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Medicinal Plant 2024年第3期15卷 60-62页

作者： yanfeng huang Guoqiang LIANG Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215009China

[Objectives]To observe the effect of Jianpi Xiaowei Decoction on gastric function and quality of life in elderly patients with chronic atrophic gastritis(CAG)of liver-stomach heat stagnation type.[Methods]Seventy-two elderly patients with CAG of liver-stomach stagnation-heat type were randomly divided into study group and control group.The two groups were treated with Jianpi Xiaowei Decoction and Rabeprazole Enteric-coated Tablets respectively.The curative effect of TCM syndromes,serum pepsinogen I and II(PG-I and PG-II),gastrin-17(G-17)and quality of life(SF-36 table)scores of gastric function indicators before and after treatment were observed.[Results]After treatment,the total effective rate of the study group was 97.22%(35/36),which was significantly higher than that of the control group 77.78%(28/36)(P0.05).After treatment,the indicators of the study group were significantly lower than those of the control group(t=12.239,6.010,5.928,10.420,P0.05).After treatment,the SF-36 scores in the study group were significantly lower than those in the control group(t=3.520,10.335,11.300,9.693,P<0.05).[Conclusions]Jianpi Xiaowei Decoction can achieve significant curative effect in the treatment of CAG with liver and stomach stagnation heat type in the elderly,and can significantly improve the key gastrointestinal hormone levels and quality of life of elderly patients.It is worthy of promotion in the same clinical cases.

关键词： Chronic atrophic gastritis Liver and stomach heat type Jianpi Xiaowei decoction Gastrointestinal hormones Quality of life

Haraguchi Ⅱ型后踝骨折3种内固定方式的有限元分析

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实用医学杂志 2024年第8期40卷 1137-1141页

作者：程邦君黄燕峰罗轶上海市第六人民医院金山分院骨科上海201599

目的基于计算机三维有限元技术方法研究HaraguchiⅡ型后踝骨折不同内固定材料的生物力学特性,确定后踝骨折的最佳内固定材料,为临床提供基础理论支持。方法通过计算机三维有限元技术,建立后踝空心螺钉固定+内踝空心螺钉(A组)、后踝支... 详细信息

目的基于计算机三维有限元技术方法研究HaraguchiⅡ型后踝骨折不同内固定材料的生物力学特性,确定后踝骨折的最佳内固定材料,为临床提供基础理论支持。方法通过计算机三维有限元技术,建立后踝空心螺钉固定+内踝空心螺钉(A组)、后踝支撑钢板固定+内踝空心螺钉(B组)和后踝重建钢板固定+内踝空心螺钉(C组)三种不同内固定材料固定HaraguchiⅡ型后踝骨折的三维有限元模型,并对模型行生物力学分析,比较各组内固定材料的优劣性。结果两组钢板固定模型的最大主应力和胫骨应力要明显低于3枚空心螺钉固定模型组,而重建钢板组的应力又低于支撑钢板组;三组模型中内踝处空心螺钉的应力重建钢板组最小,空心螺钉组最大;胫骨的总位移变化范围空心螺钉组最大,支撑钢板组次之,重建钢板组最小。结论重建钢板固定HaraguchiⅡ型后踝骨折的生物力学稳定性最强,为一种比较理想的固定方法,对临床具有一定的指导性。

关键词：后踝骨折内固定生物力学有限元

Co/MOF-808(Zr)复合材料的制备及其对有机磷化合物的降解性能

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天津工业大学学报 2024年第1期43卷 50-55页

作者：黄艳凤焦克楠王晓荣潘杰万冬天津工业大学化学工程与技术学院天津300387

为了解决普通单金属MOFs材料几乎不能直接将双(4-硝基苯)磷酸酯(BNPP)直接降解为毒性更低的对氨基苯酚(4-AP)的问题,通过油浴法制备出MOF-808(Zr)后,采用后修饰法将草酸钴负载于MOF-808(Zr)上,制备出Co/MOF-808(Zr)复合材料,并对所制材... 详细信息

为了解决普通单金属MOFs材料几乎不能直接将双(4-硝基苯)磷酸酯(BNPP)直接降解为毒性更低的对氨基苯酚(4-AP)的问题,通过油浴法制备出MOF-808(Zr)后,采用后修饰法将草酸钴负载于MOF-808(Zr)上,制备出Co/MOF-808(Zr)复合材料,并对所制材料进行XRD和TEM表征。结果表明:MOF-808(Zr)具有高晶体结构稳定性,Co/MOF-808(Zr)的粒径在250 nm左右且分布均匀;Co/MOF-808(Zr)通过级联反应成功将有机磷神经毒剂模拟物BNPP直接降解为毒性更低的4-AP,而非一般的毒性较高的降解产物对硝基苯酚(4-NP)。其最佳级联降解反应条件为:温度45℃,Co/MOF-808(Zr)剂量为2 mg/mL,底物BNPP为0.6 mmol/L,硼氢化钠0.06 mmol/L。实践得出,Co/MOF-808(Zr)在将有机磷化合物直接降解为毒性更低的4-AP方面表现出良好的应用潜力。

