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一个具有Hamilton结构的反应扩散系统的空间离散化整体吸引子

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Journal of Mathematical Research and Exposition 2000年第2期20卷 213-214页

作者： huang,jh Lzi,G 国防科技大学湖南长沙 410079 华中师范大学湖北武汉 430070

In recent years there has been a growing interest on discrete models, see e.g.[1].[2].We consider a reaction diffusion equation which space-independent system is a Hamilton system with one degree of freedom:

关键词：反应扩散系统哈密顿结构整体吸引子

Mouse model test of extracellular polysaccharide from Candida parapsilosis inhibiting mycelial growth of Candida albicans

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Mouse model test of extracellular polysaccharide from Candid...

第六届海南省生命科学联合学术会议

作者： Hua Pei Yi.Li Rao LY Niu LN Wang YX. Wang Y Yang W Lin YZ huang jh. Huamin Wang Department of Immunology School of Laboratory Medicine & Tropical MedicineHainan Medical University Department of Immunology Norman Bethune College of MedicineJilin University

Objective:To investigate the therapeutical efficacy of extracellular polysaccharide(EPS)from Candida parapsilosis on the ***:Construct a murine model of vaginal candidiasis,then continuous in funding100 μl EPS of 20mg/L for seven days,then observing the douche smear with the microscope,counting colony count of mycetes capacity value in vagina douche and histopathology detection of vaginal ***:In EPS group there are only a few inflammatory cells(HE dyeing),little hypha,a few spores in vaginal mucosa(PAS dyeing),a low mycetes counting Colony in vagina douche and little hypha,a few spores in the douche ***:EPS from Candida parapsilosisin can inhibit mycelial growth and Sporogony of Candida albicans in Mouse model,and has strikingly therapeutical efficacy on the candidiasis of the mouse.

关键词： Candida parapsilosis EPS Mouse model

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异体肌腱移植重建伸肌腱止点治疗锤状指畸形

中国组织工程研究与临床康复 2007年第4期11卷 714-716页

作者：黄建华吴继彬杨善华东南大学医学院附属徐州医院骨科江苏省徐州市221009

目的:观察异体肌腱移植重建伸肌腱止点治疗锤状指畸形的疗效。方法:选择于2003-01/2006-03在东南大学医学院附属徐州医院骨科采用改良伸肌腱止点重建术治疗的锤状指畸形患者15例,均自愿参加观察。开放损伤2例患者于急诊1期予以手术治疗... 详细信息

目的:观察异体肌腱移植重建伸肌腱止点治疗锤状指畸形的疗效。方法:选择于2003-01/2006-03在东南大学医学院附属徐州医院骨科采用改良伸肌腱止点重建术治疗的锤状指畸形患者15例,均自愿参加观察。开放损伤2例患者于急诊1期予以手术治疗,闭合损伤13例患者在1周内予以手术治疗。①手术方法:臂丛麻醉,于末节指骨基底以远4mm偏背侧的尺桡两边对向钻孔,形成骨隧道,采用修剪合适的异体肌腱穿过骨隧道,在远侧指间关节背侧交叉后分别与伸指肌腱的侧腱束吻合(吻合前选直径1.0mm克氏针将远侧指间关节固定过伸位10°￣15°),石膏托外固定,6周后拔除克氏针及拆除石膏进行末节屈伸功能锻炼。术后定期随访。②功能测评:测量手指最大伸直位掌指关节、近指间关节、远指间关节伸直受限角度的总和及手指屈曲位时指端与掌横纹之间的距离。优:伸指0°,屈指指端过掌横纹;良:伸指受限≤-15°,屈指指端达掌横纹。结果:15例患者全部进入结果分析,无脱落。术后随访2个月￣3年,平均19.5个月。所有患者伤口甲级愈合,无异物排斥反应。按Dargan功能评定标准,优12例(占80%),良2例(占13.3%),优良率达93.3%。1例因远侧指间关节僵硬而屈伸活动功能欠佳。结论:异体肌腱移植伸肌腱止点重建术是治疗锤状指畸形的有效方法。

关键词：骨关节病,继发肥大性/外科学腱/移植

文献快报(9)：大学生大学前和大学时期欺凌经历与健康相关生命质量的关系

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中国学校卫生 2015年第6期36卷 808-808页

作者： CHEN YY huang jh 苏普玉不详安徽医科大学公共卫生学院儿少卫生与妇幼保健学系合肥230032

同伴欺凌在青少年中已经成为一种常见的行为,欺凌可能对健康产生长期不良的影响。美国公共健康协会报告显示,在美国每年有320万名以上学生报道遭受过欺凌,每天有16万名学生因害怕遭受欺凌而逃学。中国台湾学者Chen等探讨了台湾大学生欺... 详细信息

