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变电站一次拓扑图自动生成方法的研究与实现

自动化应用 2024年第12期65卷 70-73,76页

作者：徐康许华平李银银孙一民南京电研电力自动化股份有限公司江苏南京211112

绝大多数变电站综合自动化监控系统采用工程人员手绘的方式创建变电站一次拓扑图,效率较低且易出错,为此,研究并实现一种基于全站系统配置文件(SCD)生成变电站一次拓扑图的方法。首先,根据电力系统里常见的间隔类型和接线方式创建典型... 详细信息

绝大多数变电站综合自动化监控系统采用工程人员手绘的方式创建变电站一次拓扑图,效率较低且易出错,为此,研究并实现一种基于全站系统配置文件(SCD)生成变电站一次拓扑图的方法。首先,根据电力系统里常见的间隔类型和接线方式创建典型间隔库。然后,通过SCD文件格式和一次设备拓扑识别规则解析SCD文件,将其识别成典型间隔库中的诸个典型间隔及其各自之间的连接关系。最后,根据解析结果绘制变电站一次拓扑矢量图。变电站自动化监控系统通过上述方法实现了一次拓扑图的自动生成,有效提升了一次拓扑图绘制的效率和准确性。

关键词：全站系统配置文件一次拓扑图典型间隔变电站自动化监控系统

Polyamorphism mediated by nanoscale incipient concentration wave uncovering hidden amorphous intermediate state with ultrahigh modulus in nanostructured metallic glass

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Materials Futures 2023年第2期2卷 123-133页

作者： Qiang Luo Weiran Cui huaping Zhang liangliang li liliang Shao Mingjuan Cai Zhengguo Zhang lin Xue Jun Shen Yu Gong Xiaodong li Maozi li Baolong Shen School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast UniversityNanjing 211189People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Institute of Physics Chinese Academy of SciencesBeijing 100190People’s Republic of China Department of Physics Renmin University of ChinaBeijing 100872People’s Republic of China Inner Mongolia University of Science&Technology Baotou 014010People’s Republic of China College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China

Comprehending the pressure-/temperature-induced structural transition in glasses,as one of the most fascinating issues in material science,is far from being well understood.Here,we report novel polyamorphic transitions in a Cu-based metallic glass(MG)with apparent nanoscale structural heterogeneity relating to proper Y addition.The low-density MG compresses continuously with increasing pressure,and then a compression plateau appears after∼8.1 GPa,evolving into an intermediate state with an ultrahigh bulk modulus of∼467 GPa.It then transforms to a high-density MG with significantly decreased structural heterogeneity above∼14.1 GPa.Three-dimensional atom probe tomography reveals concentration waves of Cu/Zr elements with an average wavelength of∼5-6 nm,which promote the formation of interconnected ringlike networks composed of Cu-rich and Zr-rich dual-glass domains at nanometer scale.Our experimental and simulation results indicate that steplike polyamorphism may stem from synergic effects of the abnormal compression of the Zr-Zr bond length at the atomic scale and the interplay between the applied pressure and incipient concentration waves(Cu and Zr)at several nanometer scales.The present work provides new insights into polyamorphism in glasses and contributes to the development of high-performance amorphous materials by high-pressure nanostructure engineering.

关键词： metallic glasses heterogeneity concentration wave polyamorphism

Robust Estimation for Poisson Integer-Valued GARCH Models Using a New Hybrid Loss

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Journal of Systems Science & Complexity 2021年第4期34卷 1578-1596页

作者： li Qi CHEN huaping ZHU Fukang College of Mathematics Changchun Normal UniversityChangchun 130032China School of Mathematics and Statistics Henan UniversityKaifeng 475004China School of Mathematics Jilin UniversityChangchun 130012China

The Poisson integer-valued GARCH model is a popular tool in modeling time series of counts.The commonly used maximum likelihood estimator is strongly influenced by outliers,so there is a need to develop a robust M-estimator for this model.This paper has three aims.First,the authors propose a new loss function,which is a hybrid of the tri-weight loss for relatively small errors and the exponential squared loss for relatively large ones.Second,Mallows’quasi-likelihood estimator(MQLE)is proposed as an M-estimator and its existence,uniqueness,consistency and asymptotic normality are established.In addition,a data-adaptive algorithm for computing MQLE is given based on a datadriven selection of tuning parameters in the loss function.Third,simulation studies and analysis of a real example are conducted to illustrate the performance of the new estimator,and a comparison with existing estimators is made.

