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FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

Current Medical Science 2024年第1期44卷 187-194页

作者： xiao-mei huang E LIAO Jun-qun LIAO Ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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Oxygen-assisted zinc recovery from electric arc furnace dust using magnesium chloride

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2300-2311页

作者： Jingdong huang xiao Yang School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China School of Engineering Westlake UniversityHangzhou 310030China

Electric arc furnace(EAF)dust is an important secondary resource containing metals,such as zinc(Zn)and iron(Fe).Recover-ing Zn from EAF dust can contribute to resource recycling and reduce environmental ***,the high chemical stability of ZnFe_(2)O_(4)in EAF dust poses challenges to Zn *** address this issue,a facile approach that involves oxygen-assisted chlorination using molten MgCl_(2)is *** work focused on elucidating the role of O2 in the reaction between ZnFe_(2)O_(4)and molten MgCl_(2).The results demonstrate that MgCl_(2)effectively broke down the ZnFe_(2)O_(4)structure,and the high O2 atmosphere considerably promoted the sep-aration of Zn from other components in the form of ZnCl_(2).The presence of O2 facilitated the formation of MgFe_(2)O_(4),which stabilized Fe and prevented its ***,the excessive use of MgCl_(2)resulted in increased evaporation loss,and high temperatures pro-moted the rapid separation of *** on these findings,we successfully extracted ZnCl_(2)-enriched volatiles from practical EAF dust through oxygen-assisted *** optimized conditions,this method achieved exceptional Zn chlorination percentage of over 97%within a short period,while Fe chlorination remained below 1%.The resulting volatiles contained 85wt%of ZnCl_(2),which can be further processed to produce metallic *** findings offer guidance for the selective recovery of valuable metals,particularly from solid wastes such as EAF dust.

关键词： electric arc furnace dust zinc oxygen magnesium chloride chlorination

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Meta label associated loss for fine-grained visual recognition

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Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao LI Fu xiao Hao LI qun LI Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which makes the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework, which can reduce the overfitting of models and learn the network parameters to be noise-tolerant. Extensive experiments are performed on benchmark datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

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Cause analysis of expressway traffic accidents based on accident statistics of Hunan provincial expressway in 2012-2018

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Transportation Safety and Environment 2024年第1期6卷 83-92页

作者： Xinyu Liu Shengjun huang qun Chen Business school Foshan UniversityFoshan 528225GuangdongChina School of Traffic and Transportation Engineering Central South UniversityChangsha 410075HunanChina Hunan Provincial Expressway Traffic Police Station Law Enforcement DepartmentChangsha 410007HunanChina

Based on the 2012–2018 accident statistics on the Hunan Provincial Expressway in China,this paper analyses the proportion to which various factors contribute to accidents,as well as the trends over *** 2012 to 2018,the total number of general procedure handling accidents(*** accidents)increased first and then decreased,while the number of accidents and deaths per 1000 kilometres decreased year by *** total number of simple procedure handling accidents(*** accidents)increased year by year,but the number of accidents per 1000 kilometres remained relatively ***,fatigued driving,improper driving operation,failure to maintain a safe distance from the preceding vehicle and pedestrians entering the expressway are the main causes of general procedure handling *** to maintain a safe distance from the preceding vehicle as required and improper driving operation accounted for approximately 2/3 of the simple procedure handling *** view of the accidents caused by these factors,how to use law enforcement,education,science and technology and facilities construction to further reduce the occurrence of expressway traffic accidents is discussed.

