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Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma

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World Journal of Gastroenterology 2024年第17期30卷 2321-2331页

作者： Zhi-Peng Lin Xiao-Long Hu Du Chen Da-bei huang Xu-Gong Zou Hai Zhong Sheng-Xiang Xu Yuan Chen Xiao-Qun Li Jian Zhang Department of Interventional Medicine Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more efficacious than mono-therapy.However,the mechanisms underlying this innovative treatment modality have not been elucidated.AIM To evaluate the clinical efficacy of targeted therapy plus immunotherapy combined with hepatic arterial infusion chemotherapy(HAIC)of FOLFOX in patients with unresectable HCC.METHODS We enrolled 53 patients with unresectable HCC who received a combination of targeted therapy,immunotherapy,and HAIC of FOLFOX between December 2020 and June 2021 and assessed the efficacy and safety of the treatment regimen.RESULTS The objective response rate was 60.4%(32/53),complete response was 24.5%(13/53),partial response was 35.9%(19/53),and stable disease was 39.6%(21/53).The median duration of response and median progression-free survival were 9.1 and 13.9 months,respectively.The surgical conversion rate was 34.0%(18/53),and 1-year overall survival was 83.0%without critical complicating diseases or adverse events(AEs).CONCLUSION The regimen of HAIC of FOLFOX,targeted therapy,and immunotherapy was curative for patients with unresectable HCC,with no serious AEs and a high rate of surgical conversion.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Targeted therapy Immunotherapy Adverse events

Asymmetric Oscillation and Acoustic Response from an Encapsulated Microbubble Bound within a Small Vessel

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Chinese Physics Letters 2010年第6期27卷 114-117页

作者： huang bei ZHENG Hai-Rong ZHANG Dong Institute of Acoustics Key Laboratory of Modern Acoustics (Ministry of Education) Nanjing University Nanjing 210093 Paul C. Lauterbur Research Center for Biomedical imaging IBHE Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055

Understanding the dynamics of ultrasonic excited microbubbles bound within microvessels is of significance for novel ultrasonic imaging, drug delivery and therapeutic biomedicad applications. A finite element model （FEM） considering acoustic nonlinearity is developed to describe the asymmetric oscillation and acoustic response from mn encapsulated microbubble bound within a small vessel. Numerical simulation is performed for a 2 μm encapsulated microbubble bound within 8-20μm vessels using 2 MHz ultrasound excitation. The oscillation of the bound microbubble becomes more asymmetric under larger ultrasound pressure or within the smaller vessel. The normalized difference between the major and minor axes of epllipse is estimated to be 2.16%for the 8 μm vessel at an acoustic pressure of 0.5 MPa. In addition, the fundamental component of the acoustic scattering from the bound microbubble is enhanced by 6 dB while the second harmonic component is decreased by approximately 29 dB compared with the free microbubble.

关键词： Ultrasonics Encapsulation Pressure

Discussion on the influence of truncation of ground motion residual distribution on probabilistic seismic hazard assessment

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 379-392页

作者： Wu Jian Gao Mengtan Chen Kun huang bei Institute of Geophysics China Earthquake Administration Beijing 100081 China Institute of Geology China Earthquake Administration Beijing 100029 China

Recent studies on assessment of a very low annual probability of exceeding （APE） ground motions, 10-4 or less, have highlighted the importance of the upper bound of ground motions when very low probability results are acquired. The truncation level adopted in probabilistic seismic hazard analysis （PSHA） should be determined by an aleatory uncertainty model （i.e., distribution model） of ground motions and the possible maximum and minimum ground motion values of a specific earthquake. However, at the present time, it is impossible to establish the upper bound model for ground motions based on the source characteristics and/or ground motion propagation. McGuire suggested a truncation level be fixed at a number of = 6, or the distribution of residuals be truncated in such a manner that site intensity cannot be greater than the epicenter intensity. This study aims to find a reasonable and feasible truncation level to be used in PSHA when the physical mechanism is not available to find the extreme ground motion. A mathematical analysis of the influence of the truncation level on PSHA, case studies of sites in different seismotectonic settings, and a distribution analysis of ground motion residuals are conducted in this study. It is concluded that = 4 is the minimum acceptable value for engineering applications for APEs within 0.002 to 10-4, and for low APEs, such as 10-5 and 10-6, the value of should be no less than 5 in most regions of China.

