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Meta-Auto-Decoder:a Meta-Learning-Based Reduced Order Model for Solving Parametric Partial Differential Equations

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1096-1130页

作者： Zhanhong Ye xiang huang Hongsheng Liu Bin Dong Beijing International Center for Mathematical Research Peking UniversityBeijing 100871China School of Computer Science and Technology University of Science and Technology of ChinaHefei 230027AnhuiChina Central Software Institute Huawei Technologies Co.LtdHangzhou 310007ZhejiangChina Center for Machine Learning Research Peking UniversityBeijing 100871China

Many important problems in science and engineering require solving the so-called parametric partial differential equations(PDEs),i.e.,PDEs with different physical parameters,boundary conditions,shapes of computational domains,*** reduced order modeling techniques accelerate the solution of the parametric PDEs by projecting them onto a linear trial manifold constructed in the ofline *** methods often need a predefined mesh as well as a series of precomputed solution snapshots,and may struggle to balance between the efficiency and accuracy due to the limitation of the linear *** the nonlinear representation of neural networks(NNs),we propose the Meta-Auto-Decoder(MAD)to construct a nonlinear trial manifold,whose best possible performance is measured theoretically by the decoder *** on the meta-learning concept,the trial manifold can be learned in a mesh-free and unsupervised way during the pre-training *** adaptation to new(possibly heterogeneous)PDE parameters is enabled by searching on this trial manifold,and optionally fine-tuning the trial manifold at the same *** numerical experiments show that the MAD method exhibits a faster convergence speed without losing the accuracy than other deep learning-based methods.

关键词： Parametric partial differential equations(PDEs) Meta-learning Reduced order modeling Neural networks(NNs) Auto-decoder

Recent progress of two-dimensional metal-base catalysts in urea oxidation reaction

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Rare Metals 2024年第8期43卷 3607-3633页

作者： Qi-xiang huang Fang Wang Yong Liu Bi-Ying Zhang Fang-Ya Guo Zhong-Qiu Jia Hao Wang Tian-xiang Yang Hai-Tao Wu Feng-Zhang Ren Ting-Feng Yi School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China Henan Province International Joint Laboratory of Materials for Solar Energy Conversion and Lithium Sodium Based Battery Luoyang 471023China School of Chemistry and Life Sciences Suzhou University of Science and TechnologySuzhou 215009China School of Materials Science and Engineering Northeastern UniversityShenyang110819China

Urea oxidation reaction(UOR)is an auxiliary water electrolysis hydrogen production technology developed in recent years to replace oxygen evolution reaction and reduce energy consumption,which can produce hydrogen more efficiently by low theoretical potential,reduce the average cost of electrochemical hydrogen production,and is a frontier research hotspot for renewable hydrogen ***-dimensional(2D)nanomaterials as electrocatalysts have many favorable potential,such as it can effectively reduce the resistivity of materials and increase the specific surface area with *** paper reviews the application of 2D materials in UOR in alkaline *** a cross-sectional comparison of various material performance data including overpotential,Tafel slope,electrochemical active surface area(ECSA)and it stability test was conducted,which could illustrate the differences between materials composed of different *** addition,the main challenges hindering the progress of research on 2D materials in urea electrocatalysis processes and promising materials in this field in future are summarized and *** is believed that this review will contribute to designing and analyzing highperformance 2D urea electrocatalysts for water splitting.

关键词： Water splitting Urea oxidation reaction Two-dimensional Transition metal compounds Noble/non-noble metals

Two-stage extraction by partial grinding of impacted mandibular third molar in close proximity to the inferior alveolar nerve

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World Journal of Clinical Cases 2024年第10期12卷 1728-1732页

作者： Guang-Ming Luo Zhang-Shun Yao Wei-xiang huang Lei-Yan Zou Yan Yang Kunbaida Outpatient Department Kunming Medical University School and Hospital of StomatologyKunming 650106Yunnan ProvinceChina Yunnan Key Laboratory of Stomatology Kunming 650106Yunnan ProvinceChina

BACKGROUND Extraction of impacted third molars often leads to severe complications caused by damage to the inferior alveolar nerve(IAN).AIM To proposes a method for the partial grinding of an impacted mandibular third molar(IMM3)near the IAN to prevent IAN injury during IMM3 *** Between January 1996 and March 2022,25 patients with IMM3 roots near the IAN were *** first stage of the operation consisted of grinding a major part of the IMM3 crown with a high-speed turbine dental drill to achieve sufficient space between the mandibular second molar and *** 6 months,when the root tips were observed to be away from the IAN on X-ray examination,the remaining part of the IMM3 was completely *** All IMM3s were extracted easily without symptoms of IAN injury after *** Partial IMM3 grinding may be a good alternative treatment option to avoid IAN injury in high-risk cases.

