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SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

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BIOCELL 2024年第3期48卷 453-462页

作者： JIYU WANG LIUYING YI keke huang YANGYANG WANG HUIPING WANG ZHIMIN ZHAI Department of Hematology The Second Affiliated Hospital of Anhui Medical UniversityHefei230601China Department of Hematology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China

Background:The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma(r/r B-NHL)is resistance to current therapies,and therapy-induced senescence(TIS)stands out as a crucial mechanism contributing to tumor drug ***,we analyzed SENEX/Rho GTPase Activating Protein 18(ARHGAP18)expression and prognostic signiﬁcance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients,investigating its target in B-NHL cell senescence and the effect of combining speciﬁc inhibitors on apoptosis resistance in B-NHL-TIS ***:Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector(Sh-SENEX)and the empty vector negative(NC)to construct a stable transfection cell line with knockdown of *** of SENEX-silencing on B-NHL-TIS formation,cell function and cell cycle-related pathways was *** doxorubicin(DOX)-inducible senescent B-NHL cells combined with the speciﬁc cyclin dependent kinase 4/6(CDK4/6)inhibitor Palbociclib to observe that blocking CDK4/6 effects on TIS *** expression of 21 B-NHL patients and 8 healthy controls were analyzed by qRT-PCR,and the correlation between its expression and clinical indicators were ***:The downregulation of SENEX expression promotes G1-S phase transition and apoptosis while inhibiting cell proliferation,collectively suppressing the formation of TIS in *** of CDK4/6 promotes the DOX-induced G1 phase arrest to enhance TIS formation in B-NHL cells which can reverse the regulatory effect of silencing SENEX on B-NHL cell cycle regulation and *** expression levels of SENEX were notably elevated in B-NHL patients compared to healthy controls,and Elevated expression levels of SENEX were associated with poor prognosis of B-NHL ***:SENEX enhances apoptosis resistance in B-NHL by inhibiting CDK4/6,thereby preventing G1-S phase transition and promoting TIS formation.

关键词： SENEX B-cell non-Hodgkin lymphoma CDK4/6 G1-S phase transition Therapy-induced senescence Apoptosis resistance

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An emerging platform for electrocatalysis: perovskite exsolution

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Science Bulletin 2016年第23期61卷 1783-1784页

作者： keke huang State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University

The design of cost-effective, highly active, stable electro- catalysts for oxygen reduction reaction （ORR） and oxygen evolution reaction （OER） is a critical element in the development of a new generation of energy technologies （e.g., fuel cells, metal-air batteries） because the ORR and OER are inherently sluggish and require large over-po- tentials to drive a complex four-electron process.

关键词：电催化剂钙钛矿平台金属空气电池氧还原反应燃料电池能源技术析氧反应

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The relationship between dolomite textures and their formation temperature: a case study from the Permian-Triassic of the Sichuan Basin and the Lower Paleozoic of the Tarim Basin

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Petroleum Science 2014年第1期11卷 39-51页

作者： huang Sijing huang keke Lü Jie Lan Yefang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology Institute of Sedimentary Geology Chengdu University of Technology College of Earth Sciences Chengdu University of Technology

Study of dolomite texture can contribute to understanding the process of *** research reports textures and homogenization temperatures of dolomites from the Permian-Triassic strata in the Sichuan Basin and the Lower Paleozoic strata in the Tarim Basin,which provided insights into relationships between dolomite textures and their formation *** results are summarized as follows：1） dolomites with well-preserved texture indicate low dolomitization ***,in certain diagenetic environments,the hydrothermal dolomitization may completely or partially preserve the original texture of dolomites.2） The formation temperatures of non-planar dolomites are always higher than those of planar dolomites.3） The formation temperatures of dolomite cements are generally higher than those of replacive dolomites.4） Although the formation temperatures of saddle dolomite cements have a wide range,they show higher values than those of the planar subhedral to euhedral dolomite ***,saddle dolomites could generally be an indicator of high precipitation temperature.5） The fluid Mg/Ca ratio is another element controlling dolomite *** dolomites,which precipitate from hypersaline fluids with a high Mg/Ca ratio in a subaerial environment could also have features of non-planar anhedral crystal shape because of rapid nucleation and crystallization during dolomitization.

