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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-14页

作者： Li, Yun-Xiang Yang, Run-Sheng Li, Yue Su, Xing-Kang huang, zi-nan Meng, Lu Li, Song Xi, Bin Zhang, You-Peng Zhang, Lu Jiang, Wei Fudan Univ Inst Modern Phys Shanghai 200433 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Chinese Acad Sci Inst Modern Phys Lanzhou 730000 Peoples R China

To improve the heat transfer efficiency of the coolant in lead-based fast reactors, this study optimized the configuration and rotational direction of the spacer wires in fuel assemblies to design a new-pattern fuel assembly. This study conducted detailed comparisons between traditional and new pattern fuel assembly rod bundles utilizing the open-source computational fluid dynamics platform, OpenFOAM. The results indicated that the new design may significantly reduce the pressure drop along the rod bundle, which is beneficial for lowering the pressure drop. Furthermore, this new design improved coolant mixing in the subchannels, which facilitated a more uniform temperature distribution and lower thermal gradients at the assembly outlet. These factors collectively reduced the thermal fatigue and creep in nearby internal components. Overall, the new-pattern fuel assembly proposed in this study may have better heat transfer performance, thereby enhancing the Integrated Thermal-Hydraulic Factor by 48.2% compared to the traditional pattern.

关键词： Spacer wires Enhanced coolant mixing OpenFOAM CFD simulations 3-DIMENSIONAL FLOW

Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang Shi-lin huang nan-nan Chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 130 mg/kg(≤30 pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:31.5–93.1)and 37.5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

An Interpolation Method for Karhunen-Loève Expansion of Random Field Discretization

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工程与科学中的计算机建模(英文) 2024年第1期138卷 245-272页

作者： zi Han Zhentian huang Department of Engineering Mechanics Hohai UniversityNanjing211100China College of Civil and Transportation Engineering Shenzhen UniversityGuangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and UtilizationInstitute of Deep Earth Sciences and Green EnergyShenzhenChina

In the context of global mean square error concerning the number of random variables in the representation,the Karhunen–Loève(KL)expansion is the optimal series expansion method for random field *** computational efficiency and accuracy of the KL expansion are contingent upon the accurate resolution of the Fredholm integral eigenvalue problem(IEVP).The paper proposes an interpolation method based on different interpolation basis functions such as moving least squares(MLS),least squares(LS),and finite element method(FEM)to solve the *** with the Galerkin method based on finite element or Legendre polynomials,the main advantage of the interpolation method is that,in the calculation of eigenvalues and eigenfunctions in one-dimensional random fields,the integral matrix containing covariance function only requires a single integral,which is less than a two-folded integral by the Galerkin *** effectiveness and computational efficiency of the proposed interpolation method are verified through various one-dimensional ***,based on theKL expansion and polynomial chaos expansion,the stochastic analysis of two-dimensional regular and irregular domains is conducted,and the basis function of the extended finite element method(XFEM)is introduced as the interpolation basis function in two-dimensional irregular domains to solve the IEVP.

关键词： Random field discretization KL expansion IEVP MLS FEM stochastic analysis

A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： Hong-Jin Liao Zhu Zhuo Qing Li Yoshihito Shiota Jonathan P.Hill Katsuhiko Ariga zi-Xiu Lu Lu-Yao Liu zi-Ang nan Wei Wang You-Gui huang CAS Key Laboratory of Design and Assembly of Functional nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World Premier International(WPI)Center for Materials nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular Photochromic X-ray induced Anion-directed folding Electron-deficient viologens

Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells

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Chinese Chemical Letters 2024年第2期35卷 451-454页

作者： Jiahao Zhang Haiyue Peng zi'an Chen Guorui Li Jing huang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Animal Models and Molecular MedicineSchool of Biomedical SciencesHunan UniversityChangsha 410082China

Protein S-sulfenylation(protein sulfenic acid),as one of the most significant oxidative post-translational modifications(OxiPTMs),plays a vital role in regulating protein function.A variety of activity-based probes have been developed to profile sulfenic acid in living ***,due to the transient presence and low content of sulfenic acid in living cell,high doses of probes are needed to achieve efficient *** importantly,current probes have no temporal control over sulfenic acid *** overcome these limitations,two caged cysteine sulfenic acid probes DYn-2-ONB and DYn-2-Cou with either an o-nitrobenzyl or coumarin protecting group were developed in this *** probes can be efficiently uncaged via irradiation to produce the active C-nucleophile probe *** assay in living cells demonstrated DYn-2-ONB exhibited better labeling capacity compared with DYn-2,providing it as a powerful tool for improved monitoring of protein S-sulfenylation in living cells.

