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Science China(Life Sciences) 2019年第8期62卷 1104-1106页

作者： Jiliang Tan Shanshan Gu Yanjun Zheng huangtian yang CAS Key Laboratory of Tissue Microenvironment and Tumor Laboratory of Molecular CardiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing100101China

Dear Editor,Myocardial injury following ischemia/reperfusion(I/R)is a common clinical scenario in patients suffering from ischemic heart disease(Hausenloy et al.,2016).The involvement of proteins and signaling pathways is well studied in myocardial I/R injury and protection(Hausenloy et al.,2016;yang et al.,2012),however,more than 98%of the transcriptional output in mammals are noncoding RNAs(ncRNAs).These products range from short microRNAs(miRNAs)to long noncoding RNAs(lncRNAs,Das et al.,2018)and modulate critical pathophysiologic mechanisms,such as apoptosis,oxidative stress,Ca2+overload and inflammation,during myocardial I/R injury and protection(Das et al.,2018).

关键词： circRNA Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning profile

心肌微组织的构建及其在心肌损伤修复中的研究进展

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中华细胞与干细胞杂志（电子版） 2022年第4期12卷 224-229页

作者：柯敏霞杨黄恬中国科学院中国科学院大学上海营养与健康研究所肿瘤与微环境重点实验室分子心脏学研究组上海200031

心肌梗死(MI)及其导致的心力衰竭(HF)是疾病致死的主要原因,严重威胁人类健康。现有药物和介入治疗手段无法补偿MI引起的心肌细胞丢失这一导致HF的关键病理性改变。随着干细胞生物学、材料科学和工程技术的进展和整合,心肌微组织(CMTs)... 详细信息

心肌梗死(MI)及其导致的心力衰竭(HF)是疾病致死的主要原因,严重威胁人类健康。现有药物和介入治疗手段无法补偿MI引起的心肌细胞丢失这一导致HF的关键病理性改变。随着干细胞生物学、材料科学和工程技术的进展和整合,心肌微组织(CMTs)构建的探索成为心脏再生医学研究领域的新生长点。本文回顾CMTs构建的研究进展及对MI后损伤修复的作用,重点讨论CMTs的构建策略、在MI后心肌损伤修复中的移植方式和效果,并探讨CMTs用于缺血性心肌损伤修复需解决的问题。

关键词：心肌梗死多能干细胞心肌细胞微组织

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干细胞

科学 2005年第5期57卷 54-55页

作者：杨黄恬中国科学院上海生命科学院/上海第二医科大学健康科学中心

干细胞是一类具有自我复制能力和多向分化潜能的原始未分化细胞,是机体或组织器官的起源细胞,具有形成完整个体的分化潜能或分化成特定/多种细胞组织器官的潜能.干细胞在理论上突破了细胞分化的单向性,由于体外培养的成功,日益显示出对... 详细信息

干细胞是一类具有自我复制能力和多向分化潜能的原始未分化细胞,是机体或组织器官的起源细胞,具有形成完整个体的分化潜能或分化成特定/多种细胞组织器官的潜能.干细胞在理论上突破了细胞分化的单向性,由于体外培养的成功,日益显示出对人类健康的潜在价值.最显见的医学应用潜能,是有望成为细胞组织移植甚至器官的新来源,以取代病人体内损坏的细胞组织甚至器官,达到治疗组织缺损、遗传缺陷、器官障碍等难治疾病的目的.此外,干细胞在帮助人类了解自身的形成过程、认识遗传物质对正常发育过程的调控、揭示人类疾病机理等方面也显示出巨大的研究价值.

关键词：胚胎干细胞组织干细胞治疗性克隆干细胞多向分化潜能组织器官自我复制能力分化细胞细胞分化潜在价值

干细胞及其衍生细胞外泌体在心肌梗死损伤修复中的作用

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中国细胞生物学学报 2018年第S1期40卷 2198-2208页

作者：吴强杨黄恬中国科学院肿瘤与微环境重点实验室中国科学院上海营养与健康研究所中国科学院上海生命科学研究院中国科学院大学上海200031 中国科学院干细胞与再生医学创新研究院北京100101

移植干细胞及其衍生细胞为心肌梗死后心肌修复带来希望。其中,旁分泌效应被认为是移植细胞心肌保护作用的新型机制。越来越多的实验证据表明,各种干细胞分泌的外泌体通过向靶细胞递送特定物质(如某些蛋白质和小RNA)而成为心脏细胞间重... 详细信息

