检索结果-南通市图书馆

Stress proteins:the biological functions in virus infection,present and challenges for target-based antiviral drug development

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 1363-1402页

作者： Qianya Wan Dan Song huangcan li Ming-liang He Department of Biomedical Sciences City University of Hong KongKowloonHong KongChina CityU Shenzhen Research Institute ShenzhenChina

Stress proteins(SPs)including heat-shock proteins(HSPs),RNA chaperones,and ER associated stress proteins are molecular chaperones essential for cellular *** major functions of HSPs include chaperoning misfolded or unfolded polypeptides,protecting cells from toxic stress,and presenting immune and inflammatory *** as a double-edged sword,HSPs also cooperate with numerous viruses and cancer cells to promote their *** chaperones are a group of heterogeneous nuclear ribonucleoproteins(hnRNPs),which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase *** involve in a large number of cellular processes,including chromatin remodelling,transcription regulation,RNP assembly and stabilization,RNA export,virus replication,histonelike nucleoid structuring,and even intracellular *** of stress proteins is associated with many human diseases including human cancer,cardiovascular diseases,neurodegenerative diseases(e.g.,Parkinson’s diseases,Alzheimer disease),stroke and infectious *** this review,we summarized the biologic function of stress proteins,and current progress on their mechanisms related to virus reproduction and diseases caused by virus *** SPs also attract a great interest as potential antiviral targets(e.g.,COVID-19),we also discuss the present progress and challenges in this area of HSP-based drug development,as well as with compounds already under clinical evaluation.

关键词： metabolism stabilization summarized

Overview of Rattan Plantation Management

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Forestry Science and Technology 2003年第3期2卷 96-102页

作者： YANG Jinchang YIN Guangtian XU huangcan li Rongsheng YANG HuaResearch Institute of Tropical forestry. Chinese Academy of Forestry. Guangzhou 510520. P.R.China

Rattans are climbing spiny plants that are regarded as an important kind of commercial non-timber forest products. Rattan resources are dwindling rapidly due to over-exploitation in the wild and the loss of tropical forest cover. These threaten the sustainable utilization of rattan resources and long-term survival of the rattan industry. The development of rattan plantation and the improvement of management technique are hence important. The major issues on plantation management are reviewed in this pap...

关键词： rattan plantation management

Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第4期12卷 1963-1975页

作者： Zhiwei Xiao Huiyi Wei Yi Xu Ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong li Weibin Zhang huangcan Chen Yuefeng li lingling Zhang Jiyun Sun Shaojuan Zhang Hai-Bin Luo Sen Yan Qijun Cai Lu Hou Chao Che Steven H.liang Lu Wang Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Department of Cardiology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Guangdong Landau Biotechnology Co.Ltd. Guangzhou 510555China Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570228China Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhou 510632China

As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium spiny neurons of the striatum,it has been implicated in a variety of neurological ***,inhibition of PDE10A has proven to be of potential use for the treatment of central nervous system(CNS)pathologies caused by dysfunction of the basal ganglia–of which the striatum constitutes the largest component.A PDE10A-targeted positron emission tomography(PET)radioligand would enable a better assessment of the pathophysiologic role of PDE10A,as well as confirm the relationship between target occupancy and administrated dose of a given drug candidate,thus accelerating the development of effective PDE10A *** this study,we designed and synthesized a novel ^(18)F-aryl PDE10A PET radioligand,codenamed[^(18)F]P10A-1910([^(18)F]9),in high radiochemical yield and molar activity via spirocyclic iodonium ylide-mediated radiofluorination.[^(18)F]9 possessed good in vitro binding affinity(IC_(50)=2.1 nmol/L)and selectivity towards ***,[^(18)F]9 exhibited reasonable lipophilicity(logD=3.50)and brain permeability(P_(app)>10×10^(−6) cm/s in MDCK-MDR1 cells).PET imaging studies of[^(18)F]9 revealed high striatal uptake and excellent in vivo specificity with reversible tracer *** studies in rodents revealed an improved plasma and brain stability of[^(18)F]9 when compared to the current reference standard for PDE10A-targeted PET,[^(18)F]***,dose–response experiments with a series of escalating doses of PDE10A inhibitor 1 in rhesus monkey brains confirmed the utility of[^(18)F]9 for evaluating target occupancy in vivo in higher *** conclusion,our results indicated that[^(18)F]9 is a promising PDE10A PET radioligand for clinical translation.