关键词： expressway traffic accident cause analysis

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Study on Effectiveness of Solitary-Wave-Like Form Based on Overtopping Data from Irregular Wave Tests

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China Ocean Engineering 2024年第4期38卷 701-710页

作者： LI xiao-liang huang Gui-biao School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

The previous study conducted by Li(2022)demonstrates that the Goda graph can be adequately represented by a solitary-wave-like form across the entire range of relative water depth,with the exception of the extremely shallow ***,it remains uncertain whether this form is equally effective when applied to test data generated by irregular waves,as the Goda graph was initially developed based on overtopping data from regular wave ***,it is unclear whether this form is suitable for formulating overtopping discharge at composite vertical *** order to address these questions,a 2D overtopping experiment was conducted,incorporating both simple and composite types of vertical walls,with various relative water depths across the entire range,excluding the extremely shallow zone.A novel analysis procedure was developed,which proved to be highly productive and can be considered a general method for data ***,the study yielded two conclusions:(1)the solitary-wave-like form is remarkably effective in formulating overtopping test data generated by irregular waves,regardless of whether the vertical wall is simple or composite,and(2)the resulting formulas exhibit definitely better performance compared with existing formulas.

关键词： solitary-wave-like form overtopping discharge overtopping formula vertical wall

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Remnants and fragments of the subducted paleo-Pacific plate:Constraints from geochemistry and geophysics

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Science China Earth Sciences 2024年第10期67卷 3041-3061页

作者： Xisheng XU Zhouchuan huang Dingsheng JIANG Gang ZENG Li-qun DAI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China

The subduction and rollback of the paleo-Pacific plate during Mesozoic time was the key engine for the evolution of the continental margin in eastern China. It led to lateral accretion of continental crust in Northeast China, lithospheric destruction beneath the North China Craton, and the generation of huge volumes of felsic magmatic rocks in South China. This had a profound influence on deep material cycles and the evolution of epigenetic environmental systems along the continental margin of East Asia. To fully understand the transformation of the dynamic mechanism during the subduction and rollback of the paleoPacific plate, we have attempted to trace the remnants and fragments of the subducted paleo-Pacific plate at great depths. Such remnants in both temporal and spatial dimensions can be tracked by using geochemical and geophysical approaches. Studies of the trace elements, Mg-Zn isotopes and Os-Nd-Hf-Pb-O isotopes in continental basalts from eastern China reveal a significant number of the remnants of subduction of the paleo-Pacific plate, and the initial subduction can be traced back to the Early Jurassic. Large-scale geophysical imaging unveils a multitude of high-velocity anomalies in the lower mantle of East ***, many high-velocity bodies, aptly referred to as “slab graveyards”, are nestled at the base of the lower mantle. Numerous isolated high-velocity anomalies are also present in the upper part of the lower mantle, creating conduits for the descent of the subducted slabs into the lower mantle. However, a resolution of the remnants for the subducted slabs within the lower mantle are quite low. Consequently, their impact on the lower mantle's dynamics is yet to be thoroughly investigated. Finally, the presently observed big mantle wedge(BMW) in East Asia has developed through subduction of the Pacific plate in the ***, following the rollback of the paleo-Pacific plate(began at ~145 Ma), a Cretaceous BMW system would also form above

关键词： Paleo-Pacific plate Big mantle wedge Late Mesozoic Remnants and fragments Geochemistry Geophysics

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Role of biochar in raising blue carbon stock capacity of salt marshes

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Pedosphere 2024年第1期34卷 19-22页

作者： Yuzhou huang Xi xiao Ocean College Zhejiang UniversityZhoushan 316021China Key Laboratory of Marine Ecological Monitoring and Restoration Technologies of the Ministry of Natural Resources of China Shanghai 201306China Donghai Laboratory Zhoushan 316021China Ocean Academy Zhejiang UniversityZhoushan 316021China Key Laboratory of Watershed Non-point Source Pollution Control and Water Eco-security of Ministry of Water Resources College of Environmental and Resources SciencesZhejiang UniversityHangzhou 310058China

