检索结果-南通市图书馆

Rare loss-of-function variants in FLNB cause non-syndromic orofacial clefts

Journal of Genetics and Genomics 2024年第2期51卷 222-229页

作者： Wenbin huang Shiying Zhang Jiuxiang Lin Yi Ding nan Jiang Jieni Zhang Huaxiang Zhao Feng Chen Department of Orthodontics Peking University School and Hospital of StomatologyBeijing100081China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’anShaanxi710004China Guangdong Provincial High-level Clinical Key Specialty Guangdong Province Engineering Research Center of Oral Disease Diagnosis and TreatmentDepartment of OrthodonticsStomatological CenterPeking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Physiology and Pathophysiology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anShaanxi710049China National Center for Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory for Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100101China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081China

Orofacial clefts (OFCs) are the most common congenital craniofacial disorders, of which the etiology is closely related to rare coding variants. Filamin B (FLNB) is an actin-binding protein implicated in bone formation. FLNB mutations have been identified in several types of syndromic OFCs and previous studies suggest a role of FLNB in the onset of non-syndromic OFCs (NSOFCs). Here, we report two rare heterozygous variants (p.P441T and p.G565R) in FLNB in two unrelated hereditary families with NSOFCs. Bioinformatics analysis suggests that both variants may disrupt the function of FLNB. In mammalian cells, p.P441T and p.G565R variants are less potent to induce cell stretches than wild type FLNB, suggesting that they are loss-of-function mutations. Immunohistochemistry analysis demonstrates that FLNB is abundantly expressed during palatal development. Importantly, Flnb^(−/−) embryos display cleft palates and previously defined skeletal defects. Taken together, our findings reveal that FLNB is required for development of palates in mice and FLNB is a bona fide causal gene for NSOFCs in humans.

关键词： Or ofacial clefts FLNB Loss-of-function mutati on Cleft palate Filamin B Actin flannent Knockout mouse

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Astronomical influence of the development of Paleogene thin coal seam groups in offshore Lacustrine basins:A case study of the ZhuⅠDepression's Enping Formation located in the northern South China Sea

引用

Acta Oceanologica Sinica 2024年第4期43卷 136-150页

作者： Yan Liu Shengbing huang Dongdong Wang nan Li Yuting Yin Ying Chen Zengxue Li College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China CNOOC Research Institute Co. Ltd.Beijing 100028China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK

The development of the Paleogene coal seams in China's offshore basin areas generally had the characteristics of coal measures with large thicknesses,large numbers of coal seams,thin single coal seams,poor stability,scattered vertical distribution,and a wide distribution *** study selected the Enping Formation of the ZhuⅠDepression in the northern section of the South China Sea as an example to determine the macro-control factors of the development of the Paleogene coal seam *** analysis was carried out on the influencing effects and patterns of the astronomical cycles related to the development of the thin coal seam groups in the region.A floating astronomical time scale of the Enping Formation was established,and the sedimentary time limit of the Enping Formation was determined to be approximately 6.15 Ma±.In addition,the cyclostratigraphy analysis results of the natural gamma-ray data of Well XJ in the Enping Formation of the Xijiang Sag revealed that the development of the thin coal seams had probably been affected by short eccentricity and precession *** formation process of coal seams was determined to have been affected by high seasonal contrast,precipitation,and *** the periods with high values of short eccentricity,the seasonal contrasts tended to be *** those periods,fluctuations in the precession controls resulted in periodic volume changes in precipitation and insolation of the region,resulting in the development of thin coal *** was also found that the periods with low precession were the most conducive to coal seam *** that basis,combined with such factors as sedimentary environmental conditions conducive to the development of thin coal seam groups,this study established a theoretical model of the comprehensive influences of short eccentricity and precession on the development and distribution of Paleogene thin coal seam groups in offshore lacustrine *** patterns of the Paleogene astrono

关键词： Paleogene Pearl(Zhujiang)River Mouth Basin coal seam development astronomical cycles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Addressable structured light system using metasurface optics and an individually addressable VCSEL array

引用

Photonics Research 2024年第6期12卷 1129-1137页

作者： CHENYANG WU XUANLUN huang YIPENG JI TINGYU CHENG JIAXING WANG nan CHI SHAOHUA YU CONNIE J.CHANG-HASNAIN School of Information Science and Technology Fudan UniversityShanghai 200433China Berxel Photonics Co. Ltd.Shenzhen 518071China Peng Cheng Laboratory Shenzhen 518055China Chinese University of Hong Kong Shenzhen 518172China

