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Frontiers of Environmental Science & Engineering 2010年第3期4卷 321-328页

作者： Chao QIN Shaogui YANG Cheng SUN Manjun ZHAN Rongjun WANG huanxing cai Jia ZHOU State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210093China Nanjing Research Institude of Environmental Protection Nanjing 210013China Changzhou Environmental Monitoring Center Changzhou 210093China

A solution of atrazine in a TiO_(2)suspension,an endocrine disruptor in natural water,was tentatively treated by microwave-assisted photocatalytic *** effects of mannitol,oxygen,humic acid,and hydrogen dioxide on the photodegradation rate were *** results could be deduced as follows:the photocatalytic degradation of atrazine fits the pseudo-first-order kinetic well with k=0.0328 s–1,and·OH was identified as the dominant *** of atrazine was hindered in the presence of humic acid,and the retardation effect increased as the concentration of humic acid increased.H_(2)O_(2)displayed a significant negative influence on atrazine photocatalysis *** on intermediates identified with gas chromatography-mass spectrometry(GC-MS)and Liquid chromatography-mass spectrometry(LC-MS/MS)techniques,the main degradation routes of atrazine are proposed.

关键词： atrazine retardation effect photocatalysis TiO_(2)

精细化管理在福清核电5号机组主控室可用节点的应用

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核科学与工程 2021年第1期41卷 194-200页

作者：蔡欢星马宁刘文杰胡驰华中国核电工程有限公司华东分公司浙江嘉兴314000

"华龙一号"机组DCS系统采用三新设备,在前期供货和安装阶段产生大量制约。为避免首堆重大节点拖期现象出现,福清5号机组项目调试部采用精细化管理的方法,精准把控首堆主控室可用节点进度和施工质量。本文详细描述了项目调试部在主控室... 详细信息

"华龙一号"机组DCS系统采用三新设备,在前期供货和安装阶段产生大量制约。为避免首堆重大节点拖期现象出现,福清5号机组项目调试部采用精细化管理的方法,精准把控首堆主控室可用节点进度和施工质量。本文详细描述了项目调试部在主控室可用节点准备阶段和执行阶段采取的进度和质量控制专项管理方式,也为华龙机组后续节点提供了一种已经验证的有效的管理方式。

关键词： “华龙一号” 精细化管理主控室可用节点

成组生物毒性测试法综合评价典型工业废水毒性

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生态毒理学报 2012年第4期7卷 381-388页

作者：邹叶娜蔡焕兴薛银刚徐东炯常州大学环境与安全工程学院常州213164 江苏省环境保护水环境生物监测重点实验室常州市环境监测中心常州213001 南京大学环境学院污染控制与资源化研究国家重点实验室南京210093

为了更加准确地评估典型工业废水的综合生物毒性以及处理工艺对废水毒性的削减情况,采用发光细菌急性毒性实验、大型溞急性毒性实验和单细胞凝胶电泳实验,结合潜在生态毒性效应探测(potential ecotoxic effects probe,PEEP)指数对常州市... 详细信息

为了更加准确地评估典型工业废水的综合生物毒性以及处理工艺对废水毒性的削减情况,采用发光细菌急性毒性实验、大型溞急性毒性实验和单细胞凝胶电泳实验,结合潜在生态毒性效应探测(potential ecotoxic effects probe,PEEP)指数对常州市7种典型工业废水的综合生物毒性进行了评价。结果表明,7种工业原水都表现出了急性毒性或遗传毒性,综合生物毒性强度的排序为电子厂>电镀厂>综合污水处理厂>印染厂>化工厂>食品厂>制药厂。而7种工业废水的处理后出水综合生物毒性强度的排序为印染厂>化工厂>电子厂>综合污水处理厂>食品厂>制药厂>电镀厂。其中,印染和化工厂出水综合生物毒性高于原水,分别增加了43.3%和38.7%,PEEP评价结果显示分别属于剧毒和高毒,而电镀、电子、综合污水处理和食品厂出水的综合生物毒性削减明显,分别比原水削减了76.9%、53.1%、48.3%和26.6%,PEEP结果表明基本无毒。建立在成组生物毒性实验基础上的PEEP评价方法可全面反映工业废水的综合生物毒性,进而更客观地评价废水对水生态系统乃至人类健康的潜在影响。

关键词：成组生物毒性测试工业废水 PEEP 发光细菌大型溞单细胞凝胶电泳

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化工园区大气环境特征及其对健康的影响

环境工程 2014年第1期32卷 84-87,125页

作者：李丹戴玄吏董黎静蔡焕兴常州大学环境与安全工程学院江苏常州213164 常州市环境监测中心江苏常州213001

区域大气环境质量恶化是目前我国经济发展中新出现的重要问题之一。随着经济的快速发展,城市工业企业数量在急剧增加,规模也在不断扩大,其对区域环境空气质量的影响也越来越大。同时园区的大气环境污染也给周围居民带来了健康问题,致使... 详细信息

