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Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 1-9页

作者： Ching-hung LIN huang-chun lien Fu-chang HU Yen-shen LU Sung-hsin KUO Ling-chu WE San-lin YOU Ann-lii CHENG King-jen CHANG Department of Oncology National Taiwan University Hospital Taiwan Taipei 10016 Department of Pathology National Taiwan University Hospital Taiwan Taipei 10016 National Center of Excellence for General Clinical Trial and Research National Taiwan University Hospital Taiwan Taipei 1001 6 Graduate Institute of Epidemiology College of Public Health National Taiwan University Taiwan Taipei 10055 Department of Surgery National Taiwan University Hospital Taiwan Taipei 10016

Objective： To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods： Patients with stages Ⅰ-Ⅲ breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor （ER） and progesterone receptor （PR） was evaluated by immu- nohistochemistry （IHC）. A fractionated score （F score）, the percentage of positive-staining nuclei （0=none, 1=1%-10% 2= 11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%）, was assigned to each case. The dichotomized scoring method defines an F score 〉1 as positive. The prognostic values of both scores were compared by multiple Cox＇s proportional hazard models of disease-free survival （DFS） and overall survival （OS）. Results： Four hundred and six- teen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox＇s proportional hazard models. Conclusion： Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

关键词： Breast cancer Fractionated evaluation Estrogen receptor Progesterone receptor

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Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors

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World Journal of Gastroenterology 2005年第40期11卷 6373-6380页

作者： Yen-Shen Lu huang-chun lien Pei-Yen Yeh Kun-Huei Yeh Min-Liang Kuo Sung-Hsin Kuo Ann-Lii Cheng Department ofOncology National Taiwan University Hospital Graduate Instituteof Clinical Medicine National Taiwan University College ofMedicine Taipei Taiwan China Departments of Pathology National TaiwanUniversity Hospital Taipei Taiwan China Department of Oncology National Taiwan UniversityHospital Taipei Taiwan Department of Oncology and Departments of InternalMedicine National Taiwan University Hospital Departments ofInternal Medicine and Medical Research Far Eastern MemorialHospital Taipei Taiwan China Department of Oncology and Department ofInternal Medicine National Taiwan University Hospital TaipeiTaiwan China

AIM： To determine how glucocorticoids （GCs） may affect the growth and chemosensitivity of common carcinoma cells. METHODS： The effect of dexamethasone （DEX） on growth and chemosensitivity was assessed in 14 carcinoma cell lines. The function of GC receptors （GR） was assessed by MMTV reporter assay. Overexpression of GR was done by in vitro transfection and expression of a GR-expressing vector. Immunohistochemical stain of tissues and ceils were done by PA1-511A, an anti-GR monodonal antibody. RESULTS： DEX inhibited cell growth of four （MCF-7, MCF- 7/MXR1, MCF-7/TPT300, and HeLa）, increased cisplatin cytoxicity of one （SiHa）, and decreased dsplatin cytotoxicity of two （H460 and Hep3B） cell lines. The GR content of the seven cell lines affected by DEX was significantly higher than those of the seven cell lines unaffected by DEX （5.2±2.5×10^4 sites/cell vs1.3±1.4×10^4 sites/cell, P= 0.005）. Only two DEX-unresponsive cell lines {NPC-TW01 and NPC- TW04） oontained high GR amounts in the range （1.9-8.1×10^4 sites/cell） of the seven DEX-responsive cell lines. The GR function of NPC-TW01 and NPC-TW04, however, was foundto be impaired. The importance of high cellular amount of GR in mediating DEX susceptibility of the cells was further exemplified by GR dose-dependent drug resistance to cisplatin of AGS, a cell line with low GR content and was unaffected by DEX before transfection of GR-expressing vector. Immunohistochemical studies of human cancer tissues showed that 5 of the 45 （11.1%） breast cancer and 43 of the 85 （50.6%） non-small cell lung cancer had high GR contents at the ranges of the GC-responsive carcinoma cell lines. CONCLUSION： The growth and chemosensitivity of human carcinomas with high GR contents may be affected by GC. However, in light of the heterogeneous and even contradictive effects of GC on these cells, routine examination of GR contents of human carcinoma tissues may not be clinically useful until other markers that help predict the ultimate effect of

关键词： Glucocorticoids Glucocorticoid receptor Carcinoma Cell growth Chemosensitivility Drug resistance

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Forecasting measured responses of structures using temporal deep learning and dual attention

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 832-850页

作者： Viet-Hung DANG Trong-Phu NGUYEN Thi-lien PHAM Huan X.NGUYEN Department of Structural Mechanics Hanoi University of Civil EngineeringHanoi 11600Vietnam Faculty of Applied Science University of Economics-Technology for IndustriesHanoi 11600Vietnam London Digital Twin Research Centre Faculty of Science and TechnologyMiddlesex UniversityLondon NW44BTUK International School Vietnam National UniversityHanoi 11600Vietnam

