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Hemorrhagic transformation in patients with large-artery atherosclerotic stroke is associated with the gut microbiota and lipopolysaccharide

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Neural Regeneration Research 2024年第7期19卷 1532-1540页

作者： qin huang Minping Wei Xianjing Feng Yunfang Luo Yunhai Liu Jian Xia Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Peking University People’s HospitalBeijingChina Clinical Research Center for Cerebrovascular Disease of Hunan Province Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Hemorrhagic transformation is a major complication of large-artery atheroscle rotic stroke(a major ischemic stro ke subtype)that wo rsens outcomes and increases *** of the gut microbiota is an important feature of stroke,and some specific bacteria and bacterial metabolites may contribute to hemorrhagic transformation *** aimed to investigate the relationship between the gut microbiota and hemorrhagic transformation in largearte ry atheroscle rotic stro *** observational retrospective study was *** May 2020 to September 2021,blood and fecal samples were obtained upon admission from 32 patients with first-ever acute ischemic stroke and not undergoing intravenous thrombolysis or endovascular thrombectomy,as well as 16 healthy *** with stro ke who developed hemorrhagic transfo rmation(n=15)were compared to those who did not develop hemorrhagic transformation(n=17)and with healthy *** gut microbiota was assessed through 16S ribosomal ribonucleic acid *** also examined key components of the lipopolysaccharide pathway:lipopolysaccharide,lipopolysaccharide-binding protein,and soluble *** observed that bacterial diversity was decreased in both the hemorrhagic transformation and non-hemorrhagic transfo rmation group compared with the healthy *** patients with ischemic stro ke who developed hemorrhagic transfo rmation exhibited altered gut micro biota composition,in particular an increase in the relative abundance and dive rsity of members belonging to the Enterobacteriaceae *** lipopolysaccharide and lipopolysaccharide-binding protein levels were higher in the hemorrhagic transformation group compared with the non-hemorrhagic transfo rmation ***,lipopolysaccharide-binding protein,and soluble CD14 concentrations were associated with increased abundance of Enterobacte ***,the role of the gut microbiota in hemorrhagic transformation was evaluated using

关键词： gut microbiota hemorrhagic transformation inflammation lipopolysaccharide stroke

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Biomechanical analysis of an absorbable material for treating fractures of the inferior orbital wall

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1331-1336页

作者： Jin-Hai Yu Ze-Xi Sang huang Zhang Qi-Hua Xu qin huang Hong-Fei Liao Yao-Hua Wang School of Optometry Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Research Institute of Ophthalmology and Visual Science Nanchang 330006Jiangxi ProvinceChina Jiangxi Provincial Key Laboratory for Ophthalmology Nanchang 330006Jiangxi ProvinceChina National Clinical Research Center for Ocular Diseases Jiangxi Province Division Nanchang 330006Jiangxi ProvinceChina The Affiliated Eye Hospital Jiangxi Medical CollegeNanchang 330006Jiangxi ProvinceChina Jiangxi Clinical Research Center for Ophthalmic Disease Nanchang 330006Jiangxi ProvinceChina

AIM:To investigate the biomechanical properties and practical application of absorbable materials in orbital fracture ***:The three-dimensional(3D)model of orbital blowout fractures was reconstructed using Mimics21.0 *** repair guide plate model for inferior orbital wall fracture was designed using 3-matic13.0 and Geomagic wrap 21.0 *** finite element model of orbital blowout fracture and absorbable repair plate was established using 3-matic13.0 and ANSYS Workbench 21.0 *** mechanical response of absorbable plates,with thicknesses of 0.6 and 1.2 mm,was modeled after their placement in the *** patients with inferior orbital wall fractures volunteered to receive single-layer and double-layer absorbable plates combined with 3D printing technology to facilitate surgical treatment of orbital wall ***:The finite element models of orbital blowout fracture and absorbable plate were successfully *** element analysis(FEA)showed that when the Young’s modulus of the absorbable plate decreases to 3.15 MPa,the repair material with a thickness of 0.6 mm was influenced by the gravitational forces of the orbital contents,resulting in a maximum total deformation of approximately 3.3 ***,when the absorbable plate was 1.2 mm thick,the overall maximum total deformation was around 0.4 *** half-year follow-up results of the clinical cases confirmed that the absorbable plate with a thickness of 1.2 mm had smaller maximum total deformation and better clinical ***:The biomechanical analysis observations in this study are largely consistent with the clinical *** use of double-layer absorbable plates in conjunction with 3D printing technology is recommended to support surgical treatment of infraorbital wall blowout fractures.

