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Investigation of calcium phosphate (CaP) tribofilms from commercial automatic transmission fluids (ATFs) and their correlation with antishudder performance

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Friction 2020年第5期8卷 882-892页

作者： Zechao DI Jingjing XU Yang LIU Yu JIANG dongsheng huang Haitao CUI Zhongguo LIU Zhiyu ZHAO Shaohui LI Dalian Lubricating Oil Research&Development Institute PetroChinaDalian 116032China

The friction properties of wet clutches are highly dependent on the surface tribofilms formed by automatic transmission fluids (ATFs). Here, four commercial ATFs were evaluated with a disc-on-disc tribometer to study tribofilm formation on steel surfaces and the effects of tribofilms on the friction properties. The chemical composition, stoichiometry, structure, and thickness of the tribofilms were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), secondary ion mass spectrometry (SIMS), and X-ray photoelectron spectroscopy (XPS). Calcium phosphate (CaP) tribofilms form on the friction surface with all ATFs, which contributes to their antishudder characteristics. The thickness and surface coverage of CaP tribofilms are positively correlated with their antishudder properties.

关键词： tribofilm commercial ATF antishudder hydroxyapatite

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylationmediated mitophagy

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Acta Pharmaceutica Sinica B 2022年第2期12卷 838-852页

作者： Xin Sun Yuhan Shu Guiqin Ye Caixia Wu Mengting Xu Ruilan Gao dongsheng huang Jianbin Zhang Department of Oncology Cancer Center of Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Clinical Research Institute Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Hangzhou Medical CollegeHangzhou 310014China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou 310028China Department of Hematology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China

Parkin,an E3 ubiquitin ligase,plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for *** evidence suggests that the acetylation modification of the key mitophagy machinery influences mitophagy level,but the underlying mechanism is poorly ***,our study demonstrated that inhibition of histone deacetylase(HDAC)by treatment of HDACis activates mitophagy through mediating Parkin acetylation,leading to inhibition of cervical cancer cell *** analysis shows that Parkin expression is inversely correlated with HDAC2 expression in human cervical cancer,indicating the low acetylation level of *** mass spectrometry,Parkin is identified to interact with two upstream molecules,acetylase acetyl-Co A acetyltransferase 1(ACAT1)and deacetylase *** treatment of suberoylanilide hydroxamic acid(SAHA),Parkin is acetylated at lysine residues 129,220 and 349,located in different domains of Parkin *** in vitro experiments,combined mutation of Parkin largely attenuate the interaction of Parkin with PTEN induced putative kinase 1(PINK1)and the function of Parkin in mitophagy induction and tumor *** tumor xenografts,the expression of mutant Parkin impairs the tumor suppressive effect of Parkin and decreases the anticancer activity of *** results reveal an acetylation-dependent regulatory mechanism governing Parkin in mitophagy and cervical carcinogenesis,which offers a new mitophagy modulation strategy for cancer therapy.

关键词： Parkin Mitophagy ACAT1 HDAC2 Acetylation Ubiquitination Tumor suppression Cervical cancer

CCWELD:A CIM system for robotic arc welding

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China Welding 1996年第2期5卷 132-139页

作者： KONG Yu DAI Ming WU Lin and huang dongsheng(Welding Department,Harbin Institue of technology,Harbin,150001,China) Welding Department Harbin Institute of Technology Harbin 150001 China su.edu

This paper describes a CIM system for robotic arc *** system is specially designed for producing workpieces in small and medium batch *** on the development of AUTOCAD and a structure-light visual *** cost CIM is implemented. Feature modeling of weld workpiece is *** provides complete geometric information and process information for off-line *** system provides powerful tools for programming of torch orientation to meet the requirents of achieving good welding quality,avoiding collision and not violating kinematics constraints.

