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原发性及转移性腺泡状软组织肉瘤临床及影像学特点

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医学影像学杂志 2024年第9期34卷 102-105页

作者：许还予潘志立夏睿中国科学技术大学附属第一医院放射科安徽合肥230001 中国科学技术大学附属第一医院创伤骨科安徽合肥230001

目的探讨腺泡状软组织肉瘤(ASPS)及其转移灶的临床特征及影像学表现。方法选取经病理证实的15例ASPS患者资料,分析病灶部位、大小、形态、密度、信号、强化、毗邻关系、转移特征及随访情况。结果15例患者中原发性6例,继发性9例,发病中... 详细信息

目的探讨腺泡状软组织肉瘤(ASPS)及其转移灶的临床特征及影像学表现。方法选取经病理证实的15例ASPS患者资料,分析病灶部位、大小、形态、密度、信号、强化、毗邻关系、转移特征及随访情况。结果15例患者中原发性6例,继发性9例,发病中位年龄25岁;原发肿瘤部位:下肢10例,上肢2例,髂窝1例,腹壁1例,颈部1例。肿瘤体积较大,CT和MRI平扫呈不均匀密度信号,增强均呈显著不均匀强化,肿瘤内部及周围见多发迂曲增粗血管影。患者中12例肺转移,5例骨转移,4例淋巴结转移,2例肝转移,2例脑转移,增强部分病灶明显强化。结论ASPS发病年龄较小,生长缓慢,多好发于下肢,增强后瘤周及瘤内明显增粗增多的血管影为其影像学特征,易转移,肺转移最常见。

关键词：腺泡状软组织肉瘤体层摄影术 X线计算机磁共振成像

Conformational sensitivity of tetraphenyl-1,3-butadiene derivatives with aggregation-induced emission characteristics

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Science China Chemistry 2019年第10期62卷 1393-1397页

作者： Yahui Zhang huanyu xu Weiquan xu Chen Zhang Jianbing Shi Bin Tong Zhengxu Cai Yuping Dong Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of Technology

Organic dyes with conformational sensitivity can be used to probe weak interactions at the molecular ***,three molecules based on tetraphenyl-1,3-butadienes(TPBs)were synthesized and studied with respect to their synthesis,structural characterization and potential *** TPBs showed aggregation-induced emission(AIE)characteristics and sensitive conformational properties,in which the emission wavelengths could be changed in different *** TPBs single crystals revealed that the phenyl groups at the 4-position of the 1,3-butadienes contributed to their conformational ***,the potential application for monitoring the interactions among polyelectrolyte complexes and metal ions was explored,and the results showed that TPBs could be used for sensitively probing some weak interactions by changing the emission wavelengths due to their conformation-sensitive *** may become a new star in AIE research fields.

关键词： tetraphenyl-1 3-butadienes(TPBs) aggregation-induced emission(AIE) polyelectrolyte complexes(PEC) conformational sensitivity

葡萄MYB转录因子基因VvMYB30的克隆及其耐盐性分析

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中外葡萄与葡萄酒 2024年第1期 20-27页

作者：解振强许桓瑜黄金霞蔡善亚李刚赵鹏程江苏农林职业技术学院江苏句容212400 扬中市经济开发区管委会江苏扬中212200

MYB转录因子在响应各类非生物胁迫中发挥着重要作用。本研究以‘阳光玫瑰’葡萄为材料,鉴定了1个盐胁迫响应MYB转录因子基因VvMYB30,并对其特性及功能进行研究。该基因cDNA全长为984 bp,编码327个氨基酸。生物信息学分析发现,VvMYB30含... 详细信息

MYB转录因子在响应各类非生物胁迫中发挥着重要作用。本研究以‘阳光玫瑰’葡萄为材料,鉴定了1个盐胁迫响应MYB转录因子基因VvMYB30,并对其特性及功能进行研究。该基因cDNA全长为984 bp,编码327个氨基酸。生物信息学分析发现,VvMYB30含有1个保守的R2R3蛋白结构域,与甜橙CsMYB30转录因子的同源性最高,相似度为64.75%,归属于SubgroupⅠ亚类。亚细胞定位及转录激活分析表明,VvMYB30定位于细胞核,且具有转录激活活性。qRT-PCR结果表明,VvMYB30受盐胁迫诱导,处理24 h表达量达到最高,为对照的6.86倍。将VvMYB30基因转化拟南芥,盐胁迫下VvMYB30转基因拟南芥种子萌发率和幼苗的成活率均显著高于野生型,表明过表达VvMYB30可增强转基因拟南芥的耐盐性。

关键词：阳光玫瑰 MYB转录因子盐胁迫功能分析

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Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer

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Aggregate

Aggregate 2024年第1期5卷 377-384页

作者： Renfa Liu huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue xu Zhifei Dai Linxue Qian Department of Biomedical Engineering College of Future TechnologyNational Biomedical Imaging CenterPeking UniversityBeijingChina Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijingChina

Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and ***,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ***,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal *** antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 *** micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem *** a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem *** research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.