移植干细胞及其衍生细胞为心肌梗死后心肌修复带来希望。其中,旁分泌效应被认为是移植细胞心肌保护作用的新型机制。越来越多的实验证据表明,各种干细胞分泌的外泌体通过向靶细胞递送特定物质(如某些蛋白质和小RNA)而成为心脏细胞间重要的物质和信息传播者,发挥对缺血损伤心肌的保护作用。因此,干细胞来源的外泌体有可能成为促进心肌修复的生物制剂。该文简要总结了干细胞及其衍生细胞外泌体对心肌梗死后心脏损伤修复的研究进展,聚焦于外泌体的形成、特征和功能,各类成体干细胞和多能干细胞及其衍生细胞外泌体成分及作用机制,并探讨了外泌体作为促进缺血性心脏病损伤修复制剂的可能性和亟需解决的问题。

关键词：干细胞外泌体心肌梗死心肌修复

KINEMATIC DESIGN OF A RECONFIGURABLE MINIATURE PARALLEL KINEMATIC MACHINE

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Chinese Journal of Mechanical Engineering 2003年第1期16卷 79-82页

作者： huangtian DJWhitechouse 等 SchoolofMechanicalEngineering TianjinUniversityTianjing300072China SchoolofEngineering UniversityofWarwickConventryCV47ALUK

The kinematic design of a reconfigurable miniature parallel kinematic machineis dealt with. It shows that the reconfigurability may be realized by packaging a tripod-basedparallel mechanism with fixed length struts into a compact and rigid frame with which the differentconfigurations can be formed. Utilizing a dual parameter model, the influences of the geometricalparameters on the dexterous performance and the workspace/machine volume ratio are investigated. Anovel global performance index for the dimensional synthesis is proposed and optimized, resulting ina set of dimensionless geometrical parameters.

关键词： Parallel kinematic machine Modularity Kinematic design

RED-DTB: A Dual Token Bucket Based Queue Management Algorithm

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Wuhan University Journal of Natural Sciences 2003年第2A期8卷 388-392页

作者： YinJian-hua Caoyang LingJun huangtian-xi SchoolofElectronicInformation WuhanUniversityWuhan430072HubeiChina StateKeyLaboratoryofSoftwareEngineering WuhanUniversityWuhan430072HubeiChina

Improving the Quality of Service (QoS) of Internet traffic is widely recognized as a critical issue for the next-generation networks. In this paper, we present a new algorithm for the active queue management, namely RED-DTB. This buffer control technique is used to enforce approximate fairness among a large number of concurrent Internet flows. Like RED (Random Early Detection) algorithm, the RED-DTB mechanism can be deployed to actively respond to the gateway congestion, keep the gateway in a healthy state, and protect the fragile flows from being stolen bandwidth by greedy ones. The algorithm is based on the so-called Dual Token Bucket (DTB) pattern. That is, on the one hand, every flow is rate-limited by its own token bucket, to ensure that it can not consume more than its fair share of bandwidth; On the other hand, to make some compensations to less aggressive flows, such as connections with larger round trip time or smaller sending window, and to gain a relatively higher system utilization coefficient, all flows, depending on their individual behavior, may have a chance to fetch tokens from the public token bucket when they run out of their own share of tokens. The algorithm is analyzed and evaluated by simulations, and is proved to be effective in protecting the gateway buffer and controlling the fair allocation of bandwidth among flows.

关键词： Key words congestion control active queue management Dual Token Bucket fair bandwidth allocation network simulation

New Parallel Interference Cancellation for Convolutionally Coded CDMA Systems

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Wuhan University Journal of Natural Sciences 2004年第1期9卷 78-82页

作者： XuGuo-xiong GanLiang-cai huangtian-xi ＼ SchoolofElectronicInformation.WuhanUniversity Wuhan430072HubeiChina

Based on BCJR algorithm proposed by Bahlet al and linear soft decision feedback, a reduced-complexity parallel interference cancellation (simplified PIC) for convolutionally coded DS CDMA systems is proposed. By computer simulation, we compare the simplified PIC with the exact PIC. It shows that the simplified PIC can achieve the performance close to the exact PIC if the mean values of coded symbols are linearly computed in terms of the sum of initiala prior log-likelihood rate (LLR) and updateda prior LLR, while a significant performance loss will occur if the mean values of coded symbols are linearly computed in terms of the updateda prior LLR only. Meanwhile, we also compare the simplified PIC with MF receiver and conventional PICs. The simulation results show that the simplified PIC dominantly outperforms the MF receiver and conventional PICs, at signal-noise rate (SNR) of 7 dB, for example, the bit error rate is about 10?4 for the simplified PIC, which is far below that of matched-filter receiver and conventional PIC. Key words convolutionally coded CDMA - parallel interference cancellation - BCJR CLC number TN 914 Foundation item: Supported by the National Natural Science Foundation of China (69772015)Biography: Xu Guo-xiong (1967-), male, Ph. D candidate, research direction: wireless communication.

