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Journal of Oceanology and Limnology 2023年第5期41卷 1706-1728页

作者： Ling GUO huanmeng zhang Xiaoxia PENG State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Shandong Provincial Key Laboratory of Depositional Mineralization&Sedimentary Mineral Shandong University of Science and TechnologyQingdao 266590China

Six outcrop sections in Fenghe River,Northwestern China,were sampled and *** study aims to determine provenance,tectonic setting,and source-area paleoweathering of the sediments of Fenghe River in combination of lithofacies analysis and bulk-rock geochemical *** lithofacies in the studied area were classified as gravel,sand,and fine-grained clastic lithofacies,reflecting generally channel fill deposits,channel bar deposits,and over-bank deposits,*** Chemical Index of Alteration(CIA),Plagioclase Index of Alteration(PIA),and Chemical Index of Weathering(CIW)values ranged 50.10–62.29,50.13–66.35,56.52–71.12,respectively,together with element ratios such as Rb/Sr,K/Na,Rb/K,Th/K,Rb/Ti,and Cs/Ti indicate that the source area was under a low to moderate chemical weathering condition probably in cold and semi-arid ***,plot of SiO_(2)vs.(Al_(2)O_(3)+K_(2)O+Na_(2)O)suggests that the sediments were deposited in a semi-arid *** of Cr/Th ***/Sc,TiO_(2)***,La/Yb *** earth element(REE),and La-Th-Sc ternary diagrams,along with the lithology,indicate that the sediments in Fenghe River were mainly originated from felsic igneous *** elements-based discrimination diagrams and Th-Sc-Zr/10 and La-Th-Sc ternary diagram of the samples indicates that the source rocks of Fenghe River developed in a composite active continental margin and continental island arc field.

关键词： geochemistry lithofacies sediments provenance paleoweathering Fenghe River

沣河西安段现代河流沉积特征及其沉积环境变化解译

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地质科学 2023年第3期58卷 1045-1062页

作者：张寰萌郭岭方泽鑫杨永祯西北大学地质学系西安710069 西北大学大陆动力学国家重点实验室西安710069

本文对沣河西安段现代河流沉积体的岩石类型、沉积相类型、沉积模式及气候变化进行了综合研究,并对该地区现代河流体系的Google卫星影像、实地勘察、样品采集以及地球化学元素含量及其比值进行分析。结果表明,西安沣河现代沉积体岩性主... 详细信息

本文对沣河西安段现代河流沉积体的岩石类型、沉积相类型、沉积模式及气候变化进行了综合研究,并对该地区现代河流体系的Google卫星影像、实地勘察、样品采集以及地球化学元素含量及其比值进行分析。结果表明,西安沣河现代沉积体岩性主要为土黄色泥岩、灰白色砂岩及泥质粉砂岩和少量的浅灰色细砾岩系;识别出3种亚相,即河道充填亚相、河道边缘亚相、泛滥盆地亚相;4种微相,即河床滞留沉积、点沙坝、河口扇和泛滥平原;在垂向上发育有3套不同的沉积层序:下部层序具有反韵律特征,中部和上部表现为明显的正韵律沉积,指示了水动力先增大再逐渐减弱的过程;通过分析沉积物中Co、Cr、Cu、Ni、Rb、Sr、V、Zn和Zr等微量元素含量的变化,以及锶铜法(Sr/Cu)、钒镍法(V/(V+Ni))、钒铬法(V/Cr)、镍钴法(Ni/Co)和锶钡法(Sr/Ba),确定沉积时期的环境主体为干旱气候,伴有季节性降雨,水体呈弱氧化-氧化性的淡水环境。

关键词：现代沉积沣河沉积相沉积层序沉积环境

渭河西安段沉积物中重金属元素含量分布及其风险评价

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湿地科学 2022年第6期20卷 838-845页

作者：张寰萌郭岭徐凯师宇翔武芳芳西北大学地质学系陕西西安710069 西北大学大陆动力学国家重点实验室陕西西安710069

为了分析渭河西安段沉积物中的重金属元素的污染现状、风险和来源,在渭河西安段及其支流沣河,共设置了38个采样点,采集了沉积物样品,测定了沉积物中重金属元素Cr、Co、Ni、Cu、Zn、V、Ba和Pb的含量;采用克里金插值法,分析重金属元素含... 详细信息