The objective of this study is to develop a novel and efficient model for forecasting the nonlinear behavior of structures in response to time-varying random *** key idea is to design a deep learning architecture to leverage the relationships,between external excitations and structure's vibration signals,and between historical values and future values,within multiple time-series *** proposed method consists of two main steps:the first step applies a global attention mechanism to combine multiple-measured time series and time-varying excitation into a weighted time series before feeding it to a temporal architecture;the second step utilizes a self-attention mechanism followed by a fully connected layer to predict multi-step future *** viability of the proposed method is demonstrated via two case studies involving synthetic data from a three-dimensional(3D)reinforced concrete structure and experimental data from an 18-story steel ***,comparison and robustness studies are carried out,showing that the proposed method outperforms conventional methods and maintains high performance in the presence of noise with an amplitude of less than 10%.

关键词： structural dynamic time-varying excitation deep learning signal processing response forecasting

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Light-Controlled Chemical Reaction Pathways in Disulfide-Based Nonequilibrium Systems

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CCS Chemistry 2024年第6期6卷 1571-1580页

作者： Yingshuai Zhao Peng Zhao Jingyi Zhang Yuanfeng Zhao Bohan Li Guoxiu Hao Yuanyuan An Wei Zhou Yan Lu lien-Yang Chou Yijun Zheng School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210

Pathway selection in a complex chemical reaction network(CRN)enables organisms to adapt,evolve,and even learn in response to changing *** by this,herein we report an artificial system,where light signal was used to manipulate the reaction pathways in a disulfide-based nonequilibrium *** changing the photon energy and irradiation window,the anion or new radical-mediated pathways were selectively triggered,resulting in a user-defined evolution *** photodissipative cycles were achieved by UV(365 nm)irradiation,increasing the total number of reactions from 3 to *** emerging pathway selection of the CRN is accurately predictable and controllable even in complex organo-hydrogel *** demonstrate up to five-state autonomous sol-gel transitions and the formation of fuel-driven dissipative organo-hydrogel through both chemical and light *** work represents a new approach to allowing CRNs to communicate with the environment that can be used in the development of materials with lifelike behaviors.

关键词： chemical reaction networks light regulation kinetic control pathway selection disulfide

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杜预对《春秋》政治合法性的重建——以《春秋左氏传序》为中心

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孔子研究 2024年第2期 37-48,156,157页

作者：张立恩西北师范大学马克思主义学院暨哲学学院兰州730000

在《春秋》诠释史上,回应《春秋》的政治合法性问题成为构建新《春秋》诠释体系的基本前提。汉代公羊家董仲舒、何休等提出的孔子素王、《春秋》为汉制法等观点建立起《春秋》的政治合法性。晋代杜预虽然与他们一样主张《春秋》为孔子... 详细信息

在《春秋》诠释史上,回应《春秋》的政治合法性问题成为构建新《春秋》诠释体系的基本前提。汉代公羊家董仲舒、何休等提出的孔子素王、《春秋》为汉制法等观点建立起《春秋》的政治合法性。晋代杜预虽然与他们一样主张《春秋》为孔子“制作之文”,但认为公羊家以上说法无异于以孔子为乱臣贼子,故杜预认为《春秋》非“天子之事”,而是史官之事,孔子“制作之本意”是要替代史官遵周公之志而修正鲁史。为证其说,杜预构设了《春秋》的三种存在形态:周德未衰时之《春秋》、周德已衰时之《春秋》及孔子之《春秋》。周德已衰时之《春秋》的出现构成孔子作《春秋》的必要条件。孔子之《春秋》与周德未衰时之《春秋》同遵周公之制,具有相同属性,因此,孔子之《春秋》在本质上是鲁史。杜预此举又出现两个问题:一是,据其将韩宣子所见鲁《春秋》视为“周之旧典礼经”,则周德未衰时之《春秋》与周德已衰时之《春秋》难以相容;二是,如其所述,史之策书皆君所命,因而孔子何以具有替代史官著史的政治合法性又成为其需要回答的一个问题。

关键词：《春秋》孔子杜预政治合法性

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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

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Designing a location update strategy for free-moving and network-constrained objects with varying velocity

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第8期15卷 675-686页

作者： Yuan-Ko huang lien-Fa LIN Department of Information Communication Kao-Yuan University

Spatio-temporal databases aim at appropriately managing moving objects so as to support various types of queries. While much research has been conducted on developing query processing techniques, less effort has been made to address the issue of when and how to update location information of moving objects. Previous work shifts the workload of processing updates to each object which usually has limited CPU and battery capacities. This results in a tremendous processing overhead for each moving object. In this paper, we focus on designing efficient update strategies for two important types of moving objects, free-moving objects(FMOs) and network-constrained objects(NCOs), which are classified based on object movement models. For FMOs, we develop a novel update strategy, namely the FMO update strategy(FMOUS), to explicitly indicate a time point at which the object needs to update location information. As each object knows in advance when to update(meaning that it does not have to continuously check), the processing overhead can be greatly reduced. In addition, the FMO update procedure(FMOUP) is designed to efficiently process the updates issued from moving objects. Similarly, for NCOs, we propose the NCO update strategy(NCOUS) and the NCO update procedure(NCOUP) to inform each object when and how to update location information. Extensive experiments are conducted to demonstrate the effectiveness and efficiency of the proposed update strategies.

