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Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy

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Genes & Diseases 2024年第1期11卷 1-3页

作者： Kaiyan Chen Ying Yu Zhiyu huang Lei Gong Yun Fan The Cancer Hospital of the university of Chinese Academy of sciences(Zhejiang Cancer Hospital) HangzhouZhejiang 310022China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesHangzhouZhejiang 310022China department of Thoracic medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310022China department of Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

With morphological features resembling hepatocellular carcinoma,hepatoid adenocarcinoma of the lung(HAL)is a rare and aggressive subtype of lung cancer with a 5-year survival of only 8%.1 Most HAL patients present increased serum alpha-fetoprotein(AFP)levels that are commonly related to poor *** insights into HAL have come from case series or reports,and TP53 is frequently mutated in *** heterogeneity of HAL complicates the *** no established standard,the management of HAL is modeled on that of classical lung adenocarcinoma,although with dismal outcomes.2 Herein,we reported the effective management of a stage IIIb HAL patient with perioperative chemoimmunotherapy and curative-intent *** patient remained disease-free and minimal residual disease(MRD)-negative for more than one year after surgery.

关键词： adenocarcinoma patient lung

Origin of the Red Earth sequence on the northeastern Tibetan Plateau and its implications for regional aridity since the middle Miocene

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Science China Earth sciences 2006年第5期49卷 505-517页

作者： WANG Xianyan1,7, LU Huayu1,2, JI Junfeg3, WANG Xiaoyong1,7, ZHAO Jingbo4, huang Baochun5 & LI Zhen6 1. SKLLQG, Institute of Earth Environment, Chinese Academy of sciences, Xi’an 710075, China 2. department of Urban and Resources sciences, Nanjing university, Nanjing 210093, China 3. department of Earth sciences, Nanjing university, Nanjing 210093, China 4. department of Geography, Shaanxi Normal university, Xi’an 710062, China 5. Institute of Geology and Geophysics, Chinese Academy of sciences, Beijing 100029, China 6 department of Geography, Qinghai Normal university, Xining 810008, China 7. Graduate School of the Chinese Academy of sciences, Beijing 100039, China 1. SKLLQG Institute of Earth Environment Chinese Academy of Sciences Xi’an 710075 China 7. Graduate School of the Chinese Academy of sciences Beijing 100039 China 2. department of Urban and Resources sciences Nanjing University Nanjing 210093 China 3. department of Earth sciences Nanjing University Nanjing 210093 China 4. department of Geography Shaanxi Normal University Xi’an 710062 China 5. Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China 6. department of Geography Qinghai Normal University Xining 810008 China

The Red Earth deposit around Xining, northeastern Tibetan Plateau, has beenstudied in terms of soil micro-structure, grain-size distribution, major- and trace-elementchemistry and magne-tostratigraphy. Field investigations indicate that the Red Earth sequenceconsists of 25 visually definable yellow-brown and weakly-developed soils interbedded with reddishstrongly-developed soils, and has a similar structure to the aeolian Red Clay deposit on the ChineseLoess Plateau. Grain-size analysis shows that the Red Earth deposit is very fine-grained with anegligible sand fraction ( > 63 μm). Thin-section observations under light microscopy show that thedeposit has a clayey texture and the coarse fraction ( > 10 μm) mainly consists of quartz,feldspar and micas. Pyroxene and hornblende were also observed. This mineralogical composition ofthe coarse fraction is similar to that of the Quaternary loess. In addition, all of the mineralgrains are semi angular semi-angular and are generally finer than 63 μm. There is a good agreementbetween the major and minor trace element chemistry of loess-soil units and the Red Earth *** REE distributions of the loess-soil and the Red Earth deposit are similar in shape, withenriched LREE and fairly flat HREE profiles and a clear negative Eu anomaly. The geochemicalcharacteristics of the Red Earth deposit are also identical to those of upper continental crust,thus indicating a wind-blown origin. Magnetostratigraphic investigation shows that onset of the RedEarth deposition predates 11.4 Ma BP (13.6 Ma at a nearby site). The distribution of the reportedMiocene aeolian loess at Qin''an of the Loess Plateau is still unknown. Our results indicate thatthis aeolian deposit had extended to the northeastern Tibetan Plateau by at least the middleMiocene. The similarity of the element geochemistry between the Red Earth deposit and the overlyingloess shows that they may have similar sources and dynamic transport system, and may indicate thatthe