关键词： Co/MOF-808(Zr) 级联反应水解BNPP 氢化4-NP 有机磷化合物降解

基于SDF-1/CXCR4轴探讨补肾壮筋汤促进小鼠BMSCs归巢和保护关节软骨的机制研究

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康复学报 2024年第1期34卷 44-54页

作者：黄艳峰马德尊付长龙叶锦霞黄云梅李西海福建中医药大学中西医结合研究院福建福州350122 福建省中西医结合老年性疾病重点实验室福建福州350122 福建中医药大学中西医结合学院福建福州350122

目的探讨补肾壮筋汤调控SDF-1/CXCR4轴促进小鼠BMSCs归巢和保护关节软骨的作用机制,为膝骨关节炎(KOA)的康复治疗提供实验依据。方法①动物实验中,选用8周龄SPF级C57BL/6雄性小鼠30只,采用随机数字表法分为假手术组、模型组、补肾壮筋汤... 详细信息

目的探讨补肾壮筋汤调控SDF-1/CXCR4轴促进小鼠BMSCs归巢和保护关节软骨的作用机制,为膝骨关节炎(KOA)的康复治疗提供实验依据。方法①动物实验中,选用8周龄SPF级C57BL/6雄性小鼠30只,采用随机数字表法分为假手术组、模型组、补肾壮筋汤组,每组10只,干预12周。采用micro-CT、HE染色观察各组软骨形态变化;激光共聚焦显微镜观察骨组织SDF-1荧光强度;qPCR、Western blot检测各组归巢相关调控因子mRNA转录水平和蛋白相对表达量。②细胞实验中,选用4周龄SPF级C57BL/6雄性小鼠,采用全骨髓贴壁法提取原代BMSCs,流式细胞术对所提取的细胞进行鉴定后,筛选最佳慢病毒MOI值;随机将细胞分为空白组、空载组、补肾壮筋汤组、sh-SDF-1组、sh-SDF-1+补肾壮筋汤组5组,采用划痕实验观察各组BMSCs迁移情况;阿利新蓝、CollagenⅡ免疫细胞学染色观察各组细胞成软骨分化能力;激光共聚焦显微镜观察各组SDF-1、CXCR4的荧光强度;qPCR检测各组归巢相关调控因子mRNA转录水平。结果①动物实验中,关节组织形态学结果(micro-CT、HE染色)显示:与假手术组比较,模型组股骨髁间可见一圆形缺损,骨皮质失连,软骨细胞缺失;与模型组比较,补肾壮筋汤组股骨髁间环形缺损好转,软骨细胞排列稍紊乱。关节组织免疫荧光显示:与假手术组比较,模型组SDF-1蛋白相对表达量升高;与模型组比较,补肾壮筋汤组SDF-1的蛋白相对表达量升高(P<0.05)。qPCR与Western blot结果显示:与假手术组比较,模型组归巢关键调控因子(SDF-1、CXCR4、MIP-1α、MCP-1、MIP-1β、RANTES、VEGF、G-CSF、NCAM-1、MMP-2)的mRNA转录水平和蛋白相对表达量升高(P<0.05);与模型组比较,补肾壮筋汤组归巢关键调控因子mRNA转录水平和蛋白相对表达量升高(P<0.05)。②细胞实验中,BMSCs经细胞流式术鉴定:CD44、CD105呈阳性表达,CD34呈阴性表达。当病毒MOI值为100时,SDF-1基因感染率最高。BMSCs迁移和成软骨分化能力检测结果显示:与空白组比较,sh-SDF-1组细胞向划痕区域迁移的细胞数量、酸性黏多糖及CollagenⅡ蛋白相对表达量显著减少(P<0.05);补肾壮筋汤组和sh-SDF-1+补肾壮筋汤组迁移的细胞数量、阿利新蓝染色及CollagenⅡ蛋白相对表达量显著增多(P<0.05)。细胞免疫荧光显示:与空白组比较,sh-SDF-1组细胞SDF-1、CXCR4蛋白相对表达量显著减少;补肾壮筋汤组和sh-SDF-1+补肾壮筋汤组细胞SDF-1、CXCR4蛋白相对表达量显著增多(P<0.05)。qPCR结果显示:与空白组比较,sh-SDF-1组归巢关键调控因子的mRNA转录水平降低(P<0.05),补肾壮筋汤组归巢关键调控因子的mRNA转录水平升高(P<0.05)。结论补肾壮筋汤可通过上调SDF-1/CXCR4轴促进小鼠BMSCs归巢保护关节软骨。