区域大气环境质量恶化是目前我国经济发展中新出现的重要问题之一。随着经济的快速发展,城市工业企业数量在急剧增加,规模也在不断扩大,其对区域环境空气质量的影响也越来越大。同时园区的大气环境污染也给周围居民带来了健康问题,致使各种疾病的发病率增高。综述了目前区域性大气污染的研究状况和成果及其与健康影响之间的关系。

关键词：化工园区大气环境健康影响

罐采样与气相色谱/质谱结合在VOCs监测中的应用

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环境工程 2013年第4期31卷 133-136页

作者：李丹戴玄吏董黎静蔡焕兴常州大学环境与安全工程学院江苏常州213164 常州市环境监测中心江苏常州213001

气态挥发性有机物(VOCs)引起的污染严重威胁人们的健康,因而对其监测技术的研究也越来越多。其中罐采样与气相色谱/质谱联用的检测技术在VOCs气态污染物测定中的应用逐步受到关注。对罐采样技术进行了综述,重点介绍了罐采样与气相色谱/... 详细信息

气态挥发性有机物(VOCs)引起的污染严重威胁人们的健康,因而对其监测技术的研究也越来越多。其中罐采样与气相色谱/质谱联用的检测技术在VOCs气态污染物测定中的应用逐步受到关注。对罐采样技术进行了综述,重点介绍了罐采样与气相色谱/质谱联用技术在环境空气、室内空气、废气中VOCs检测的应用。

关键词：挥发性有机化合物(VOCs) 罐采样气相色谱质谱气态污染物

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南京市表层土壤重金属污染特征及污染来源

环境科学与管理 2010年第10期35卷 31-34,77页

作者：段雪梅蔡焕兴巢文军常州市环境监测中心站江苏常州213001

以南京市表层土壤为对象,研究了南京市不同功能区土壤重金属的污染特征,并采用主成分分析法对南京市土壤重金属的主要可能来源予以判别。结果表明:重金属污染主要在工业区和交通繁忙区相对较重,而居民区和公园区的重金属污染相对较轻。... 详细信息

以南京市表层土壤为对象,研究了南京市不同功能区土壤重金属的污染特征,并采用主成分分析法对南京市土壤重金属的主要可能来源予以判别。结果表明:重金属污染主要在工业区和交通繁忙区相对较重,而居民区和公园区的重金属污染相对较轻。从本次调查的土壤重金属污染水平的对应分析结果来看,重金属Pb的富集系数为3.21,表现为强富集;而Cu、Zn的富集系数分别为:1.72和1.80,表现为一定的弱富集;Cr和N i的富集系数分别为0.99和1.00表现相对贫化,基本与背景值较接近.对南京市土壤重金属主成分分析结果表明:南京市市区的土壤重金属污染主要来自于交通排放和工业释放;同时,也应该看到对于城市公园和居民住宅区,城市垃圾、市政工程等也是目前环境污染的一个重要原因。

关键词：重金属污染主成分分析功能区

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浅析化工园区大气特征因子自动监测综合分析

环境科学与管理 2013年第2期38卷 136-138页

作者：余益军戴玄吏李春玉孙佳蔡焕兴江苏省常州市环境监测中心江苏常州213001

从总体状况评价、浓度变化特征、疑似源探寻等角度初步分析了某化工园区大气特征因子自动监测数据。分析表明,合理选用不同水平的数据集可以突出大气特征因子的规律性,尤其是疑似源探寻;采用现场检查等手段与自动监测的相互校核十分必要... 详细信息

从总体状况评价、浓度变化特征、疑似源探寻等角度初步分析了某化工园区大气特征因子自动监测数据。分析表明,合理选用不同水平的数据集可以突出大气特征因子的规律性,尤其是疑似源探寻;采用现场检查等手段与自动监测的相互校核十分必要,特别是便携式气相色谱质谱仪对特征因子自动监测系统"假阳性"识别。

关键词：大气自动监测综合分析特征因子假阳性

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还原法修复六价铬污染土壤的研究

环境科学与管理 2013年第3期38卷 80-83页

作者：梁金利蔡焕兴段雪梅戴玄吏余益军常州大学环境与安全工程学院江苏常州213164 常州市环境监测中心江苏常州213001

铬渣中含有毒性较强的六价铬化合物,其严重污染环境。本文通过实验室模拟试验,研究了硫代硫酸钠、亚硫酸钠、抗坏血酸和硫酸亚铁等还原剂对铬渣污染土壤中六价铬的解毒效果。探讨了还原剂的浓度、pH和反应时间对六价铬还原效果的影响。... 详细信息

