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Efficacy and safety of the Qiguiyin formula in severe pneumonia: study protocol for a randomized, double-blind, placebo-controlled clinical trial

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Journal of Traditional Chinese Medicine 2020年第2期40卷 317-323页

作者： huang po Guo Yuhong Zhao Jingxia Li Bo Wu Yanqing Liu Qingquan Department of Emergency Medicine Beijing Hospital of Traditional Chinese MedicineClinical Medical College of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Laboratory of Infection and Immunity Beijing Institute of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE: To evaluate the clinical efficacy and safety of Qiguiyin(QGY) formula in patients with severe pneumonia in China compared with a ***: This is a multicenter double-blind, placebo-controlled, randomized clinical trial with two parallel arms. There will be 530 patients enrolled and randomized into either the experimental group(QGY formula) or the control group(placebo). Therapies for patients in the two groups above will be based on the conventional therapy. The primary outcome is 28-day mortality. Secondary outcomes include:(a) duration of hospital stay;(b) duration of time in the intensive care unit(ICU) stays;(c) duration of mechanical ventilation;(d) antibiotic DDD value(which means the doses of antibotics during the treatment period);(e) serum procalcitonin(PCT) level;(f) serum C-reactive protein(CRP)level;(g) Pneumonia severity index(PSI) score;(h)Sequential Organ Failure Assessment(SOFA) score;(i) sputum culture results;(j) blood routine examination results;(k) routine urine test results;(l) stool routine examination results;(m) electrocardiogram results;(n) alanine aminotransferase levels;(o) aspartate amino transferase levels;(p) total bilirubin;(q) creatinine levels;(r) urea nitrogen levels;and(s)adverse *** AND DISSEMINATION: The protocol has been approved by the Research Ethics Committee of Beijing Hospital of Traditional Chinese Medicine,Affiliated with Capital Medical University(2018 BL-053-02). This trial aims to provide evidence for QGY formula combined with conventional therapy in treating patients with severe bacterial pneumonia,and to verify the clinical effectiveness and safety of QGY formula in China compared with placebo. Additionally, this trial will reveal the effect of QGY formula on delaying/reversing the characteristics of drug-resistant *** registration number: Chi CTR1800019785.

关键词： Drug resistance Pneumonia Pseudomonas aeruginosa Treatment outcome Safety Clinical protocols

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Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant

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World Journal of Gastroenterology 2021年第25期27卷 3948-3950页

作者： Chao-Ming Hung po-huang Lee Hui-Ming Lee Chong-Chi Chiu Department of General Surgery E-Da Cancer HospitalKaohsiung 82445Taiwan College of Medicine I-Shou UniversityKaohsiung 82445Taiwan Department of Surgery E-Da HospitalKaohsiung 82445Taiwan School of Medicine College of MedicineI-Shou UniversityKaohsiung 82445Taiwan

Yang et al reported an immunocompetent infant with gastrointestinal cytomegalovirus disease secondary to measles *** express our opinion about the diagnosis and treatment of this rare disease.

关键词： Gastrointestinal cytomegalovirus disease Measles Diarrhea Immunocompetent infant Rare disease

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Epitaxial Pb (Zr_(0.52)Ti_(0.48)) O_(3)/Y_(1)Ba_(2)Cu_(3)O_(7-x) Heterostructure Prepared by Pulsed Laser Deposition

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Chinese Physics Letters 1998年第10期15卷 764-766页

作者： huang Bi-ping ZHENG Li-rong GAO Jian-xia WANG Lian-wei huang Ji-po LIN Cheng-lu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of MetallurgyChinese Academy of SciencesShanghai 200050

C-axis oriented Y1Ba_(2)Cu_(3)O_(7-x)(YBCO)thin films and PbZr_(0.52)Ti_(0.48)O_(3)(PZT)/(YBCO)heterostructures were deposited on single-crystal LaAIO3 by Nd:YAG pulsed laser *** results showed that the YBCO films exhibited superconducting transition temperature above 86 K and ion beam channeling minimum yields xmin of 49%,indicating the relatively good quality of YBCO films deposited on the LaAIO3 *** PZT films in situ grown on the YBCO films were epitaxially c-axis oriented with a saturation polarization and remanence as high as 57μC/cm_(2) and 39μC/cm^(2)(at 204 kV/cm),*** coercive field of PZT films is about 55 kV/cm.

