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生物医学领域碳纳米材料10年研究前沿与热点

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中国组织工程研究 2025年第4期29卷 752-760页

作者：党小雯黄海量黄雷王亚洁山东中医药大学康复医学院山东省济南市250355

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索... 详细信息

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索研究热点及发展趋势,为此领域未来发展提供参考。方法:以Web of Science核心集数据库为文献来源,检索2012-2023年生物医学领域碳纳米材料的相关文献,运用Citespace软件以国家、机构、作者、关键词、共被引为节点生成知识图谱并进行可视化分析。结果与结论:①共纳入2932篇文献,碳纳米材料在医学领域年发文量多且增长速度较快;美国发文量较多;中国是该领域的新兴力量,发文量虽然最多,但研究水平和影响力还有待提高;中国科学院是最大的合作网络机构,主要以国内机构为合作对象,缺少与国外知名单位的合作。②关键词分析显示,碳点的绿色合成方式及应用是近年来的研究热点;其次碳纳米材料与癌症光疗、免疫疗法相结合的新方法是未来研究中的重点方向。③共被引动态发展趋势提示,组织工程是生物医学领域碳纳米材料的热点研究主题,主要包括碳纳米材料对于心脏和神经组织修复和再生的研究以及作为3D和4D生物打印的生物墨水添加剂。④未来随着生物医学领域朝着以治疗为中心的精准方向发展,科研人员应加快创建科学有效的碳纳米材料与科技、新型聚合物或有机分子及新治疗方法等结合形成的碳基体系,发挥碳纳米材料的最大效应。

关键词：碳纳米材料生物医学可视化共被引文献计量学生物安全性研究热点癌症组织工程 Citespace

Spatial distribution of Agriophyllum squarrosum Moq. (Chenopodiaceae) in the straw checkerboards at a revegetated land of the Tengger Desert, northern China

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Journal of Arid Land 2017年第2期9卷 176-187页

作者： huang lei Shapotou Desert Research and Experimental Station Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou 730000 China Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province Lanzhou 730000 China

The present study focuses on straw checkerboards established in the Shapotou Desert Research and Experimental Station at the southeastern edge of the Tengger Desert and their effects on the species richness and the abundance of Agriophyllum squarrosu Moq. Specifically, detailed analyses on the spatial distribution of A. squarrosum and the related soil properties were carried out at a small scale in the straw checkerboards. A. squarrosum is an excellent pioneer plant for revegetation in desert areas. However, the distribution pattern of A. squarrosum and the influencing factors have not been sufficiently delineated. The results showed that the species richness and the abundance of A. squarrosum were decreased exponentially from the border to the center of the straw checkerboards. At the micro-geomorphological scale, the soil texture, soil organic matter （SOM）, soil nutrients （nitrogen, phosphorus and potassium）, and soil infiltration rate in the topsoil tended to increase from the center to the border within a straw checkerboard, while soil moisture presented an opposite tendency. The soil seed bank ofA. squarrosum, soil bulk density, electrical conductivity, sand content, CaCO3 accumulation, and pH showed no significant difference （P〉0.05） between the border and the center of the straw checkerboards. Multiple linear regression analysis indicated that the abundance of A. squarrosum was mainly determined by the concentrations of SOM, nitrogen, and the infiltration rate, implying that nutrient acclimation was the optimal competitive strategy ofA. squarrosum for surviving in a barren natural environment of an arid desert region.

关键词： Agriophyllum squarrosum seed banks soil moisture soil infiltration rate nutrient acclimation

A Class of Constacyclic Codes over Ring R+vR

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Journal of Systems Science & Complexity 2016年第3期29卷 805-813页

作者： huang lei ZHU Shixin School of Mathematics Hefei University of Technology

By constructing a Gray map, a class of constacyclic codes over ring R = R＋ vR is studied. Using cyclic codes and negacyclic codes of length p^s over ring R, the structure of （1 - 2v）-constacyclic codes and dual codes of length p^s over ring R are given, the Gray images of （1 - 2v）-constacyclic codes in a particular case are also studied. It is shown that linear codes of length pS over ring R are （1 -2v）-constacyclic codes if and only if their Gray images are distance-invariant cyclic codes of length 2p^s over ring R.

关键词： Constacyclic code cyclic code dual code Gray map.