Structured-light(SL)based 3D sensors have been widely used in many *** SL is the most widely deployed among all SL sensors due to its light weight,compact size,fast video rate,and low *** transmitter(known as the dot projector)consists of a randomly patterned vertical-cavity surface-emitting laser(VCSEL)array multiplicated by a diffractive optical element(DOE)with a fixed repeated *** that the separation of any two speckles is only one known and fixed number(albeit random),there are no other known scales to cal-ibrate or ***,typical SL sensors require extensive in-factory calibrations,and the depth resolution is limited to 1 mm at-60 cm *** this paper,to the best of our knowledge,we propose a novel dot projector and a new addressable SL(ASL)3D sensor by using a regularly spaced,individually addressable VCSEL array,multiplicated by a metasurface-DOE(MDOE)into a random pattern of the *** turning on or off the VCSELs in the array provides multiple known distances between neighboring speckles,which is used as a“built-in caliper”to achieve higher accuracy of *** as a precise“vernier caliper,”the addressable VCSEL array enables fine control over speckle positions and high detection *** experimentally dem-onstrated that the proposed method can result in sub-hundred-micron level *** new concept opens new possibilities for applications such as 3D computation,facial recognition,and wearable devices.

关键词： speckle light surface

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

瓶颈与路径:全国数据要素统一大市场建设探析

引用

南京社会科学 2022年第10期 35-45页

作者：黄南南京市社会科学院经济发展研究所南京210018 江苏省扬子江创新型城市研究院

建设数据要素统一大市场是全国统一大市场建设中的重要内容。其建设目标就是要在遵循数字经济下市场发展规律的基础上,构建起统一的市场环境,促进数据要素的顺畅流通和高效使用,充分激发其内在价值。但是,在全国数据要素统一大市场的建... 详细信息

建设数据要素统一大市场是全国统一大市场建设中的重要内容。其建设目标就是要在遵循数字经济下市场发展规律的基础上,构建起统一的市场环境,促进数据要素的顺畅流通和高效使用,充分激发其内在价值。但是,在全国数据要素统一大市场的建设过程中存在着市场设施的联通性不高、制度缺失和标准不统一,以及数据监管和治理能力不强等瓶颈问题。为此,需要通过进一步提高数字基础设施建设水平,建立健全相关的制度体系,完善数据监管和协同治理机制等,推动全国数据要素统一大市场的建设,促进数据要素的价值实现。

关键词：数据要素统一大市场价值实现瓶颈和路径

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Confidence Estimation Transformer for Long-Term Renewable Energy Forecasting in Reinforcement Learning-based Power Grid Dispatching

引用

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1502-1513页

作者： Xinhang Li nan Yang Zihao Li Yupeng huang Zheng Yuan Xuri Song Lei Li Lin Zhang Beijing University of Posts and Telecommunications Beijing 100876China Beijing Key Laboratory of Research and System Evaluation of Power Dispatching Automation Technology

Expansion of renewable energy could help realize the goals of peaking carbon dioxide emissions and carbon *** existing grid dispatching methods integrating short-term renewable energy prediction and reinforcement learning(RL)have been proven to alleviate the adverse impact of energy fluctuations ***,these methods omit long-term output prediction,which leads to stability and security problems on optimal power *** paper proposes a confidence estimation Transformer for long-term renewable energy forecasting in reinforcement learning-based power grid dispatching(Conformer-RLpatching).Conformer-RLpatching predicts long-term active output of each renewable energy generator with an enhanced Transformer to ensure stable operation of the hybrid energy grid and improve the utilization rate of renewable energy,thus boosting dispatching ***,a confidence estimation method is proposed to reduce the prediction error of renewable ***,a dispatching necessity evaluation mechanism is put forward to decide whether the active output of a generator needs to be *** carried out on the SG-126 power grid simulator show that Conformer-RLpatching achieves great improvement over the second best algorithm DDPG in security score by 25.8%and achieves a better total reward compared with the golden medal team in the power grid dispatching competition sponsored by State Grid Corporation of China under the same simulation *** are outsourced in https://***/BUPT-ANTlab/Conformer-RLpatching.

关键词： Conformer-RLpatching optimal power flow reinforcement learning renewable energy prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Governance of Violence Risk in Patients with Severe Mental Disorders:From a Case of a Schizophrenic’s Filicide

引用

Journal of Forensic Science and Medicine 2023年第2期9卷 190-193页

作者： Da‑Ming Sun Jun‑nan huang Criminal Law College East China University of Political Science and LawShanghaiChina

