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Chinese Chemical Letters 2001年第12期12卷 1071-1074页

作者： huang, jm Chen, RY Nankai Univ Inst Elementoorgan Chem Tianjin 300071 Peoples R China

The novel 2-propyl-5-phenyl-1, 4-dioxo-1,2,3,4,5,6,7,8-octahydro-[1,4,2]diaza phosphorino[1,2-a][1,3,2]benzodiazaphosphorine 3-oxide has been synthesized by incorporating the proximate carbonyl and phosphoryl groups i... 详细信息

关键词： synthesis diazaphosphorino[1,2-a] benzodiazaphosphorine

A Convenient Method for the Synthesis of 1,3,2-Oxazaphospholidin-[3,2-a]-8-oxo-10-thio(or seleno)-[1,3,2]-benzodiazaphosphorines

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Chinese Chemical Letters 2000年第10期11卷 867-870页

作者： Deng, SL huang, jm Chen, RY Nankai Univ Natl Key Lab Elementoorgan Chem Inst Elementoorgan Chem Tianjin 300071 Peoples R China

A Convenient method for the synthesis of fused phosphorusheterocycle 1,3,2-oxazaphosphorin-[3.2-a]-8-oxo-10-thio(or seleno)-[1,3,2]-benzodiazaphosphorines was carried out in one pot by the reaction of Tris(diethylamino)phosphine with multifunctional compounds 2-(N-(beta or gamma-hydroxyl) alkylene) amino-benzamides 1. When PCL3 was used, only chlorinated product was obtained.

关键词： convenient method synthesis multifunctional compounds fused phosphorus heterocycle one-pot

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis

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World Journal of Gastroenterology 2000年第1期6卷 115-118页

作者： Xia Q Jiang jm Gong X Chen GY Li L huang ZW Department of TCM The First University Hospital of West China University of Medical SciencesChengdu 610041Sichuan ProvinceChina.

AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung *** Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury *** Elevation of TNF activity was moreprominent in BALF than in *** activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin *** Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF.

关键词： Subject headings pancreatitis/therapy lung disease tumor necrosis factor Tong Xia method

输尿管镜气压弹道碎石术治疗输尿管结石560例

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第四军医大学学报 2005年第11期26卷 997-997页

作者：郭建功黄金明张晓勇付亚军南阳医学高等专科学校附属医院泌尿外科河南南阳473058

1 临床资料输尿管结石560(男324，女236)例，年龄16～68(平均38)岁．其中左侧输尿管246例，右侧输尿管268例，双侧输尿管46例，合并肾功能减退者28例，合并妊娠12例，孤肾合并输尿管结石5例，上段输尿管139例，中段输尿管154例，下段... 详细信息

1 临床资料输尿管结石560(男324，女236)例，年龄16～68(平均38)岁．其中左侧输尿管246例，右侧输尿管268例，双侧输尿管46例，合并肾功能减退者28例，合并妊娠12例，孤肾合并输尿管结石5例，上段输尿管139例，中段输尿管154例，下段输尿管267例，合并输尿管狭窄68例，合并输尿管息肉156例，合并输尿管扩张及不同程度肾积水286例，36例有肾或输尿管切开取石史，196例行体外震波碎石效果不佳，其中16例形成石街．本组经X线诊断的阳性结石388例，经B超或静脉肾盂造影诊断的阴性结石148例，未发现结石经输尿管镜诊断的结石24例。

关键词：结石,泌尿系输尿管碎石术

Prolonged cholestasis following successful removal of common bile duct stones:Beware patients on estrogen therapy

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World Journal of Gastroenterology 2007年第46期13卷 6277-6280页

作者： jm Dunn A McNair The Queen Elizabeth Hospital WoolwichLondonUnited Kingdom

There are various well described forms of chronic cholestatic jaundice in adults, such as autoimmune cholangitis, drug-induced cholangitis and intrahepatic cholestasis of pregnancy. We present two cases of prolonged cholestasis following removal of gallstones at endoscopic retrograde cholangiopancreatography （ERCP） and subsequent clear cholangiography. Both patients were taking oral estrogens at the time of presentation, which were subsequently withdrawn. The first case responded rapidly to corticosteroid treatment, and the second case had a much slower resolution with ursodeoxycholic acid. Both cases highlighted the significance of estrogen-induced cholestasis in female patients with protracted jaundice following ERCP and removal of intra-ductal stones. After oral estrogens are discontinued, a short course of steroids needs to be considered.