关键词： Loss function M-estimation time series of counts tuning parameter

燃料组件堵流工况下铅铋-氩气两相流的传热压降特性分析

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核安全 2024年第1期23卷 33-47页

作者：夏凡刘书勇李桃生梅华平汪振赵吉运中国科学院合肥物质科学研究院核能安全技术研究所合肥230031 中国科学技术大学合肥230026 香港城市大学机械工程系中国香港

带绕丝燃料组件的堵流事故是铅冷快堆安全分析的重要工况之一。由于在铅铋自由液面处的气体夹带或在气体增强自然循环条件下存在铅铋-氩气的两相流情况,可能引起燃料组件堵流工况下的局部热工水力特性变化。本文通过计算流体力学软件Flu... 详细信息

带绕丝燃料组件的堵流事故是铅冷快堆安全分析的重要工况之一。由于在铅铋自由液面处的气体夹带或在气体增强自然循环条件下存在铅铋-氩气的两相流情况,可能引起燃料组件堵流工况下的局部热工水力特性变化。本文通过计算流体力学软件Fluent,对带绕丝19棒束燃料组件进行建模,模拟分析了堵流工况下的铅铋-氩气两相流传热压降特性,并对两相流模型进行了对比验证,对入口雷诺数、堵块孔隙率、氩气气泡直径等因素进行参数敏感性分析。结果表明:在堵流条件下氩气气泡的流动行为包括逃逸、耗散和受限,在气相体积分率较高的区域会产生局部微正压及过热现象。研究结果可为铅冷快堆堵流事故的安全分析提供参考。

关键词：铅冷快堆燃料组件堵流两相流 CFD数值模拟

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2751-2777页

作者： Yurong Lai Xiaoyan Chu li Di Wei Gao Yingying Guo Xingrong liu Chuang Lu Jialin Mao Hong Shen huaping Tang Cindy Q.Xia Lei Zhang Xinxin Ding Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA Department of Pharmacokinetics Pharmacodynamics and Drug MetabolismMerck&Co.Inc.KenilworthNJ 07033USA Pharmacokinetics Dynamics and MetabolismPﬁzer Worldwide Research and DevelopmentGrotonCT 06340USA Eli lilly and Company IndianapolisIN 46221USA Drug Metabolism and Pharmacokinetics BiogenCambridgeMA 02142USA Drug Metabolism and Pharmacokinetics Accent TherapeuticsInc.LexingtonMA 02421USA Department of Drug Metabolism and Pharmacokinetics GenentechA Member of the Roche GroupSouth San FranciscoCA 94080USA Drug Metabolism and Pharmacokinetics Department Bristol-Myers Squibb CompanyPrincetonNJ 08540USA Bioanalysis and Biomarkers Glaxo Smith KlineKing of the PrussiaPA 19406USA Department of Drug Metabolism and Pharmacokinetics Takeda Pharmaceuticals International Co.CambridgeMA 02139USA Ofﬁce of Research and Standards Ofﬁce of Generic DrugsCDERFDASilver SpringMD 20993USA Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Current afﬁliation:Translational Medicine EMD Serono Research&Development InstituteInc.BillericaMA 01821USA Current afﬁliation:Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA

Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical sciences.The nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological systems.Tremendous progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the attritions.The importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly recognized.Dramatic increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME properties.In this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.

关键词： Drug discovery and development New drug application Biologics license application Pharmacokinetics ADME New modalities Model-informed drug development Micro-physiological systems

Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease:A case report

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生物安全与健康(英文) 2023年第4期5卷 250-253页

作者： Wenzhe Su Qing Zeng Jinmei Geng Jingwen liu huaping Xie Kuibiao li Pengzhe Qin Chaojun Xie Biao Di Guangzhou Center for Disease Control and Prevention Guangzhou 510000China Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou 510000China Huadu Center for Disease Control and Prevention Guangzhou 510803China

Human enterovirus(EV)infections can lead to various manifestations,with variable correlations between genotypes and symptoms.Human enterovirus D68(EV-D68)was considered to be associated with acute respiratory disease and acute flaccid myelitis.In this short report,both EV-D68 and poliovirus 3 were detected in the stool of a hospitalized 5-month child who presented with acute respiratory symptoms and who was recently vaccinated with oral polio vaccine(OPV),using a metatranscriptomic high-throughput sequencing method.The nearly full-length genome sequences with complete open reading frames of EV-D68 and poliovirus 3 were assembled.One previously-reported neurovirulence-related amino acid substitution(T860N)in the EV-D68 VP1 region was observed,but the patient showed no neurological symptoms.More attention should be paid to EV-D68,and continuous multiple syndrome-based surveillance on non-polio enterovirus is called for.