Measurement of self-development capacity in the contiguous destitute mountainous areas, China

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Journal of Mountain Science 2021年第6期18卷 1646-1661页

作者： XUE Yao-zu huang lei School of Humanities and Social Sciences Xi'an Jiaotong UniversityXi'an 710049China Research Institute of Transition of Resource-based Economics Shanxi University of Finance&EconomicsTaiyuan 030006China

Affected by the mountainous location and ecological vulnerability, the incidence of poverty in contiguous destitute mountainous areas is higher than that in other regions of China. Regional selfdevelopment capacity is an internal driving force for poverty reduction in contiguous destitute mountainous areas. This study selects 17 indicators from the four dimensions: industrial capacity, market capacity, spatial capacity and soft power to measure the overall self-development capacity of 658 counties in 14 different mountain areas in China. The results show that self-development capacity is at a low level and the development of the different regions is unbalanced. The self-development capacity is low in the southwest and high in the east and "low in the middle, high around" in each study region. It has achieved a certain degree of improvement in 2011, 2013 and 2015. From the perspective of the four dimensions, industrial capacity is the constraint on the promotion of self-development capacity. Based on this, we should develop green industries in line with local realities and achieve industrial poverty eradication, but the expansion of space capacity should take into account the resources and environmental carrying capacity in these areas and should not be blindly expanded. Local leaders should be made to improve the local education level and public service level, improve social infrastructure, develop reserve strength for the future, and enhance future development potential.

关键词： Regional self-development capacity Contiguous Destitute Mountainous Areas Industrial capacity Market capacity Soft power

Base communication model of IP covert timing channels

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Frontiers of Computer Science 2016年第6期10卷 1130-1141页

作者： Changda WANG Yulin YUAN lei huang School of Computer Science and Communication Engineering Jiangsu University Zhenjiang 212013 China

IP covert timing channel （IPCTC） is an unconventional communication channel which attaches time information to the packets of an overt channel as messages carders, e.g., using different inter-packet delays to transmit messages in a packet-switched network. Although the IPCTCs have many different communication methods, based on the concept of time, we categorized the base communication model of the IPCTCs into three types and then utilized the signal processing theory to build their mathematical models. As a result, the basic characteristics of the IPCTCs＇ base model were formally derived. Hence, the characteristics of any IPCTC can be derived from the base models that consist of the IPCTC. Furthermore, a set of approaches was devised to implement the base model of the IPCTCs in a TCP/IP network. Experimental results show the correctness of the pro- posed base model of the IPCTCs in this paper.

关键词： network timing channel base communication model bandwidth error rate stealthiness

Prediction model of slurry pH based on mechanism and error compensation for mineral flotation process

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Chinese Journal of Chemical Engineering 2018年第8期26卷 1766-1772页

作者： Xiaoli Wang lei huang Chunhua Yang School of Information Science and Engineering Central South University

A suitable pH value of the slurry is a key to efficient mineral flotation. Considering the control delay problem of pH value caused by offline pH measurement, an integrated prediction model for pH value in bauxite froth flotation is proposed, which considers the effect of ore compositions on pH value. Firstly, a regression model is obtained for alkali(Na_2CO_3) consumed by the reaction between ore and alkali. According to the first-order hydrolysis of the remaining alkali, a mechanism-based prediction model is presented for the pH value. Then, considering the complexity of the flotation mechanism, an error prediction model which uses time series of the error of the mechanism model as inputs is presented based on autoregressive moving average(ARMA) method to compensate the mechanism model. Finally, expert rules are established to correct the error compensation direction, which could reflect the dynamic changes during the process accurately and effectively. Simulation results using industrial data show that the presented model meets the needs of the industrial process, which laid the foundation for predictive control of pH regulator.