关键词： Partial grinding Impacted mandibular third molar Inferior alveolar nerve Cone-beam computed tomography

Development and Validation of a Carbohydrate Metabolism-related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

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当代医学科学（英文） 2024年第4期44卷 771-788页

作者： Hong-xiang huang Pei-yuan ZHONG Ping LI Su-juan PENG Xin-jing DING xiang-lian CAI Jin-hong CHEN Xie ZHU Zhi-hui LU Xing-yu TAO Yang-yang LIU Li CHEN Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Oncology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Objective:The activities and products of carbohydrate metabolism are involved in key processes of ***,its relationship with hepatocellular carcinoma(HCC)is ***:The cancer genome atlas(TCGA)-HCC and ICGC-LIRI-JP datasets were acquired via public *** expressed genes(DEGs)between HCC and control samples in the TCGA-HCC dataset were identified and overlapped with 355 carbohydrate metabolism-related genes(CRGs)to obtain differentially expressed CRGs(DE-CRGs).Then,univariate Cox and least absolute shrinkage and selection operator(LASSO)analyses were applied to identify risk model genes,and HCC samples were divided into high/low-risk groups according to the median risk ***,gene set enrichment analysis(GSEA)was performed on the risk model *** sensitivity of the risk model to immunotherapy and chemotherapy was also ***:A total of 8 risk model genes,namely,G6PD,PFKFB4,ACAT1,ALDH2,ACYP1,OGDHL,ACADS,and TKTL1,were ***,the risk score,cancer status,age,and pathologic T stage were strongly associated with the prognosis of HCC *** the stromal score and immune score had significant negative/positive correlations with the risk score,reflecting the important role of the risk model in immunotherapy ***,the stromal and immune scores had significant negative/positive correlations with risk scores,reflecting the important role of the risk model in immunotherapy ***,we found that high-/low-risk patients were more sensitive to 102 drugs,suggesting that the risk model exhibited sensitivity to chemotherapy *** results of the experiments in HCC tissue samples validated the expression of the risk model ***:Through bioinformatic analysis,we constructed a carbohydrate metabolism-related risk model for HCC,contributing to the prognosis prediction and treatment of HCC patients.

关键词： bioinformatics carbohydrate metabolism hepatocellular carcinoma the cancer genome atlas

Laser speckle contrast imaging to predict the effect of temporary spinal cord stimulation in postherpetic neuralgia patients: A prospective observational study

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 69-75页

作者： xiang huang Dacheng Tang Pan Chen Lumiao Chen Xiaohong Li Xiaoping Wang Department of Pain Management The First A±liated Hospital Jinan University Guang ZhouGuangdong 510630P.R.China Department of Pain Management The First People's Hospital of Foshan Foshan City Guangdong 528000P.R.China

Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on *** speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of *** assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational *** analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS *** results showed that the VAS scores of all patients decreased ***,the bloodflow index(BFI)values were signi-cantly higher than they were before the *** bloodflow and pain alleviation were positively ***-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by *** alleviation by tSCS was positively correlated with increased bloodflow in the *** effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.

关键词： Laser speckle contrast imaging temporary spinal cord stimulation postherpetic neuralgia

Seismogenic model of the 2023 M_(W)5.5 Pingyuan earthquake in North China Plain and its tectonic implications

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Earthquake Science 2024年第6期37卷 499-513页

作者： Shiguang Wang Libo Han Junju Xie Liping Fan xiang huang Jinmeng Bi Hongfeng Yang Lihua Fang Institute of Geophysics China Earthquake AdministrationBeijing 10081China Tianjin Earthquake Agency Tianjin 300201China Earth System Science Programme The Chinese University of Hong KongShatinHong Kong 999077China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 100095China

The 6 August 2023 M_(W)5.5 Pingyuan earthquake is the largest earthquake in the central North China Plain(NCP)over the past two *** to the thick sedimentary cover,no corresponding active faults have been reported yet in the epicenter ***,this earthquake presents a unique opportunity to delve into the buried active faults beneath the *** integrating strong ground motion records,high-precision aftershock sequence relocation,and focal mechanism solutions,we gain insights into the seismotectonics of the Pingyuan *** aftershocks are clustered at depths ranging from 15 to 20 km and delineate a NE-SW trend,consistent with the distribution of ground motion records.A NE-SW nodal plane(226°)of the focal mechanism solutions is also derived from regional waveform inversion,suggesting that the mainshock was dominated by strike-slip motion with minor normal faulting *** regional geological data,we propose that an unrecognized fault between the NE-SW trending Gaotang and Lingxian-Yangxin faults is the seismogenic fault of this *** on the S-wave velocity structure beneath the NCP,this fault probably extends into the lower crust with a high *** the tectonic regime and stress state,we speculate that the interplay of shear strain between the Amurian and South China blocks and the hot upwelling magma from the subducted paleo Pacific flat slab significantly contributed to the generation of the Pingyuan earthquake.

