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Superior comprehensive properties of LaFe_(11.8)Si_(1.2)/Ce_(60)Co_(40) magnetocaloric composites

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Journal of Rare Earths 2024年第6期42卷 1073-1086,I0003页

作者： Xichun Zhong Yuanxin Li yucai Wu Jiaohong huang Cuilan Liu Jian Liu Zhongwu Liu Minglong Zhong Zhenchen Zhong R.V.Ramanujan School of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Baotou Research Institute of Rare Earths Baotou014030China Center for Advanced Solidification Technology School of Materials Science and EngineeringShanghai UniversityShanghai200444China Jiangxi KeyLaboratory for Rare Earth Magnetic Materials and Devices&Institute for Rare Earth Magnetic Materials and Devices(IREMMD) Jiangxi University of Science and TechnologyGanzhou341000China School of Materials Science and Engineering Nanyang Technological University639798Singapore Singapore-HUJ Alliance for Research and Enterprise(SHARE) The Smart Grippers for Soft Robotics(SGSR)ProgrammeCampus for Research Excellence and Technological Enterprise(CREATE)138602Singapor

LaFe_(11.8)Si_(1.2)/Ce_(60)Co_(40) composites were prepared by spark plasma sintering and subsequent diffusion annealing.A novel core-shell structure is observed with the LaFe11.8Si1.2 particles as the core and the(La,Ce)_(2)(Fe,Co,Si)_(17)(2:17)phase as the shell.As diffusion annealing time(t_(a))increases,this core-shell structure is replaced by the formation of the(La,Ce)_(1)(Fe,Co,Si)_(13) phase.Annealing at 1323 K for 12 h results in samples with(-ΔSM)^(max) of 9.30 J/(kg·K)(Δμ0H=2 T),good mechanical properties((σbc)^(max)=402 MPa,ε=4.21%)and thermal conductivity of 8.7 W/(m·K).Thus,bulk composites with excellent comprehensive properties for magnetic refrigeration are obtained in this work.

关键词： LaFe_(11.8)Si_(1.2)/Ce_(60)Co_(40)composites Spark plasma sintering Diffusion annealing Microstructure evolution Magnetocaloric effect Rareearths

Identification of clinical subphenotypes of sepsis after laparoscopic surgery

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 16-26页

作者： Jie Yang Bo Zhang Chaomin Hu Xiaocong Jiang Pengfei Shui Jiajie huang yucai Hong Hongying Ni Zhongheng Zhang Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Emergency Medicine Huzhou Central HospitalHuzhou 313000China Department of Critical Care Medicine Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Objective:Some patients exhibit septic symptoms following laparoscopic surgery,leading to a poor prognosis.Effective clinical subphenotyping is critical for guiding tailored therapeutic strategies in these cases.By identifying predisposing factors for postoperative sepsis,clinicians can implement targeted interventions,potentially improving outcomes.This study outlines a workflow for the subphenotype methodology in the context of laparoscopic surgery,along with its practical application.Methods:This study utilized data routinely available in clinical case systems,enhancing the applicability of our findings.The data included vital signs,such as respiratory rate,and laboratory measures,such as blood sodium levels.The process of categorizing clinical routine data involved technical complexities.A correlation heatmap was used to visually depict the relationships between variables.Ordering points were used to identify the clustering structure and combined with Consensus K clustering methods to determine the optimal categorization.Results:Our study highlighted the intricacies of identifying clinical subphenotypes following laparoscopic surgery,and could thus serve as a valuable resource for clinicians and researchers seeking to explore disease heterogeneity in clinical settings.By simplifying complex methodologies,we aimed to bridge the gap between technical expertise and clinical application,fostering an environment where professional medical knowledge is effectively utilized in subphenotyping research.Conclusion:This tutorial could primarily serve as a guide for beginners.A variety of clustering approaches were explored,and each step in the process contributed to a comprehensive understanding of clinical subphenotypes.