关键词： orbital blowout fracture absorbable material finite element analysis 3D printing technology

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Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 563-570页

作者： Yu-qing Cheng Geng-Fang Wang Xiao-Li Zhou Min Lin Xin-Wen Zhang qin huang Department of Pathology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Gastroenterology Center The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215United States

BACKGROUND Early adenocarcinoma mixed with a neuroendocrine carcinoma(NEC)component arising in the gastroesophageal junctional(GEJ)region is rare and even rarer in young ***,we report such a case in a 29-year-old Chinese *** SUMMARY This patient presented to our hospital with a 3-mo history of dysphagia and *** endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line,without Barrett’s esophagus or involvement of the gastric *** nodule was completely resected by endoscopic submu-cosal dissection(ESD).Pathological examination confirmed diagnosis of intra-mucosal adenocarcinoma mixed with an NEC component,measuring 1.5 ***,both adenocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%;NEC was positive for synaptophysin and ***-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene,a common gastric cancer driver gene,in addition to pathogenic somatic mutations in P53 and CHEK2 *** patient was alive without evidence of the disease 36 mo after *** Early adenocarcinoma with an NEC component arising in the distal esophageal side of the GEJ region showed evidence of gastric origin.

关键词： Adenocarcinoma Neuroendocrine carcinoma Gastroesophageal junction Next generation sequencing Case report

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Dynamic interwell connectivity analysis of multi-layer waterflooding reservoirs based on an improved graph neural network

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Petroleum Science 2024年第2期21卷 1062-1080页

作者： Zhao-qin huang Zhao-Xu Wang Hui-Fang Hu Shi-Ming Zhang Yong-Xing Liang Qi Guo Jun Yao School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Exploration and Development Research Institute Shengli OilfieldSINOPECDongying257015ShandongChina

The analysis of interwell connectivity plays an important role in the formulation of oilfield development plans and the description of residual oil distribution. In fact, sandstone reservoirs in China's onshore oilfields generally have the characteristics of thin and many layers, so multi-layer joint production is usually adopted. It remains a challenge to ensure the accuracy of splitting and dynamic connectivity in each layer of the injection-production wells with limited field data. The three-dimensional well pattern of multi-layer reservoir and the relationship between injection-production wells can be equivalent to a directional heterogeneous graph. In this paper, an improved graph neural network is proposed to construct an interacting process mimics the real interwell flow regularity. In detail, this method is used to split injection and production rates by combining permeability, porosity and effective thickness, and to invert the dynamic connectivity in each layer of the injection-production wells by attention *** on the material balance and physical information, the overall connectivity from the injection wells,through the water injection layers to the production layers and the output of final production wells is established. Meanwhile, the change of well pattern caused by perforation, plugging and switching of wells at different times is achieved by updated graph structure in spatial and temporal ways. The effectiveness of the method is verified by a combination of reservoir numerical simulation examples and field example. The method corresponds to the actual situation of the reservoir, has wide adaptability and low cost, has good practical value, and provides a reference for adjusting the injection-production relationship of the reservoir and the development of the remaining oil.

关键词： Graph neural network Dynamic interwell connectivity Production-injection splitting Attention mechanism Multi-layer reservoir

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Preparation of MXene-based hybrids and their application in neuromorphic devices

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International Journal of Extreme Manufacturing 2024年第2期6卷 164-188页

作者： Zhuohao Xiao Xiaodong Xiao Ling Bing Kong Hongbo Dong Xiuying Li Bin He Shuangchen Ruan Jianpang Zhai Kun Zhou qin huang Liang Chu School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403JiangxiPeople’s Republic of China School of Mechanical and Vehicle Engineering Linyi UniversityLinyi 276000ShandongPeople’s Republic of China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118GuangdongPeople’s Republic of China School of Mechanical&Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Ningbo Institute of Materials Engineering and Technology Chinese Academy of ScienceNingbo 315201ZhejiangPeople’s Republic of China Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangPeople’s Republic of China