关键词： Estrogen Cholestasis Gallstones Steroids Ursodeoxycholic acid

A Monte-Carlo Approach to Cellular Pattern Evolution for Binary Alloys during Directional Solidification

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Journal of Materials Science & Technology 1995年第2期11卷 127-132页

作者： LIU, jm LIU, ZG WU, ZC Nanjing Univ Nanjing China

A Monte-Carlo approach of cellular pattern evolution during directional solidification of a binary alloy has been carried out by imposing a non-uniform probability distribution of particle emission from the particle source, as an approach to the contribution of solute redistribution to the interface evolution. Both the bulk and interface diffusion have been involved in the simulation, and coarsening of the cellular patterns with time has been clearly revealed. The remarkable influence of the interface relaxation and the solute redistribution on the profile bf;solidifying interface has been presented.

关键词： Monte Carlo methods

Etiological study for a case of multi-bacterial synergistic gangrene

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Chinese Science Bulletin 1997年第6期42卷 511-517页

作者： Xu, JG Yang, HM Lai, XH Fu, XL Wu, jm huang, LB Yu, XJ Wu, YP Wu, YJ Liu, BY Priority Laboratory of Molecular Medical Bacteriology Ministry of Health Institute of Epidemiology and Microbiology Chinese Academy for Preventive Medicine Beijing China Laboratory of Bacteriology Beijing Army General Hospital Beijing China

IN July of 1994, a 13-year old girl from Shandong Province, China, found a dark point on her middle finger of the right hand. She licked it with a needle, and washed clothes with pool water by hands afterwards. Intolerable pain was experienced about 10h later. The gangrene was developed in a week and spread gradually up to the right forearm and two fingers of the left hand. In November of 1994, she visited Beijing Army General Hospital, and radical amputations of the right forearm and two fingers of the left hand were carried out after 3d of

关键词： gangrene anaerobes antibiotics.

Leakage in Mold Slit during Inverse Solidification

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Journal of University of Science and Technology Beijing 2001年第2期8卷 101-104页

作者： Zhang, jm Wang, XH Wang, WJ Univ Sci & Technol Beijing Met Sch Beijing 100083 Peoples R China

The liquid steel will be leaked from the slit between the bottom of solidification mold and mother sheet during inversion casting process. By substitution of the actual liquid steel, the Ph-Sn alloy and the numerical simulation can be used to study the fluid flow in the inversion solidification mold, the mother sheet critical speed is determined for preventing the leakage from the slit of bottom. When the mother sheet speed is more than 0.06 m/s, Pb-Sn liquid alloy will not leak from the slit of the mold. Otherwise, the Ph-Sn liquid alloy can leak from the slit of the mold.

关键词： leakage slit inverse solidification mold

Annealing Embrittlement in Fe-Mo-Si-B Amorphous Alloy

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Journal of Materials Science & Technology 1997年第1期13卷 61-64页

作者： Li, jm Quan, MX Hu, ZQ National Key Lab. of RSA Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

Annealing at T-a=200 degrees C or so, the enhancement in the average tensile fracture strength of as-quenched (Fe0.99Mo0.01)(78)Si9B13 metallic glass increases about 7 similar to 8%. The origin of the annealing embrittlement at 244 degrees C in the metallic glass (Fe0.99Mo0.01)(78)Si9B13 was revealed that due to the formation of nanoscale granular with bcc structure resulting in the stress localization. The temperature of annealing embrittlement was in agreement with the calculated value from T-bcc=0.637 T-c (T-c is the crystallized temperature), based on micromechanism of crystallization of metallic glass.

关键词： Metallic glass