关键词： deposition. films saturation

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Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B_1 exposure

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World Journal of Hepatology 2012年第5期4卷 169-175页

作者： Hulya Yazici Ming-Whei Yu po-huang Lee Regina M Santella Department of Oncology Oncology InstituteIstanbul UniversityIstanbul 34093Turkey Graduate Institute of Epidemiology College of Public HealthNational Taiwan University Department of Surgery College of MedicineNational Taiwan University Department of Environmental Health Sciences Mailman School of Public Health of Columbia University630 W 168 Th St.New YorkNY 10032United States

AIM:To determine global DNA methylation in paired hepatocellular carcinoma(HCC) samples using several different assays and explore the correlations between hypomethylation and clinical parameters and biomarkers,including that of aflatoxin B 1 ***:Using the radio labeled methyl acceptance assay as a measure of global hypomethylation,as well as two repetitive elements,including satellite 2(Sat2) by MethyLight and long interspersed nucleotide elements(LINE1),by ***:By all three assays,mean methylation levels in tumor tissues were significantly lower than that in adjacent *** acceptance assay log(mean ± SD) disintegrations/min/ng DNA are 70.0 ± 54.8 and 32.4 ± 15.6,respectively,P = 0.040;percent methylation of Sat2 42.2 ± 55.1 and 117.9 ± 88.8,respectively,P posure to this dietary carcinogen,were inversely correlated with LINE1 methylation(r =-0.36,P = 0.034).CONCLUSION:Consistent hypomethylation in tumor compared to adjacent tissue was found by the three different *** 1 exposure is associated with DNA global hypomethylation,suggesting that chemical carcinogens may influence epigenetic changes in humans.

关键词： Hepatocellular carcinoma Epigenetics Hypomethylation [3 H]-methyl acceptance assay Satellite 2 Long interspersed nucleotide element-1 Aflatoxin B_1

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Prophylactic liver transplantation for high-risk recurrent hepatocellular carcinoma

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World Journal of Hepatology 2016年第31期8卷 1309-1317页

作者： po-Chih Yang Cheng-Maw Ho Rey-Heng Hu Ming-Chih Ho Yao-Ming Wu po-huang Lee Department of Surgery National Taiwan University Hospital Hsinchu Branch Department of Surgery National Taiwan University Hospital Department of Surgery National Taiwan University Hospital

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. Radical treatment of HCC in early stages results in a long disease-free period and improved overall survival. The choice of optimal management strategy for HCC mainly depends on the severity of the underlying liver disease. For patients with decompensated liver cirrhosis and HCC within Milan criteria (MC), liver transplant (LT) is the choice of treatment. However, for patients with good residual liver reserve and HCC within MC, selection of other curative treatments such as liver resection (LR) or radiofrequency ablation may be a reasonable alternative. For patients without cirrhosis, LR can result in an overall survival similar to that provided by LT. Therefore, it is an accepted alternative to LT especially in areas with organ shortage. However, the cumulative 5-year recurrence rate of HCC post LR might be as high as 70%. For initial transplant-eligible (within MC) patients with recurrent HCC post LR, salvage liver transplant (SLT) was first proposed in 2000. However, most patients with recurrent HCC considered for SLT are untransplantable cases due to HCC recurrence beyond MC or comorbidity. Thus, the strategy of opting for SLT results in the loss of the opportunity of LT for these patients. Some authors proposed the concept of “de principe liver transplant” (i.e., prophylactic LT before HCC recurrence) to prevent losing the chance of LT for these potential candidates. Factors associated with the failure of SLT will be dissected and discussed in three parts: Patient, tumor, and underlying liver disease. Regarding patient-related factors, the rate of transplantability depends on patient compliance. Patients without regular follow-up tend to develop HCC recurrence beyond MC at the time of tumor detection. Advancing age is another factor related to severe comorbidities when LT is considered for HCC recurrence, and these elderly candidates become ineligibl

关键词： Liver transplant Hepatocellular carcinoma Salvage Risk factor Resection Microvascular invasion Recurrence Prophylactic

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Management of early hepatic artery occlusion after liver transplantation with failed rescue