The traditional von Neumann computing architecture has relatively-low information processing speed and high power consumption,making it difficult to meet the computing needs of artificial intelligence(AI).Neuromorphic computing systems,with massively parallel computing capability and low power consumption,have been considered as an ideal option for data storage and AI computing in the ***,as the fourth basic electronic component besides resistance,capacitance and inductance,is one of the most competitive candidates for neuromorphic computing systems benefiting from the simple structure,continuously adjustable conductivity state,ultra-low power consumption,high switching speed and compatibility with existing CMOS *** memristors with applying MXene-based hybrids have attracted significant attention in recent ***,we introduce the latest progress in the synthesis of MXene-based hybrids and summarize their potential applications in memristor devices and neuromorphological *** explore the development trend of memristors constructed by combining MXenes with other functional materials and emphatically discuss the potential mechanism of MXenes-based memristor ***,the future prospects and directions of MXene-based memristors are briefly described.

关键词： MXene etching fabrication memristor neuromorphic

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lmpact of non-canonical ALK fusion on the efficacy of targeted therapy in non-small cell lung cancer

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Chinese Medical Journal 2024年第12期137卷 1468-1470页

作者： Hao Zeng Qi Wei Yuan Tang Yuanyuan Zhang Sihan Tan qin huang Xin Pu Yalun Li Panwen Tian Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pulmonary and Critical Care Medicine Lung Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and MultimorbidityPrecision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:With the wide application of next-generation sequencing(NGS),a number of EML4-ALK fusion partners or coexisting(non)-EML4-ALK and non-EML4-ALK have been detected in non-small cell lung cancer(NSCLC).Although targeted therapies for patients with metastatic NSCLC and actionable mutations dramatically change how these patients are treated,studies have demonstrated differences in progression-free survival(PFS)among patients based on different ALK fusion partners.

关键词： targeted lung NSCLC

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Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases:A prospective,blind clinical study

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World Journal of Gastroenterology 2024年第9期30卷 1121-1131页

作者： Yan-Ling Yang huang-Wen qin Zhao-Yu Chen Hui-Ning Fan Yi Yu Wei Da Jin-Shui Zhu Jing Zhang Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Traditional esophagogastroduodenoscopy(EGD),an invasive examination method,can cause discomfort and pain in *** contrast,magnetically controlled capsule endoscopy(MCE),a noninvasive method,is being applied for the detection of stomach and small intestinal diseases,but its application in treating esophageal diseases is not *** To evaluate the safety and efficacy of detachable string MCE(ds-MCE)for the diagnosis of esophageal *** Fifty patients who had been diagnosed with esophageal diseases were pros-pectively recruited for this clinical study and underwent ds-MCE and conven-tional *** primary endpoints included the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for patients with esophageal *** secondary endpoints consisted of visualizing the esophageal and dentate lines,as well as the subjects'tolerance of the *** Using EGD as the gold standard,the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for esophageal disease detection were 85.71%,86.21%,81.82%,89.29%,and 86%,***-MCE was more comfortable and convenient than EGD was,with 80%of patients feeling that ds-MCE examination was very comfortable or comfortable and 50%of patients believing that detachable string v examination was very *** This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD,providing a novel noninvasive method for treating esophageal diseases.

关键词： Clinical trial Detachable string magnetically controlled capsule endoscopy Esophagogastroduodenoscopy Noninvasive diagnosis Esophageal diseases

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基于XGBoost算法的亚热带地区生态旅游适宜性评价方法研究

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地球信息科学学报 2024年第2期26卷 303-317页

作者：黄钦谭翠杨波湖南师范大学地理科学学院长沙410081 湖南师范大学地理空间大数据挖掘与应用湖南省重点实验室长沙410081 东风高级中学十堰442011

近年来,随着公众环境保护意识的提升,追求人与自然和谐共生的生态旅游方式越来越受到人们的普遍关注。面对丰富多样的生态旅游资源及国内生态旅游的供需矛盾,如何在大保护的前提下有序开发、合理利用,将“绿水青山”科学、合理地转化为... 详细信息

