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Measurement of the free concentrations of alkyl phenols and bisphenol A to determine their biodegradation kinetics by activated sludge

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Chinese Science Bulletin 2007年第20期52卷 2766-2770页

作者： SHEN Gang huang jun YU Gang Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

A negligible depletion-solid phase microextraction (nd-SPME) method is developed to measure free concentrations of two alkyl phenols (4-t-octylphenol, nonylphenol) and bisphenol A in activated sludge, with which aerobic biodegradation kinetics of three pollutants was determined. For the degradation of octylphenol, nonylphenol and bisphenol A, the apparent rate constant based on total concentration is 0.02, 0.01 and 0.03 h-1, respectively; with the half life being 34.9, 54.3 and 22.3 h correspondingly. Meanwhile, real rate constants based on free concentration are 0.74, 0.60 and 1.03 h-1, respectively; with the half life being 0.9, 1.2 and 0.7 h accordingly. Differences between two constants revealed that desorption of targeted pollutants from activated sludge should be the rate-limiting step. Compared to the rapid biodegradation of alkyl phenols and bisphenol A in free state, the desorption of pollutants from the sludge is relatively slow, which made the apparent biodegradation rate constants much lower.

关键词：烷基酚 2,2-双对羟苯基丙烷生物降解化学分析

Effect of Internet+continuous midwifery service model on psychological mood and pregnancy outcomes for women with highrisk pregnancies

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World Journal of Psychiatry 2023年第11期13卷 862-871页

作者： Cao-jun huang Wei Han Cui-Qin huang Delivery Room Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Department of Maternity Ward Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND There are many drawbacks to the traditional midwifery service management model,which can no longer meet the needs of the new *** Internet+continuous midwifery service management model extends maternal management from prenatal to postpartum,in-hospital to out-of-hospital,and offline to online,thereby improving maternal and infant *** the Internet+continuous midwifery service management model to manage women with highrisk pregnancies(HRP)can improve their psycho-emotional opinion and,in turn,minimize the risk of adverse maternal and/or fetal *** To explore the effectiveness of a midwife-led Internet+continuous midwifery service model for women with *** We retrospectively analyzed the clinical data of 439 women with HRP who underwent prenatal examination and delivered at Shanghai Sixth People's Hospital(affiliated to the Shanghai Jiao Tong University School of Medicine)from April to December *** them,239 pregnant women underwent routine obstetric management,and 200 pregnant women underwent Internet+continuous midwifery service mode *** used the State-Trait Anxiety Inventory,Edinburgh Postnatal Depression Scale,and analysis of delivery outcomes to compare psychological mood and the incidence of adverse delivery outcomes between the two *** The data showed that in early pregnancy,the anxiety and depression levels of the two groups were similar;the levels gradually decreased as pregnancy progressed,and the decrease in the continuous group was more significant[31.00(29.00,34.00)vs 34.00(32.00,37.00),8.00(6.00,9.00)vs 12.00(10.00,13.00),P<0.05].The maternal self-efficacy level and strategy for weight gain management were better in the continuous group than in the traditional group,and the effective rate of midwifery service intervention in the continuous group was significantly higher than in the control group[267.50(242.25,284.75)vs 256.00(233.00,278.00),74.00(69.00,78.00)vs 71.00(63.00,78.00),P<0.05

关键词： Internet+continuous midwifery service High-risk-pregnancy management Psychological mood Pregnancy outcome Traditional midwifery service model Midwife

Microstructure evolution of rare earth Pr modified alumina-silicate short fiber-reinforced Al-Si metal matrix composites

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Rare Metals 2009年第2期28卷 164-168页

作者： Peng Jihua Li Wenfang huang Fangliang Tian jun Liu Gang Du jun S China Univ Technol Sch Mat Sci & Engn Guangzhou 510640 Guangdong Peoples R China

Al-Si metal matrix composites (MMCs) reinforced with 20 vol.% alumina-silicate shot fibers (Al2O3-SiO2(sf)) were fabricated by an infiltration squeeze method. Pure Pr metal was added into these composites. The effect of Pr addition on the microstructure evolution of Al-Si MMCs was investigated by SEM,TEM,and EDS. Pr addition is favorable to make uniform microstructures with the modified eutectic Si crystal. PrAlSi phase with high contents of Pr and Si is observed on the interface between the fiber and the m...