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World Journal of Gastroenterology 2015年第44期21卷 12729-12734页

作者： Chih-Yang Hsiao Cheng-Maw Ho Yao-Ming Wu Ming-Chih Ho Rey-Heng Hu po-huang Lee Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine

Hepatic artery thrombosis is a serious complication after liver transplantation which often results in biliary complications, early graft loss, and patient death. It is generally thought that early hepatic artery thrombosis without urgent re-vascularization or retransplantation almost always leads to mortality, especially if the hepatic artery thrombosis occurs within a few days after transplantation. This series presents 3 cases of early hepatic artery thrombosis after living donor liver transplantation, in which surgical or endovascular attempts at arterial re-vascularization failed. Unexpectedly, these 3 patients survived with acceptable graft function after 32 mo, 11 mo, and 4 mo follow-up, respectively. The literatures on factors affecting this devastating complication were reviewed from an anatomical perspective. The collective evidence from survivors indicated that modified nonsurgical management after liver transplantation with failed revascularization may be sufficient to prevent mortality from early hepatic artery occlusion. Re-transplantation may be reserved for selected patients with unrecovered graft function.

关键词： Complication Hepatic artery Thrombosis Liver trans

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Nanocavities:an Effective Gettering Method for Silicon-on-Insulator Wafers

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Chinese Physics Letters 1998年第7期15卷 516-518页

作者： ZHANG Miao ZENG Jian-min huang Ji-po LIN Zi-xin ZHOU Zu-yao LIN Cheng-lu State Key Laboratory of Functional Materials for Informatics Ion Beam Laboratory Shanghai Institute of MetallurgyChinese Academy of SciencesShanghai 200050

The 4×10^(16)/cm^(2) H+and 9×10^(16)/cm^(2) He+have been implanted into the silicon substrate of separation-by-implantation-of oxygen(SIMOX)wafers,respectively,followed by a 700℃ annealing to form nanocavities beneath the buried oxide(BOX)*** SIMOX wafers were intentionally contaminated with Cu impurities by implanting different doses of Cu in the top Si *** ion mass spectroscopy and cross-sectional transmission electron microscopy technologies have been employed to investigate the gettering effect of nanocavities to the Cu *** cavities induced either by H^(+) or He^(+) implantation are effective gettering centers for Cu in SIMOX *** annealing at 1000℃ for 90 min,up to 4×10^(15)/cm^(2) Cu has diffused through the BOX layer and been captured by the *** gettering efficiency of cavities increases with the decrease of Cu implantation *** nanocavities provide an attractive method for gettering transition metal impurities in SIMOX materials.

关键词： implantation annealing doses

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C-axis Oriented AIN Thin Films on Silicon Prepared by Ultrahigh Vacuum Evaporation of AI Combined with post-Nitridation

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Chinese Physics Letters 1998年第10期15卷 732-733页

作者： huang Ji-po WANG Lian-wei SHEN Qin-wo GAO Jian-xia NI Ru-shan LIN Cheng-lu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of MetallurgyChinese Academy of SciencesShanghai200050

A new technique for the preparation of AlN thin films by ultrahigh vacuum electron beam evaporation of AI followed by nitridation is reported and by using this method c-axis oriented AJN thin films have been success-fully grown on Si(111)substrates.X-ray diffraction,Fourier transform infrared spectroscopy,x-ray photoelectron spectroscopy and cross-sectional transmission electron microscope were employed to characterize AIN *** of nitridation was found to play an important role in the formation of AIN *** post-nitridation of as-deposited film at 1000℃ for lh in N2,the crystalline AlN film with(002)orientation has been obtained.

关键词： Si(111) film sectional

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定量PCR快速检测牙科综合治疗椅用水中伯克氏菌及变异蛋白菌分布

定量PCR快速检测牙科综合治疗椅用水中伯克氏菌及变异蛋白菌分布

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作者： huang po Jui 山东大学

学位级别：硕士

研究背景:牙科治疗椅供水管路(Dental Unit Waterlines)中的微生物污染最近几年广为被医疗各界关注,主要讨论管道的供水一旦被污染,可疑致病菌就能够通过不同方式进入患者口腔,或化成水气雾散发在科诊室的空气中,对医务人员和患者都是... 详细信息