近年来,随着公众环境保护意识的提升,追求人与自然和谐共生的生态旅游方式越来越受到人们的普遍关注。面对丰富多样的生态旅游资源及国内生态旅游的供需矛盾,如何在大保护的前提下有序开发、合理利用,将“绿水青山”科学、合理地转化为“金山银山”是现阶段亟需面对和解决的重大问题。本文以神农架林区为例,基于多源地理空间数据,运用XGBoost算法对其生态旅游适宜性进行评估,得出如下结论:(1)基于XGBoost算法的生态旅游适宜性评价模型融合了机器学习技术与数据挖掘思想并取得了良好的分类效果,模型在10折交叉验证下的整体分类精度为89.44%,同时兼有良好的召回率(89.68%),F1分数为0.874 5,兼顾了精确度和召回率,模型AUC值为0.959 3,模型整体分类性能表现优秀;(2)根据特征重要性排序结果,生态环境要素NDVI(26.86%)、年平均气温(11.61%)和社会经济因素距道路距离(8.90%)对模型贡献度最高,位列所有特征前3位;(3)生态旅游适宜性分类结果表明,神农架林区整体生态旅游资源丰富,高度适宜区、中度适宜区、边际适宜区和不适宜区的覆盖面积分别占林区总面积的44.13%、15.93%、11.89%和28.05%。本文研究方法突破了传统生态旅游适宜性评估方法主观性较强的局限,立足于数据挖掘思想和机器学习技术解决实际问题,可为区域国土空间规划、乡村振兴战略和生态旅游资源整合提供决策依据。

关键词：生态旅游适宜性评价 XGBoost算法机器学习亚热带地区多源地理空间数据神农架林区可持续发展

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《齐物论》的异样佛解——以《庄子内篇注·齐物论》与《齐物论释》为例

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北京社会科学 2024年第6期 53-63页

作者：周黄琴广东石油化工学院

近人较多地从知识论角度来解析《齐物论》,从而易得出相对主义的否弃论。然晚明憨山德清与近代章太炎虽皆以佛解《齐物论》,但在异样的时代需求与教育观念下,他们不仅在文本主旨上存在着“齐‘物论’”与“‘齐物’论”的异样判定,而且... 详细信息

近人较多地从知识论角度来解析《齐物论》,从而易得出相对主义的否弃论。然晚明憨山德清与近代章太炎虽皆以佛解《齐物论》,但在异样的时代需求与教育观念下,他们不仅在文本主旨上存在着“齐‘物论’”与“‘齐物’论”的异样判定,而且在佛学的解读基点上亦存在着南宗迷悟与唯识思想的异样性。在运用“立于心旨与工夫”、训诂与唯识名相解析诸法的异样诠释方法的基础上,他们通过禅老思想与华严、般若以及西学的异样融汇解读,彰显出“世人迷真执妄”与“心之主动”的观念,建构出破执而归真宰与“不齐而齐”的异样图景。无疑,这无不与二人背后所深蕴的化解庄佛矛盾、解庄传佛、振兴佛教与用国粹激动种性,以及佛庄联手的最大化救世功能之异样解读意图有着密不可分的关系。

关键词：齐物论憨山德清章太炎迷悟唯识

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商业混淆反不正当竞争法规制要点分析

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上海对外经贸大学学报 2024年第3期31卷 60-74页

作者：黄彦钦福州大学法学院福州350108

商业混淆行为的违法性在于破坏商业标识的指引功能,扰乱消费者在商业标识、商品和商品来源之间建立的联系。认定商业混淆行为需要界定有一定影响的商业标识、该商业标识所附的商品和商品的来源,可以采用“剥离法”将商业标识和商品的各... 详细信息

商业混淆行为的违法性在于破坏商业标识的指引功能,扰乱消费者在商业标识、商品和商品来源之间建立的联系。认定商业混淆行为需要界定有一定影响的商业标识、该商业标识所附的商品和商品的来源,可以采用“剥离法”将商业标识和商品的各个要素分解与组合,找到具有值得法律保护最低限度指引功能的拟制商业标识和商品。考察涉案商业标识是否会构成混淆,可以从客观上判断商业标识外观的近似度,也可以直接考察消费者主观上是否对相关商业标识产生误认或误认的可能。对商业标识权益的归属问题可以选择采用权利保护模式和利益保护模式:权利保护模式将商业标识作为权利客体,适用在先使用标准确权;利益保护模式则通过过去的利益结构和未来可能的利益结构对商业标识利益进行再分配。

关键词：商业标识商业混淆反不正当竞争法红罐之争剥离法

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