关键词： CIM robotic arc welding,low cost

Collagen type Ⅱ suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction

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Bone Research 2019年第1期7卷 76-90页

作者： Chengjie Lian Xudong Wang Xianjian Qiu Zizhao Wu Bo Gao Lei Liu Guoyan Liang Hang Zhou Xiaoming Yang Yan Peng Anjing Liang Caixia Xu dongsheng huang Peiqiang Su Department of Orthopedics The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Orthopedics Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Orthopedics The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdongChina Division of Orthopaedic Surgery Department of SurgeryGuangdong General HospitalGuangdong Academy of Medicine ScienceGuangzhouGuangdongChina Research Centre for Translational Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic *** type II(COL2A1)was previously considered to be only a structural component of the cartilage matrix,but recently,it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte ***,the mechanisms by which COL2A1 regulates hypertrophic differentiation remain *** our study,a Col2a1 ***1170Ser mutant mouse model was constructed,and Col2a1 loss was demonstrated in *** of Col2a1 was found to accelerate chondrocyte hypertrophy through the bone morphogenetic protein(BMP)-SMAD1 *** interacting with COL2A1,integrinβ1(ITGB1),the major receptor for COL2A1,competed with BMP receptors for binding to SMAD1 and then inhibited SMAD1 activation and nuclear ***2A1 could also activate ITGB1-induced ERK1/2 phosphorylation and,through ERK1/2-SMAD1 interaction,it further repressed SMAD1 activation,thus inhibiting BMP-SMAD1-mediated chondrocyte ***,COL2A1 expression was downregulated,while chondrocyte hypertrophic markers and BMP-SMAD1 signaling activity were upregulated in degenerative human articular *** study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression.

关键词： integrin Collagen COL2A1 Col2a1 receptor SMAD1 matrix ERK1/2

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变转速模型旋翼挥舞摆振低阶载荷试验研究

航空学报 2016年第3期37卷 873-882页

作者：黄东盛吴世杰韩东南京航空航天大学直升机旋翼动力学国家级重点实验室南京210016

为研究变转速旋翼挥舞和摆振方向低阶载荷,以无铰式复合材料模型旋翼为研究对象,通过试验研究,探讨了旋翼桨叶根部挥舞和摆振零阶及前3阶载荷随旋翼转速、前飞速度和旋翼拉力的变化关系。试验结果表明,在相同的配平条件(前飞速度、旋翼... 详细信息

为研究变转速旋翼挥舞和摆振方向低阶载荷,以无铰式复合材料模型旋翼为研究对象,通过试验研究,探讨了旋翼桨叶根部挥舞和摆振零阶及前3阶载荷随旋翼转速、前飞速度和旋翼拉力的变化关系。试验结果表明,在相同的配平条件(前飞速度、旋翼拉力、俯仰力矩及滚转力矩)下,降低旋翼转速有利于减小模型旋翼摆振零阶载荷,明显降低旋翼需用功率,进而提升直升机性能。当旋翼转速较低时,随着旋翼转速的降低,挥舞前3阶载荷幅值均较大。旋翼转速较低时,摆振弯矩前3阶也较大。当旋翼工作于摆振1阶共振转速附近时,旋翼挥舞前2阶和摆振前2阶载荷突增较为明显,挥舞3阶和摆振3阶变化相对较小,其中以摆振1阶载荷变化最为明显,需特别注意旋翼工作于共振转速附近时的载荷问题。

关键词：旋翼变转速载荷挥舞摆振风洞试验

Neuronal tolerance to hypoxia-ischemia through recombinant adeno-associated viral vectors expressing neuronal and inducible nitric oxide synthase An in vivo study

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Neural Regeneration Research 2008年第2期3卷 157-161页

作者： Chunmei Chen Weizhong Yang Chunhua Wang Songsheng Shi Jianping Chen Yong huang dongsheng Cai Department of Neurosurgery Union Hospital Fujian Medical University Fujian Institute of Neurosurgery Fuzhou 350001 Fujian Province China

