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胡黄连苷Ⅱ对非小细胞肺癌恶性进展的影响

中国药房 2024年第4期35卷 430-435页

作者：郭寰宇王卫芳徐丽伟董文博长春中医药大学临床医学院实验中心长春130117 长春中医药大学临床医学院生物化学教研室长春130117 长春中医药大学附属医院肿瘤血液科长春130112 吉林大学第一医院二部检验科长春130061

目的探讨胡黄连苷Ⅱ对非小细胞肺癌(NSCLC)恶性进展的影响及机制。方法将A549细胞分组为对照组,胡黄连苷Ⅱ低、中、高浓度组,K6PC-5[鞘氨醇激酶1(SPHK1)激活剂]组,胡黄连苷Ⅱ高剂量+K6PC-5组,检测细胞增殖、迁移、侵袭情况,以及细胞中... 详细信息

目的探讨胡黄连苷Ⅱ对非小细胞肺癌(NSCLC)恶性进展的影响及机制。方法将A549细胞分组为对照组,胡黄连苷Ⅱ低、中、高浓度组,K6PC-5[鞘氨醇激酶1(SPHK1)激活剂]组,胡黄连苷Ⅱ高剂量+K6PC-5组,检测细胞增殖、迁移、侵袭情况,以及细胞中增殖细胞核抗原(PCNA)、基质金属蛋白酶2(MMP-2)、MMP-9、SPHK1、1-磷酸鞘氨醇受体3(S1PR3)及胞外信号调节激酶1/2(ERK1/2)蛋白的表达情况。以BALB/c裸鼠为对象,通过皮下接种A549细胞悬液建立NSCLC裸鼠移植瘤模型,并将其分为裸鼠-对照组,裸鼠-胡黄连苷Ⅱ低、中、高剂量组,裸鼠-K6PC-5组,裸鼠-胡黄连苷Ⅱ高剂量+K6PC-5组(每组5只),考察胡黄连苷Ⅱ对其瘤体质量及体积的影响。结果与对照组比较,胡黄连苷Ⅱ低、中、高浓度组的细胞OD450值、EdU阳性细胞率、划痕愈合率、细胞侵袭数及PCNA、MMP-2、MMP-9、SPHK1、S1PR3、ERK1/2蛋白的相对表达量均显著降低;与裸鼠-对照组比较,裸鼠-胡黄连苷Ⅱ低、中、高剂量组裸鼠体内的瘤体质量及体积均显著降低或缩小,上述指标均呈浓度/剂量依赖性变化(P<0.05);K6PC-5组细胞和裸鼠-K6PC-5组裸鼠对应指标的变化趋势则相反(P<0.05)。与胡黄连苷Ⅱ高浓度组或裸鼠-胡黄连苷Ⅱ高剂量组比较,胡黄连苷Ⅱ高浓度+K6PC-5组细胞和裸鼠-胡黄连苷Ⅱ高剂量+K6PC-5组裸鼠的上述定量指标均显著升高或增大(P<0.05)。结论胡黄连苷Ⅱ可能通过抑制SPHK1/1-磷酸鞘氨醇/S1PR3信号通路来抑制NSCLC的恶性进展。

关键词：胡黄连苷Ⅱ 非小细胞肺癌增殖迁移侵袭鞘氨醇激酶1/1-磷酸鞘氨醇/1-磷酸鞘氨醇受体3信号通路

Distributed regularized online optimization using forward-backward splitting

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Control Theory and Technology 2023年第2期21卷 212-221页

作者： Deming Yuan Baoyong Zhang Shengyuan xu huanyu Zhao School of Automation Nanjing University of Science and TechnologyNanjing 210094China Faculty of Automation Huaiyin Institute of TechnologyHuai'an 223003China

This paper considers the problem of distributed online regularized optimization over a network that consists of multiple interacting *** node is endowed with a sequence of loss functions that are time-varying and a regularization function that is fixed over time.A distributed forward-backward splitting algorithm is proposed for solving this problem and both fixed and adaptive learning rates are *** both cases,we show that the regret upper bounds scale as O(VT),where T is the time *** particular,those rates match the centralized ***,we show the effectiveness of the proposed algorithms over an online distributed regularized linear regression problem.

关键词： Distributed online optimization Regularized online learning Regret Forward-backward splitting

Production quality and pricing strategy for substitutable products under comparison effects

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Journal of Management Science and Engineering 2023年第4期8卷 529-557页