关键词： Red Earth deposit, Northeastern Tibetan Plateau, aeolian deposit, aridity of Asia, the middle Miocene.

Influence of Irregular Coastlines on a Tornadic Mesovortex in the Pearl River Delta during the Monsoon Season. Part Ⅰ:Pre-storm Environment and Storm Evolution

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Advances in Atmospheric sciences 2024年第9期41卷 1115-1131页

作者： Lanqiang BAI Dan YAO Zhiyong MENG Yu ZHANG Xianxiang huang Zhaoming LI Xiaoding YU Foshan Tornado Research Center and China Meteorological Administration Tornado Key LaboratoryGuangdong Meteorological Serviceand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Guangdong 528000China Meteorological Observation Centre CMABeijing 100081China department of Atmospheric and Oceanic sciences and China Meteorological Administration Tornado Key LaboratorySchool of PhysicsPeking UniversityBeijing 100871China Guangzhou Meteorological Observatory CMAGuangdong 511430China Foshan Tornado Research Center and China Meteorological Administration Tornado Key LaboratoryCMAGuangdong 528000China China Meteorological Administration Training Center CMABeijing 528000China

The Pearl River Delta(PRD),a tornado hotspot,forms a distinct trumpet-shaped coastline that concaves toward the South China *** the summer monsoon season,low-level southwesterlies over the PRD’s sea surface tend to be turned toward the west coast,constituting a convergent wind field along with the landward-side southwesterlies,which influences regional convective *** two-part study explores the roles of this unique land–sea contrast of the trumpet-shaped coastline in the formation of a tornadic mesovortex within monsoonal flows in this *** I primarily presents observational analyses of pre-storm environments and storm *** rotating storm developed in a lowshear environment(not ideal for a supercell)under the interactions of three air masses under the influence of the land–sea contrast,monsoon,and storm cold *** intersection zone(or“triple point”)is typically characterized by local enhancements of ambient vertical vorticity and *** on a rapid-scan X-band phased-array radar,finger-like echoes were recognized shortly after the gust front intruded on the triple *** over the triple point,they rapidly wrapped up with a well-defined low-level *** is thus presumed that the triple point may have played roles in the mesovortex genesis,which will be demonstrated in Part II with multiple sensitivity numerical *** findings also suggest that when storms pass over the boundary intersection zone in the PRD,the expected possibility of a rotating storm occurring is relatively high,even in a low-shear *** knowledge of such environments provides additional guidance to assess the regional tornado risk.

关键词： tornado mesovortex surface boundary land–sea contrast monsoon

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Stable hydrogen-bonded organic frameworks and their photo-and electro-responses

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Nano Research 2024年第8期17卷 7675-7699页

作者： Ying Hou Xin-Song huang Sheng-Hao Gong Chen Liu Yangyang Liu Tian-Fu Liu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China university of Chinese Academy of sciences Beijing 100049China department of Chemistry and Biochemistry California State UniversityLos AngelesCalifornia 90032USA College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China