关键词： Phosphodiesterase 10A PET radioligand 18F Spirocyclic iodonium ylide Nonhuman primate Target occupancy

在线全文

学校读者我要写书评

暂无评论

棕榈藤的电镜观察 Ⅰ藤基部分的电镜观察

林业科学 1998年第3期34卷 104-109页

作者：腰希申许煌灿曾炳山中国林业科学研究院森林生态环境研究所中国林业科学研究院热带林业研究所

对单叶省藤ＣａｌａｍｕｓｓｉｍｐｌｉｃｉｆｏｉｕｓＷｅｉ、白藤Ｃ．ｔｅｔｒａｄａｃｔｙｌｕｓＨａｎｃｅ及黄藤Ｄａｅｍｏｎｏｒｏｐｓｍａｒｇａｒｉｔａｅ（Ｈａｎｃｅ）Ｂｅｃｃ茎的微观及超微观结构进行了电镜解剖观察，对... 详细信息

对单叶省藤ＣａｌａｍｕｓｓｉｍｐｌｉｃｉｆｏｉｕｓＷｅｉ、白藤Ｃ．ｔｅｔｒａｄａｃｔｙｌｕｓＨａｎｃｅ及黄藤Ｄａｅｍｏｎｏｒｏｐｓｍａｒｇａｒｉｔａｅ（Ｈａｎｃｅ）Ｂｅｃｃ茎的微观及超微观结构进行了电镜解剖观察，对藤茎中段的表面，表皮，皮层及维管束分布，基本薄壁组织，叶的表面纹饰和气孔都作了详细描述；结果表明，利用藤茎的微观构造特征来分类鉴定藤种及选育良种，改善栽培技术有重要参考价值。

关键词：藤茎维管束超微结构棕榈藤

A Review of Relationship Between Rattan and Water

在线全文

学校读者我要写书评

暂无评论

Forestry Studies in China 2002年第1期4卷 65-68页

作者：李荣生许煌灿杨锦昌尹光天中国林业科学研究院热带林业研究所广州510520

The importance of water on rattan is described in the paper. Up to date, some researches have witnessed that rain determines the distribution and the number of species of rattan in wild, and is helpful to dispersal of rattan seeds with slope. Rattan plays a role in intercepting the splash effect of rain and improves the water holding capacity of soil. The viability of rattan seed decreases quickly with the decrease of water content of seeds, hence to reduce the germination rate of seeds. With enough water, rattan grows more quickly in terms of leaf, leaf area, and stem. Water stress improves the ratio of root to shoot of rattan, and humidity plays a role in the distribution and growth of rattan.

关键词： rattan water rain water stress humidity

在线全文

学校读者我要写书评

暂无评论

藤文化浅析

世界林业研究 2005年第4期18卷 54-59页

作者：杨锦昌蔡登谷尹光天许煌灿李荣生杨华中国林业科学研究院热带林业研究所广州510520 中国林业科学研究院北京100091

自古以来,藤以其广泛的实用价值和独有的魅力深受人们的喜爱,并在中华民族悠久文化的画卷中绘上了浓墨重彩。为弘扬中华民族文化,拓展藤产业和贸易,促进社会经济的发展,文中概述了藤类的地理分布、植物分类、材料特性,力求循着人类文明... 详细信息

自古以来,藤以其广泛的实用价值和独有的魅力深受人们的喜爱,并在中华民族悠久文化的画卷中绘上了浓墨重彩。为弘扬中华民族文化,拓展藤产业和贸易,促进社会经济的发展,文中概述了藤类的地理分布、植物分类、材料特性,力求循着人类文明发展的脉络,详尽介绍我国各民族的藤类利用水平,分析我国藤产业与商品贸易的沿革与发展。

关键词：中国藤文化利用产业贸易

四数九里香挥发油对离体蟾蜍坐骨神经动作电位的影响

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2017年第1期39卷 9-10页

作者：李旭伟伏清尧包煜忠蔡雪敏陈珍张世鹏川北医学院基础医学院机能实验中心四川南充637000 川北医学院麻醉学系四川南充637000 川北医学院药学院四川南充637000

目的:研究四数九里香挥发油对离体蟾蜍坐骨神经动作电位的传导阻滞作用。方法:采用水蒸气蒸馏法提取四数九里香挥发油,观察四数九里香挥发油对离体蟾蜍坐骨神经复合动作电位的振幅和传导速度的影响。结果:四数九里香挥发油使坐骨神经复... 详细信息

目的:研究四数九里香挥发油对离体蟾蜍坐骨神经动作电位的传导阻滞作用。方法:采用水蒸气蒸馏法提取四数九里香挥发油,观察四数九里香挥发油对离体蟾蜍坐骨神经复合动作电位的振幅和传导速度的影响。结果:四数九里香挥发油使坐骨神经复合动作电位的振幅变小(P<0.01),传导速度变慢(P<0.01),并最终使坐骨神经动作电位消失。结论:四数九里香挥发油能阻滞神经动作电位的传导。

关键词：四数九里香挥发油离体坐骨神经复合动作电位阻滞