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Monascus vinegar alleviates high-fat-diet-induced inflammation in rats by regulating the NF-κB and PI3K/AKT/mTOR pathways

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Food Science and Human Wellness 2022年第4期11卷 943-953页

作者： huanmei meng Jia Song Bingqian Fan Yingqi Li Jiaojiao Zhang Jinping Yu Yu Zheng Min Wang State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial Fermentation MicrobiologyTianjin Engineering Research Centre of Microbial Metabolism and Fermentation Process ControlCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Shandong Engineering Research Centre of Condiment Fermentation Technology Shandong Yutu Co.LtdZibo 255300China

Monascus vinegar(MV) is a typical fermented food with various health-promoting effects. This study aimed to evaluate the role of MV in alleviating high-fat-diet-induced inflammation in rats with hyperlipidemia and elucidate the possible regulatory mechanisms. In the study, serum lipid profiles, liver pathology and liver inflammatory cytokines were analyzed in hyperlipidemia rats with MV(0.5 mL/kg mb, 2 mL/kg mb). Results showed that the administration of MV alleviated dyslipidemia by decreasing the serum and liver levels of triglyceride and total cholesterol. Increase in hepatic lipase and carnitine palmitoyl transferase 1(CPT-1)levels and decrease in hepatocyte steatosis, nephritis, and intestinal tissue injury in the HD group showed that high-dose MV can significantly suppress hepatic lipid accumulation and steatosis. In addition, compared with the model(MOD) group, the HD group showed significantly down-regulated the level of serum or hepatic alanine aminotransferase(ALT), aspartate aminotransferase(AST), CPT-1, interleukin(IL)-2, IL-6, IL-12,and tumor necrosis factor α(TNF-α). Moreover, the HD group showed repressed hepatic nuclear factor κB(NF-κB) pathway and inactivated phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR) pathway mitigated liver inflammation. Similar results were obtained from cell experiments. Collectively, these findings revealed that MV might attenuate high-fat-diet-induced inflammation by inhibiting the NF-κB and PI3K/Akt/mTOR pathways.

关键词： Monascus vinegar Hyperlipidemia Inflammation NF-κB PI3K/AKT/mTOR

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创新创业背景下食品科学专业实践教学改革研究

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科教文汇 2018年第9期 48-49,62页

作者：李坤朱传合孟换美山东农业大学食品科学与工程学院山东泰安2071018

实践教学是理论联系实际及培养食品类高级复合人才的核心途径,在食品科学专业本科教学计划占着举足重要的地位,对学生创新精神与实践动手能力的培养至关重要。实践教学质量的优劣已成为制约创新创业背景下食品科学专业人才培养质量提升... 详细信息

实践教学是理论联系实际及培养食品类高级复合人才的核心途径,在食品科学专业本科教学计划占着举足重要的地位,对学生创新精神与实践动手能力的培养至关重要。实践教学质量的优劣已成为制约创新创业背景下食品科学专业人才培养质量提升的瓶颈。因此,本文立足于创新创业背景这一时代大背景,结合我校多年办学经验,分析食品科学专业实践教学中存在的问题,探索解决相关问题的具体措施,构建创新创业背景下食品科学专业实践教学改革的思路。

关键词：食品科学实践教学改革

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代谢手术治疗代谢疾病中肠道菌群作用的研究进展

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国际外科学杂志 2017年第8期44卷 553-557页

作者：刘欢妹张忠涛孟化首都医科大学附属北京友谊医院普外科北京 100050

代谢疾病患者肠道微生态与正常人群存在差异。代谢手术治疗代谢疾病疗效确切，而术后肠道菌群发生改变，并趋于正常肠道菌群结构。近年来已发现脂多糖、短链脂肪酸、胆汁酸、胰升血糖素样肽、氧化三甲胺参与代谢手术后病情缓解过程。本... 详细信息

代谢疾病患者肠道微生态与正常人群存在差异。代谢手术治疗代谢疾病疗效确切，而术后肠道菌群发生改变，并趋于正常肠道菌群结构。近年来已发现脂多糖、短链脂肪酸、胆汁酸、胰升血糖素样肽、氧化三甲胺参与代谢手术后病情缓解过程。本文总结了代谢疾病中肠道菌群的特点和代谢手术后肠道菌群的变化，并对这些规律与上述指标关系展开综述。

关键词：代谢疾病肥胖症糖尿病 2型代谢手术肠道菌群

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运用Excel及VBA语言快速智能地处理土工试验数据

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山东国土资源 2010年第4期26卷 28-30页

作者：孙怀文齐孔让孟焕梅山东省地矿工程勘察院山东济南250014 山东省地质环境监测总站山东济南250014

运用Excel及其内置的VBA语言开发设计了土工试验数据处理程序"数据处理小旋风",用代码建立一个模块包含10个子过程,一个工作簿事件。该程序具有简洁友好的界面,快速化智能化,能有效地提高了工作效率。