Schizophrenia is a chronic,prolonged illness with a significant tendency to relapse and a high disease *** are often affected by psychotic symptoms and commit violent assaults that manifest as criminal *** the same time,such patients generally have poor medication adherence,which also makes them more likely to commit *** our case,a single mother with a history of psychiatric illness strangled her 4-year-old biological son to death with a rope,put the body in a bathtub and divided it,ate some of the victim’s organs;the results of her forensic mental health identification indicated she was in a period of illness at the time of the offense and did not have the competence for criminal *** adherence is an important factor affecting relapse in patients with *** new medications have been introduced and researchers have been improving medication adherence through many ways such as patient education and family therapy since the 1980s,the level of medication adherence is still poor,with a nonadherence rate of about 50%.This report suggests that in practice,attention should be given to improving patients’medication adherence,guardians of patients and their communities should strengthen their monitoring and care,including knowing the patients’medication adherence and monitoring them to take their medication as prescribed,together with systematic psychotherapy for patients to prevent them from relapsing and committing violent ***,when assessing the patient’s risk of violence,the realistic factors in crime motives and the impact of guardians(family)should be taken into account to evaluate the risk of violence objectively and comprehensively.A final point is that social support for patients with mental disorders and their families should be improved.

关键词： Community care governance of violence risk guardianship schizophrenic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

集成电路废水的达标排放、资源回收和再生处理

引用

工业水处理 2024年第4期44卷 1-9页

作者：肖卓远黄南巫寅虎张倬玮徐雨晴吴乾元王文龙熊江磊罗嘉豪廖翔胡洪营清华大学环境学院环境模拟与污染控制国家重点联合实验室生态环境部环境微生物利用与安全控制重点实验室环境前沿技术北京实验室北京100084 北京工业大学城镇污水深度处理与资源化利用技术国家工程实验室北京100124 清华大学深圳国际研究生院生态环境部环境微生物利用与安全控制重点实验室广东深圳518055 中国电子系统工程第二建设有限公司江苏无锡214135 清华苏州环境创新研究院江苏苏州215163

集成电路产业是支撑经济社会发展的战略性、先导性产业,其用水量和排水量均较高。分析了集成电路废水的水质特征,主要包括各生产环节产生的含氨、含氟、酸碱、有机、含铜和研磨废水。针对含不同物质废水,总结了废水达标排放、资源回收... 详细信息

集成电路产业是支撑经济社会发展的战略性、先导性产业,其用水量和排水量均较高。分析了集成电路废水的水质特征,主要包括各生产环节产生的含氨、含氟、酸碱、有机、含铜和研磨废水。针对含不同物质废水,总结了废水达标排放、资源回收和再生处理技术的应用现状与研究进展。在废水达标排放方面,实际工程中常采用混凝沉淀、过滤和吸附等处理含氟、含铜和研磨废水;采用活性污泥法、膜生物反应器、水解酸化和内循环厌氧反应器等处理含氨和有机废水;近年来磁混凝和高级氧化等技术也备受关注。在资源回收方面,目前主要采用超滤和电渗析等技术回收氟、铜和四甲基氢氧化铵等。废水回用方面,主要采用混凝沉降,膜生物反应器和膜过滤技术;反渗透技术是废水再生处理的核心,其目标是制备工业纯水用于集成电路制造。最后针对集成电路废水处理系统现存的问题,建议完善废水分类分质收集系统;强化去除重金属和难降解有机物,降低废水的生物毒性;使用预处理、污堵监测、膜清洗、开发新型膜材料等方法控制反渗透膜的污堵。

关键词：集成电路废水达标排放资源回收再生处理处理技术和工艺

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

d-d Orbital coupling induced by crystal-phase engineering assists acetonitrile electroreduction to ethylamine

引用

Journal of Energy Chemistry 2024年第2期89卷 216-225,I0006页

作者： Honggang huang Yao Chen Hui Fu Cun Chen Hanjun Li Zhe Zhang Feili Lai Shuxing Bai nan Zhang Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122JiangsuChina Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071ShandongChina

The d-d orbital coupling induced by crystal-phase engineering can effectively adjust the electronic structure of electrocatalysts,thus showing significant catalytic performance,while it has been rarely explored in electrochemical acetonitrile reduction reaction(ARR)to ***,we successfully realize the structural transformation of Pd Cu metallic aerogels(MAs)from face-centered cubic(FCC)to body-centered cubic(BCC)through annealing ***,the BCC Pd Cu MAs exhibit excellent ARR performance with high ethylamine selectivity of 90.91%,Faradaic efficiency of 88.60%,yield rate of 316.0 mmol h^(-1)g^(-1)_(Pd+Cu)and long-term stability for consecutive electrolysis within 20 h at-0.55 V *** hydrogen electrode,outperforming than those of FCC Pd Cu *** the membrane electrode assembly system,BCC Pd Cu MAs also demonstrate excellent ethylamine yield rate of 389.5 mmol h^(-1)g^(-1)_(Pd+Cu).Density functional theory calculation reveals that the d-d orbital coupling in BCC Pd Cu MAs results in an evident correlation effect for the interaction of Pd and Cu sites,which boosts up the Cu sites electronic activities to enhance ARR *** work opens a new route to develop efficient ARR electrocatalysts from the perspective of crystalline structure transformation.

