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2型糖尿病患者正常水平血清肌酐与糖尿病肾病的前瞻性队列研究

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中华内分泌代谢杂志 2024年第5期40卷 380-385页

作者：程旦汤芳丽汪文俊刘欢欢李洮俊楼青青海南医学院国际护理学院海口571199 海南医学院第一附属医院 (海南省)代谢性疾病临床医学研究中心海口570102 海南省人民医院内分泌科海口570311 中国台湾李氏联合诊所内分泌科中国台湾屏东900

目的探讨正常水平血清肌酐(serum creatinine, Scr)与2型糖尿病(type 2 diabetes mellitus, T2DM)患者糖尿病肾病(diabetic kidney disease, DKD)的关系。方法本研究为前瞻性队列研究, 选取2002年1月1日至2018年12月31日在中国台湾李氏... 详细信息

目的探讨正常水平血清肌酐(serum creatinine, Scr)与2型糖尿病(type 2 diabetes mellitus, T2DM)患者糖尿病肾病(diabetic kidney disease, DKD)的关系。方法本研究为前瞻性队列研究, 选取2002年1月1日至2018年12月31日在中国台湾李氏联合诊所6个中心定期随访的T2DM患者作为研究对象。基线时患者无DKD, 收集患者的一般资料、实验室检查指标。根据患者随访时间内是否发生DKD将患者分为DKD组和无DKD组(nondiabetic kidney disease, NDKD)。暴露因素是Scr(μmol/l)值, 并作为分类变量, 根据Scr四分位数分为4组:Q1组(Scrl/l)、Q2组(57.68 μmol/l≤Scrl/l)、Q3组(68.51 μmol/l≤Scrl/l)和Q4组(Scr≥80.44 μmol/l)。使用Cox回归模型来探讨Scr水平与DKD发病之间的关系, 采用受试者工作特征(receiver operating characteristic, ROC)曲线分析正常水平Scr对DKD的预测作用。结果共纳入在基线时无DKD的2 202例T2DM患者, 经过(5.2±2.17)年随访时间后, 共有966例患者发生了DKD, 1 236例患者未发生DKD。与NDKD组相比, DKD组年龄更大, 糖尿病病程更长, 体重指数、收缩压、舒张压、低密度脂蛋白胆固醇、Scr、尿蛋白/肌酐比值更高(均PuC)为0.70(95%CI 0.678~0.722), 最佳截断值为74.27 μmol/l, 敏感度为0.54, 特异度为0.76。累积风险图显示:在校正混杂因素后Q4组患者DKD发病累积风险高于Q1、Q2、Q3组, 差异有统计学意义(均P74.27 μmol/l时, 更应高度关注DKD发生的可能性。

关键词：糖尿病肾病糖尿病 2型血清肌酐

Morphology and phylogenetic placement of Mallomonas vietnamica(Synurales,Chrysophyceae)from China

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Journal of Oceanology and limnology 2024年第4期42卷 1325-1335页

作者： Junxue HAO Fangru NAN Junping lÜ Qi l.u Xudong l.u Shulian XIE Jia FENG School of life Science Shanxi UniversityTaiyuan 030006China

The newly described chrysophyte,Mallomonas vietnamica,is reported for the first time in China from specimens collected in Guizhou Province,SW *** morphological characteristics were studied using light and scanning electron *** species was described based on morphological characteristics,including cell size,scale size,dome,V-rib,and ***,molecular sequencing of *** was conducted and a phylogenetic tree was constructed based on concatenated SSu,l.u,and rbc l *** phylogenetic tree led us to suggest raising a new section named uncatusipedae for this *** study provides new molecular data from the genus Mallomonas and enriches our understanding of the species diversity and geographical distribution of the genus Mallomonas in China.