关键词： metal matrix composite microstructure evolution microscope Al-Si alloys rare earth

Natural okra-based hydrogel for chronic diabetic wound healing

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Chinese Chemical Letters 2023年第8期34卷 248-253页

作者： Peikun Xin Shuyan Han jun huang Conglai Zhou Jiayuan Zhang Xinru You jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Guizhou University of Chinese Traditional Medicine Guiyang 550025China School of Life Science Jilin UniversityChangchun 130012China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina

As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound *** edible natural biomaterials rich in terpenes,phenols,and flavonoids can act as efficient *** this study,okra extract was selected as the main component of a wound *** okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple *** robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production,thereby accelerating the wound healing *** results showed that okra extracts and their hydrogel dressings increased cell migration,angiogenesis,and re-epithelization of the chronic wound area,considerably promoting wound remodeling in diabetic ***,okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications.

关键词： Okra Antioxidant Angiogenesis Wound healing Tissue engineering

Targeting the Rac1 pathway for improved prostate cancer therapy using polymeric nanoparticles to deliver of NSC23766

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Chinese Chemical Letters 2022年第5期33卷 2496-2500页

作者： Zean Li jun huang Tao Du Yiming Lai Kaiwen Li Man-Li Luo Dingjun Zhu jun Wu Hai huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510220China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Obstetrics and Gynecology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China

Prostate cancer(PCa)is the second most commonly diagnosed cancer in *** Rac1-GTP inhibitor NSC23766 has been shown to suppress PCa ***,these therapies have low tumor-targeting efficacy in ***,it is essential to produce a drug delivery system that specifically targets the tumor ***,novel l-phenylalanine-based poly(ester amide)(Phe-PEA)polymers were synthesized and loaded with NSC23766(NSC23766@8P6 NPs),which had a small particle size(162.3±6.7nm)and high NSC23766 loading(8.0%±1.1%)with a more rapid release of NSC23766 at pH *** vitro cellu-lar uptake and cytotoxicity assays demonstrated that NSC23766@8P6 NPs were rapidly taken up by PC3 cells and showed significant effects of PCa cell proliferation inhibition and G2/M phase ***-more,in vivo studies using PC3-bearing mice demonstrated that NSC23766@8P6 NPs delivered by in-travenous injection not only increased the drug concentration with prolonged retention(96h)at the tumor site,but also inhibited tumor growth and induced *** conclusion,we have discovered that NSC23766@8P6 NPs can serve as a delivery system that targets the tumor site and is therefore a promising therapeutic approach for PCa treatment.

关键词： Prostate cancer NSC23766 Rac1 Nanoparticle Poly(ester amide)

Evaluation of sensory function and recovery after replantation of fingertips at ZoneⅠin children

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Neural Regeneration Research 2017年第11期12卷 1911-1917页

作者： Zhao-wei Zhu Xiao-yan Zou Yong-jun huang Jiang-hui Liu Xi-jun huang Bo He Zeng-tao Wang Department of Plastic Surgery the First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong ProvinceChina Department of Orthopedics and Microsurgery the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics Guangdong Second Provincial General HospitalGuangzhouGuangdong ProvinceChina Department of Emergency the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Hand and Foot Surgery Provincial Hospital Affiliated to Shandong UniversitylinanShandong ProvinceChina

Sensory function is the most significant criterion when evaluating the prognosis of replanted fingers. Current clinical research has focused on surgical techniques and indications for finger replantation; however, few studies have focused on recovery of finger sensory function af- ter replantation. This study retrospectively assessed data of eight patients who had undergone nine Zone I replantations of the fingertips in the First Affiliated Hospital of Sun Yat-sen University of China from July 2014 to January 2016. Variations in the extent of damage, with the residual vessels or nerves in some fingers being too short or even missing, prevented tension-free suture repair in some patients. Thus, re- pair of four of the nine fingertips included arteriovenous anastomosis, the remaining five undergoing arterial anastomosis during replanta- tion of the amputated fingers. Three patients underwent nerve repair, whereas the remaining six cases did not. Fingertip replantations were successful in all eight patients. Compared with the patients without vascular anastomosis, no obvious atrophy was visible in the fingertips of patients who did undergo vascular anastomosis during replantation and their sensory function did recover. Fingertip replantation pro- vides good sensory function and cosmetic outcomes when good artery and vein anastomoses have been created, even when digital nerves have not been repaired.