关键词： Spatio-temporal databases Moving objects Free-moving objects Network-constrained objects

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Three-Dimensional Parallel Simulation of Formation of Spinning Detonation in a Narrow Square Tube

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Chinese Physics Letters 2012年第11期29卷 136-139页

作者： huang Yue JI Hua lien Fue-Sang TANG Hao College of Energy&Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 2100162Waterloo CFD Engineering Consulting Inc.WaterlooOntario N2T 2N7Canada 3Department of Mechanical EngineeringUniversity of WaterlooWaterlooOntario N2L 3G1Canada

Four different formation processes of spinning detonation in a narrow square tube are investigated by three-dimensional parallel ***-resolution simulations are performed with a Riemann solver of the HLLC-type,high-order,parallel AMR reactive flow *** simulations clearly show that the detonation structure transforms from rectangular and diagonal modes into spinning mode respectively during the propagation *** wave dynamic and periodic oscillation of the front plays a significant role in the spinning detonations'formation.

关键词： diagonal narrow oscillation

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Optimal design theories of tuned mass dampers with nonlinear viscous damping

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 547-560页

作者： Lap-Loi chung Lai-Yun Wu Hsu-Hui huang chung-Hsin Chang Kuan-Hua lien Center for Research on Earthquake Engineering （NCREE） Chinese Taipei Department of Civil Engineering Taiwan University. Chinese Taipei

Optimal design theory for linear tuned mass dampers （TMD） has been thoroughly investigated, but is still under development for nonlinear TMDs. In this paper, optimization procedures in the time domain are proposed for design of a TMD with nonlinear viscous damping. A dynamic analysis of a structure implemented with a nonlinear TMD is conducted first. Optimum design parameters for the nonlinear TMD are searched using an optimization method to minimize the performance index. The feasibility of the proposed optimization method is illustrated numerically by using the Taipei 101 structure implemented with TMD. The sensitivity analysis shows that the performance index is less sensitive to the damping coefficient than to the frequency ratio. Time history analysis is conducted using the Taipei 101 structure implemented with different TMDs under wind excitation. For both linear and nonlinear TMDs, the comfort requirements for building occupants are satisfied as long as the TMD is properly designed. It was found that as the damping exponent increases, the relative displacement of the TMD decreases but the damping force increases.

关键词： optimal design theory tuned mass damper (TMD) nonlinear performance index sensitivity analysis Taipei 101

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Clinical values of Barcelona Clinic Liver Cancer subgroup and up-to-7 criteria in intermediate stage hepatocellular carcinoma with transcatheter arterial chemoembolization

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World Journal of Clinical Cases 2022年第21期10卷 7275-7284页

作者： Shou-Wu Lee Yen-chun Peng Han-chung lien chung-Wang Ko chun-Fang Tung Chi-Sen Chang Division of Gastroenterology and Hepatology Department of Internal MedicineTaichung Veterans General HospitalTaichung 40705Taiwan Department of Internal Medicine Yang Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichung 40227Taiwan Department of Internal Medicine Chung Shan Medical UniversityTaichung 40201Taiwan

BACKGROUND Transarterial chemoembolization(TACE)is a recommended treatment for patients with intermediate stage hepatocellular carcinoma(HCC)but with variable treatment *** To determine factors for predicting outcomes of TACE in patients with intermediate stage B *** Patients with Barcelona Clinic Liver Cancer(BCLC)stage B HCC who underwent TACE as the primary treatment were enrolled at Taichung Veterans General Hospital from January 2005 to December *** were assigned to either the objective responder(OR)group or the non-OR group according to mRECIST *** and radiological characteristics were compared between the 2 *** overall survival of enrolled subjects was *** In 128 enrolled patients,66(51.6%)were in the OR group and 62(48.4%)in the non-OR *** with the non-OR group,the OR group had a significantly smaller HCC size(6.55 cm vs 9.50 cm,P=0.001)and was within the up-to-7 criteria(50%vs 26.7%,P=0.001).After multivariable analyses,these significant associations still *** survival rate of all the subjects averaged 20.65±13.26 *** survival rate at 1-year was 64.8%,2-year was 46.9%,and 3-year was 31.2%.For those patients with OR to TACE,smaller tumor size and within up-to-7 criteria were associated with significantly better overall *** patients with subgroup B1 had the highest OR ratio(75%)and better overall survival(26.70±12.07 mo)after *** BCLC stage B HCC patients with smaller tumor size or within up-to-7 criteria had better survival outcomes to *** stage B subgroup is useful to predict refractoriness to TACE.

关键词： Hepatocellular carcinoma Objective response Overall survival Transcatheter arterial chemoembolization Barcelona Clinic Liver Cancer

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