关键词： Laparoscopic surgery Phenotype Precision medicine Sepsis

不同温度盐度下饵料对卤虫生长及体内类胡萝卜素积累的影响

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上海海洋大学学报 2024年第1期33卷 86-98页

作者：舒皝薛毓才黄旭雄上海海洋大学农业农村部淡水水产种质资源重点实验室上海201306 上海海洋大学上海市水产养殖工程技术研究中心上海201306 上海海洋大学水产科学国家级实验教学示范中心上海201306

以螺旋藻粉、酵母、酵母+β-胡萝卜素为饵料,分别在不同盐度(10、30、50、70和90)和不同温度(20、25和30℃)下,探究饵料对卤虫(Artemia sp.)生长及体内类胡萝卜素积累的影响。结果表明:相同温度盐度条件下,投喂螺旋藻粉组卤虫存活率和... 详细信息

以螺旋藻粉、酵母、酵母+β-胡萝卜素为饵料,分别在不同盐度(10、30、50、70和90)和不同温度(20、25和30℃)下,探究饵料对卤虫(Artemia sp.)生长及体内类胡萝卜素积累的影响。结果表明:相同温度盐度条件下,投喂螺旋藻粉组卤虫存活率和体长优于其它饵料组;养殖第10天,在温度25℃下投喂螺旋藻粉组和酵母组卤虫均在盐度30时有最大平均体长(7.5 mm,5.9 mm),而投喂酵母+β-胡萝卜素卤虫在盐度10时平均体长最大(4.0 mm);在盐度50下各饵料组卤虫平均体长在温度30℃组均显著大于其他温度组(P<0.05)。养殖第15天,在温度25℃下投喂螺旋藻粉组卤虫在盐度30时存活率(93.7%)最高;在盐度50下投喂螺旋藻粉组卤虫存活率在温度20℃(94.0%)和25℃(92.0%)均显著大于30℃组(P<0.05)。投喂螺旋藻粉各组卤虫抱卵率显著大于其他饵料(P<0.05),且随盐度或温度升高而逐步增大。对养殖15 d卤虫体内类胡萝卜素检测表明,各饵料组卤虫均只检测到海胆酮和角黄素,未检测出β-胡萝卜素、β-隐黄质、玉米黄质和虾青素。投喂螺旋藻粉卤虫总类胡萝卜素含量显著高于其他组(P<0.05),且随盐度升高呈下降趋势,盐度10组最高(46.25µg/g);随温度升高呈先上升后下降趋势,温度25℃组最高(46.28µg/g)。综上所述,投喂螺旋藻粉的卤虫生长最好,卤虫可以将β-胡萝卜素转化成海胆酮和角黄素,温度升高会降低卤虫存活率,加快卤虫生长、性成熟及类胡萝卜素代谢;盐度过高或过低会降低卤虫存活率和生长速度,但是高盐可以促进卤虫性成熟,且消耗体内类胡萝卜素。

关键词：卤虫温度盐度饵料生长类胡萝卜素积累

A New Discovery of Mineralization as Subseafloor Hydrothermal Replacement in the Duddar Super-Large SEDEX Lead-Zinc Deposit in Pakistan

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Journal of Earth Science 2024年第3期35卷 1075-1078页

作者： Huishan Zhang yucai Song Jianing Sun Jun Hong Yasir Shaheen Khalil Yanguang Li Haidi Zhang Zhihua Wang MNR Key Laboratory for the Study of Focused Magmatism and Giant Ore Deposits Xi’an Center of Geological SurveyChina Geological SurveyXi’an 710054China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Chengdu Center of Geological Survey China Geological SurveyChengdu 610081China China Huaye Group Co. LtdBeijing 100037China Geological Survey of Pakistan Islamabad 44000Pakistan

0 INTRODUCTION Sedimentary exhalative(SEDEX)lead-zinc deposit was traditionally considered as a result of submarine hydrothermal exhalation,including exhalative plume and brine pool models(Izanloo et al.,2022;Spinks et al.,2021;Maghfouri et al.,2020;Sangster,2020,2018;huang et al.,2019;Rajabi et al.,2015;Goodfellow and Lydon,2007;Large et al.,2005,2001;Peng et al.,2000;Goodfellow et al.,1993;Figures 1a,1b).However,recognition of mineralization as subseafloor hydrothermal replacement in a few SEDEX deposits has challenged the traditional consideration(Magnall et al.,2023,2021,2020a,b;Hayward et al.,2021;Figure 1c).Researchers come to believe that subseafloor replacement rather than submarine exhalation is a dominant process for SEDEX mineralization,but this needs to be examined through more case studies.