关键词： Pingyuan earthquake aftershock relocation focal mechanism S-wave velocity structure North China Plain

基于“史哲兼修”的“大写的和小写的”科学革命关系究竟如何?——兼与肖显静教授商榷

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自然辩证法研究 2024年第7期40卷 10-16页

作者：黄翔复旦大学哲学学院上海200433

肖显静教授的近著是一部“史哲兼修”的学术大作。只有在合理地理解科学史与科学哲学之间的关系后,才能正确地评价其研究的合法性和学术贡献。从麦克马林提供的概念资源出发,肖著可以被理解为一种“外在科学哲学”。这一研究进路所依赖... 详细信息

肖显静教授的近著是一部“史哲兼修”的学术大作。只有在合理地理解科学史与科学哲学之间的关系后,才能正确地评价其研究的合法性和学术贡献。从麦克马林提供的概念资源出发,肖著可以被理解为一种“外在科学哲学”。这一研究进路所依赖的理论概念,即“大写的科学革命”与“小写的科学革命”及其之间的关系,存在着值得商榷和修补的地方。

关键词：科学史和科学哲学科学革命内在科学哲学外在科学哲学

论智能行为的演化——从激进生成认知的视角看

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山西大学学报(哲学社会科学版) 2024年第1期47卷 53-61页

作者：黄翔复旦大学哲学学院

对动物心灵和认知的自然化理解需要同时给出两个说明：(I)动物与人有哪些心灵与认知能力；(II)人的心灵与认知能力在哪些方面不同于动物的心灵与认知能力。在进行这两个说明的过程中，常常会遇到两种陷阱：一方面，超智能主义陷阱将民... 详细信息

对动物心灵和认知的自然化理解需要同时给出两个说明：(I)动物与人有哪些心灵与认知能力；(II)人的心灵与认知能力在哪些方面不同于动物的心灵与认知能力。在进行这两个说明的过程中，常常会遇到两种陷阱：一方面，超智能主义陷阱将民间心理学用来言说人类认知能力的概念(如表征、信念、意识等)滥用于动物认知，从而使得在对(I)进行说明的过程中容易将隐喻当成实在性的描述；另一方面，极端物理功能主义陷阱将动物与人共有的神经系统对外在刺激的因果功能反应能力赋予了过多的说明力，从而使得在对(II)进行说明时面临说明鸿沟或“难问题”。文章通过区分人类认知演化过程中的四种智能行为，论证了激进生成认知在给出上述两个说明时可以成功地避免这两种陷阱，并且优于目的论语义学。

关键词：动物智能超智能主义目的论语义学表征主义心灵的演化

Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial

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Cancer Pathogenesis and Therapy 2024年第1期2卷 31-37页

作者： Nan Jin Yi Xu Siqi Wang Chunxiao Sun Xueqi Yan Fan Yang Yan Liang Weiwei Chen xiang huang Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Radiology Department The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210000China

Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resistance to *** this study,we investigated the efficacy and safety of inetetamab,another anti-HER2 antibody,combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the *** In this prospective,single-arm,phase 2 trial,patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were *** received a combination of inetetamab(loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks),pyrotinib(400 mg orally once daily),and vinorelbine(60 mg/m^(2)orally once weekly)until disease progression or intolerable *** primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),overall survival(OS),disease control rate(DCR),and *** Between February 13,2022 and December 25,2022,30 patients were screened and enrolled in this *** median age of the patients at enrollment was 54 years,12 patients(40.0%)had hormone-receptor-positive disease and 23 patients(76.7%)had visceral *** median PFS was 8.63 months(95%confidence interval[CI]4.15-13.12 months).The median OS was not *** ORR was 53.3%(16/30)and the DCR was 96.7%(29/30).The most common Grade III/IV adverse events were leukopenia(n=5,16.7%),neutropenia(n=4,13.3%),and diarrhea(n=3,10%).No treatment-related serious adverse events or deaths *** The combination regimen of inetetamab,pyrotinib,and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.

关键词： Human epidermal growth factor receptor 2 Breast cancer Inetetamab Pyrotinib Vinorelbine