作者： huanyu Yue Yifan xu School of Management Fudan UniversityShanghai200433China

Comparison effects have been studied extensively in many *** particular,existing operations management articles have discussed the impact of comparison effects on enterprises'production and pricing *** has also shown that consumers'purchasing decisions are primarily determined by three factors:product quality,selling price,and comparison *** current study introduces the concepts of social and temporal comparison effects to examine how comparison effects influence a monopolist's production quality and pricing strategy for substitutable *** reveal the following:(1)Setting different prices for even two types of substitutable products with negligible quality differences can divide customers into three groups under the influence of social comparison effects in a single-stage model.(2)The monopolist should avoid using a price discrimination strategy in which products with a short market life cycle have the same quality but different prices.(3)When the market life cycle of products is sufficiently long in the single-product market and the market with two substitutable products,the monopolist's optimal choice in the second stage is to keep production quality constant and increase the selling ***,the number of buyers does not decrease because of temporal comparison ***,the firm increases its revenue.(4)For the market with two substitutable products with quality differences,one approximate optimal strategy for the enterprise in the second stage is to keep the selling price constant with the assumption that product quality cannot be adjusted after the first *** this point,the consumption situation in the market is the same as that in the first ***,when no external constraints exist,the monopolist firm can obtain more benefits in the second stage than in the first stage by exploiting the temporal comparison effects of consumers in the second stage.(5)When consumer identity information can b

关键词： Production quality and pricing strategy Behavioral operations Social comparison effects Temporal comparison effects

Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment

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Nano-Micro Letters 2021年第2期13卷 246-261页

作者： huanyu Yang Renfa Liu Yunxue xu Linxue Qian Zhifei Dai Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityNo.95 Yongan RoadXicheng DistrictBeijing 100050People’s Republic of China Department of Biomedical Engineering College of EngineeringPeking UniversityNo.5 Yiheyuan RoadHaidian DistrictBeijing 100871People’s Republic of China

Patients with pancreatic cancer(PCa)have a poor prognosis apart from the few suitable for *** therapy(PDT)is a minimally invasive treatment modality whose efficacy and safety in treating unresectable localized PCa have been corroborated in ***,it suffers from certain limitations during clinical exploitation,including insufficient photosensitizers(PSs)delivery,tumor-oxygenation dependency,and treatment escape of aggressive *** overcome these obstacles,an increasing number of researchers are currently on a quest to develop photosensitizer nanoparticles(NPs)by the use of a variety of nanocarrier systems to improve cellular uptake and biodistribution of *** of PSs with NPs endows them significantly higher accumulation within PCa tumors due to the increased solubility and stability in blood circulation.A number of approaches have been explored to produce NPs co-delivering multi-agents affording PDT-based synergistic therapies for improved response rates and durability of response after *** review provides an overview of available data regarding the design,methodology,and oncological outcome of the innovative NPs-based PDT of PCa.

关键词： Photodynamic therapy Photosensitizer Nanoparticle Pancreatic cancer Combined therapy

SURF算法和RANSAC算法相结合的遥感图像匹配方法

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计算机科学与探索 2012年第9期6卷 822-828页

作者：陈艺虾孙权森徐焕宇耿蕾蕾南京理工大学计算机科学与技术学院南京210094

综合利用了SURF(speeded up robust features)算法和RANSAC(random sample consensus)算法各自的优势,提出了一种SURF算法和RANSAC算法相结合的遥感图像匹配方法。首先利用SURF算法提取特征点并进行预匹配,然后用RANSAC算法剔除误匹配点... 详细信息

综合利用了SURF(speeded up robust features)算法和RANSAC(random sample consensus)算法各自的优势,提出了一种SURF算法和RANSAC算法相结合的遥感图像匹配方法。首先利用SURF算法提取特征点并进行预匹配,然后用RANSAC算法剔除误匹配点对,解决了SURF算法中存在的误差匹配和错误匹配问题。通过实验验证了所提算法的有效性,并且该算法在实际应用中也取得了良好的效果。

关键词：积分图像盒滤波器 SURF算法 Hession矩阵 RANSAC算法遥感图像

涠西南凹陷流二段油页岩与泥岩形成环境及生烃特征差异性

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中国海上油气 2024年第3期36卷 25-36页

作者：徐建永郑瑞辉李宏义肖伶俐曹磊夏环宇中海油研究总院有限责任公司北京100028 西安科技大学地质与环境学院陕西西安710054 中国石油大学(北京)地球科学学院北京102249 西安石油大学地球科学与工程学院陕西西安710065

始新统流沙港组二段(流二段)油页岩和泥岩是涠西南凹陷古近系的主力烃源岩,二者形成环境和生烃特征差异研究对北部湾盆地新区优质烃源岩预测和凹陷评价意义重大。本文根据有机地球化学、元素地球化学及有机岩石学的原理和方法,基于烃源... 详细信息

始新统流沙港组二段(流二段)油页岩和泥岩是涠西南凹陷古近系的主力烃源岩,二者形成环境和生烃特征差异研究对北部湾盆地新区优质烃源岩预测和凹陷评价意义重大。本文根据有机地球化学、元素地球化学及有机岩石学的原理和方法,基于烃源岩地球化学特征综合分析和实验室模拟研究,对比了两类烃源岩形成环境和生烃特征的差异。结果表明,涠西南凹陷流二段油页岩有机质丰度高、类型好,为很好烃源岩;泥岩有机质丰度较低、类型较差,为好烃源岩。油页岩与泥岩地球化学特征及有机质富集程度的差异是由母岩性质、生源构成、古生产力和有机质保存条件等因素共同作用的结果。油页岩沉积时期湖盆古生产力高、藻类勃发,主要形成于还原环境,有利于有机质的保存;泥岩沉积时期弱还原的水体环境、较快的沉积速率和陆源物质的大量输入不利于有机质的保存。有机质类型和生源构成的差别造成两类烃源岩生烃动力学特征和生烃演化模式存在较大差异,其中油页岩活化能分布相对集中,而泥岩活化能分布相对分散;油页岩的生油高峰早于泥岩,且生油高峰期油页岩的生油率明显高于泥岩。