关键词： submarine mineralization seafloor

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抽水蓄能机组励磁绕组匝间短路漏磁检测研究

电机与控制学报 2024年第2期28卷 32-43页

作者：齐鹏李永刚马明晗武玉才黄嘉华北电力大学新能源电力系统国家重点实验室河北保定071003 河北张河湾蓄能发电有限责任公司河北石家庄050300

抽水蓄能机组定子铁心背部漏磁场可有效反应励磁绕组的运行状态,通过对励磁绕组匝间短路前后的漏磁特征进行研究,以实现对其匝间绝缘健康水平的在线监测。首先,推导励磁绕组健康状态与匝间短路状态下的漏磁表达式,得到不同状态所对应的... 详细信息

抽水蓄能机组定子铁心背部漏磁场可有效反应励磁绕组的运行状态,通过对励磁绕组匝间短路前后的漏磁特征进行研究,以实现对其匝间绝缘健康水平的在线监测。首先,推导励磁绕组健康状态与匝间短路状态下的漏磁表达式,得到不同状态所对应的磁密特征谐波;其次,搭建发电容量为278 MVA的抽水蓄能机组二维有限元仿真模型,据此分析匝间短路故障前后径向漏磁及切向漏磁时/频域特征的演变规律,并得到空载工况的径向、切向漏磁峰值分别为111、102μT,负载工况的径向、切向漏磁峰值分别为115、112.5μT,可为漏磁传感器选型提供参考;最后,通过在同步发电机定子铁心背部加装磁通门传感器,采集不同匝间短路程度下的径向、切向及轴向漏磁信号,获其空载工况峰值分别为51.9、40.4、28.2μT,负载工况峰值分别为56.5、47.3、38.4μT,动模机组监测结果证明了,漏磁信号时域特征波形及频谱特征谐波变化可有效表征励磁绕组匝间绝缘健康水平,为励磁绕组匝间短路状态监测拓展了新的技术路径。

关键词：抽水蓄能机组励磁绕组匝间短路漏磁特性在线监测

三河牛β-乳球蛋白基因型及其启动子序列特点

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生物技术 2024年第1期34卷 1-5,75页

作者：王丽婷郑艺娜金素钰黄林郑玉才西南民族大学畜牧兽医学院四川成都610041 呼伦贝尔农垦谢尔塔拉农牧场有限公司内蒙古呼伦贝尔021012

[目的]分析三河牛β-乳球蛋白(β-Lg)的基因型,并探索其启动子序列与乳中含量的关系。[方法]采用聚丙烯酰胺凝胶电泳(PAGE)检测乳中β-Lg遗传变异体及其相对表达量,并通过PCR扩增,比对不同遗传变异体启动子的序列差异。[结果]三河牛(n=... 详细信息

[目的]分析三河牛β-乳球蛋白(β-Lg)的基因型,并探索其启动子序列与乳中含量的关系。[方法]采用聚丙烯酰胺凝胶电泳(PAGE)检测乳中β-Lg遗传变异体及其相对表达量,并通过PCR扩增,比对不同遗传变异体启动子的序列差异。[结果]三河牛(n=62)乳清中β-Lg有AA、AB和BB共3种基因型,频率依次为0.290、0.403和0.307,A和B两种等位基因频率接近;对37个纯合型β-Lg启动子的部分序列进行PCR扩增(636 bp)和测序,并与普通牛β-Lg基因序列(GenBank登录号:U31361.1)比对,共检测到6个突变位点,其中-430、-362、-216和-204位点基本上是等位基因特异的,且有3个突变点在3种转录因子结合基序中;建立了三河牛乳中β-Lg含量的高效液相色谱测定方法,发现β-Lg含量在AA型中极显著高于AB型(P<0.01),但AA、AB型与BB型之间均无显著差异。[结论]三河牛β-Lg A和B两种等位基因频率接近,其启动子-430、-362、-216和-204位点具有等位基因特异性,并可能影响等位基因表达。