关键词： d-d Orbital coupling Crystal-phase engineering Metallic aerogels Acetonitrile electroreduction reaction Ethylamine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

铜绿假单胞菌感染支气管上皮细胞诱导铁死亡及丁酸钠的免疫调控作用

引用

温州医科大学学报 2024年第7期54卷 554-562页

作者：周娈何一帆赵伊敏任锡凯耿轩黄楠苏苗赏温州医科大学附属第二医院育英儿童医院儿童呼吸科浙江温州325027 龙湾区第一人民医院内分泌科浙江温州325024 温州医科大学第二临床医学院浙江温州325035

目的:探究铜绿假单胞菌(PA)感染对人支气管上皮细胞(BEAS-2B)铁死亡与炎症反应的诱导作用及丁酸钠(NaB)对炎症的调节作用。方法:体外培养BEAS-2B细胞,加入不同浓度NaB后通过CCK-8筛选其安全浓度和作用时间,Westernblot检测酰基辅酶A合... 详细信息

目的:探究铜绿假单胞菌(PA)感染对人支气管上皮细胞(BEAS-2B)铁死亡与炎症反应的诱导作用及丁酸钠(NaB)对炎症的调节作用。方法:体外培养BEAS-2B细胞,加入不同浓度NaB后通过CCK-8筛选其安全浓度和作用时间,Westernblot检测酰基辅酶A合成酶长链家族成员4(ACSL4)、磷酸化蛋白激酶B(P-AKT)蛋白表达水平,确定NaB的用药条件。PA感染BEAS-2B细胞(MOI=1)不同时间后,CCK-8检测细胞存活率,倒置显微镜观察细胞形态变化,透射电镜观察细胞线粒体形态变化,二价铁离子探针检测细胞内Fe^(2+)水平;加入NaB预处理后,BODIPY581/591C11荧光探针检测细胞内脂质过氧化水平,Westernblot检测ACSL4、P-AKT、谷胱甘肽过氧化物酶4(GPX4)蛋白表达水平;加入ACSL4抑制剂吡格列酮(PIO)后,Westernblot验证其抑制效果,ELISA检测各组细胞上清液中炎症因子水平变化。结果:NaB对BEAS-2B细胞的安全浓度在2.5mmol/L以下,2.5mmol/LNaB处理细胞36h后,ACSL4和P-AKT蛋白表达水平显著下降(P0.05)。结论:PA感染导致支气管上皮细胞内Fe^(2+)及脂质过氧化物的积累从而发生铁死亡并引起炎症反应,NaB可能通过抑制ACSL4和AKT磷酸化途径起到免疫调节作用。

关键词：铜绿假单胞菌支气管上皮细胞铁死亡丁酸钠炎症因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transcriptome Analysis and Physiological Responses of Economic Macroalga Gracilariopsis lemaneiformis under Sulfate Deficiency

引用

Phyton-International Journal of Experimental Botany 2023年第1期92卷 91-110页

作者： Haojie Jia Hong Du Muhmmad Aslam Tangcheng Li Canqi Zheng Xihui Xie nan huang Honghao Liang Pengbing Pei Ping Li Weizhou Chen Xiaojuan Liu Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China Institute of Marine Sciences Guangdong Provincial Key Laboratory of Marine Biotechnology and STU-UNIVPM Joint Algal Research CenterCollege of SciencesShantou UniversityShantou515063China

Sulfur is an essential macronutrient for the growth of all photosynthetic organisms and plays important roles in different metabolic ***,sulfur metabolism and its related research on macroalgae with important ecological value is rather *** this study,marine ecological valued macroalga Gracilariopsis lemaneiformis was used to study the general physiological responses and transcriptome profiling under the sulfate *** relative growth rate of algae under sulfate deficiency was statistically significantly lower than that of control after 6 ***,no significant differences were observed in the pigments content and Fv/Fm value,indicating that the photosynthesis was not obviously affected under the sulfate ***,the significantly increased soluble protein and carbohydrate contents,and indistinctively differentially expressed sulfate transporter/permease(ST)and ATP sulfurylase(ATPS)genes suggesting that *** cells did not use sulfur from internal protein and carbohydrate pools but utilize stored sulfur from vacuole to satisfy their nutritional requirements during the sulfate *** data showed that most annotated differentially expressed genes(DEGs)were down-regulated under the sulfate deficiency,including a large proportion of genes involved in the pathway of sulfur ***,it was concluded that the pathway of sulfur metabolism was suppressed under the sulfate deficiency in *** results and analysis in this study provide a comprehensive understanding for the physiological and molecular response of *** to sulfate deficiency.

关键词： Gracilariopsis lemaneiformis sulfate deficiency sulfate sufficiency transcriptome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：