关键词： antimicrobial peptide gemcitabine resistance intratumoral microbiota pancreatic ductal adenocarcinoma photodynamic antibacterial therapy

Microwave shock motivating the Sr substitution of 2D porous GdFeO_(3) perovskite for highly active oxygen evolution

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Journal of Energy Chemistry 2024年第1期88卷 232-241,I0006页

作者： Jinglin Xian Huiyu Jiang Zhiao Wu Huimin Yu Kaisi Liu Miao Fan Rong Hu Guangyu Fang Liyun Wei Jingyan Cai Weilin xu huanyu Jin Jun Wan State Key Laboratory of New Textile Materials and Advanced Processing Technologies Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&FinishingWuhan Textile UniversityWuhan 430200HubeiChina Future Industries Institute STEMUniversity of South AustraliaAdelaideSA 5095Australia Institute for Sustainability Energy and ResourcesThe University of AdelaideAdelaideSA 5005Australia

The incorporation of partial A-site substitution in perovskite oxides represents a promising strategy for precisely controlling the electronic configuration and enhancing its intrinsic catalytic *** methods for A-site substitution typically involve prolonged high-temperature *** these processes promote the development of unique nanostructures with highly exposed active sites,they often result in the uncontrolled configuration of introduced ***,we present a novel approach for synthesizing two-dimensional(2D)porous GdFeO_(3) perovskite with A-site strontium(Sr)substitution utilizing microwave shock *** technique enables precise control of the Sr content and simultaneous construction of 2D porous structures in one step,capitalizing on the advantages of rapid heating and cooling(temperature~1100 K,rate~70 K s^(-1)).The active sites of this oxygen-rich defect structure can be clearly revealed through the simulation of the electronic configuration and the comprehensive analysis of the crystal *** electrocatalytic oxygen evolution reaction application,the synthesized 2D porous Gd_(0.8)Sr_(0.2)FeO_(3) electrocatalyst exhibits an exceptional overpotential of 294 mV at a current density of 10 mA cm^(-2)and a small Tafel slope of 55.85 mV dec^(-1)in alkaline *** study offers a fresh perspective on designing crystal configurations and the construction of nanostructures in perovskite.

关键词： 2D materials Perovskite Microwave Electrocatalysis Oxygen evolution reaction

Microwave-assisted exploration of the electron configuration-dependent electrocatalytic urea oxidation activity of 2D porous NiCo_(2)O_(4) spinel

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Journal of Energy Chemistry 2024年第4期91卷 226-235页

作者： Jun Wan Zhiao Wu Guangyu Fang Jinglin Xian Jiao Dai Jiayue Guo Qingxiang Li Yongfei You Kaisi Liu Huimin Yu Weilin xu Huiyu Jiang Minggui Xia huanyu Jin State Key Laboratory of New Textile Materials and Advanced Processing Technologies Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&FinishingWuhan Textile UniversityWuhan 430200HubeiChina Institute for Sustainability Energy and ResourcesThe University of AdelaideAdelaideSA 5005Australia Future Industries Institute University of South AustraliaMawson Lakes CampusAdelaideSA 5095Australia

Urea holds promise as an alternative water-oxidation substrate in electrolytic ***-valence nickelbased spinel,especially after heteroatom doping,excels in urea oxidation reactions(UOR).However,traditional spinel synthesis methods with prolonged high-temperature reactions lack kinetic precision,hindering the balance between controlled doping and highly active two-dimensional(2D)porous structures *** significantly impedes the identification of electron configuration-dependent active sites in doped 2D nickel-based ***,we present a microwave shock method for the preparation of 2D porous NiCo_(2)O_(4)*** the transient on-off property of microwave pulses for precise heteroatom doping and 2D porous structural design,non-metal doping(boron,phosphorus,and sulfur)with distinct extranuclear electron disparities serves as straightforward examples for *** tuning of lattice parameter reveals the impact of covalent bond strength on NiCo_(2)O_(4)structural *** introduced defect levels induce unpaired d-electrons in transition metals,enhancing the adsorption of electron-donating amino groups in urea ***,Bode plots confirm the impact mechanism of rapid electron migration caused by reduced band gaps on UOR *** prepared phosphorus-doped 2D porous NiCo_(2)O_(4),with optimal electron configuration control,outperforms most reported *** controlled modification strategy advances understanding theoretical structure-activity mechanisms of high-performance 2D spinels in UOR.