关键词：三河牛乳 β-乳球蛋白高效液相色谱启动子等位基因表达聚合酶链式反应聚丙烯酰胺凝胶电泳

Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation

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Chinese Medical Journal 2022年第21期135卷 2585-2595页

作者： Zhenliang Wen Xi Xiong Dechang Chen Lujing Shao Xiaomeng Tang Xuan Shen Sheng Zhang Sisi huang Lidi Zhang Yizhu Chen yucai Zhang Chunxia Wang Jiao Liu Department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine Shanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China Institute of Pediatric Infection Immunityand Critical Care MedicineShanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China Institute of Pediatric Critical Care Shanghai Jiao Tong UniversityShanghai 200062China

Background: Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immune cell differentiation. We therefore set out to investigate the role of ATF4-regulated monocytes-to-gMacs differentiation in sepsis-induced intestinal injury.Methods: Sepsis was induced in C57BL/6 wild type (WT) mice andAtf4-knockdown (Atf4+/-) mice by cecal ligation and puncture or administration of lipopolysaccharide (LPS). Colon, peripheral blood mononuclear cells, sera, lung, liver, and mesenteric lymph nodes were collected for flow cytometry, hematoxylin and eosin staining, immunohistochemistry, quantitative reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively.Results: CD64, CD11b, Ly6C, major histocompatibility complex-II (MHC-II), CX3CR1, Ly6G, and SSC were identified as optimal primary markers for detecting the process of monocytes-to-gMacs differentiation in the colon of WT mice. Monocytes-to-gMacs differentiation was impaired in the colon during sepsis and was associated with decreased expression of ATF4 in P1 (Ly6Chi monocytes), the precursor cells of gMacs.Atf4 knockdown exacerbated the impairment of monocytes-to-gMacs differentiation in response to LPS, resulting in a significant reduction of gMacs in the colon. Furthermore, compared with WT mice,Atf4+/- mice exhibited higher pathology scores, increased expression of inflammatory factor genes (TNF-α, IL-1β), suppressed expression of CD31 and vascular endothelial-cadherin in the colon, and increased translocation of intestinal bacteria to lymph nodes and lungs following exposure to LPS. However, the aggravation of sepsis-induced intestinal injury resulting fromAtf4 knockdown was not caused by the enhanced inflammatory effect of Ly6Chi monocytes and gMacs.Conclusion: ATF4, as a novel regulator of monocytes-to-gMacs differentiation, plays a critical role in protecting mice against sepsis-induc

关键词： Activating transcription factor 4 Mice Lipopolysaccharides Monocytes Leukocytes,mononuclear Cell differentiation Macrophages Sepsis Homeostasis gMacs Intestinal injury

基于转录组测序筛选乌苏里白鲑肌肉生长关键候选基因研究

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渔业科学进展 2024年第3期45卷 87-100页

作者：李文文徐革锋黄天晴谷伟刘恩慧王高超潘玉财周金鑫姜再胜王炳谦上海海洋大学水产与生命学院上海201306 冷水性鱼类产业技术创新战略联盟、中国水产科学研究院、黑龙江水产研究所黑龙江哈尔滨150070 安徽省桐城市水产服务中心安徽桐城231400

为了挖掘调控乌苏里白鲑(Coregonus ussurinsis Berg)肌肉生长的关键候选基因,本研究对不同生长速度乌苏里白鲑的肌肉组织进行转录组测序,以期为乌苏里白鲑群体选育提供基础数据。首先,在同等条件下(从混合池中)随机选择乌苏里白鲑F2个... 详细信息