铬渣中含有毒性较强的六价铬化合物,其严重污染环境。本文通过实验室模拟试验,研究了硫代硫酸钠、亚硫酸钠、抗坏血酸和硫酸亚铁等还原剂对铬渣污染土壤中六价铬的解毒效果。探讨了还原剂的浓度、pH和反应时间对六价铬还原效果的影响。结果表明:亚硫酸钠浓度为1 mol/L、pH 9.5和反应时间为15 min时对六价铬的还原效果最佳。

关键词：还原修复六价铬污染土壤

Natural alkaloid Harmine activates Ubiquitin-Proteasome System to promote alpha-synuclein degradation and prevent its neuronal toxicity

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Natural alkaloid Harmine activates Ubiquitin-Proteasome Syst...

Validity of distress thermometer for screening of anxiety and depression in family caregivers of Chinese breast cancer patients receiving postoperative chemotherapy

中国神经科学学会第十二届全国学术会议

作者： Cuizan cai Jieqiong Tan Mingyue Wu Shengfang Wang Hefeng Zhou Mingyuen Lee huanxing Su Min Li Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau State Key Laboratory of Medical Genetics Xiangya Medical School Central South University School of Chinese Medicine Hong Kong Baptist University Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research Hong Kong Baptist University

Parkinson’s disease（PD） is an age-dependent progressive movement disorder characterized by a profound and selective loss of nigrostriatal dopaminergic neurons. Accumulation of α-synuclein（α-syn） positive protein aggregates in the substantianigra is a pathological hallmark of PD, indicating that protein turnover defect is implicated in PD pathogenesis. The ubiquitin-proteasome system（UPS） is the primary degradation pathway for protein turnover in mammals, and impairment of UPS has been linked to the development of PD. In this study we have identified a natural UPS enhancer Harmine through a high throughput screening of α-syn lowering compounds. Functional analysis indicates that Harmine promotes the degradation of α-syn in a dose-and time-dependent manner. The autophagy inhibitor SAR405 and the lysosomal inhibitor CQ, as well as the Si RNA of ATG7 and ATG5, do not block the activity of Harmine in degrading α-syn. In contrast, proteasome inhibitor MG132 and bortezomib substantially blocks Harminepromoted degradation of α-syn. Furthermore, we observed that Harmine could dramatically promote the degradation of UPS substrate GFP-CL1, Ub-R-GFP, and UbG76 V-GFP and activate cellular proteasome activity. Mechanistically, Harmine enhances proteasome activity via activating PKA pathway to up-regulated the expression of proteasome subunit PSMD1. Finally, we find that harmine rescues cell death induced by constant over-expression of α-syn in neuronal cells, as evidenced by the alleviation of DNA breakage and LDH release. These results indicate that Harmine, as a new proteasome enhancer, may have potential as a therapeutic agent, in combating PD and other diseases associated with proteasome dysfunction.

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Chinese Journal of Cancer Research 2020年第4期32卷 476-484页

作者： Min Yang Fei Ma Bo Lan Jianqiang cai Xiaoying Sun Binghe Xu Comprehensive Oncology Department National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology Cancer Hospital of Huanxing Chaoyang DistrictBeijing 100122China

Objective:Family caregivers(FCs)of breast cancer patients play a vital role throughout the treatment *** distress of FCs is common and often ignored.A simple and effective instrument for screening psychological distress would help in selecting those FCs requiring special attention and ***,the validity of distress thermometer(DT)in FCs of Chinese breast cancer patients receiving postoperative chemotherapy was assessed,and the prevalence of anxiety and depression was ***:We recruited 200 FCs of hospitalized breast cancer patients in this cross-sectional descriptive *** the first cycle of adjuvant chemotherapy,the levels of anxiety and depression among FCs were assessed using DT and Hospital Anxiety and Depression Scale(HADS).In total,191 valid cases were *** was used as the diagnostic standard to assess the effectiveness of DT as a screening tool for anxiety and depression as well as to analyze the diagnostic efficiency of DT at various cutoff ***:The definitive prevalence of both anxiety and depression was 8.90%.The mean level of anxiety and depression among FCs was 5.64±3.69 and 5.09±3.85,respectively,both of which were significantly higher than corresponding Chinese norms(P<0.01).The areas under receiver operating characteristic curves of DT for the diagnoses of FCs'anxiety and depression were 0.904 and 0.885,respectively.A cutoff value of 5 produced the best diagnostic effects of DT for anxiety and ***:The levels of both anxiety and depression were higher in the FCs of Chinese breast cancer patients receiving postoperative chemotherapy than the national *** might be an effective tool to initially screen psychological distress among *** process could be integrated into the palliative care of breast cancer patients and warrant further research.

关键词： Breast cancer distress thermometer anxiety depression