关键词： The Permian-Triassic of the Sichuan Basin the Lower Paleozoic of the Tarim Basin dolomite textures formation temperature of dolomites

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Smart manufacturing of nonferrous metallurgical processes:Review and perspectives

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 611-625页

作者： Bei Sun Juntao Dai keke huang Chunhua Yang Weihua Gui School of Automation Central South UniversityChangsha 410083China Peng Cheng Laboratory Shenzhen 518000China

The nonferrous metallurgical(NFM)industry is a cornerstone industry for a nation’s *** the development of artificial technologies and high requirements on environment protection,product quality,and production efficiency,the importance of applying smart manufacturing technologies to comprehensively percept production states and intelligently optimize process operations is becoming widely recognized by the *** a brief summary of the smart and optimal manufacturing of the NFM industry,this paper first reviews the research progress on some key facets of the operational optimization of NFM processes,including production and management,blending optimization,modeling,process monitoring,optimization,and ***,it illustrates the perspectives of smart and optimal manufacturing of the NFM ***,it discusses the major research directions and challenges of smart and optimal manufacturing for the NFM *** paper will lay a foundation for the realization of smart and optimal manufacturing in nonferrous metallurgy in the future.

关键词： nonferrous metallurgical industry smart and optimal manufacturing online perception intelligent control operational optimiza-tion automation of knowledge-based work

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Label propagation dictionary learning based process monitoring method for industrial process with between-mode similarity

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Science China(Information Sciences) 2022年第1期65卷 39-55页

作者： keke huang Shijun TAO Yishun LIU Chunhua YANG Weihua GUI School of Automation Central South University

With the development of the industrial cyber-physical systems, a small amount of labeled data and a large amount of unlabeled data are collected from the industrial process. Due to the variation of internal operation conditions and external environment, there is a between-mode similarity between data samples. The scarcity of labeled data and the existence of similarity make it challenging to extract data characteristics. In addition, it creates new challenges to process monitoring. To solve these problems, this study proposes a label propagation dictionary learning method. We first establish the connection between atoms and corresponding profiles and realize the propagation of their labels through graph Laplacian regularization. Then, considering the similarity of samples in the same class, the low-rank constraint is added to sparse coding to strengthen the mutual propagation of labels. Finally, an optimization method is designed to obtain the dictionary and classifier simultaneously. When new data samples arrive, we conduct process monitoring and condition prediction based on the learned dictionary and classifier. Experiments show that the proposed method can achieve satisfactory monitoring performance when compared to several state-of-the-art methods, indicating the superiority of the proposed method.

关键词： process monitoring label propagation dictionary learning between-mode similarity graph Laplacian regularization

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Saddle-Dolomite-Bearing Fracture Fillings and Records of Hot Brine Activity in the Jialingjiang Formation,Libixia Section,Hechuan Area of Chongqing City

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Acta Geologica Sinica(English Edition) 2016年第1期90卷 195-208页

作者： huang keke ZHONG Yijiang huang Sijing LI Xiaoning FENG Mingshi State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology Institute of Sedimentary Geology Chengdu University of Technology

Most vein minerals deposited in fractures of the Jialingjiang Formation from Libixia section, Hechan area include a large amount of saddle dolomite and accompanying celestite, calcite and fluorite. This study analyzed the nature, source, evolution of the fluids by plane-light petrography, fluid-inclusion methods, cathodoluminescence images, and stable isotopic compositions. The homogenization temperatures of two-phase aqueous fluid inclusions in dolomite range between 100 and 270℃. Combined with the jlSO data, it is suggested that the fluid responsible for the precipitation of fracture fillings have δ18O values between 10%o and 18‰ （relative to SMOW）. The saddle dolomite and the accompanying minerals were the result of activity of dense brines at elevated temperatures. Moreover, analysis shows that the fluid was derived from a mixture of marine-derived brine and deeper circulating flow. This fluid was enriched in Sr during diagenesis and formed celestite in fracture and for regional mineralization. Dissolution of saddle dolomite was attributed to the cooling of Mg/Ca-decreased fluids, which may relate to a leaching of gypsum to celestite in surrounding carbonates.