关键词： 2D materials Spinel Microwave Electrocatalysis Urea oxidation reaction

Serological Investigation into the Infected Genotypes of Patients with Japanese Encephalitis in the Coastal Provinces of China

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Biomedical and Environmental Sciences 2024年第7期37卷 716-725页

作者： Weijia Zhang Jierong Zhao Qikai Yin Shenghui Liu Ruichen Wang Shihong Fu Fan Li Ying He Kai Nie Guodong Liang Songtao xu Guang Yang huanyu Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Basic Medicine and Public Health Jinan UniversityGuangzhou 510000GuangdongChina

Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains *** searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis(JE)in the coastal provinces of *** In this study,we collected serum specimens from patients with JE in three coastal provinces of China(Guangdong,Zhejiang,and Shandong)from 2018 to 2020 and conducted JEV cross-neutralization tests against G1,G3,and *** Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong(92 patients),Zhejiang(192 patients),and Guangdong(77 patients),China,from 2018 to *** of the 361 serum specimens were laboratory-confirmed to be infected with *** cases were confirmed to be infected with G1 JEV,32 with G3 JEV,and two with G5 *** G3 was the primary infection genotype among JE cases with a definite infection genotype,and the infection caused by G5 JEV was confirmed serologically in China.

关键词： Japanese encephalitis virus Serological investigation Plaque reduction neutralization test Cross-neutralization test Genotype

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使用复合注意力的文本图像超分辨率算法研究

国外电子测量技术 2023年第12期42卷 102-107页

作者：丁天徐萌兮徐焕宇南京信息工程大学南京210044 无锡学院无锡214105

现实场景下,低分辨率的文本图像会导致识别准确率降低。为了解决这个问题,提出一种使用复合注意力的文本图像超分辨率方法。在复合注意力模块中,将空间注意力模块改进为优化残差模块,并在优化残差模块中融入增强型空间注意力模块,从而... 详细信息

现实场景下,低分辨率的文本图像会导致识别准确率降低。为了解决这个问题,提出一种使用复合注意力的文本图像超分辨率方法。在复合注意力模块中,将空间注意力模块改进为优化残差模块,并在优化残差模块中融入增强型空间注意力模块,从而重建出清晰的超分辨率文本图像。同时,引入多层训练损失函数即均方误差损失和小波损失,增加文本边缘的锐度,使生成图像中的文本具有清晰的边缘和正确的结构。实验结果证明,提出方法相较于对比方法,视觉感受方面,文字结构和边缘细节更清晰,对比度更高;客观指标方面,图像质量评价指标与文本识别准确率均得到了有效提升。

关键词：超分辨率注意力机制残差网络损失函数

Chromosome-scale genome assembly provides insights into the evolution and flavor synthesis of passion fruit (Passiflora edulis Sims)

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Horticulture Research 2021年第1期8卷 181-194页

作者： Zhiqiang Xia Dongmei Huang Shengkui Zhang Wenquan Wang Funing Ma Bin Wu Yi xu Bingqiang xu Di Chen Meiling Zou huanyu xu Xincheng Zhou Rulin Zhan Shun Song Haikou Experimental Station Chinese Academy of Tropical Agricultural SciencesKey Laboratory of Genetic Improvement of Bananas571101 HaikouHainanP.R.China Hainan University 571101 HaikouHainanP.R.China State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology(Shandong Academy of Sciences)250353 JinanShandongP.R.China The Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences571101 HaikouHainanP.R.China

Passion fruit(Passiflora edulis Sims)is an economically valuable fruit that is cultivated in tropical and subtropical regions of the ***,we report an~1341.7Mb chromosome-scale genome assembly of passion fruit,with 98.91%(~1327.18Mb)of the assembly assigned to nine *** genome includes 23,171 protein-coding genes,and most of the assembled sequences are repetitive sequences,with long-terminal repeats(LTRs)being the most *** analysis revealed that passion fruit diverged after Brassicaceae and before *** analysis showed that two whole-genome duplication events occurred in passion fruit at 65 MYA and 12 MYA,which may have contributed to its large genome *** integrated analysis of genomic,transcriptomic,and metabolomic data showed that‘alpha-linolenic acid metabolism’,‘metabolic pathways’,and‘secondary metabolic pathways’were the main pathways involved in the synthesis of important volatile organic compounds(VOCs)in passion fruit,and this analysis identified some candidate genes,including GDP-fucose Transporter 1-like,Tetratricopeptide repeat protein 33,protein NETWORKED 4B isoform X1,and Golgin Subfamily A member 6-like protein *** addition,we identified 13 important gene families in fatty acid pathways and eight important gene families in terpene *** family analysis showed that the ACX,ADH,ALDH,and HPL gene families,especially ACX13/14/15/20,ADH13/26/33,ALDH1/4/21,and HPL4/6,were the key genes for ester synthesis,while the TPS gene family,especially PeTPS2/3/4/24,was the key gene family for terpene *** work provides insights into genome evolution and flavor trait biology and offers valuable resources for the improved cultivation of passion fruit.

关键词： metabolism synthesis insight