关键词：形成环境生烃特征油页岩泥岩涠西南凹陷北部湾盆地

新一代水文水资源监测卫星SWOT数据特征、应用与展望

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地球科学进展 2024年第4期39卷 374-390页

作者：么嘉棋常奂宇王梦然陈敏莫凡徐南温振曹永强天津师范大学京津冀生态文明发展研究院天津300387 清华大学水圈科学与水利工程全国重点实验室北京100084 自然资源部国土卫星遥感应用中心北京100048 河海大学地球科学与工程学院江苏南京211100 山东科技大学测绘与空间信息学院山东青岛266590

水文水资源监测是对地观测系统的重要任务之一,是支撑新时代水利高质量发展、满足“三水”共治需求和践行“十六字”治水策略的直接有效途径,而卫星遥感技术提供了一种大范围、快速和高精度的数据获取渠道。但是现有卫星遥感在水文水资... 详细信息

水文水资源监测是对地观测系统的重要任务之一,是支撑新时代水利高质量发展、满足“三水”共治需求和践行“十六字”治水策略的直接有效途径,而卫星遥感技术提供了一种大范围、快速和高精度的数据获取渠道。但是现有卫星遥感在水文水资源应用上存在多星同步观测难、应急响应能力差和易受天气影响等问题,因此美国国家航空航天局于2022年12月发射了地表水和海洋地形卫星(SWOT),这是全球第一颗通过多传感器协同观测全球陆地和海洋水资源的卫星,预期将极大提升水文水资源监测的时空分辨率和精度。系统梳理了水文水资源监测卫星发展现状、应用和技术难点等概况,并分析了SWOT卫星的参数、科学任务、算法流程和应用产品等内容,对我国后续卫星设计规划和数据处理关键技术有一定的参考价值。

关键词：水资源水文学卫星遥感卫星测高地表水和海洋地形卫星(SWOT)任务

火焰原子吸收法与分光光度法测定锌灰中铜含量

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煤炭与化工 2021年第3期44卷 138-142页

作者：许焕钰牛佳如冯漫玉王璇次立杰石家庄学院化学工程与工艺河北石家庄050035

锌灰为热镀锌厂和电解锌厂的工业废料,主要含有Al、Zn、Fe、Mn、Cu、Pb。为了探究锌灰中铜含量的浓度,分别采用火焰原子吸收分光光度法和双环己酮草酰二腙分光光度法测定了锌灰中的铜含量。根据实验探究所得铜的标准曲线,测定了锌灰中... 详细信息

锌灰为热镀锌厂和电解锌厂的工业废料,主要含有Al、Zn、Fe、Mn、Cu、Pb。为了探究锌灰中铜含量的浓度,分别采用火焰原子吸收分光光度法和双环己酮草酰二腙分光光度法测定了锌灰中的铜含量。根据实验探究所得铜的标准曲线,测定了锌灰中的铜含量,与火焰原子吸收法测出的含量数据相比较,考察了双环己酮草酰二腙分光光度法测定铜含量的最适温度和所用试剂的最佳用量。探究的试剂分别为掩蔽剂柠檬酸、显色剂双环己酮草酰二腙。

关键词：锌灰铜含量变量探究分光光度法火焰原子标准曲线

Software defined industrial network architecture for edge computing offloading

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The Journal of China Universities of Posts and Telecommunications 2019年第1期26卷 49-58页

作者： xu Fangmin Ye huanyu Cui Shaohua Zhao Chenglin Yao Haipeng School of Telecommunication Engineering Beijing University of Posts and Telecommunications China Petroleum Technology and Development Corporation

The integration of the Internet and the traditional manufacturing industry makes the industrial Internet of things(IIoT) as a popular research topic. However, traditional industrial networks continue to face challenges of resource management and limited raw data storage and computation capacity. A novel software defined industrial network(SDIN) architecture was proposed to address the existing drawbacks in IIoT such as resource utilization, data processing and storage, and system compatibility. The architecture is developed based on the software defined network(SDN) architecture, combining hierarchical cloud and fog computing and content-aware caching technologies. Based on the SDIN architecture, two types of edge computing strategies in industrial applications are discussed. Different scenarios and service requirements are considered. The simulation results confirm that the SDIN architecture is feasible and effective in the application of edge computing offloading.

关键词： software defined industrial network(SDIN) industrial Internet of things(IIoT) edge computing computing offloading time delay