为了分析渭河西安段沉积物中的重金属元素的污染现状、风险和来源,在渭河西安段及其支流沣河,共设置了38个采样点,采集了沉积物样品,测定了沉积物中重金属元素Cr、Co、Ni、Cu、Zn、V、Ba和Pb的含量;采用克里金插值法,分析重金属元素含量的空间分布;采用Pearson相关分析法,分析了重金属元素的来源;采用污染负荷指数法和潜在生态风险指数法,对渭河西安段沉积物中重金属元素污染现状和生态风险进行评价。研究结果表明,渭河西安段沉积物中的8种重金属元素含量在部分区域富集,其中重金属元素Co和Ba的富集程度相对较大;重金属元素Cr、Ni、Cu、Zn和V主要来源于生活污染物,重金属元素Co、Ba和Pb主要来源于工业污染物;重金属元素Co的污染最为严重,其次为Ba元素,二者是造成渭河西安段沉积物中重金属污染的主要元素;渭河西安段干流沉积物中重金属污染的综合潜在生态风险总体为低风险,而支流沣河沉积物中重金属污染的综合潜在生态风险为中等风险或者较高风险。

关键词：沉积物重金属分布来源风险渭河西安段

安塞油田黑山梁区长6油层组单砂体构型分析及平面展布特征

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地质科学 2024年第4期59卷 1018-1033页

作者：马江波冯纪慧李刚韩彦斌张寰萌郭岭延长石油股份有限公司杏子川采油厂陕西延安717400 西北大学地质学系西安710069

安塞油田黑山梁区块位于延安市安塞区,三叠系延长组长6油层组是其主力产油层。目前该区已进入注水开发阶段,但砂体展布、非均质性、砂体叠置规律等认识不清,导致开发过程中存在注水受效程度不均衡,整体水驱效果差等问题。为此,本次研究... 详细信息

安塞油田黑山梁区块位于延安市安塞区,三叠系延长组长6油层组是其主力产油层。目前该区已进入注水开发阶段,但砂体展布、非均质性、砂体叠置规律等认识不清,导致开发过程中存在注水受效程度不均衡,整体水驱效果差等问题。为此,本次研究依托丰富的测井、录井资料,以及岩心、镜下薄片资料和分析测试数据,开展地层精细刻画、沉积微相、砂体平面分布及单砂体叠置规律的综合研究。结果表明:黑山梁地区长6时期主要发育三角洲前缘亚相,岩性以细粒长石砂岩为主,分选性中等-好,磨圆度中等,水下分流河道和分流间湾微相较为多见,河口坝微相发育较少;水下分流河道为优势相,砂岩分布广、厚度大,沿河道方向延伸,早期形成的河口坝由于波浪作用和分流河道侵蚀作用被破坏,河口坝无法保存完整,仅有部分痕迹。砂体类型包括水下分流河道砂和河口坝砂两种,单砂体垂向叠置可分为孤立型、叠加型和切叠型3种;侧向拼接样式可分为孤立式、对接式和侧切式3种。研究区内砂体沿北东-南西方向呈长条状展布,由于河道频繁摆动和分叉,砂体切叠现象明显,顺物源方向砂体连通性较好,垂直物源方向砂体被分流间湾泥隔开,砂体连通性较差,并结合生产动态数据,认为砂体连通程度越高,水驱动用效果越好。基于该研究成果建立了研究区曲流河三角洲沉积模式,为后期油藏完善注采井网、分层注水开发方案调整提供地质依据。

关键词：曲流河三角洲砂体构型沉积模式长6油层组黑山梁区安塞油田

康滇古陆东缘筇竹寺组沉积物源的风化特征——以云南省楚雄市武定县乌龙村剖面为例

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沉积学报 2024年第1期42卷 324-341页

作者：杨永祯郭岭方泽鑫徐凯张寰萌师宇翔武芳芳陶威西北大学大陆动力学国家重点实验室西安710069 西北大学地质学系西安710069

【目的】扬子地区筇竹寺组是目前页岩气勘探的重要层位,为了揭示康滇古陆东缘筇竹寺组沉积岩的风化程度、古气候、构造背景以及物源等。【方法】选择位于康滇古陆东缘的武定县乌龙村剖面进行采样,并对样品的主量元素和微量元素进行分析... 详细信息