关键词： Froth flotation PH value prediction Hydrolysis Mechanism model ARMA Expert rule

MEAN-VARIANCE MODEL BASED ON FILTERS OF MINIMUM SPANNING TREE

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Journal of Systems Science and Systems Engineering 2011年第4期20卷 495-506页

作者： Feixue huang lei SUN Yun WANG 1Economics School Faculty of Management and Economics Dalian University of Technology Dalian 116024 China

This study aims to reduce the statistical uncertainty of the correlation coefficient matrix in the mean-variance model of Markowitz. A filtering algorithm based on minimum spanning tree （MST） is proposed. Daily data of the 30 stocks of the Hang Seng Index （HSI） and Dow Jones Index （DJI） from 2004 to 2009 are selected as the base dataset. The proposed algorithm is compared with the Markowitz method in terms of risk, reliability, and effective size of the portfolio. Results show that （1） although the predicted risk of portfolio built with the MST is slightly higher than that of Markowitz, the realized risk of MST filtering algorithm is much smaller; and （2） the reliability and the effective size of filtering algorithm based on MST is apparently better than that of the Markowitz portfolio. Therefore, conclusion is that filtering algorithm based on MST improves the mean-variance model of Markowitz.

关键词： Mean-variance model correlation matrix minimum spanning tree (MST) portfoliooptimization

Closed form of the inverse Plücker correspondence in line geometry

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Science China Mathematics 2019年第12期62卷 2617-2630页

作者： lei Dong Hongbo Li lei huang Changpeng Shao Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems ScienceChinese Academy of Sciences

By mapping the homogeneous coordinates of two points in space to the Plücker coordinates of the line they determine, any transformation of type SL(4) upon points in space is mapped to a transformation of type SO0(3, 3), the latter being the connected component containing the identity of the special orthogonal transformation group of the linear space spanned by Plücker coordinates. This is the classical Plücker correspondence, two-to-one and onto. It has important applications in line geometry and projective *** the explicit form of Plücker correspondence is trivial to present, its inverse in explicit form, which is also important in application, is not found in the literature. In this paper, we present a simple and unified formula for the inverse of the Plücker correspondence.

关键词： Plücker correspondence inverse Plücker correspondence line geometry SL(4) SO(3,3)

Nanograins on Ti-25Nb-3Mo-2Sn-3Zr alloy facilitate fabricating biological surface through dual-ion implantation to concurrently modulate the osteogenic functions of mesenchymal stem cells and kill bacteria

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Journal of Materials Science & Technology 2021年第14期73卷 31-44页

作者： Run huang lei Liu Bo Li Liang Qin lei huang Kelvin W.K.Yeung Yong Han School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina State-key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi'an710049China Department of Gastrointestinal Surgery Hubei Cancer HospitalWuhan430060China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053China

Surface mechanical attrition treatment(SMAT)method is an effective way to generate nanograined(NG)surface on Ti-25 Nb-3 Mo-2 Sn-3 Zr(wt.%)(named as TLM),a kind ofβ-type titanium alloy,and the achieved nanocrystalline surface was proved to promote positive functions of osteoblastic *** this work,to further endow the NG TLM alloy with both good osteogenic and antibacterial properties,magnesium(Mg),silver(Ag)ion or both were introduced onto the NG TLM surface by ion implantation process,as a comparison,the Mg and Ag ions were also co-implanted onto coarsegrained(CG)TLM *** obtained results show that subsequent ion implantation does not remarkably induce the surface roughness and topography alteration of the SMAT-treated layers,and it also has little impact on the microstructure of the SMAT-derivedβ-Ti *** addition,the implanted Mg and Ag ions are observed to exist as MgO and metallic Ag na noparticles(NPs)embedding tightly in theβ-Ti matrix with grain size of about 15 and 7 nm,*** cell adhesion and functions(including proliferation,osteo-differentiation and extracellular matrix mineralization)of rabbit bone marrow mesenchymal stem cells(rBMMSCs)and the bacterial colonization of Staphylococcus aureus(***)on the different surfaces were *** in-vitro experimental results reveal that the Mg and Ag single-ion implanted NG surface either significantly promotes the rBMMSCs response or inhibits the growth ***,whereas the Mg/Ag coimplanted NG surface could concurrently enhance the rBMMSCs functions as well as inhibit the bacterial growth compared to the NG surface,and this efficacy is more pronounced as compared to the Mg/Ag co-implantation in the CG *** SMAT-achieved nanograins in the TLM surface layer are identified to not only play a leading role in determining the fate of rBMMSCs but also facilitate fabricating dualfunctio nal surface with both good osteogenic and antibacterial activities through co-imp

关键词： β-Type titanium Nanograined surface Ion implantation Stem cells Antibacterial property