关键词： Chrysophyta Mallomonas vietnamica phylogenetic study taxonomy

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高强钢激光熔透焊接接头残余应力数值分析

制造技术与机床 2024年第7期 55-62页

作者：吴若麟程开甲戴威严威李欢欢武汉工程大学机电工程学院湖北武汉430205 化工装备强化与本质安全湖北省重点实验室湖北武汉430205

为探究高强钢大功率激光单道熔透焊接接头中的残余应力及塑性应变分布规律,基于峰值指数递增双锥体热源模型对焊接接头进行热-弹-塑性有限元分析,发现采用该热源模型仿真计算的温度场与实际焊缝轮廓吻合较好,关键参数对比最大误差为-3.4... 详细信息

为探究高强钢大功率激光单道熔透焊接接头中的残余应力及塑性应变分布规律,基于峰值指数递增双锥体热源模型对焊接接头进行热-弹-塑性有限元分析,发现采用该热源模型仿真计算的温度场与实际焊缝轮廓吻合较好,关键参数对比最大误差为-3.45%;焊接接头残余应力沿着焊缝中心至两边呈对称分布,沿路径l2在起焊与止焊处的应力分布波动较大,这与节点温度历程曲线相一致;焊接接头在焊缝区发生了塑性应变,而远离焊缝区范围内未发生塑性应变。沿路径l1的焊缝区最大塑性应变峰值及峰值梯度均为等效塑性应变;沿路径l2在起焊及止焊处的纵向、横向及等效塑性应变波动幅值较大,且等效塑性应变峰值最高,横向塑性应变峰值梯度最大,它们的值分别为0.064及0.079。

关键词：高强钢大功率激光热弹塑性有限元残余应力塑性应变

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TEGDME Electrolyte Additive for High-performance Zinc Anodes

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Chemical Research in Chinese universities 2023年第6期39卷 1037-1043页

作者： ZHANG Weiguo ZHANG Chong WANG Hongzhi WANG huanhuan Department of Applied Chemistry School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350P.R.China

Aqueous zinc ion batteries(AZIBs)are expected to have a wide range of applications for large-scale electrochemical energy storage systems,but their practical application is severely limited by the presence of zinc dendrites,hydrogen evolution reactions(HER),corrosion reactions,and other *** optimization is considered to be one of the most effective methods for improving zinc anodes due to its simplicity,low production cost and remarkable effectiveness in suppressing zinc dendrite *** this paper,a tetra(ethylene glycol)dimethyl ether(TEGDME)electrolyte additive was used to improve the stability of the zinc anode by adding 0.1 g/l TEGDME to the conventional ZnSO_(4) electrolyte to prepare a mixed *** effect of TEGDME on the side reactions of zinc anode was first assessed by linear sweep voltammetry(lSV)and potentiodynamic *** effect of TEGDME on the structure and morphology of zinc surfaces was observed using an X-ray diffractometer(XRD)and a scanning electron microscope(SEM).And finally,the electrochemical performance of Zn|Zn symmetric cells,Zn||Ti asymmetric cells and Zn-MnO_(2) full cells with ZnSO_(4)+TEGDME electrolyte was tested by cyclic voltammetry(CV)and galvanostatic *** results show that the addition of TEGDME improves the surface wettability of the Zn anode and reduces the growth of dendrites through solvation structure modulation to suppress HER and zinc ***,TEGDME keeps the Zn anode to maintain a flat surface during charging and discharging,improving the reversibility of plating/*** cycle life of the Zn||Ti asymmetric cell was improved and the Coulombic efficiency was 100%after 100 *** Zn||Zn symmetric cells can be cycled stably for 1800 h at a current density of 1 mA/cm^(2) and a fixed capacity of 1 mA·h/cm^(2),while the capacity retention of the Zn-MnO_(2) full cell can be effectively improved from 51.46%to 68.29%at 100 *** using TEGDME electrolyte additives,the

关键词： Aqueous zinc ion battery Zinc dendrite Hydrogen evolution reaction Solvation structure Cycle life

大豆生物质基多位点Co_(2)P催化甲酸脱氢

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燃料化学学报（中英文） 2024年第6期52卷 883-892页

作者：王碧溪刘泽宇吴亚北杨言言杨颂王荀叶子董洪亮朱峰余焕焕吕英英余钟亮上饶师范学院化学与环境科学学院江西上饶334001 太原理工大学化工学院山西太原030024 太原理工大学安全与应急管理学院山西太原030024 山西焦煤集团山西太原030024 北京高压科学研究中心上海分中心上海201203