关键词： Enterovirus EV-D68 Poliovirus 3 Acute respiratory disease Whole genome sequencing Co-infection

Lattice Effect on Magnetic and Electrical Properties of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)Films

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Journal of Materials Science & Technology 2008年第5期24卷 709-711页

作者： li＇an HAN huaping YANG Yongjun HE Department of Basic Courses Xi＇an University of Science and Technology Xi＇an 710054 China

Lattice effect on magnetic and electrical transport properties of Ln2/3Pb1/3MnO3 （Ln=La, Pr, Nd） films prepared by RF magnetron sputtering technique were investigated. With the decrease of the average ions radius 〈rA〉, the structure of Ln2/3Pb1/3MnO3 （Ln=La, Pr, Nd） targets transit from the rhombohedral phase to the orthorhombic phase, and the Curie temperature reduces rapidly with the decrease of 〈rA〉. The electrical properties show that films are the metallic state which can be fitted to the formula： ρ（T）=ρ0 ＋ ρ1T^2 ＋ ρ2T^4.5 at low temperatures. The temperature range of the ferromagnetic metallic state becomes narrow with the decrease of 〈rA〉. The phenomenon can be explained by the lattice effect.

关键词： Lattice effect Ln2/3Pb1/3MnO3 films Electrical properties

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分布式光纤传感技术研究和应用的现状及未来

光学学报 2024年第1期44卷 3-65页

作者：张旭苹张益昕王亮余贶琭刘波尹国路刘琨李璇李世念丁传奇汤玉泉尚盈王奕首王晨王峰樊昕昱孙琪真谢尚然吴慧娟吴昊王花平赵志勇南京大学智能光感知与调控技术教育部重点实验室江苏南京210023 华中科技大学光学与电子信息学院湖北武汉430074 北京交通大学信息科学研究所北京100044 之江实验室光纤传感研究中心浙江杭州311100 重庆大学光电技术及系统教育部重点实验室重庆400044 天津大学精密仪器与光电子工程学院天津300072 中国电力科学研究院有限公司北京100192 中国煤炭地质总局勘查研究总院北京100039 中油奥博(成都)科技有限公司四川成都611731 中国科学院合肥物质科学研究院安徽光学精密机械研究所光子器件与材料安徽省重点实验室安徽合肥230031 齐鲁工业大学(山东省科学院) 山东省科学院激光研究所山东济南250104 厦门大学航空航天学院福建厦门361005 上海交通大学电子信息与电气工程学院区域光纤通信网与新型光通信系统国家重点实验室上海200240 北京理工大学光电学院信息光子技术工信部重点实验室北京100081 电子科技大学光纤传感与通信教育部重点实验室四川成都611731 兰州大学土木工程与力学学院甘肃兰州730000

我国大型基础设施的建设规模已多年位居世界之首,分布式光纤传感技术(DOFS)作为大型基础设施健康状态实时监测最有潜力的技术,近年来得到了迅速发展。针对DOFS在技术和应用的突破上面临的挑战,在介绍DOFS各技术基本工作原理、发展历史... 详细信息

我国大型基础设施的建设规模已多年位居世界之首,分布式光纤传感技术(DOFS)作为大型基础设施健康状态实时监测最有潜力的技术,近年来得到了迅速发展。针对DOFS在技术和应用的突破上面临的挑战,在介绍DOFS各技术基本工作原理、发展历史、现状以及典型应用原理和方案等的基础上,对其工作新机理、系统设计方案、研究发展方向等进行了阐述和讨论。

关键词：光纤光学分布式光纤传感技术光时域反射仪光频域反射仪干涉型分布式光纤传感

Pseudo-concentrated electrolytes for lithium metal batteries

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eScience 2022年第5期2卷 557-565页

作者： huaping Wang Jiandong liu Jian He Shihan Qi Mingguang Wu Fang li Junda Huang Yun Huang Jianmin Ma School of Physics and Electronics Hunan UniversityChangsha410082China

lithium metal batteries suffer from short lifespans and low Coulombic efficiency (CE) due to the high reactivity of li and the poor stability of the solid electrolyte interphase (SEI). Herein, we propose the concept of a pseudo-concentrated electrolyte (PCE) induced by an electron-deficient additive (4-pyridylboronic acid;4-PBA) to form a robust, liF-rich SEI, thus addressing the above issues. Molecular dynamics simulations confirm that 4-PBA can increase the coordination number of PF6^(-) anions in the li+ solvation sheath to achieve pseudo-concentrated liPF6 in the electrolyte. Moreover, the 4-PBA can scavenge harmful PF5 decomposed from liPF6 to stabilize the liF-rich SEI. The resulting robust liF-rich SEI promotes li growth along the SEI/li interface and represses the growth of li dendrites. Thus, excellent performance is achieved, with a high CE of 97.1% for a li||Cu cell at 1.0 mA cm^(−2), and over 950 cycles at 0.5 mA cm^(−2) for li||li symmetric cells with 1.0 wt% 4-PBA electrolyte. Meanwhile, the resulting stable boron-containing cathode electrolyte interphase enables li||liNi0·6Co0·2Mn0·2O_(2) (NCM622) cells to achieve excellent stability, with a capacity retention of 86.9% after 200 cycles.

关键词： lithium metal batteries Pseudo-concentrated electrolyte Solid electrolyte interphase Solvation structure 4-Pyridylboronic acid