关键词： truncation of ground motions annual probability of exceeding PSHA distribution of ground motion residuals

蓝宝石光学曲面柱形宽缎带磁流变抛光仿真分析及实验研究

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表面技术 2024年第4期53卷 140-151页

作者：阎秋生汪涛黄展亮黄蓓潘继生陈缘靓夏江南广东工业大学机电工程学院广州510006

目的针对目前光滑无损伤光学曲面蓝宝石加工成本高、效率低的问题,对加工过程中磁流变抛光缎带进行流体仿真,进而优化抛光轮表面结构。方法设计并提出3种表面结构柱形宽缎带磁流变抛光轮,介绍了磁流变抛光轮加工的基本原理,建立了磁流... 详细信息

目的针对目前光滑无损伤光学曲面蓝宝石加工成本高、效率低的问题,对加工过程中磁流变抛光缎带进行流体仿真,进而优化抛光轮表面结构。方法设计并提出3种表面结构柱形宽缎带磁流变抛光轮,介绍了磁流变抛光轮加工的基本原理,建立了磁流变抛光垫Bingham流体特性加工仿真模型,分析了3种抛光轮表面结构对工件表面磁通密度模、流场流速、流场压力分布的影响。同时对3种抛光轮的抛光效果进行了实验探究,探究了抛光轮表面结构对材料去除率和抛光后表面粗糙度的影响规律。结果仿真结果表明,抛光轮表面槽型结构具有能增强磁通密度模、增大流体流速和流体压力的特性。实验结果表明,螺旋槽抛光轮的抛光效果最好,在螺旋抛光轮作用下,材料去除率为0.22mg/h,抛光后蓝宝石表面粗糙度为1.08nm。最终抛光轮近壁区总压力和速度的乘积结果与抛光轮实验去除率结果具有较好的一致性。结论槽型结构可以提高抛光液在抛光轮表面的固着效果,影响工件表面流场运动状态,增强工件表面受到抛光垫的作用力。相较于光滑和横条槽抛光轮,螺旋槽抛光轮的抛光效率最高,表面粗糙度最低,可有效提高抛光效果。

关键词：抛光缎带蓝宝石 Bingham流体抛光轮槽型结构数值计算流场

PD-1/PD-L1抑制剂在治疗恶性黑色素瘤中引起白癜风样脱色的机制及研究进展

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药学与临床研究 2024年第3期32卷 254-257页

作者：黄蓓马鞍山市中医院科教科安徽马鞍山243000

近年来,越来越多的肿瘤患者从免疫检查点抑制剂(ICPIs)中获得了显著疗效。其中,程序性细胞死亡受体-1/配体-1(PD-1/PD-L1)抑制剂是第二代ICPIs,已被批准用于多种晚期恶性肿瘤的治疗。随着其广泛使用,免疫相关不良反应(irAEs)也逐渐引起... 详细信息

近年来,越来越多的肿瘤患者从免疫检查点抑制剂(ICPIs)中获得了显著疗效。其中,程序性细胞死亡受体-1/配体-1(PD-1/PD-L1)抑制剂是第二代ICPIs,已被批准用于多种晚期恶性肿瘤的治疗。随着其广泛使用,免疫相关不良反应(irAEs)也逐渐引起人们的关注,白癜风就是其中一种,尤其在恶性黑色素瘤患者治疗中较多出现。本文对恶性黑色素瘤患者使用PD-1/PD-L1免疫抑制剂引起白癜风样脱色的发生机制进行综述,旨在为阐明PD-1/PD-L1与免疫相关不良反应的关系提供可能的理论依据。

关键词：程序性细胞死亡受体-1/配体-1 免疫抑制剂恶性黑色素瘤白癜风样脱色发生机制

生成式人工智能融入高等教育生态系统的风险表征、预警及化解

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现代教育技术 2024年第5期34卷 16-26页

作者：黄蓓蓓宋子昀钱小龙南通大学未来教育研究所江苏南通226019

在生成式人工智能迅猛发展的背景下,认识、防范和化解生成式人工智能给高等教育生态系统带来的教育风险迫在眉睫。对此,文章首先剖析了生成式人工智能融入高等教育生态系统的风险表征,主要表现为师生主权消解、知识内容扭曲、安全包容... 详细信息

在生成式人工智能迅猛发展的背景下,认识、防范和化解生成式人工智能给高等教育生态系统带来的教育风险迫在眉睫。对此,文章首先剖析了生成式人工智能融入高等教育生态系统的风险表征,主要表现为师生主权消解、知识内容扭曲、安全包容破坏和人才培养异化。随后,文章构建了由风险预警主体、风险预警内容、风险预警保障、风险预警流程四个模块组成的生成式人工智能融入高等教育生态系统的风险预警机制。最后,文章提出从激发主体意识、鉴别知识内容、优化数字环境、培养创新人才等方面入手,来化解生成式人工智能融入高等教育生态系统的风险。文章的研究可为生成式人工智能教育风险治理提供理论指导,并推动生成式人工智能在高等教育中的安全应用,从而为高等教育数字化转型和高质量发展保驾护航。