关键词： Cysteine Sulfenic acid Activity-based probe Photocage Light activation Protein S-sulfenylation

Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3932-3954页

作者： Guo-Qing Chen Yi nan Na Ning Shi-Cong huang Yu-Ting Bai zi-Ying Zhou Gu Qian Wei-Qiang Li Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pharmacy Ningxia Chinese Medicine Research CenterYinchuan 750021Ningxia Hui Autonomous RegionChina Department of Pharmacy General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastroenterology The Affiliated TCM Hospital of Ningxia Medical UniversityWuzhong 751100Ningxia Hui Autonomous RegionChina

BACKGROUND Cancer is one of the most serious threats to human health *** treatments such as surgery and chemotherapy are associated with some *** recent years,traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from clinicians,and has become an indispensable part of the comprehensive treatment for gastric *** To investigate the mechanism of Xiaojianzhong decoction(XJZ)in the treatment of gastric cancer(GC)by utilizing network pharmacology and experimental validation,so as to provide a theoretical basis for later experimental *** We analyzed the mechanism and targets of XJZ in the treatment of GC through network pharmacology and ***,we verified the impact of XJZ treatment on the proliferative ability of GC cells through CCK-8,apoptosis,cell cycle,and clone formation ***,we performed Western blot analysis and real-time quantitative PCR to assess the protein and mRNA expression of the core *** XJZ mainly regulates IL6,PTGS2,CCL2,MMP9,MMP2,HMOX1,and other target genes and pathways in cancer to treat *** inhibition of cell viability,the increase of apoptosis,the blockage of the cell cycle at the G0/G1 phase,and the inhibition of the ability of cell clone formation were observed in AGS and HGC-27 cells after XJZ *** addition,XJZ induced a decrease in the mRNA expression of IL6,PTGS2,MMP9,MMP2,and CCL2,and an increase in the mRNA expression of *** significantly inhibited the expression of IL6,PTGS2,MMP9,MMP2,and CCL2 proteins and promoted the expression of the heme oxygenase-1 *** XJZ exerts therapeutic effects against GC through multiple components,multiple targets,and multiple *** findings provide a new idea and scientific basis for further research on the molecular mechanisms underlying the therapeutic effects of XJZ in the treatment of GC.

关键词： Xiaojianzhong decoction Gastric cancer Network pharmacology Molecular mechanism In vitro experiment

Cooperative Anti-Jamming and Interference Mitigation for UAV Networks: A Local Altruistic Game Approach

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China Communications 2024年第2期21卷 183-196页

作者： Yueyue Su nan Qi Zanqi huang Rugui Yao Luliang Jia College of Electronic Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China School of Space Information Space Engineering UniversityBeijing 101416China

To improve the anti-jamming and interference mitigation ability of the UAV-aided communication systems, this paper investigates the channel selection optimization problem in face of both internal mutual interference and external malicious jamming. A cooperative anti-jamming and interference mitigation method based on local altruistic is proposed to optimize UAVs’ channel selection. Specifically, a Stackelberg game is modeled to formulate the confrontation relationship between UAVs and the jammer. A local altruistic game is modeled with each UAV considering the utilities of both itself and other UAVs. A distributed cooperative anti-jamming and interference mitigation algorithm is proposed to obtain the Stackelberg equilibrium. Finally, the convergence of the proposed algorithm and the impact of the transmission power on the system loss value are analyzed, and the anti-jamming performance of the proposed algorithm can be improved by around 64% compared with the existing algorithms.

