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Joining of C_f/SiBCN composite with two Ni-based brazing fillers and interfacial reactions

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Journal of Materials Science & Technology 2017年第5期33卷 487-491页

作者： Wenwen li Bo Chen Yi Xiong huaping Xiong Yaoyong Cheng Wenjiang Zou Welding and Plastic Forming Division Beijing Institute of Aeronautical Materials School of Materials University of Manchester

G/SiBCN ceramic composite was joined using Ni-19Cr-10Si （BNi5） and Ni-33Cr-24Pd-3.5Si-0.5B filler alloys at 1170 ℃ for 10 min. Two kinds of Ni-based filler alloys exhibited good wettability on the CdSiBCN com- posite, with a contact angle of 13° and 4°, respectively, The microstructures of the brazed joints were investigated by electron-probe microanalysis （EPMA）, and three-point bend test was conducted for the joints at room temperature. When being brazed with BNi5 filler alloy, no evident reaction layer was ob- served at the surface of the joined composite, and the joint microstructure was characterized by Ni2Si matrix with scatteringly distributing mixture compounds of Cr23C6, Ni2Si and CrB. While Ni-Cr-Pd（Si,B） brazing alloy was used, a Cr23C6 reaction layer with a thickness of 11 μm was formed at the surface of the base composite. In the central part of the brazed joint, the phases were composed of Ni（Cr, Si） solid solution and complex compounds including Pd2Si, （Ni,Pd）2Si and Ni-B. The strength of Cf/SiBCN joint brazed with BNi5 filler alloy was 62.9 MPa at room temperature, whereas that with Ni-Cr-Pd（Si,B） filler alloy was at the same level.

关键词： Cf/SiBCN composite Brazing Microstructure Joint strength Interracial reaction

Bronchial Fistula: Rare Complication of Treatment with Anlotinib

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中国肺癌杂志 2020年第10期23卷 858-865页

作者： Pengbo DENG Chengping HU Yuanyuan li liming CAO huaping YANG Min li Jian AN Juan JIANG Qihua GU Department of Respiratory Medicine Xiangya Lung Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China

Background and objective Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase(RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cases of rare complication of anlotinib-bronchial fistula(BF) during the treatment of lung cancer patients and summarize the possible causes.Methods We collected three patients who developed BF due to anlotinib treatment, and conducted a search of Medline and Pub Med for medical literature published between 2018 and 2020 using the following search terms: "anlotinib," "lung cancer," and "fistula."Results Our literature search produced two case reports(three patients) which, in addition to our three patients. We collated the patients’ clinical characteristics including demographic information, cancer type, imaging features, treatment received, risk factors for anlotinib related BF, and treatment-related outcomes. The six patients shared some common characteristics: advanced age, male, concurrent infection symptoms, diabetes mellitus(DM), advanced squamous cell and small cell lung cancers, centrally located tumors, tumor measuring ≥5 cm in longest diameter, and newly formed tumor cavitation after multi-line treatment especially after receiving radiotherapy. Fistula types included broncho-pericardial fistula, broncho-pleural fistula, and esophagotracheobronchial fistula. Six patients all died within 6 months.Conclusion Although anlotinib is relatively safe, it is still necessary to pay attention to the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients.

关键词： lung cancer fistula

柴胡当归散加减联合穴位注射丹参注射液治疗乙肝肝纤维化临床观察

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陕西中医 2024年第4期45卷 477-480,489页

作者：孙素红周晓玲李泽鹏覃杏幸孙东琪磨奕玲黄华萍广西中医药大学研究生院广西南宁530001 广西科技大学第一附属医院广西柳州545001 柳州市中医医院广西柳州545001

目的:观察柴胡当归散加减联合穴位注射丹参注射液治疗乙肝肝纤维化的临床疗效。方法:选取乙肝肝纤维化患者86例,采用随机数字表法分为两组,每组43例,对照组予恩替卡韦治疗,观察组在恩替卡韦的基础上予柴胡当归散加减配合穴位注射丹参注... 详细信息