关键词：生成式人工智能 ChatGPT 高等教育生态系统教育风险风险预警

结核分枝杆菌诱导IFN-β产生在免疫调控中的作用

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微生物学报 2024年第2期64卷 331-343页

作者：黄蓓孟祥苗田江瑶宋厚辉杨杨浙江农林大学动物科技学院·动物医学院动物健康互联网检测技术浙江省工程研究中心、浙江省动物医学与健康管理国际科技合作基地、浙江省畜禽绿色生态健康养殖应用技术研究重点实验室、中澳动物健康大数据分析联合实验室浙江杭州311300

结核分枝杆菌是导致结核病的病原体,也是影响全球数百万人健康的病原体之一。机体中多种模式识别受体(pattern recognition receptor,PRR)可识别入侵的结核分枝杆菌,如DNA和RNA传感器,从而激活天然免疫系统并诱导干扰素-β(interferon-... 详细信息

结核分枝杆菌是导致结核病的病原体,也是影响全球数百万人健康的病原体之一。机体中多种模式识别受体(pattern recognition receptor,PRR)可识别入侵的结核分枝杆菌,如DNA和RNA传感器,从而激活天然免疫系统并诱导干扰素-β(interferon-β,IFN-β)产生。虽然IFN-β是先天抗病毒应答的主要效应因子,但其在结核分枝杆菌感染中的作用仍具有争议。结核分枝杆菌感染诱导的IFN-β产生可以促进细菌生长,并增强细菌在宿主中的存活率,但用IFN-β处理细胞后再感染结核分枝杆菌,则可增强抗菌作用,保护宿主。因此,本综述将重点关注可识别结核分枝杆菌并诱导的IFN-β产生的PRR及其下游信号通路,并着重探讨IFN-β在介导结核分枝杆菌调控免疫功能中的作用,尤其是IFN-β与IL-1β之间的相互抑制性调节,旨在为进一步揭示结核分枝杆菌致病机制及结核病治疗药物研发提供新思路。

关键词：结核分枝杆菌干扰素β 信号通路

Analysis of trace mercury in water by solid phase extraction using dithizone modified nanometer titanium dioxide and cold vapor atomic absorption spectrometry

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Rare Metals 2007年第6期26卷 541-546页

作者： MA Xiaoguo huang bei CHENG Meiqing Faculty of Environmental Science and Engineering Guangdong University of Technology Guangzhou 510090 China Department of Chemical Engineering Maoming University Maoming 525000 China

A new method for analysis of trace mercury in water samples was developed, based on the combination of preconcentration/separation using dithizone-modified nanometer titanium dioxide （TiO2） as a solid phase extractant and determination by cold vapor atomic adsorption spectrometry （CVAAS）. Dithizone was dissolved with alcohol and loaded on the surface of nano-sized TiO2 powders by stirring. The static adsorption behavior of Hg^2＋on the dithizone-modified nanoparficles was investigated in detail. It was found that excellent adsorption ratio for Hg^2＋ could be obtained in the pH range of 7-8 with an oscillation time of 15 rain, and a 5 mL of 3.5 mol·L^-1 HCI solution could quantitatively elute Hg^2＋ from nanometer TiO2 powder. Common coexisting ions caused no obvious influence on the determination of mercury. The mechanisms for the adsorption and desorption were discussed. The detection limit （30） for Hg^2＋ was calculated to be 5 ng·L^-1. The proposed method was applied to the determination of Hg^2＋ in a mineral water sample and a Zhujiang River water sample. By the standard addition method, the average recoveries were found to be 94.4%-108.3% with RSD （n = 5） of 2.9%-3.5%.

关键词： analytical chemistry mercury solid-phase extraction TiO2 nanoparticle cold vapor atomic adsorption spectrometry （CVAAS）

劳动素养导向的幼儿园职业体验式劳动教育策略探索——以晋江市第二实验幼儿园为例

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陕西学前师范学院学报 2024年第4期40卷 107-110页

作者：黄蓓芬晋江市第二实验幼儿园福建晋江362200

幼儿园劳动教育应当充分发挥树德、增智、强体、育美的综合育人价值,为幼儿终身全面发展奠基。近年来,晋江市第二实验幼儿园积极开展职业体验式劳动教育,主要形成了以下教育策略:明确幼儿劳动素养递进性发展目标,坚持循序进阶开展全面... 详细信息

幼儿园劳动教育应当充分发挥树德、增智、强体、育美的综合育人价值,为幼儿终身全面发展奠基。近年来,晋江市第二实验幼儿园积极开展职业体验式劳动教育,主要形成了以下教育策略:明确幼儿劳动素养递进性发展目标,坚持循序进阶开展全面幼儿职业体验式劳动教育,精心设计与统筹实施幼儿职业体验式劳动教育活动,积极引导与支持幼儿初步形成基本劳动素养。

关键词：幼儿劳动教育劳动素养职业体验教育策略