、肠源性细菌（毒素）移位而导致的并发症已成为创伤／烧伤患者后期死亡的主要原因。严重创伤后机体发生的一系列炎症反应... 详细信息

创伤／烧伤可导致机体炎症反应和免疫失衡，甚至引起严重感染和脓毒症。创伤／烧伤所带来的伤道（创面）局部感染、肠源性细菌（毒素）移位而导致的并发症已成为创伤／烧伤患者后期死亡的主要原因。严重创伤后机体发生的一系列炎症反应将引起免疫功能的改变，

关键词：创伤后烧伤后细胞数量功能变化机体炎症反应淋巴肠源性细菌免疫失衡

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C/EBPε对炎症和感染调控的研究进展

中华危重病急救医学 2019年第10期31卷 1292-1294页

作者：刘亚君陈涛梁华平遵义医科大学附属医院重症医学科 563003 陆军军医大学陆军特色医学中心战伤感染与特需药品研究室重庆400042

炎症和感染是造成危重病患者高病死率的主要原因之一,传统治疗措施单一且局限.人CCAAT/增强子结合蛋白epsilon(C/EBPε)是调节中性粒细胞终末分化的关键转录因子,它通过对炎症反应细胞的调控在抗炎、抗感染过程中起重要作用.本文通过对C... 详细信息

炎症和感染是造成危重病患者高病死率的主要原因之一,传统治疗措施单一且局限.人CCAAT/增强子结合蛋白epsilon(C/EBPε)是调节中性粒细胞终末分化的关键转录因子,它通过对炎症反应细胞的调控在抗炎、抗感染过程中起重要作用.本文通过对C/EBPε在炎症和感染中的变化、相关调控机制以及相关针对性逆转加强措施进行综述,旨在为发掘新的针对炎症及感染的治疗方向和有效治疗措施提供参考.

关键词：人CCAAT/增强子结合蛋白epsilon 中性粒细胞炎症感染

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黄芪多糖对烧伤小鼠细胞免疫功能的影响

中华整形烧伤外科杂志 1994年第2期10卷 138-141页

作者：梁华平张艳耿波重庆第三军医大学野战外科研究所 630042

我们应用小鼠非麻醉状态下Ⅲ度烧伤模型,观察烧伤后6天细胞免疫功能的变化及黄芪多糖(APS)体内应用对烧伤后细胞免疫功能的影响。结果显示:烧伤后6天小鼠的脾脏指数和胸腺指数降低,脾细胞的T淋巴细胞转化、白介素2(IL-2)的产生均明显受... 详细信息

我们应用小鼠非麻醉状态下Ⅲ度烧伤模型,观察烧伤后6天细胞免疫功能的变化及黄芪多糖(APS)体内应用对烧伤后细胞免疫功能的影响。结果显示:烧伤后6天小鼠的脾脏指数和胸腺指数降低,脾细胞的T淋巴细胞转化、白介素2(IL-2)的产生均明显受抑;烧伤小鼠血清、巨噬细胞对T淋巴细胞转化的抑制作用明显增强,抑制性T细胞(Ts)的抑制指数也高于正常。APS经腹腔注射(250mg/kg,每天一次,连续5天)不仅可明显提高正常小鼠的脾脏指数和胸腺指数,还可使烧伤小鼠的脾脏指数和胸腺指数恢复正常;APS体内应用还可纠正烧伤小鼠T淋巴细胞转化,TL-2产生的受抑状态,并可使烧伤小鼠血清、巨噬细胞及Ts的抑制活性降低至正常水平。上述结果提示:烧伤小鼠细胞免疫功能受抑与烧伤后血清、巨噬细胞及Ts的抑制作用有关;黄芪多糖体内治疗可降低烧伤后血清、巨噬细胞、Ts的抑制活性,恢复烧伤后受损的细胞免疫功能。

关键词：黄芪多糖烧伤细胞免疫