目的:观察柴胡当归散加减联合穴位注射丹参注射液治疗乙肝肝纤维化的临床疗效。方法:选取乙肝肝纤维化患者86例,采用随机数字表法分为两组,每组43例,对照组予恩替卡韦治疗,观察组在恩替卡韦的基础上予柴胡当归散加减配合穴位注射丹参注射液治疗。2周为1个疗程,两组均连续治疗12个疗程。对比两组疗效,于治疗前后观察两组中医症候积分、肝纤维化指标[透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)]、肝功能指标[总胆红素(TBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)]及肝脏硬度(LSM)差异,记录并比较两组患者不良反应发生率。结果:治疗后,观察组总有效率为95.35%,较对照组的79.07%更高(P<0.05)。观察组胁肋胀痛、胸闷善太息、神疲乏力、性情急躁、脘腹痞闷、小便不利、大便溏薄症候积分低于对照组(均P<0.05)。观察组HA、LN、PC-Ⅲ、Ⅳ-C、TBIL、ALT、AST水平及LSM低于对照组(均P<0.05)。结论:采用柴胡当归散加减配合穴位注射丹参注射液治疗乙肝肝纤维化患者可提升疗效,显著改善患者肝纤维指标及肝功能,降低肝脏硬度。

关键词：乙型病毒性肝炎肝纤维化柴胡当归散丹参注射液穴位注射炎症反应

Global health education in Chinese universities and potential for collaboration with schools of nursing: A qualitative study

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International Journal of Nursing Sciences 2017年第1期4卷 12-18页

作者： Quanlei li Stephen Gloyd Dong Xu Yan Hu huaping liu Sarah Gimbel Department of Global Health University of WashingtonSeattleWAUnited States School of Nursing Johns Hopkins UniversityBaltimoreMDUnited States School of Public Health Sun Yat-Sen UniversityGuangzhouChina School of Nursing Fudan UniversityShanghaiChina School of Nursing Peking Union Medical CollegeBeijingChina School of Nursing University of WashingtonSeattleWAUnited States

Background: The Chinese Consortium of Universities for Global Health (CCUGH) was established within schools of public health in 2013 with the goal of enhancing global health in China.Expanding nursing students' exposure to global health curricula is important as nurses are essential actors in the health care system.However,information related to existing global health education within CCUGH-affiliated universities and the current engagement of Chinese schools of nursing in global health remains extremely limited.Objective: To identify and describe the current definitions and conceptualizations of global health education in Chinese universities,with a focus on schools of nursing,in order to explore potential opportunities for strengthened collaboration between global health initiative and schools of nursing in China.Methods: Purposive sampling with snowballing was used to recruit 19 key informants who were critical stakeholders in global health and nursing in China.Key informant interviews were conducted from July 2014 to February 2015,and data were updated in June 2016.Content analysis was used to analyze data via Atlas.ti 7.Results: There was a rapid growth in global health education within and beyond CCUGH-affiliated universities with nine universities establishing global health institutes.Translation and definition of global health lacked consistency in Chinese language.Though no course directly related to global health was offered,schools of nursing were gradually participating in global health education and research.Nursing was a critical component of global health,and global health and nursing mutually advanced each other.Nursing education should include global health contents,but at present independent global health curriculum in schools of nursing was not appropriate.Conclusion: Increasingly Chinese universities are promoting global health education through the platform of CCUGH.It is an ideal moment to promote and expand work across the fields of global health and nursing,specifically to highlight opport

关键词： China Education Global health Nursing Qualitative research

Laser Additive Manufacturing on Metal Matrix Composites: A Review

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Chinese Journal of Mechanical Engineering 2021年第3期34卷 195-210页

作者： Neng li Wei liu Yan Wang Zijun Zhao Taiqi Yan Guohui Zhang huaping Xiong 3D Printing Research&Engineering Technology Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

Important progresses in the study of laser additive manufacturing on metal matrix composites(MMCs)have been made.Recent efforts and advances in additive manufacturing on 5 types of MMCs are presented and reviewed.The main focus is on the material design,the combination of reinforcement and the metal matrix,the synthesis principle during the manufacturing process,and the resulted microstructures as well as properties.Thereafter,the trend of development in future is forecasted,including:Formation mechanism and reinforcement principle of strengthening phase;Material and process design to actively achieve expected performance;Innovative structure design based on the special properties of laser AM MMCs;Simulation,monitoring and optimization in the process of laser AM MMCs.