为了挖掘调控乌苏里白鲑(Coregonus ussurinsis Berg)肌肉生长的关键候选基因,本研究对不同生长速度乌苏里白鲑的肌肉组织进行转录组测序,以期为乌苏里白鲑群体选育提供基础数据。首先,在同等条件下(从混合池中)随机选择乌苏里白鲑F2个体进行实验分组(快长组和慢长组)。接着分别从快长组[体重为(219.20±38.66)g]和慢长组[体重为(74.30±17.86)g]中随机选取10尾样本,取其背部肌肉进行转录组测序。以FDR(false discovery rate)1(FC,fold change)为条件筛选差异表达基因并对其进行GO(gene ontology)和KEGG(Kyoto encyclopedia of genes and genomes)富集分析,并通过qPCR验证转录组数据的准确性。转录组测序结果显示,共筛选出2211个差异表达基因,与慢长组相比,快长组中583个差异基因表达上调及1628个基因表达下调。GO功能注释结果显示,差异基因主要参与细胞过程和结合过程,差异基因显著富集到251条KEGG通路(P<0.05),其中,MAPK信号通路(MAPKsignalingpathway)、PI3K-Akt信号通路(PI3K-Akt signaling pathway)、紧密连接(tight junction)、胰岛素信号通路(insulin signaling pathway)、糖酵解/糖异生(glycolysis/gluconeogenesis)和PPAR信号通路(PPAR signaling pathway)参与细胞生长。之后结合功能注释结果和KEGG,鉴定出肌浆/内质网钙ATP酶基因atp2a1和atp2a2、葡萄糖-6-磷酸脱氢酶基因g6pc、生长因子结合蛋白1基因igfbp1以及肌球蛋白重链基因myh1、myh4、myh6、myh7、myh9和myh13等可能与肌肉生长密切相关的基因。本研究共筛选出10个可能与乌苏里白鲑肌肉生长相关的关键候选基因,为今后乌苏里白鲑分子标记辅助育种提供了基础数据。

关键词：乌苏里白鲑转录组测序差异表达基因肌肉生长

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The application of artificial intelligence in the management of sepsis

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Medical Review

Medical Review 2023年第5期3卷 369-380页

作者： Jie Yang Sicheng Hao Jiajie huang Tianqi Chen Ruoqi Liu Ping Zhang Mengling Feng Yang He Wei Xiao yucai Hong Zhongheng Zhang Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhenjiang ProvinceChina Duke University School of Medicine DurhamNCUSA Department of Computer Science and Engineering The Ohio State UniversityColumbusOHUSA Saw Swee Hock School of Public Health and Institute of Data science National University of SingaporeSingaporeSingapore

Sepsis is a complex and heterogeneous syndrome that remains a serious challenge to healthcare worldwide.Patients afflicted by severe sepsis or septic shock are customarily placed under intensive care unit(ICU)supervision,where a multitude of apparatus is poised to produce high-granularity data.This reservoir of high-quality data forms the cornerstone for the integration of AI into clinical practice.However,existing reviews currently lack the inclusion of the latest advancements.This review examines the evolving integration of artificial intelligence(AI)in sepsis management.Applications of artificial intelligence include early detection,subtyping analysis,precise treatment and prognosis assessment.AI-driven early warning systems provide enhanced recognition and intervention capabilities,while profiling analyzes elucidate distinct sepsis manifestations for targeted therapy.Precision medicine harnesses the potential of artificial intelligence for pathogen identification,antibiotic selection,and fluid optimization.In conclusion,the seamless amalgamation of artificial intelligence into the domain of sepsis management heralds a transformative shift,ushering in novel prospects to elevate diagnostic precision,therapeutic efficacy,and prognostic acumen.As AI technologies develop,their impact on shaping the future of sepsis care warrants ongoing research and thoughtful implementation.

关键词： diagnosis treatment sepsis artificial intelligence