关键词： convolutionally coded CDMA parallel interference cancellation BCJR

A Novel Immune System Model and Its Application to Network Intrusion Detection

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Wuhan University Journal of Natural Sciences 2003年第2A期8卷 393-398页

作者： LingJun Caoyang YinJian-hua huangtian-xi SchoolofElectronicInformation WuhanUniversityWuhan430072HubeiChina StateKeyLaboratoryofSoftwareEngineering WuhanUniversityWuhan430072HubeiChina

Based on analyzing the techniques and architecture of existing network Intrusion Detection System (IDS), and probing into the fundament of Immune System (IS), a novel immune model is presented and applied to network IDS, which is helpful to design an effective IDS. Besides, this paper suggests a scheme to represent the self profile of network. And an automated self profile extraction algorithm is provided to extract self profile from packets. The experimental results prove validity of the scheme and algorithm, which is the foundation of the immune model.

关键词： Key words network Intrusion Detection System 5 Immune System self profile automated self profile extraction algorithm

New Parallel Interference Cancellation Scheme for DS/CDMA Systems

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Wuhan University Journal of Natural Sciences 2004年第1期9卷 73-77页

作者： XuGuo-xiong GanLiang-cai huangtian-xi SchoolofElectronicInformation WuhanUniversityWuhan430072HubeiChina

This paper proposes a new multi-stage parallel interference cancellation scheme by modifying the conventional multi-stage parallel interference canceller (PIC). At each stage, it first converts the interference-cancelled outputs from previous stage into thea prior information, in terms of which the bit mean values are computed and the multi-access interference (MAI) for each user is evaluated, and then an interference cancellation is performed to obtain further interference suppression. To reduce the implementation complexity, we give an approximation expression for bit mean value. The performance over AWGN channel is analyzed and compared to the conventional PIC. The user numberK=7 and spreading factorN=13 are chosen as simulation parameters. The computer simulation results show that the proposed PIC has better performance than the conventional PIC both with 2 interference cancellation (IC) stages, at bit error rate of 10?3, for example, about 3 dB performance gain is obtained by using the proposed PIC. It is also shown that our proposed PIC with 1-stage is superior to the conventional PIC with 2-stage in performance, which is of practical value because PIC with fewer stages can bring about shorter processing delay. Key words CDMA - parallel interference cancellation - multi-access interference CLC number TN 914 Foundation item: Supported by the National Natural Science Foundation of China (69772015)Biography: Xu Guo-xiong (1967-), male, Ph. D candidate, research direction: wireless communication.

关键词： CDMA parallel interference cancellation multi-access interference

Photonic Bandgap Properties of One-Dimensional Photonic Crystal Consisting of Complex Artificial Media

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Wuhan University Journal of Natural Sciences 2005年第3期10卷 534-538页

作者： ZHANGYuan-nong XUGuo-xiong ZHAOZheng-yu huangtian-xi SchoolofElectronicInformation WuhanUniversityWuhan430072HubeiChina SchoolofElectronicInformation ZhongyuanUniversityofTechnologyZhengzhou450007HenanChina

Propagation of electromagnetic waves in one-dimensional (1-D) stratifiedchiral structures is described by the 4X4 transfer-matrix method. The photonic bandgap (PBG)properties in 1-D periodical chiral media are investigated. The relation between PBGand chiralityadmittance has been analyzed. Under proper operating parameters, quite perfect multichannelfiltering properties can be obtained with the periodic structure. The photonic bandgap properties ofone-dimensional layered periodical structures that include of double negative (DNG) medium,so-called backward-wave (BW) medium are investigated. The simulation results show that the width ofthe PBG in the structure composed of chiral medium and BW medium is larger then that composed ofchiral medium and usual medium. Our analysis has shown that the usage of the negative material makesit possible to dramatically widen the band gap of one-dimensional photonic crystal.

关键词： photonic bandgap transfer-matrix chiral medium negative refraction medium