Salt marshes are an important blue carbon ecosystem, with surprisingly fast carbon accumulation rates that are 40 times higher than those of terrestrial forests. In recent decades, salt marshes have suffered great degradation and loss all over the world. The idea to enhance carbon stock in salt marshes(so-called blue carbon) using biochar (so-called black carbon) has recently been proposed. Although experiments and observations remain limited, significant enhancements in soil organic carbon and plant growth have been documented in most case studies. However, due to the limited number of observations and their relatively short time window ranging from months to less than one year, there still exists a knowledge gap regarding the process, mechanism, and effect of biochar in enhancing carbon stock in salt marshes. Future research is urgently needed in the following perspectives:1) exploring the relationship between carbon stock enhancement efficiency and biochar properties, 2) optimizing the physical and chemical properties of biochar to boost its efficiency, and 3)studying the in-situ responses of complex carbon pools to biochar addition, especially under tidal conditions and over a longer period of time.

关键词： soil stock char

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RDH12-associated retinal degeneration caused by a homozygous pathogenic variant of 146C>T and literature review

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 311-316页

作者： Jin Li Yi-qun Hu Hong-Bo Cheng Ting Wang Long-Hao Kuang Tao huang xiao-He Yan Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina

AIM:To describe the clinical,electrophysiological,and genetic features of an unusual case with an RDH12 homozygous pathogenic variant and reviewed the characteristics of the patients reported with the same ***:The patient underwent a complete ophthalmologic examination including best-corrected visual acuity,anterior segment and dilated fundus,visual field,spectral-domain optical coherence tomography(OCT)and electroretinogram(ERG).The retinal disease panel genes were sequenced through chip capture high-throughput sequencing and Sanger sequencing was used to confirm the *** we reviewed the characteristics of the patients reported with the same ***:A 30-year male presented with severe early retinal degeneration who complained night blindness,decreased visual acuity,vitreous floaters and amaurosis *** best corrected vision was 0.04 OD and 0.12 OS,*** fundus photo and OCT showed bilateral macular atrophy but larger areas of macular atrophy in the left *** shows bilateral symmetrical *** revealed that the amplitudes of a-and b-wave were severely *** ERG showed decreased amplitudes in the local macular area.A homozygous missense variant c.146C>T(chr14:68191267)was *** clinical characteristics of a total of 13 patients reported with the same pathologic variant ***:An unusual patient with a homozygous pathogenic variant in the c.146C>T of RDH12 which causes late-onset and asymmetric retinal degeneration are *** clinical manifestations of the patient with multimodal retinal imaging and functional examinations have enriched our understanding of this disease.

关键词： RDH12 gene inherited retinal degeneration homozygous pathogenic variant clinical feature multi-mode imaging

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CO2-Induced Modulation of Si-O Bonds for Low Temperature Plastic Deformation of Amorphous Silica Nanoparticles with Enhanced Photoluminescence

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Energy & Environmental Materials 2024年第4期7卷 404-412页

作者： Kang huang Wenzhuo Wu Song Xu Pengfei Yan Zhongming Wei qun Xu Henan Institute of Advanced Technology Zhengzhou University College of Materials Science and Engineering Zhengzhou University State Key Laboratory of Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences

Modulation of Si-O bonds under mild conditions has been a challenging issue in the field of material science,which is critical to manufacture highperformance silica-based optical and photonic ***,we introduce a nondestructive technique to achieve Si-O bond rearrangement,leading to plastic deformation and photoluminescence enhancement of amorphous silica nanoparticles using supercritical carbon dioxides in EtOH/H2O solution under mild temperature.

关键词： amorphous silica anisotropic stress photoluminescence plastic deformation supercritical CO2

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美洲土著人文化探源

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华中师范大学学报（人文社会科学版） 2000年第1期39卷 119-122页

作者：黄小群华中师范大学公共外语系湖北武汉430079

美洲土著人文化起源于何方 ?一直是世界各国的人类学家、史学家和考古学家感兴趣和力图解开的谜。本文梳理论证了美洲土著人文化起源于亚洲的可能性 ;阐述了前哥伦布时期 ,美洲大陆上颇具代表性的玛雅文化。

关键词：玛雅文化阿斯特克文化漂哀布罗文化土著文化

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