本研究报道了一种通过大豆和钴盐热解制备的甲酸脱氢用Co_(2)P催化剂,制备过程简单且环境友好。催化过程中,催化剂上的含K固体碱可作为路易斯酸性位点促进HCOO^(-)中间体的吸附,而自掺杂的N可作为碱性位点促进H+的吸附。大豆生物质中的... 详细信息

本研究报道了一种通过大豆和钴盐热解制备的甲酸脱氢用Co_(2)P催化剂,制备过程简单且环境友好。催化过程中,催化剂上的含K固体碱可作为路易斯酸性位点促进HCOO^(-)中间体的吸附,而自掺杂的N可作为碱性位点促进H+的吸附。大豆生物质中的P可与钴盐结合并热解成Co_(2)P,该位点可裂解HCOO^(-)的H-C键。催化剂制备过程中当Co(NO_(3))_(2)·6H_(2)O/大豆的质量比为1:15时,所得Co_(2)P催化剂对甲酸脱氢反应的产气率可达237.47 ml/(g·h),并展现出良好的稳定性。本研究结果可为甲酸选择性产氢用非贵金属非均相催化剂的开发提供一定的借鉴基础。

关键词：甲酸多相催化剂生物质脱氢反应

当归苯酞riligustilide抑制lPS诱导的RAW 264.7细胞炎症反应及机制研究

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中华中医药学刊 2024年第7期42卷 140-146,I0026页

作者：刘员王欢欢吕洁丽张来宾新乡医学院药学院河南新乡453003

目的研究当归苯酞二聚体riligustilide(DG2)对脂多糖(lipopolysaccharides, lPS)诱导的RAW 264.7巨噬细胞炎症反应的抑制作用,并探讨其作用机制。方法通过lPS诱导建立RAW 264.7细胞炎症模型,采用噻唑蓝(methyl thiazolyl tetrazol.um, MTT)法考察DG2对RAW 264.7细胞存活率的影响,Griess法考察DG2对lPS诱导的RAW 264.7细胞释放炎症介质一氧化氮(nitric oxide, NO)的影响,酶联免疫吸附测定法(enzyme-linked immunosorbent assay, ElISA)考察DG2对lPS诱导的RAW 264.7细胞分泌炎症因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白细胞介素-6(interl.ukin-6,Il-6)]的影响,Western blotting法考察DG2对lPS诱导的RAW 264.7细胞诱导型一氧化氮合酶(inducible nitric oxide synthase, iNOS)和环氧化酶-2(cyclooxygenase-2,COX-2),以及丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)、核转录因子κB(nuclear factor-κB,NF-κB)和信号传导及转录激活蛋白(signal transducer and activator of transcription, STAT)信号通路的影响,免疫荧光法考察DG2对lPS诱导的RAW 264.7细胞STAT3核转位的影响。结果DG2浓度在64μmol/l下对RAW 264.7细胞存活率无影响,DG2能显著降低lPS诱导的RAW 264.7细胞释放NO的水平(Pl/l],与阳性对照槲皮素的作用相当[IC_(50)=(26.06±2.28)μmol/l];还能够显著抑制炎症因子Il-6和TNF-α的生成(PlPS诱导的RAW 264.7细胞iNOS和COX-2蛋白的表达(PlPS诱导的RAW 264.7细胞炎症反应,其机制可能与下调STAT、NF-κB和MAPK信号通路有关。

关键词：当归苯酞二聚体抗炎 RAW 264.7细胞作用机制

不同光质对留兰香薄荷生长及次生代谢产物的影响

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江苏农业学报 2024年第6期40卷 1111-1119页

作者：王换换潘拓宇姜胜行耿芳娄玉霞明凤上海师范大学生命科学学院上海200234 上海中学上海200237

本研究以留兰香薄荷幼苗为试验材料,以自然光(W)为对照,采用红光(R)、蓝光(B)和红蓝混合光(RB)进行光照处理,探究不同光质对留兰香薄荷生长、生理指标和次生代谢物合成的影响。研究结果表明,不同光质可影响留兰香薄荷植株茎段生根率、... 详细信息