关键词： Laser additive manufacturing Metal matrix composites Microstructure Property

Endovascular stent treatment of the iliac vein stenosis caused by a pelvic lymphocele secondary to gynecologic malignancy

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Journal of Interventional Medicine 2020年第4期3卷 192-194页

作者： li Zhang Xiang li huaping Wu Kaiping Lv Cunliang Zeng Huanhuan Song Department of Vascular Surgery Dazhou Central HospitalDazhou635000PR China

Over the past two years,6 patients had iliac vein stenosis caused by radiation and pelvic lymphocele secondary to gynecologic malignancy.Patients had symptomatic lymphoceles induced lower limb edema.Poor treatment of symptomatic lymphoceles,compression symptoms persist,all patients were performed endovascular stent therapy,clinical symptoms of lower limb were completely relieved.Iliac vein stenosis caused by radiation and pelvic lymphocele secondary to gynecologic malignancy,endovascular stent placement is a nonsurgical alternative for the reestablishment of venous flow and sustained relief of symptoms.

关键词： Pelvic lymphocele Gynecologic malignancy Iliac vein stenosis Endovascular stent treatment

Comparison of Single-Step and Two-Step EBL T-Gates Fabrication Techniques for In P-Based HEMT

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Chinese Journal of Electronics 2016年第2期25卷 199-202页

作者： ZHONG Yinghui ZANG huaping SUN Shuxiang WANG Haili li Kaikai li Xinjian DING Peng JIN Zhi School of Physics and Engineering Zhengzhou University Institute of Microelectronics Chinese Academy of Sciences

T-Gate fabrication processes for In P-based High electron mobility transistors(HEMTs) are described using PMMA/Al/UVIII. The single-step and two-step Electron beam lithography(EBL) methods are proposed contrastively without dielectric support layer. The optimal gate-foot length is 196 nm for 50 nm geometry path by single-step EBL technique. Since the gate-foot and gate-head are defined independently, the two-step EBL process minimizes forward scattering and enables smaller gate-foot length, which improves to be 141 nm for 50 nm geometry path and also 88 nm for 30 nm geometry path.Both EBL methods have been incorporated into In Pbased HEMTs fabrication. With the gate-foot length decreases from 196 nm to 141 nm, the current-gain cutoff frequency(fT) is improved from 125 GHz to 164 GHz, and also the maximum oscillation frequency(fmax) increases from305 GHz to 375 GHz.

关键词： T-Gate HEMTs EBL technique Two-step EBL technique Polymethylmethacrylate(PMMA)

壮药白花蛇舌草水提物对MDA-MB-231乳腺癌裸鼠移植瘤的抑制及免疫调节作用研究

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现代中西医结合杂志 2024年第8期33卷 1029-1037页

作者：覃妮黄华萍沈新辉刘巧园张洪平邱琼华李秋萍阮博文李裕珍陆世银柳州市中医医院(柳州市壮医医院)/中药(壮瑶药)制剂研发重点实验室/中药(壮瑶药)制剂开发工程技术研究中心广西柳州545026 柳州市工人医院广西柳州545005

目的观察白花蛇舌草水提物对MDA-MB-231乳腺癌裸鼠移植瘤的抑制及免疫调节作用,并探讨其作用机制。方法取6只正常BALB/c-nu雌性裸鼠作为正常组;取30只BALB/c-nu雌性裸鼠复制MDA-MB-231乳腺癌移植瘤模型,将造模成功裸鼠随机分为模型组、... 详细信息