BACKGROUND： Studies have confirmed that neuronal nitric oxide synthase （nNOS） mediates neurotoxic effects during the early stages of hypoxia-ischemia, while inducible nitric oxide synthase （iNOS） mediates delayed neurotoxicity during advanced stages of hypoxia-ischemia. OBJECTIVE： This study was designed to observe neuronal apoptosis and the expressions of nNOS, iNOS, p38 mitogen-activated protein kinase （MAPK）, and caspase-3 mRNA following transfection of recombinant adeno-associated viral vectors separately expressing nNOS and iNOS antisense （rAAV-AsnNOS and rAVV-AsiNOS, respectively） into rat brains subjected to cerebral ischemia; to analyze mechanisms underlying elevated neuronal tolerance to hypoxia-ischemia. DESIGN： A randomized controlled in vivo experiment. SETTING： Fujian Institute of Neurosurgery ＆ Department of Neurosurgery, Union Hospital, Fujian Medical University. MATERIALS： Eighty healthy adult male Sprague Dawley rats of clean grade were provided by the Zhejiang Laboratory Animal Center, China. The protocol was performed in accordance with ethical guidelines for the use and care of animals. The following vectors, rAAV-AsnNOS, rAAV-AsiNOS, and rAAV expressing the β -galactosidase gene （rAAV-LacZ）, were successfully constructed by Fujian Institute of Neurosurgery. Rabbit anti-mouse nitrotyrosine （NT） monoclonal antibody （Zhongshan Jinqiao Biotechnology Co., Ltd., Beijing, China） and reverse transcription-polymerase chain reaction （RT-PCR） kit （two-step method）（Promega Company, USA） were used in this study. METHODS： This study was performed at the Fujian Institute of Neurosurgery in December 2003. Sixty rats were randomly divided into 3 groups, with 20 rats in each group： rAAV-AsnNOS group, rAAV-AsiNOS group, and rAAV-LacZ group. The remaining 20 rats served as controls. Pre-treated viral vectors （rAAV-AsnNOS, rAAV-AsiNOS, and rAAV-LacZ, respectively; each 50μL, virus titer of 2×10^9 viral particles/mL） were transfected into the cerebral cortex o

关键词： cerebral ischemia NOS, apoptosis rAAV

新建本科高校创建地方大学科技园的可行性及其策略

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科技管理研究 2017年第18期37卷 77-82页

作者：黄东升百色学院广西百色533000

在对新建本科高校创建地方大学科技园进行可行性分析的基础上,提出地方大学科技园的创建应理性定位办园功能,建立现代企业管理制度,结合转型设计运行机制,出台支持引导政策法规,完善创新创业激励机制,营造宽松金融服务环境。

关键词：新建本科高校地方大学科技园可行性

Clinical characteristics of malignant germ cell tumors in adolescents:A multicenter 10-year retrospective study in Beijing

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Cancer Innovation 2023年第6期2卷 524-531页

作者： Qian Zhao Miao Li Qing Sun Tian Zhi Mei Jin Wen Zhao Xisi Wang Chao Duan Xiaoli Ma Wanshui Wu Weihong Zhao dongsheng huang Yan Su Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing Key Laboratory of Pediatric Hematology OncologyKey Laboratory of Major Diseases in ChildrenMinistry of EducationBeijingChina Beijing Shijitan Hospital Capital Medical UniversityBeijingChina Peking University First HospitalBeijingChina Beijing Tongren Hospital Capital Medical UniversityBeijingChina

Background:The aim of this study was to review clinical features of adolescent malignant germ cell tumors(MGCTs)in Beijing and analyze the peculiar characteristics of this age ***:Clinical characteristics,pathological presentations,and survival outcomes of 34 patients were analyzed ***:Of 34 patients,12 girls and 22 boys,18(52.9%)had an extra-cranial tumor,including one testicular tumor,five ovarian tumors,one sacrococcygeal tumor,and 11 mediastinal ***,we found immature teratomas(n=6),yolk sac tumors(n=5),mixed malignant tumors(n=5),an embryonic carcinoma(n=1),and seminoma(n=1).Three-year event-free survival(EFS)and overall survival(OS)were 48.8%and 62.9%,*** 16(47.1%)patients had an intracranial tumor,including nine in the pineal region,five in the suprasellar region,one in basal ganglia,and one in *** patients had localized disease and an excellent outcome with 3-year EFS and OS of 93.7%and 100%,***:Adolescent MGCTs are rare with a strong dependence on gender,and the mediastina and pineal region are the most common tumor *** prognosis is promising compared with that of other adolescent tumors and MGCTs in other age *** in mediastina have a tendency to companion with other hematological malignancies,and the prognosis is extremely poor in these patients.

关键词： adolescent malignant germ cell tumors prognosis treatment

直播情境中的交叉点关系传播——央视新闻《小石榴成长记》新媒体直播报道实例分析

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电视研究 2020年第9期 27-29页

作者：黄东升太原广播电视大学文法系

本文分别从传播线脉络、主体架构以及理论启示三个方面,对央视新闻《小石榴成长记》新媒体直播报道进行实例分析,探讨其显现的公共关系学意蕴下的交叉点关系传播特征,以阐释这一实例在交叉点关系传播范式上的研究价值。

关键词：《小石榴成长记》战“疫”直播交叉点公共关系