关键词：软骨损伤补肾壮筋汤 BMSCs SDF-1/CXCR4 归巢

Experimental study of face passive failure features of a shallow shield tunnel in coastal backfill sand

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 252-271页

作者： Weifeng QIAN Ming huang Bingnan WANG Chaoshui XU yanfeng HU School of Civil Engineering Fuzhou UniversityFuzhou 350108China School of Civil Environment and Mining EngineeringUniversity of AdelaideAdelaide 5005Australia China First Highway Xiamen Engineering Co. Ltd.Xiamen 361000China

Face passive failure can severely damage existing structures and underground utilities during shallow shield tunneling,especially in coastal backfill sand.In this work,a series of laboratory model tests were developed and conducted to investigate such failure,for tunnels located at burial depth ratios for which C/D=0.5,0.8,1,and 1.3.Support pressures,the evolution of failure processes,the failure modes,and the distribution of velocity fields were examined through model tests and numerical analyses.The support pressure in the tests first rose rapidly to the elastic limit and then gradually increased to the maximum value in all cases.The maximum support pressure decreased slightly in cases where C/D=0.8,1,and 1.3,but the rebound was insignificant where C/D=0.5.In addition,the configuration of the failure mode with C/D=0.5 showed a wedge-shaped arch,which was determined by the outcropping shear failure.The configuration of failure modes was composed of an arch and the inverted trapezoid when C/D=0.8,1,and 1.3,in which the mode was divided into lower and upper failure zones.

关键词： tunnel face stability passive failure model test support pressure failure mode

Effects of resistant exercise on regulating the gutmicrobiota related to glucose control in mice with type 2 diabetes

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广西医科大学学报 2018年第10期35卷 1325-1330页

作者： Zhai Lu Wei Wei Liu Yuhua Zhao Wenpiao huang yanfeng Ma Cui Dai Xia Department of Nursing the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Geriatric Gastroenterology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Jiangbin Hospital of Guangxi Zhuang Autonomous Region Nanning 530021China

Objective:To explore the effect of resistant exercise on improvement of gut microbiota regulating glucose control in mice with type 2diabetes.Methods:Male mice with type 2diabetes aged 8 weeks were randomly assigned to control group,aerobic training(AT)group and resistant training(RT)group.One month after the intervention,the blood glucose was measured and the feces were collected to detect gut microbiota by using 16SrRNA high-throughput sequencing method.Results:The higher proportion and abundance of Firmicutesbacteria and lower proportion and abundance of Bacteroidetesbacteria were found in AT group.The number and abundance of Akkermansia muciniphila in feces of RT group were significantly higher than those of AT and control groups.Lower level of blood glucose was observed in RT group relating to control group.Conclusion:Resistant exercise to improve gut microbiota is expected to be a new method for the prevention and treatment of type 2 diabetes.

关键词： 2型糖尿病细菌医疗卫生行业发展现状

脊髓损伤炎症微环境形成机制和补阳还五汤治疗脊髓损伤作用机制的研究进展

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中医正骨 2024年第5期36卷 49-53页

作者：吴祥夏双琳付长龙叶锦霞黄云梅黄艳峰郑春松马德尊福建中医药大学中西医结合研究院福建福州350122 福建省中西医结合老年疾病重点实验室福建福州350122

脊髓损伤是一种严重的中枢神经创伤性疾病。脊髓损伤会引起一系列的免疫应答,进而在损伤部位形成炎症微环境,阻碍损伤神经的修复。补阳还五汤是临床上治疗脊髓损伤的常用方剂。许多学者针对脊髓损伤炎症微环境的形成机制及补阳还五汤治... 详细信息

脊髓损伤是一种严重的中枢神经创伤性疾病。脊髓损伤会引起一系列的免疫应答,进而在损伤部位形成炎症微环境,阻碍损伤神经的修复。补阳还五汤是临床上治疗脊髓损伤的常用方剂。许多学者针对脊髓损伤炎症微环境的形成机制及补阳还五汤治疗脊髓损伤的作用机制进行了研究,但目前这些机制均尚未完全明确。本文从脊髓损伤炎症微环境的形成机制及补阳还五汤治疗脊髓损伤的作用机制两个方面对相关研究进行了综述,以期为补阳还五汤治疗脊髓损伤的深入研究提供参考。