关键词：土工试验 Excel VBA 数据处理快速智能

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山东大学齐鲁医院综合楼工程对济南泉水的影响分析

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山东国土资源 2010年第3期26卷 18-21页

作者：李生清赵振华韩琳孟焕梅山东省地矿工程勘察院山东济南250014

通过对山东大学齐鲁医院门诊保健综合楼工程建设对泉水是否影响的论证,认为场区内第四系碎屑岩孔隙裂隙水与奥陶系裂隙岩溶水为2个不同的含水系统。拟建工程在开挖深度内未揭穿第四系砾岩层,保留部分砾岩层作为基底持力层,并保持了下伏... 详细信息

通过对山东大学齐鲁医院门诊保健综合楼工程建设对泉水是否影响的论证,认为场区内第四系碎屑岩孔隙裂隙水与奥陶系裂隙岩溶水为2个不同的含水系统。拟建工程在开挖深度内未揭穿第四系砾岩层,保留部分砾岩层作为基底持力层,并保持了下伏黏土的天然隔水性能,不会阻挡地下水径流补给通道,对泉水不会造成影响。

关键词：泉水保护工程建设齐鲁医院山东济南

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Gold and Silver Nanoparticles Supported on Metal-organic Frameworks： a Highly Active Catalyst for Three-component Coupling Reaction

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Chemical Research in Chinese Universities 2016年第3期32卷 443-450页

作者： LIU Lili TAI Xishi YU Guanglin GUO huanmei meng Qingguo School of Chemistry & Chemical Engineering and Environmental Engineering Weifang University Weifang 261061 P. R. China School of Environment Tsinghua University Beijing 100084 P. R. China

Engineering metal-organic frameworks（MOF） for heterogeneous catalysts have been of extreme interest since they have large pore size within the crystalline framework and well defined pore architecture. Ni-containing MOF Ni2（3,5-Pydc）2（H2O）8·2H2O（1·H2O） was prepared by solvothermal method from 3,5-pyridinedicarboxylic acid, D-camphoric acid and Ni（NO3）2·6H2O in dimethylformamide（DMF）/water（volume ratio 2：1）. And two gold and silver functionalized 1·H2O catalysts were prepared by impregnation method. Catalysts 2.53%Au/MOF and 4.23%Ag/MOF were in-depth characterized by single crystal X-ray diffraction, powder X-ray diffraction（PXRD）, thermogravimetric analysis（TGA）, transmission electron microscopy（TEM）, and inductively coupled plasma-atomic emission spectroscopy（ICP-AES）. Their catalytic performance was examined in one-pot synthesis of structurally divergent propargylamines via three component coupling of aldehyde, alkyne, and amine（A3） in 1,4-dioxane. The resuits show that the catalysts all displayed high reactivities, and a selectivity of 100% for propargylamines. Catalysts 2.53%Au/MOF and 4.23%Ag/MOF have proved to be applicable to a wide range of substrates. Catalysts 2.53%Au/MOF and 4.23%Ag/MOF can be easily recycled and used repetitively at least 3 times with a slight drop in activity. These features render the catalysts particularly attractive in the practice of propargylamines synthesis in an environmentally friendly manner.

关键词： Metal-organic framework Three component coupling reaction Gold Silver Immobilization

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A Communication Security Protocol of Mobile Agent System

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Wuhan University Journal of Natural Sciences 2010年第2期15卷 117-120页

作者： GUAN huanmei ZHANG Huanguo meng Xuejun ZHANG Jingwei Computer Center Wuhan University Wuhan 430072Hubei China School of Computer Wuhan University Wuhan 430072Hubei China State Key Laboratory of Software Engineering WuhanUniversity Wuhan 430072 Hubei China Network Center Wuhan University Wuhan 430072 HubeiChina

The security issues of mobile agent system have embarrassed its widespread implementation. The paper analyses communication security threats and countermeasures of mobile agent system and proposes a communication security protocol of mobile agent system. It provides multifactor authentication, encryption transmission, and integrity protection of mobile agent.