本研究以留兰香薄荷幼苗为试验材料,以自然光(W)为对照,采用红光(R)、蓝光(B)和红蓝混合光(RB)进行光照处理,探究不同光质对留兰香薄荷生长、生理指标和次生代谢物合成的影响。研究结果表明,不同光质可影响留兰香薄荷植株茎段生根率、茎段腋芽萌发率、茎粗、叶片数、地上部分鲜重、叶片含水率等生长指标;红光和红蓝混合光可显著增加叶片中可溶性糖含量。叶片中可溶性蛋白质含量随蓝光比例升高而升高;红蓝混合光处理叶片中叶绿素含量显著高于对照,红光和蓝光处理叶片中叶绿素含量也均有一定的提升。其中红光主要影响叶绿素a含量,而蓝光影响叶绿素b含量。与对照相比,红光和蓝光处理留兰香薄荷次生代谢产物香芹酮含量降低。红蓝混合光可促进留兰香薄荷香芹酮的积累,降低D-柠檬烯含量,并提高部分萜烯类化合物占比。不同光质可影响留兰香薄荷生长及生理指标,且红蓝混合光可改变留兰香薄荷次生代谢产物含量,为提高薄荷药用价值及工厂化繁育提供了依据。

关键词：留兰香薄荷光质生长次生代谢产物

Multi-Agent Few-Shot Meta Reinforcement learning for Trajectory Design and Channel Selection in uAV-Assisted Networks

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China Communications 2022年第4期19卷 166-176页

作者： Shiyang Zhou Yufan Cheng Xia lei huanhuan Duan National Key laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

unmanned aerial vehicle(uAV)-assisted communications have been considered as a solution of aerial networking in future wireless networks due to its low-cost, high-mobility, and swift features. This paper considers a uAV-assisted downlink transmission,where uAVs are deployed as aerial base stations to serve ground users. To maximize the average transmission rate among the ground users, this paper formulates a joint optimization problem of uAV trajectory design and channel selection, which is NP-hard and non-convex. To solve the problem, we propose a multi-agent deep Q-network(MADQN) ***, the agents that the uAVs act as perform actions from their observations distributively and share the same reward. To tackle the tasks where the experience is insufficient, we propose a multi-agent meta reinforcement learning algorithm to fast adapt to the new tasks. By pretraining the tasks with similar distribution, the learning model can acquire general knowledge. Simulation results have indicated the MADQN scheme can achieve higher throughput than fixed allocation. Furthermore, our proposed multiagent meta reinforcement learning algorithm learns the new tasks much faster compared with the MADQN scheme.

关键词： uAV trajectory design channel selection MADQN meta reinforcement learning

Influences of ultrasonic irradiation on the morphology and structure of nanoporous Co nanoparticles during chemical dealloying

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Progress in Natural Science:Materials International 2016年第6期26卷 562-566页

作者： Hui li Mu Zhu Yu Pang huanhuan Du Tong l.u Key laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang University

The Co-61.8 wt% Al nanoparticles of 45 nm were prepared by hydrogen plasma-metal reaction（HPMR）method. The nanoparticles display core shell structure with Al13Co4and CoAl core and aluminum oxide shell（about 2 nm）. under ultrasonic irradiation, nanoporous fcc-Co nanoparticles were produced successfully by chemically dealloying the Co-Al nanoparticles at room temperature, whereas, without ultrasonic irradiation CoAl phase could hardly react with sodium hydroxide solution. At 323 K the Co-Al nanoparticles could be dealloyed to fcc-Co and hcp-Co phases even without ultrasonic irradiation. The surface area of the dealloyed nanoparticles under ultrasonic irradiation was larger than that of the dealloyed sample without ultrasonic irradiation at the same temperature. It is believed that the microjet and shock-wave induced by ultrasonic irradiation give rise to particles size reduction, interparticle collision and surface cleaning, and accelerate the dealloying process and the phase transformation.

关键词： Nanoporous nanoparticles Co ultrasonic irradiation Chemical dealloying Microstructure