目的观察白花蛇舌草水提物对MDA-MB-231乳腺癌裸鼠移植瘤的抑制及免疫调节作用,并探讨其作用机制。方法取6只正常BALB/c-nu雌性裸鼠作为正常组;取30只BALB/c-nu雌性裸鼠复制MDA-MB-231乳腺癌移植瘤模型,将造模成功裸鼠随机分为模型组、环磷酰胺组及白花蛇舌草水提物低、高剂量组,每组6只。环磷酰胺组给予环磷酰胺25 mg/kg腹腔注射,每7 d注射1次;白花蛇舌草水提物低、高剂量组分别按照1500 mg/(kg·d)、6000 mg/(kg·d)灌胃白花蛇舌草水提物溶液,正常组和模型组灌胃等体积灭菌注射用水,均1次/d。各组均连续干预21 d,监测裸鼠活动状况,每间隔2 d测量1次肿瘤大小。干预结束后,测量体重、瘤重与脾重,计算脾脏指数、抑瘤率;HE染色观察移植瘤的病理学形态;脾淋巴细胞增殖试验评价脾脏中T淋巴细胞和B淋巴细胞的增殖能力;血液分析仪测定外周血中白细胞数目和淋巴细胞占比;EliSA法检测血清中白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、γ干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平;Western blot法测定模型组和白花蛇舌草水提物低、高剂量组裸鼠肿瘤组织中磷脂酰肌醇3-激酶(PI3K)/蛋白激B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)通路蛋白及凋亡相关蛋白[B细胞淋巴瘤/白血病-2蛋白(Bcl-2)、Bcl-2相关X蛋白(Bax)、半胱天冬氨酸蛋白酶-7(Caspase-7)、半胱天冬氨酸蛋白酶-9(Caspase-9)]表达情况。结果与正常组比较,模型组裸鼠脾脏指数、外周血中白细胞数量均明显升高(P均<0.05),脾脏T淋巴细胞和B淋巴细胞增殖能力指数、外周血淋巴细胞占比及血清中IL-2、IL-6、IFN-γ、TNF-α水平均明显降低(P均<0.05);肿瘤组织中肿瘤细胞密集丰富排列无序,肿瘤细胞异型性明显。与模型组比较,白花蛇舌草水提物高、低剂量组裸鼠脾脏指数、脾脏T淋巴细胞和B淋巴细胞增殖能力指数、外周血淋巴细胞占比及血清中IL-2、IL-6、IFN-γ、TNF-α水平均明显升高(P均<0.05),瘤重、外周血中白细胞数量均明显降低(P均<0.05);肿瘤组织中肿瘤细胞数目大量减少,细胞凋亡,组织结构破损;肿瘤组织中p-PI3K、PI3K、p-Akt、Akt、mTOR、Bcl-2蛋白相对表达量均明显降低(P均<0.05),Bax、Caspase-7、Caspase-9蛋白相对表达量均明显升高(P均<0.05)。环磷酰胺组裸鼠脾脏指数、瘤重、脾脏T淋巴细胞和B淋巴细胞增殖能力指数、外周血白细胞数量和淋巴细胞占比均明显低于模型组(P均<0.05);肿瘤组织中肿瘤细胞数量明显减少。结论白花蛇舌草水提物可显著抑制MDA-MB-231乳腺癌裸鼠移植瘤生长,诱导乳腺癌细胞发生凋亡,增强移植瘤裸鼠免疫功能,其机制可能与抑制PI3K/Akt/mTOR通路激活,下调凋亡相关蛋白表达、上调促凋亡蛋白表达相关。

关键词：白花蛇舌草乳腺癌 MDA-MB-231 裸鼠移植瘤免疫调节凋亡

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Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils

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Chinese Chemical Letters 2021年第3期32卷 949-953页

作者： Yiyun Gao Yan Gao Yuanfu Ding huaping Tan Aihua Zou Shengke li School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Shanghai Key Laboratory of Functional Materials Chemistry State Key Laboratory of Bioreactor Engineering and Institute of Applied ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Quality Research in Chinese Medicine.Institute of Chinese Medical Sciences.University of Macao.Macao.China College of Chemistry and Materials Science Shanghai Normal University.Shanghai 200234China

With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and therapeutics.Cucurbit[n]uril(CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and enzyme.Through host-guest interactions between CB[6]and aliphatic diamines,functional tags covalently connected with CB[6]can be readily anchored into polysaccharidebased hydrogels,realizing multiple functionalization.The rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other polymers.In this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6]and CB[8],covering both bulk hydrogels and particular systems.At the end,possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed.

关键词： Cucurbit[n]uril Host-guest interaction Polysaccharides Hydrogel Drug delivery Tissue engineering