研究背景:牙科治疗椅供水管路(Dental Unit Waterlines)中的微生物污染最近几年广为被医疗各界关注,主要讨论管道的供水一旦被污染,可疑致病菌就能够通过不同方式进入患者口腔,或化成水气雾散发在科诊室的空气中,对医务人员和患者都是一种潜在的危险。在之前采用常规培养的方法及16s高通量测序研究结果表明,牙科治疗椅水系统细菌污染主要由放线菌、葡萄球菌和大肠杆菌等等引起。根据目前临床的标准,牙科治疗的供应用水不完全符合微生物学要求的微生物参数,由于牙椅使用的消毒模式和每天频率和年限也不同,其被污染的可能性和程度也不一样,使用的水管道中的细菌污染及主要的可疑致病菌除了目前研究常见的几种之外还有哪些是危险致病菌,是本课题研究的目的。综上所述,牙科治疗椅供水系统中的细菌污染,已经是医源性感染重要危险因素,对牙科用水的消毒和微生物监控也成为目前院感工作者关心的问题之一。目的:本研究的目的是调查某大型口腔医院牙科治疗椅中高速手机及其接头的供水系统管道遭到口腔细菌污染的情况,借此通过高速手机水路调查了解管道细菌污染的现状,探究进一步改进消毒手段的必要性及相关策略。方法:对经过常规消毒的牙科治疗椅进行采样。随机抽取医院20台牙科治疗椅的水样(从高速手机取样),设为系统水样(20例),同时取得实验室蒸馏水样(1例)作为阴性对照。封口后存放在-4℃环境下待测,随机抽取样本5例做16s高通量测序后拟订可疑微生物,采用定量PCR检测供水系统内的伯克氏菌和变异蛋白菌分布,为院感控制提供实验数据和依据。结果:通过一般培养的方法,结果表明牙科治疗椅的医生用高速手机中均验出以10秒组培养结果菌数最多,检测结果符合国家标准要求。16sDNA的筛选结果表明葡萄球菌、链球菌、放线菌,放线菌居多。而在定量PCR的实验中显示伯克氏菌及变异蛋白菌在检出的微生物中占据重要位置。结论:在这次分子生物检验结果中可以确认,Burkholderia和Proteobacteria两种细菌确实存在在牙科综合治疗椅里,其在水道中的含量可能与使用频率相关。如何防止细菌污染和主要种的细菌病防治需要进一步的研究和探讨.总之,它已被证明严重的牙科水系统污染,不仅仅是钻消毒问题的一部分,而是最重要的医院内感染。水的使用和预防和控制口腔消毒是当务之急。在PCR研究中洁牙机的含量相对都是高于其他水样本的。而与蒸馏水的阴性对照相比两个菌种都是很明显的增高。综上所述伯克氏菌及变异蛋白菌都是高含量存在于用水量多的牙科综合治疗椅中的(p<0.05)。

关键词：牙科治疗椅高速手机伯克氏菌变异蛋白菌

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CFBR-Ⅱ堆增殖反应性转换系数计算

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计算物理 2010年第6期27卷 799-804页

作者：尹延朋郑春黄坡中国工程物理研究院核物理与化学研究所四川绵阳621900

CFBR-Ⅱ堆增殖反应性转换系数是利用源倍增方法获取次临界反应性的关键参数,该参数在多次标定实验中数值不同,为了解释该现象,从输运方程出发,对中子源倍增方法增殖反应性转换系数进行推导;针对不同反应性的CFBR-Ⅱ堆,采用蒙特卡罗方法... 详细信息

CFBR-Ⅱ堆增殖反应性转换系数是利用源倍增方法获取次临界反应性的关键参数,该参数在多次标定实验中数值不同,为了解释该现象,从输运方程出发,对中子源倍增方法增殖反应性转换系数进行推导;针对不同反应性的CFBR-Ⅱ堆,采用蒙特卡罗方法,对表达式中的每个参量进行计算,得到不同反应性下的增殖反应性转换系数.通过分析得出,增殖反应性转换系数取决于缓发中子份额、外源中子的相对价值、增殖系统和替代系统的泄露几率比及探测器的探测效率比;CFBR-Ⅱ堆增殖反应性转换系数不是常数,而是随反应性变化的.

关键词：增殖反应性蒙特卡罗方法

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