关键词： channel selection cooperative antijamming and interference mitigation local altruistic game Stackelberg game unmanned aerial vehicle(UAV)

Molecular mechanism for the unusual enhancement of the second-step chemiluminescence production from the carcinogenic tetrabromohydroquinone and H2O_(2)

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Journal of Environmental Sciences 2024年第7期141卷 330-342页

作者： zi-Han Wang Chun-Hua huang Zhi-Sheng Liu Li Mao Ben-Zhan Zhu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Environment and Resources University of Chinese Academy of SciencesBeijing 100049China

We have found recently that two-step intrinsic hydroxyl radical(·OH)-dependent chemiluminescence(CL)could be produced by carcinogenic tetrahaloquinone and H_(2)O_(2).However,the first-step CL was too fast to clearly detect the stepwise generation of·OH and CL,and to distinguish the exact dividing point between the first-step and second-step *** we found that,extremely clear two-step intrinsic CL could be produced by the relative slow reaction of tetrabromohydroquinone(TBHQ)with H_(2)O_(2),which was directly dependent on the two-step·OH ***,the second-step,but not the first-step CL production of TBHQ/H_(2)O_(2)(CRET donor)was markedly enhanced by fluorescein(a typical xanthene dye,CRET acceptor)through a unique chemiluminescence resonance energy transfer(CRET)*** novel CRET system of TBHQ/H_(2)O_(2)/fluorescein was successfully applied for the sensitive detection of TBHQ with the detection limit as low as 2.5μmol/*** findings will help to develop more sensitive and highly efficient CL or CRET systems and specific CL sensor to detect the carcinogenic haloquinones,which may have broad environmental applications.

关键词： Two-step chemiluminescence Bromohydroquinone Hydrogen peroxide Hydroxyl radical CRET

Deep learning-based lung sound analysis for intelligent stethoscope

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Military Medical Research 2024年第4期11卷 567-588页

作者： Dong-Min huang Jia huang Kun Qiao nan-Shan Zhong Hong-Zhou Lu Wen-Jin Wang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina The Third People’s Hospital of Shenzhen Shenzhen 518112GuangdongChina Guangzhou Institute of Respiratory Health China State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Auscultation is crucial for the diagnosis of respiratory system ***,traditional stethoscopes have inherent limitations,such as inter-listener variability and subjectivity,and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in *** emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and *** this basis,machine learning,particularly deep learning,enables the fully-automatic analysis of lung sounds that may pave the way for intelligent *** review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence(AI)in this *** focus on each component of deep learning-based lung sound analysis systems,including the task categories,public datasets,denoising methods,and,most importantly,existing deep learning methods,i.e.,the state-of-the-art approaches to convert lung sounds into two-dimensional(2D)spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung ***,this review highlights current challenges in this field,including the variety of devices,noise sensitivity,and poor interpretability of deep *** address the poor reproducibility and variety of deep learning in this field,this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension:https://***/contactless-healthcare/Deep-Learning-for-Lung-Sound-Analysis.

关键词： Deep learning Lung sound analysis Respiratory sounds

Exploring the Pathogenesis of Autoimmune Liver Diseases from the Heterogeneity of Target Cells

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 659-666页

作者： zi-Xuan Qiu Lin-Xiang huang Xiao-Xiao Wang zi-Long Wang Xiao-He Li Bo Feng Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina

The incidence of autoimmune liver diseases(ALDs)and research on their pathogenesis are increasing ***,except for autoimmune hepatitis,which responds well to immunosuppression,primary biliary cholangitis and primary sclerosing cholangitis are insensitive to immunosuppressive *** the known effects of the environment,genetics,and immunity on ALDs,the heterogeneity of target cells provides new insights into their *** review started by exploring the heterogeneity in the development,structures,and functions of hepatocytes and epithelial cells of the small and large bile *** example,cytokeratin(CK)8 and CK18 are primarily expressed in hepatocytes,while CK7 and CK19 are primarily expressed in intrahepatic ***,emerging technologies of single-cell RNA sequencing and spatial transcriptomic are being applied to study *** review offered a new perspective on understanding the pathogenic mechanisms and potential treatment strategies for ALDs.

关键词： Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Disease heterogeneity Single-cell RNA sequencing Pathogenesis