Hydrogen-bonded organic frameworks(HOFs)are a recent class of porous materials that have garnered considerable research interest owing to their distinctive *** can be constructed through judicious selection of H-bonding motifs,which are further enforced by other weak intermolecular interactions such asπ–πstacking,van der Waals forces,and framework *** advantage of these interactions,we can expand the functional field of HOFs by introducing active ***,researchers have made substantial advancements in using HOFs for chemical sensing,catalysis,proton conduction,biological applications,and *** low bonding energy of H-bonds allows for precise control over the concentration of ligands in solvents,forming diverse HOF *** varied structures offer significant advantages for producing HOFs with photo-responsive and electro-responsive ***,the presence of H-bonds in HOFs results in their inherent lower stability compared to metal-organic frameworks(MOFs)and covalent-organic frameworks(COFs)formed via coordination and covalent bonds,*** a result,the pursuit of stable and innovative HOF materials with novel functional sites remains an ongoing *** review provides an overview of recent research progress in the development of new strategies for stable HOF synthesis and applications of HOFs with stimuli-responsive *** first classified all synthetic methods reported to date and discussed the stable HOFs synthesized,as well as their unique properties and *** addition,we summarized the applications of HOFs utilizing their synergistic responses to external stimuli,including photo,electrical,pressure,and chemical *** systematically reviewed stable HOF synthesis and applications,which may lead to a deeper understanding of the structure–activity relationship for these materials and guide future HOF design.

关键词： stable hydrogen-bonded organic frameworks(HOFs) photo-response electro-response photoelectric synergistic response

An OGCM Simulation of Seasonal and Interannual Variabilities in the Surface-Layer Pacific of the Equatorial Band

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Advances in Atmospheric sciences 2002年第2期19卷 219-235页

作者： Boyin huang and Zhengyu Liu department of Atmospheric and Oceanic sciences, university of Wisconsin-Madison 1225 W. Dayton St., Madison, WI-53706, U.S.A. department of Earth Atmospheric and Planetary Sciences Massachusetts Institute of Technology Room 54-1721 77 Massachusetts Ave. 02139 Cambridge MA USA department of Atmospheric and Oceanic sciences University of Wisconsin-Madison 1225 W. Dayton St. 53706 Madison WI USA

The heat budget is analyzed in the surface-layer (0-50 m) Pacific of the equatorial band (10°S-10°N), using the simulation of an ocean general circulation model from 1945 to 1993. The analysis indicates that downward net surface heat flux from the atmosphere and ocean advective heat fluxes play distinct roles in seasonal and interannual variabilities of surface-layer ocean temperature. The surface heat flux dominantly determines the ocean temperature in the seasonal time-scale. But, it has a negative feedback to the ocean temperature in the interannual time-scale. The interannual variability of ocean temperature is largely associated with the cold advection from off-equatorial divergent flow in the central Pacific and from upwelling in the cold tongue. Both the surface heat flux and ocean advective heat fluxes are important to the ocean temperature during an El Nino event. The ocean. advective heat fluxes are further associated with local westward trade wind in the central Pacific. These results are largely consistent with some regional observational analyses.

关键词： Seasonal variability Interannual variability Heat flux

Mesenchymal stem cell-derived exosomes: Versatile nanomaterials for skin wound treatment

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Nano Research 2024年第4期17卷 2836-2856页

作者： Yuzhen Xiao Hexi Li Junhui Zhang Songyun Yang Chunsen Zhang Yizhou huang Xin Tang Huiqi Xie department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Basic medical sciences and Forensic Medicine Sichuan UniversityChengdu 610041China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041China Sports Medicine Center West China HospitalSichuan UniversityChengdu 610041China

Accumulating studies reveal that mesenchymal stem cells(MSCs)promote skin wound healing mainly through the paracrine ***,one of the crucial paracrine mediators in wound healing,are cell-derived nanosized membranous vesicles containing diverse bioactive *** the potent ability of modulating skin cell behaviors,MSC-derived exosomes(MSC-Exos)are regarded as a promising nanomaterial for regenerative wound *** hostile conditions,MSC-Exos are efficient in protecting skin cells from severe damage and restoring their *** to recent studies,MSC-Exos possess remarkable pro-healing effects in a variety of skin wounds,typically resulting in increased wound closure,inhibited scar tissue formation,and better restoration of skin *** further enhance the therapeutic potential of MSC-Exos,the development of applicable pretreatment strategies and the optimization of exosome delivery are under intensive ***,we summarize current research progress of MSC-Exos for skin wound treatment,with an emphasis on the biological effects of these nanovesicles,the repair mechanisms,and future challenges in clinical translation.

关键词： exosomes mesenchymal stem cells diabetic wounds burn wounds scar wound healing

Cytoskeleton reorganization and FAK phosphorylation are involved in lanthanum(Ⅲ)-promoted proliferation and differentiation in rat osteoblasts

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Progress in Natural Science:Materials International 2009年第3期19卷 331-335页

作者： Xi Wang,Jian huang*,Tianlan Zhang*,Kui Wang department of Chemical Biology,Peking university School of Pharmaceutical sciences,38 Xueyuan Road,Beijing 100083,China [a]department of Chemical Biology Peking University School of Pharmaceutical Sciences 38 Xueyuan Road Beijing 100083 China

The effect of lanthanum ion(La 3+ )on osteoblast function and cytoskeleton is assessed in *** were isolated from Sprague- Dawley fetal neonatal *** proliferation and gene expression levels of cbfa-1,alkaline phosphatase(ALP),osteocalcin(OC),bone sialo- protein(BSP)and osteopontin(OPN)were examined by cell counting and *** F-actin was stained with rhodamine-con- jugated phalloidin and was visualized by a confocal *** the results,10à 8-10 à4M La 3+-induced osteoblast proliferation on day 2. Data from the RT-PCR assay revealed that 10à 6M La 3+up-regulated the expression levels of ALP,BSP,and cbfa-1 on day 4,while it enhanced the expressions of OC and OPN on day *** F-actin cytoskeleton was strengthened and reorganized under the exposure of La3 +.In addition, the phosphorylation of focal adhesion kinase(FAK)was significantly promoted in 24 h evaluated by Western blot *** findings indi- cate that La3 +promotes osteoblast activity through the phosphorylation of FAK and reorganization of the cytoskeleton.

关键词： La3 + Osteoblasts Proliferation Differentiation Cytoskeleton FAK phosphorylation

Ecological-breaking zone originates and its ecosystems reconstruction in arid area

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Journal of Environmental sciences 1996年第2期8卷 203-211页

作者： huang Peiyou Lu Zili(Biology department of Xinjiang university,Urumqi 830046,China) Biology department Xinjiang University Urumqi 830046 China

In the process of arid land exploitation, the landscape of desert is divided into three types. Oasis is rising,the area of uneffected area keeps its original state,the serious degenerated area where is only limited between oasis and desert, but not overall. Its relationship with the neighbor region, the zone of ecological-breaking region or ecological rift valley is not successive. . Its ecological effect endangered the arid land overall. Rehabilitating vegetation is the basic measure for abatement. The authors proposed a new tactics that based on the properties of vegetation. Depending on the local water sources and partly regulating the composition of environmental factor to satisfy the requirement of desert community, the rehabilitate vegetation should be realized.

关键词： arid area ecological-breaking zone ecosystems reconstruction.

Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

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Chinese Chemical Letters 2024年第7期35卷 89-99页

作者： Yating Zheng Yulan huang Jing Luo Xuqi Peng Xiran Gui Gang Liu Yang Zhang State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China Shen Zhen Research Institute of Xiamen university Shenzhen 518057China Division of Urology and department of Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States Innovation Laboratory for sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high ***,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their *** can address these issues by improving the therapeutic value,bioavailability,permeability,and absorption of biomacromolecules while regulating their retention time in the ***,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental *** this review,we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine,and extensively discuss their characteristics and *** particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also *** further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.

关键词： Biomacromolecules Supercritical fluid technology Therapeutic proteins Gene therapy Nanomedicine