关键词： nerve regeneration fingertip replantation neurological function microsurgery hand surgery anatomy plastic surgery blood vessels neural regeneration

A Fiber Optic Sensor for 2-cholrophenol Analysis based on Oxygen Sensing System

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Journal of Wuhan University of Technology(Materials Science) 2014年第6期29卷 1178-1182页

作者：贡晶晶 huang Xinting huang jun DING Liyun LI Kun YUAN Yinquan National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of Technology Key Laboratory of Fiber Optic Sensing Technology and Information Processing (Wuhan University of Technology) Ministry of Education Faculty of Mechanical & Electronic Information China University of Geosciences

A fiber optic 2-cholrophenol（2-CP） sensor was developed based on the fluorescence quenching of molecular oxygen on the oxygen-sensitive membrane and O2 consumption during catalytic oxidation reaction of 2-CP. The 2-CP concentration can be determined by utilizing a lock-in amplifier to measure the change in the fluorescence lifetime of an oxygen-sensitive membrane, in which the tris（2,2′-bipyridyl） ruthenium（II） chloride complexes（Ru（II）（byp）3Cl2） were immobilized in cellulose acetate（CA） via simple hybridized approach. The experimental results show the good linear relationship between the phase delay of sensitive membrane and 2-CP concentration in its detection range of 1×10-7 to 1×10-5 mol/L and 1×10-5 to 1×10-4 mol/L. The detection limit of the sensor is 7×10-8 mol/L（S/N=3） and the response time is 5 min. Our experimental measurements confirmed good response characteristics of the as-prepared fiber optic 2-CP sensor, as well as its capability to detect the 2-CP concentration in practical water samples.

关键词： fiber optic sensor 2-chlorophenol oxygen-sensitive membrane fluorescence quenching

Incremental Multi-Label Learning with Active Queries

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Journal of Computer Science & Technology 2020年第2期35卷 234-246页

作者： Sheng-jun huang Guo-Xiang Li Wen-Yu huang Shao-Yuan Li College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Pattern Analysis and Machine Intelligence Ministry of Industry and Information Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing University Nanjing 210023China

In multi-label learning,it is rather expensive to label instances since they are simultaneously associated with multiple ***,active learning,which reduces the labeling cost by actively querying the labels of the most valuable data,becomes particularly important for multi-label learning.A good multi-label active learning algorithm usually consists of two crucial elements:a reasonable criterion to evaluate the gain of querying the label for an instance,and an effective classification model,based on whose prediction the criterion can be accurately *** this paper,we first introduce an effective multi-label classification model by combining label ranking with threshold learning,which is incrementally trained to avoid retraining from scratch after every *** on this model,we then propose to exploit both uncertainty and diversity in the instance space as well as the label space,and actively query the instance-label pairs which can improve the classification model *** experiments on 20 datasets demonstrate the superiority of the proposed approach to state-of-the-art methods.

关键词： active learning multi-label learning uncertainty diversity

Characterization and Saturable Absorption Property of Graphene Oxide on Optical Fiber by Optical Deposition

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Journal of Wuhan University of Technology(Materials Science) 2017年第4期32卷 882-887页

作者：丁莉芸 XU Chuang XU Bing huang jun National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of Technology Wuhan 430070 China Key Laboratory of Fiber Optic Sensing Technology and Information Processing Ministy of Education Wuhan University of Technology Wuhan 430070 China

We prepared graphene oxide（GO） saturable absorber（SA） successfully through optical deposition method, which is a simple but effective approach to deposit various materials onto substrate under the effects of light, and investigated several factors that influence the optical deposition result of GO onto optical fiber end, including poly（methyl methacrylate）（PMMA） concentration, light intensity, light mode, and deposition time. The efficient optically deposited GO preserving its nonlinearity guaranteed by GO/PMMA composite formation was also demonstrated. The GO SA prepared by optical deposition shows superior saturable absorption property with modulation depth and nonsaturable loss of 6% and 40%, respectively.

关键词： optical deposition graphene oxide saturable absorption optical fiber