关键词： Libixia section Jialingjiang Formation saddle dolomite hot brine Hechuan area Chongqing

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Surface polarization enables high charge separation in TiO_(2) nanorod photoanode

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Nano Research 2021年第11期14卷 4056-4062页

作者： Wei Ma keke huang Xiaofeng Wu Meng Wang Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry NMAC International Joint LaboratoryCollege of ChemistryJilin UniversityChangchun130012China

Poor charge separation efficiency of semiconductors often stands in the way of photoelectrochemical (PEC) water splitting realization. In this report, a surface polarized TiO_(2) photoanode is obtained via −OH moiety decoration, which achieves a fundamentally improved charge separation efficiency of about 94% at 1.23 VRHE. Detailed data shows that these hydroxyls with electric dipoles polarize the surface, inducing substantial electric field in the surface region, and elevating band edges so as to form a homojunction within TiO_(2). Such serves as the direct driving force for the photogenerated charge separation and migration. Moreover, these hydroxyls also facilitate water oxidation kinetics. Without typical doping or cocatalyst, surface polarized TiO_(2) photoanode delivers a considerably increased photocurrent density of about 1.41 mA·cm^(−2) at 1.23 VRHE (AM 1.5 G) and a cathodic shift on onset potential over 200 mV. This report highlights new opportunities to modulate charge separation by surface polarization for the construction of robust photoanodes.

关键词： TiO_(2)nanorod hydroxyls surface polarization charge separation photoelectrochemical water splitting

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“医院—社区—家庭”一体化管理模式对老年骨质疏松患者健康的影响研究

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当代体育科技 2024年第26期14卷 12-16页

作者：黄可可胡忠忠陈熙温州医科大学体育科学部浙江温州325035

目的:研究旨在评估“医院—社区—家庭”一体化管理模式对骨质疏松患者的影响。方法:在社区募集90名60岁以上老年骨质疏松患者,随机分为综合管理组和对照组。综合管理组患者采用“医院—社区—家庭”一体化管理模式进行综合干预,对照组... 详细信息

目的:研究旨在评估“医院—社区—家庭”一体化管理模式对骨质疏松患者的影响。方法:在社区募集90名60岁以上老年骨质疏松患者,随机分为综合管理组和对照组。综合管理组患者采用“医院—社区—家庭”一体化管理模式进行综合干预,对照组除医院治疗外,不进行其他干预。在随访开始前和随访6个月后,进行骨密度、疼痛程度、简易生命质量(SF-36)和疾病认知等指标的评价。结果:6个月干预后,综合管理组和对照组的骨密度无显著性改变,但是疼痛程度和疾病认知水平显著改善(P<0.01),且综合管理组的改善程度显著高于对照组。同时,综合管理组SF-36评价的多个维度,如健康水平、体能、情绪、社会功能等均有显著改善(P<0.01),而对照组则无显著性改变。结论:采用“医院—社区—家庭”一体化管理模式可以有效降低骨质疏松患者的疼痛感,提升生活质量,促进疾病认知。该管理模式为骨质疏松症的综合管理提供了重要的实践指导和临床参考。

关键词：老年人骨质疏松症 “医院—社区—家庭”健康管理模式随机对照 SF-36

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New perspective on the synthesis of highly efficient composites:regulating influence distance of interfacial charge transfer

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Science Bulletin 2018年第4期63卷 203-205页

作者： keke huang Zhibin Geng Yu Sun Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University

Interface effect is one of the central topics for decades[1–3].For inorganic composites,interface effect is mainly induced by interface stress[4]and interface charge transfer[4–6],in which interface charge transfer ... 详细信息

关键词：费用距离界面调整合成电子状态化学性质接口

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Epitaxial thin film of SmFeO_3 ferroelectric heterostructures

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Science China Chemistry 2014年第6期57卷 803-806页

作者： SI WenZhe huang keke WU XiaoFeng FENG ShouHua State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin University

Epitaxial growth of SmFeO3/SrRuO3 was achieved on SrTiO3 substrates by the pulsed laser deposition(PLD)method at 973 K under oxygen partial pressure of 12.5 *** Fe2+leakage was detected in our SmFeO3 *** remanent polarization and coercive electric field of the thin film with a higher degree of orientation along(110)were 1.97μC/cm2 and 0.89×104 V/cm at room temperature,*** film showed enhanced canted antiferromagnetism spin ordering compared with its corresponding powder materials.

关键词： ferroelectric materials thin films solid-oxide

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