关键词：脊髓损伤炎症补阳还五汤综述

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除钒油的选型对海绵钛中氧碳含量的影响研究

轻金属 2024年第4期 40-43,49页

作者：王丽娟许伟春朵云霞李汉魏治中黄燕峰张崇福洛阳双瑞万基钛业有限公司河南洛阳471832

植物油和矿物油作为TiCl_(4)除钒效果较好的有机物,在钛白粉和海绵钛行业应用广泛。本文通过大量的实验研究发现,7#、8#、9#矿物油和进口植物油在加入量低于0.07%时,可把VOCl_(3)除去,且植物油的除钒效果更快更好。但应用到生产中时,由... 详细信息

植物油和矿物油作为TiCl_(4)除钒效果较好的有机物,在钛白粉和海绵钛行业应用广泛。本文通过大量的实验研究发现,7#、8#、9#矿物油和进口植物油在加入量低于0.07%时,可把VOCl_(3)除去,且植物油的除钒效果更快更好。但应用到生产中时,由于植物油主要成分为不饱和脂肪酸,含有氧元素,因此生产的海绵钛氧含量偏高。但钛白粉行业对氧无要求,因此得出结论,在钛白粉行业,没有氧含量的要求,使用植物油除钒速率更快。而在海绵钛行业,氧碳作为杂质元素,对除钒油的要求更严格,因此在粗TiCl_(4)除钒环节,选用除钒油加入量不超过0.07%,碳数分布最高为C30、闪点为200℃左右的7#矿物油除钒效果更佳。

关键词：植物油矿物油四氯化钛除钒海绵钛

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海鲜菇美拉德肽的制备及其风味特性研究

食品研究与开发 2024年第3期45卷 146-155页

作者：林钦淋黄焰峰方焕新林波月缪松林灼华邓凯波福建农林大学食品科学学院福建福州350002 中国-爱尔兰国际合作食品物质学与结构设计研究中心福建福州350002 福建省特种淀粉品质科学与加工技术重点实验室福建福州350002 爱尔兰农业部Teagasc食品研究中心爱尔兰科克119634 庄臣酿酒(福建)有限公司福建福州350500

以海鲜菇(Hypsizygus marmoreus)蛋白肽为原料,采用响应面法分析优化海鲜菇美拉德肽制备工艺,并通过褐变程度、产物分子量分布、感官评价、电子舌及超滤等特征性指标和评价手段,明确美拉德反应对海鲜菇蛋白肽风味特性的影响。结果表明,... 详细信息

以海鲜菇(Hypsizygus marmoreus)蛋白肽为原料,采用响应面法分析优化海鲜菇美拉德肽制备工艺,并通过褐变程度、产物分子量分布、感官评价、电子舌及超滤等特征性指标和评价手段,明确美拉德反应对海鲜菇蛋白肽风味特性的影响。结果表明,海鲜菇美拉德肽的最佳制备条件为葡萄糖与D-木糖质量比4∶1、反应温度110℃和反应时间56 min。与海鲜菇蛋白肽相比,制备的海鲜菇美拉德肽咸味强烈,并伴有鲜味产生,整体接受度好,在294 nm和420 nm下吸光值显著增加,并推测分子量大于180~500 Da的组分可能为美拉德反应的主要活性肽段。超滤结果表示,海鲜菇美拉德肽呈咸鲜味的肽分子量主要集中在500 Da以下。该研究结果证明美拉德反应可有效提升海鲜菇蛋白肽的咸鲜味,使其风味层次更加丰富,可为扩展可替代钠盐的新型食用菌调味领域的研究和应用提供理论基础。

关键词：海鲜菇蛋白肽美拉德反应产物分子量分布风味特性咸鲜味替代钠盐

Analysis on patents of health care products with substances of medicine food homology in China

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Chinese Herbal Medicines 2024年第3期16卷 412-421页

作者： Haibo Liu yanfeng Wang Jiali huang Zhengqi Dong Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Traditional Chinese Medicine Patent Information Resources State Administration of Traditional Chinese Medicine Beijing Academy of Science and Technology

Objective:The concept of substances of medicine food homology(SMFH) has garnered significant attention in recent years.This study conducts a systematic analysis of patent literature related to SMFH,and elucidates the development trends,technical hotspots,and the overall patent protection landscape of SMFH in China over the past two decades.Methods:The patent search focused on the SMFH varieties as the objects of inquiry,with retrieval conducted in patent databases.Subsequently,the acquired data underwent processing,analysis,and visualization.Results:While the technical threshold for pharmaceutical applications surpasses that of the food service sector,the former may assume a prominent role in the future.Research and development(R&D) activities in the southeast of China demonstrate robust activity than other regions.Colleges and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future development.Conclusion:The findings of this patent analysis indicate that China's SMFH industry are presently undergoing a transition from an extensive model to a high-quality model. The quality and technical standards of SMFH products are consistently improving.Consequently,there is a need for more stringent patent application requirements to align with the evolving development needs.

关键词： patent analysis patent pattern substances of medicine food homology traditional Chinese medicine