关键词： mobile agent communication security multifactorauthentication encryption transmission

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Predicting the Results of RNA Molecular Specific Hybridization Using Machine Learning

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1384-1396页

作者： Weijun Zhu Xiaokai Liu Mingliang Xu huanmei Wu School of Information Engineering Zhengzhou UniversityZhengzhou 450001China School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China School of Informatics and Computing Indiana University-Purdue University IndianapolisIndianapolisIN 46074 USA

Ribonucleic acid(RNA)hybridization is widely used in popular RNA simulation software in *** limited by the exponential computational complexity of combin atorial problems,it is challenging to decide,within an acceptable time,whether a specific RNA hybridization is *** hereby introduce a machine learning based technique to address this *** machine learning(ML)models tested in the training phase include algorithms based on the boosted tree(BT)random forest(RF),decision tree(DT)and logistic regression(LR),and the corresponding models are *** the RNA molecular coding training and testing sets,the trained machine learning models are applied to predict the classification of RNA hybridization *** experiment results show that the op timal predictive accuracies are 96.2%,96.6%,96.0%and 69.8%for the RF,BT,DT and LR-based approaches,respectively,un der the strong constraint condition,compared with traditiona representative ***,the average computation efficiency of the RF,BT,DT and LR-based approaches are208679,269756,184333 and 187458 times higher than that o existing approach,*** an RNA design,the BT based approach demonstrates high computational efficiency and better predictive accuracy in determining the biological effective ness of molecular hybridization.

关键词： Biological effectiveness boosted tree(BT) decision tree(DT) random forest(RF) RNA design specific hybridization logistic regression(LR)

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High hydrosilylation efficiency of porous silicon SiHx species produced by Pt-assisted chemical etching for biochip fabrication

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Science China Chemistry 2013年第8期56卷 1152-1163页

作者： XIAO MinYu HAN huanmei XIAO ShouJun State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresNanjing University Jinan Entry-Exit Inspection and Quarantine Bureau Inspection

Porous silicon （PSi） prepared from Pt metal-assisted chemical etching （MACE） was demonstrated to possess higher hydrosi- lylation efficiency （-57%） than anodized PSi （-11%） by surface reaction with co-undecenyl alcohol （UO）. Deconvolution of the SiHx （x = 1-3） stretching bands revealed the abundance of SiH2 species on MaCE PSi was 53%, -10% higher than on ano- dized samples, while both of Sill1 and Sill3 were -5% lower correspondently on MaCE PSi than on anodized samples. The surface SiHx abundances were suggested to account for the higher hydrosilylation efficiency on MaCE PSi. Optimization of Pt-assisted chemical etching parameters suggested a 7-15 nm thick Pt-coating and an etching time of 3-10 min for biochip ap- plications. Scanning electron microscopy images revealed that an isotropic top meso-porous layer was beneficial for hydrosi- lylation and long-term durability under ambient conditions. To end, an example of histidine-tagged protein immobilization and microarray was illustrated. Combining the materials＇ property, surface chemistry, and micro-fabrication technology together, we envision that silicon based biochip applications have a prosperous future.

关键词： metal-assisted chemical etching porous silicon surface chemistry hydrosilylation biochip

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Diffusion tensor imaging and proton magnetic resonance spectroscopy in brain tumor Correlation between structure and metabolism

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Neural Regeneration Research 2013年第10期8卷 930-937页

作者： Zhigang Min Chen Niu Netra Rana huanmei Ji Ming Zhang Department of Radiology First Affiliated Hospital of Xi'an Jiaotong University Department of Radiology Shaanxi Provincial Cancer Hospital

Proton magnetic resonance spectroscopy and diffusion tensor imaging are non-invasive techniques used to detect metabolites and water diffusion in vivo. Previous studies have confirmed a positive correlation of individual fractional anisotropy values with N-acetylaspartate/creatine and N-acetylaspartate/choline ratios in tumors, edema, and normal white matter. This study divided the brain parenchyma into tumor, pedtumoral edema, and normal-appearing white matter according to MRI data, and analyzed the correlation of metabolites with water molecular diffusion. Results demonstrated that in normal-appearing white matter, N-acetylaspartate/creatine ratios were positively correlated with fractional anisotropy values, negatively correlated with radial diffusivities, and positively correlated with maximum eigenvalues. Maximum eigenvalues and radial diffusivities in peritumoral edema showed a negative correlation with choline, N-acetylaspartate, and creatine. Radial diffusivities in tumor demonstrated a negative correlation with choline. These data suggest that the relationship between metabolism and structure is markedly changed from normal white matter to peritumoral edema and tumor. Neural metabolism in the peritumoral edema area decreased with expanding extracellular space. The normal relationship of neural function and microstructure disappeared in the tumor region.

关键词： neural regeneration neuroimaging brain neoplasms magnetic resonance spectroscopy diffusiontensor imaging metabolism diffusion anisotropy edema nerve fiber extracellular space correlation analysis grants-supported paper neuroregeneration

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