【目的】扬子地区筇竹寺组是目前页岩气勘探的重要层位,为了揭示康滇古陆东缘筇竹寺组沉积岩的风化程度、古气候、构造背景以及物源等。【方法】选择位于康滇古陆东缘的武定县乌龙村剖面进行采样,并对样品的主量元素和微量元素进行分析,研究了康滇古陆东缘乌龙村剖面筇竹寺组沉积岩的风化程度、源区古气候、构造背景以及物源特征。【结果与结论】(1)筇竹寺组沉积岩的母岩经历了强烈的化学风化作用,物源区在该时期处于温暖湿润的气候;(2)筇竹寺组沉积岩主要形成于被动大陆边缘环境,沉积岩源岩形成于大陆岛弧环境;(3)筇竹寺组沉积岩主要来自康滇古陆元古界东川群、会理群和汤丹群的凝灰岩、凝灰质砂岩、凝灰质板岩、花岗岩以及基性岩。

关键词：康滇古陆筇竹寺组风化程度古气候物源特征构造背景

鄂尔多斯盆地西缘徐庄组风暴沉积特征及沉积模式

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沉积学报 2024年第4期42卷 1354-1369页

作者：师宇翔路向伟李国斌方泽鑫徐凯杨永祯张寰萌郭岭西北大学大陆动力学国家重点实验室西安710069 西北大学地质学系西安710069 中国石油天然气股份有限公司长庆油田分公司第六采油厂西安710299 中国石油勘探开发研究院西北分院兰州730020

【目的】鄂尔多斯盆地西缘寒武系砾屑灰岩发育,并发育典型的风暴沉积构造。然而,关于其沉积环境、形成过程及地质意义仍缺乏系统研究。【方法】通过对乌海摩尔沟、乌海老石旦、环县阴石峡、同心青龙山四条剖面实地观测以及薄片观察,详... 详细信息

【目的】鄂尔多斯盆地西缘寒武系砾屑灰岩发育,并发育典型的风暴沉积构造。然而,关于其沉积环境、形成过程及地质意义仍缺乏系统研究。【方法】通过对乌海摩尔沟、乌海老石旦、环县阴石峡、同心青龙山四条剖面实地观测以及薄片观察,详细研究了鄂尔多斯盆地西缘徐庄组砾屑灰岩发育特征以及典型的风暴沉积特征。【结果】(1)研究区徐庄组发育渠模、底冲刷面、丘状交错层理和平行层理等风暴沉积构造。(2)研究区徐庄组发育四种砾屑灰岩岩相,即颗粒支撑砾屑灰岩相,泥质充填砾屑灰岩相,放射状砾屑灰岩相和基质支撑砾屑灰岩相。(3)研究区徐庄组发育五种典型的风暴沉积序列。(4)综合研究区寒武纪陆表海环境与沉积相带以及前人研究成果,对砾屑灰岩成因进行分析并对其形成过程进行探讨,认为风暴浪与地震作用为砾屑灰岩形成的动力条件,古板块位置处于低纬度的风暴带,是风暴作用频发的原因。(5)研究区风暴沉积的发育揭示了鄂尔多斯盆地在寒武纪徐庄组时期位于赤道附近的低纬度地区,与通过古地磁学所恢复的华北板块在同时期所处位置形成相互印证。【结论】研究区风暴沉积的研究及沉积模式的建立,对鄂尔多斯盆地寒武纪时期古环境及古地理恢复具有重要意义。此外,研究区砾屑灰岩成因示意图揭示了砾屑灰岩的形成过程。

关键词：砾屑灰岩风暴沉积鄂尔多斯盆地徐庄组

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-Yi Yan Ke-Hui zhang Di zhang Xi-Mao Cui Xiao-Hua Jiang Shun zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing zhang Chun-Lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor