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Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration

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Regenerative Biomaterials 2020年第3期7卷 233-245页

作者： Yajuan Xie Cheng Hu Yi Feng Danfeng Li Tingting Ai yulei huang Xiaodan Chen Lijia huang Jiali Tan Guangdong Provincial Key Laboratory of Stomatology Department of OrthodonticsGuanghua School of StomatologyHospital of StomatologySun Yat-sen UniversityGuangzhou 510055P.R.China

Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune *** designing principles have been always aimed at minimizing the immune reactions by fabricating inert ***,clinical evidence revealed that those methods still have limitations and many of which were only feasible in the ***,osteoimmunology,the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system,which includes diverse cells,cytokines,and signaling *** of biomaterials like topography,wettability,surface charge,the release of cytokines,mediators,ions and other bioactive molecules can impose effects on immune responses to interfere with the skeletal *** on the bone formation mechanisms,the designing methods of the biomaterials change from immune evasive to immune ***,we discuss the osteoimmunomodulatory effects of the new modification strategies—adjusting properties of bone biomaterials to induce a favorable osteoimmune *** strategies showed potential to benefit the development of bone materials and lay a solid foundation for the future clinical application.

关键词： biomaterials modification osteoimmunomodulation macrophage polarization osteoimmune environment bone regeneration

BLIND SPEECH SEPARATION FOR ROBOTS WITH INTELLIGENT HUMAN-MACHINE INTERACTION

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Journal of Electronics(China) 2012年第3期29卷 286-293页

作者： huang yulei Ding Zhizhong Dai Lirong Chen Xiaoping Department of Communication Engineering Hefei University of Technology Hefei 230000 China Department of Electronic Engineering and Information Science University of Science and Technology of China Hefei 230027 China

Speech recognition rate will deteriorate greatly in human-machine interaction when the speaker's speech mixes with a bystander's voice. This paper proposes a time-frequency approach for Blind Source Seperation (BSS) for intelligent Human-Machine Interaction(HMI). Main idea of the algorithm is to simultaneously diagonalize the correlation matrix of the pre-whitened signals at different time delays for every frequency bins in time-frequency domain. The prososed method has two merits: (1) fast convergence speed; (2) high signal to interference ratio of the separated signals. Numerical evaluations are used to compare the performance of the proposed algorithm with two other deconvolution algorithms. An efficient algorithm to resolve permutation ambiguity is also proposed in this paper. The algorithm proposed saves more than 10% of computational time with properly selected parameters and achieves good performances for both simulated convolutive mixtures and real room recorded speeches.

关键词： Blind Source Separation (BSS) Blind deconvolution Speech signal processing Human-machine interaction Simultaneous diagonalization

Experimental measurement of bipartite entanglement using parameterized quantum circuits

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Science China(Physics,Mechanics & Astronomy) 2022年第8期65卷 73-84页

作者： Shunzhong Xue yulei huang Dafa Zhao Chao Wei Jun Li Ying Dong Jiancun Gao Dawei Lu Tao Xin Gui-Lu Long State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and TechnologyShenzhen518055China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China Research Center for Quantum Sensing Zhejiang LabHangzhou311121China Frontier Science Center for Quantum Information Beijing100084China Beijing National Research Center for Information Science and Technology Beijing100084China Beijing Academy of Quantum Information Sciences Beijing100193China

Entanglement in quantum systems plays a crucial role in various quantum information tasks. Measuring entanglement has been an important issue in both experiments and theories. In this work, we use parameterized quantum circuits(PQCs) to diagonalize density matrices of quantum states and obtain entanglement by only measuring the diagonal elements. With this method, full quantum state tomography can be bypassed, greatly reducing the number of measurements. A comprehensive characterization of entanglement was performed by using Rényi entropy and partially transposed moments. Mutual information, calculated from entropy is also used to characterize dynamical quantum phase transitions. We experimentally demonstrated the method on a four-qubit nuclear magnetic resonance quantum simulator. Our results agree with the theoretical descriptions. The measurement complexity of our PQC-based method grows linearly with the number of diagonal elements in the density matrix, a square root reduction over the full quantum tomography. The proposed method can have great potential in quantum systems with a large number of particles.

关键词： quantum information entanglement characterization quantum tomography

Chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor for neurotrophic keratopathy

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Neural Regeneration Research 2024年第3期19卷 680-686页

作者： Jie Wu yulei huang Hanrui Yu Kaixiu Li Shifeng Zhang Guoqing Qiao Xiao Liu Hongmei Duan Yifei huang Kwok-Fai So Zhaoyang Yang Xiaoguang Li Liqiang Wang Department of Ophthalmology the Third Medical CenterChinese PLA General HospitalBeijingChina The PLA Medical College Department of NephrologyChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanyaHainan ProvinceChina Medical School of Chinese PLA BeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina School of Engineering Medicine Beijing Key Laboratory for Biomaterials and Neural RegenerationBeihang UniversityBeijingChina Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang UniversityBeijingChina

Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of *** treatment options for neurotrophic keratopathy are *** this study,an ophthalmic solution was constructed from a chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor(CTH-mNGF).Its effectiveness was evaluated in corneal denervation(CD)mice and patients with neurotrophic *** the preclinical setting,CTH-mNGF was assessed in a murine corneal denervation ***-mNGF was transparent,thermosensitive,and ensured sustained release of mNGF for over 20 hours on the ocular surface,maintaining the local mNGF concentration around 1300 pg/mL in *** denervation mice treated with CTH-mNGF for 10 days showed a significant increase in corneal nerve area and total corneal nerve length compared with non-treated and CTH treated mice.A subsequent clinical trial of CTH-mNGF was conducted in patients with stage 2 or 3 neurotrophic *** received topical CTH-mNGF twice daily for 8 *** sodium images,Schirmer’s test,intraocular pressure,Cochet-Bonnet corneal perception test,and best corrected visual acuity were *** total,six patients(total of seven eyes)diagnosed with neurotrophic keratopathy were *** 8 weeks of CTH-mNGF treatment,all participants showed a decreased area of corneal epithelial defect,as stained by ***,six out of seven eyes had fluorescence staining scores<***,best corrected visual acuity,intraocular pressure,Schirmer’s test and Cochet-Bonnet corneal perception test results showed no significant *** increase in corneal nerve density was observed by in vivo confocal microscopy after 8 weeks of CTH-mNGF treatment in three out of seven *** study demonstrates that CTH-mNGF is transparent,thermosensitive,and has sustained-release *** effecti

关键词： chitosan corneal reinnervation murine nerve growth factor neurotrophic keratopathy thermosensitive hydrogel

CXCL1-CXCR2 axis mediates neutrophils recruitment in rat oral mucosa

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Advances in Bioscience and Biotechnology 2013年第12期4卷 1110-1117页

作者： Tong Wu Hong Wang yulei huang Yaohui Dai Wenxin Zuo Lihua Jia Bin Cheng Department of Oral Medicine Guanghua School of Stomatology Sun Yat-sen University Guangzhou China Department of Stomatology Jinan University 2nd Clinical Medicine Col-lege Shenzhen People’s Hospital Shenzhen China

A lot of researches have shown that besides acting as essential contributors in innate immune response, neutrophils involved in the interaction between innate and adaptive immune responses by generation of a cascade of chemokines. But the data on relationship between chemokines and neutrophils recruitment in oral mucosa have been little available. In the present study, on a rat model characterized by neutrophils infiltration, a distinct profile of cytokines and receptors in oral mucosa was presented by the techniques of PCR array. Moreover, among these cytokines, upexpression of CXCL1 and its receptor, CXCR2, was found to correlate with the level of myeloperoxidase (MPO), a biomarker of neutrophils infiltration, and the up-expression of CXCL1-CXCR2 was suppressed by FK506, an immunosuppressive agent. Our results indicated that CXCL1-CXCR2 axis might play an important role in mediating neutrophils recruitment in oral mucosa, which will give new insights into the mechanisms of innate and adaptive immune responses of oral mucosa.

关键词： Neutrophils Recruitment CXCL1 CXCR2 Oral Mucosa

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国际水电工程总承包商-设计方合作联盟机理

同济大学学报（自然科学版） 2019年第3期47卷 444-450页

作者：唐文哲张清振黄煜蕾刘扬清华大学水利水电工程系北京100084 水沙科学与水利水电工程国家重点实验室北京100084

基于文献调研,构建了国际水电EPC(Engineering-Procurement-Construction)项目总承包商-设计方合作联盟模型.通过问卷调研、访谈和案例收集,运用相关分析、聚类分析、典型分析等方法研究了合作联盟各要素间的关系,验证了合作联盟模型的... 详细信息

基于文献调研,构建了国际水电EPC(Engineering-Procurement-Construction)项目总承包商-设计方合作联盟模型.通过问卷调研、访谈和案例收集,运用相关分析、聚类分析、典型分析等方法研究了合作联盟各要素间的关系,验证了合作联盟模型的合理性,揭示了合作联盟作用机理.得出的主要结论有:①共同投标是总承包商与设计方进行深层次合作的基础.成功中标后,双方公平分配利益与风险,以增进信任.以信任为基础,促进双方间的有效沟通.有效沟通使双方之间的信息高效流通,可及时解决项目实施中遇到的问题.②激励是总承包商-设计方合作联盟的重要支撑,可促进双方伙伴关系的发展;同时,良好的伙伴关系有助于落实激励措施.总承包商与设计方在项目实施过程中建立的合作伙伴关系为双方长期战略合作奠定良好的基础.项目顺利实施后,激励使总承包商与设计方共享项目收益,有助于二者建立战略联盟,共同投标未来的EPC项目,拓展更大的国际市场.

关键词：合作联盟公平信任激励战略合作

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基于心理视觉调制信息显示的一屏双显电视

电视技术 2016年第8期40卷 43-47,79页

作者：唐麟朱晨黄豫蕾上海数据分析与处理技术研究所上海201112

随着显示技术的发展,高性能的显示设备对于人眼在时域和空域上产生心理视觉冗余。基于近期提出的基于时域和空域的心理视觉调制信息显示技术,提出了一屏双显电视系统。由于之前提出的显示模型仅考虑相邻两帧或两行之间的影响,显示效果... 详细信息

随着显示技术的发展,高性能的显示设备对于人眼在时域和空域上产生心理视觉冗余。基于近期提出的基于时域和空域的心理视觉调制信息显示技术,提出了一屏双显电视系统。由于之前提出的显示模型仅考虑相邻两帧或两行之间的影响,显示效果不佳。对时域和空域的心理视觉调制信息显示模型进行了改进,从而使其符合显示设备的显示特性和人眼的感知特性,为裸眼用户和佩戴辅助观看装置的用户提供更好的显示效果。同时,系统也针对安卓系统进行了优化,从而能够更流畅地观看视频。

关键词：心理视觉调制一屏多显单屏多通道显示构图基高分辨率高刷新率

燃料电池中气体循环可调型引射器建模与实验研究

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工程热物理学报 2023年第11期44卷 3060-3068页

作者：姜晓宇黄玉磊姜培学祝银海热科学与动力工程教育部重点实验室清华大学能源与动力工程系北京100084

将可调式引射器应用于燃料电池阳极气体循环系统可以适应变工况场景。本文基于准二维模型建立了含调节锥的引射器理论模型,可以预测引射器的主流和二次流流量。通过实验对模型进行验证,结果显示对主流和二次流流量的预测误差分别在在5%... 详细信息

将可调式引射器应用于燃料电池阳极气体循环系统可以适应变工况场景。本文基于准二维模型建立了含调节锥的引射器理论模型,可以预测引射器的主流和二次流流量。通过实验对模型进行验证,结果显示对主流和二次流流量的预测误差分别在在5%和20%以内。探究了可调式引射器流量调控的影响机制,研究表明:调节锥通过调节主流和二次流流量来调控引射器性能;抛物线型调节锥在主流流量线性调控方面的性能较好。

关键词：引射器调节锥理论模型型线

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数据库中分组加密算法的改进与实现

计算机应用与软件 2008年第11期25卷 39-41页

作者：罗晓霞黄玉蕾西安科技大学计算机科学与技术系陕西西安710054

通过分析数据库安全的现状和数据库加密算法选取所面临的问题,提出一种适合数据库加密的分组加密算法RC-I。该算法引入新的非线性函数,提高了字内的混淆速度,并重新定义迭代过程,加快了雪崩效应和扩散速度,提高了抗攻击的强度。最后,在V... 详细信息

通过分析数据库安全的现状和数据库加密算法选取所面临的问题,提出一种适合数据库加密的分组加密算法RC-I。该算法引入新的非线性函数,提高了字内的混淆速度,并重新定义迭代过程,加快了雪崩效应和扩散速度,提高了抗攻击的强度。最后,在VS2005中用C#实现了RC-I加密算法,并且给出了关键技术的实现方法。

关键词：分组加密 RC6 RC—I加密算法