同伴欺凌在青少年中已经成为一种常见的行为,欺凌可能对健康产生长期不良的影响。美国公共健康协会报告显示,在美国每年有320万名以上学生报道遭受过欺凌,每天有16万名学生因害怕遭受欺凌而逃学。中国台湾学者Chen等探讨了台湾大学生欺凌行为的流行情况以及欺凌行为与健康相关生命质量的关系,并于2013年按照比例整群抽样1 452名在校大学生,使用自填式问卷调查大学生不同类型欺凌行为的经历,包括不同欺凌种类（躯体欺凌、言语欺凌、关系欺凌、网络欺凌）和扮演角色（欺凌者、被欺凌者）。

关键词：生命质量自填式整群抽样青少年学生大学时期问卷调查 college 妇幼保健学儿少卫生 huang

内皮前体细胞自体移植促进缺血心肌血管的新生

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中国组织工程研究与临床康复 2007年第20期11卷 3932-3935页

作者：张端珍盖鲁粤刘宏伟黄建华钟大光朱鲜阳解放军沈阳军区总医院先心病内科辽宁省沈阳市110016 解放军总医院心内科北京市100853 解放军总医院基础医学研究室北京市100853

目的:观察内皮前体细胞自体移植后能否促进血管新生、改善心肌灌注、进而改善心脏功能。方法:实验于2004-01/05在解放军总医院心内科实验室完成。①实验分组:雄性新西兰白兔32只,体质量3.0～3.5kg,随机分为治疗组和对照组,每组16只。②... 详细信息

目的:观察内皮前体细胞自体移植后能否促进血管新生、改善心肌灌注、进而改善心脏功能。方法:实验于2004-01/05在解放军总医院心内科实验室完成。①实验分组:雄性新西兰白兔32只,体质量3.0～3.5kg,随机分为治疗组和对照组,每组16只。②实验方法:治疗组自骨髓获取内皮前体细胞培养扩增。结扎动物冠状动脉前降支根部。心电图检测至少5个胸前导联出现ST段显著抬高作为模型制作成功标志。2.5g/L胰蛋白酶消化细胞,洗涤干净后5mL磷酸盐缓冲液悬浮细胞,结扎前降支2h后将细胞悬液从耳静脉注入动物体内,移植细胞数量为(9.8±2.9)×106个/只。对照组注射磷酸盐缓冲液5mL。饲养5周。③实验评估:分别行超声心动图检查和左心室压力曲线检测心脏功能和心肌组织的梗死情况以及通过免疫组织化学检测观察血管密度。结果:纳入新西兰白兔共32只,因前降支细小排除2只。对照组因心功能衰竭和腹泻各死亡1只。治疗组结扎前降支后突发室性心律失常死亡1只。最终27只进入实验。①体外培养的内皮前体细胞生长迅速,能够在2～3周达到预定移植细胞数量。②内皮前体细胞移植5周后,超声心动图检测显示治疗组动物心肌功能指数显著降低(P<0.01),左心室射血分数显著高于对照组(P<0.01),左心室舒张末压明显低于对照组(P<0.05),而等容收缩期左室压力最大上升速率显著升高(P<0.05)。③治疗组心肌梗死面积显著减小(P<0.01),而血管密度明显高于对照组(P<0.01)。④标记细胞主要位于梗死心肌组织,大部分整合至毛细血管中,参与血管新生。结论:内皮前体细胞自体移植能促进缺血心肌血管新生,有效改善缺血心肌的灌注,进而改善心脏功能。

关键词：缺血性心脏病移植心肌缺血新血管形成

Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3

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World Journal of Gastroenterology 2011年第34期17卷 3922-3932页

作者： Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang jh, huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. Fang-Ming Gu Quan-Lin Li Qiang Gao Jia-Hao Jiang Xiao-Yong Huang Jin-Feng Pan Jia Fan Jian Zhou Liver Cancer Institute Zhongshan Hospital and Shanghai Medical School Fudan University Shanghai 200032 China

AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC ***: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and ***: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation.

关键词： Hepatocellular carcinoma Sorafenib Signal transducer and activator of transcription 3 Extracellular signal regulated kinase Akt

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing Zhao Mengjie Tao Jijun Du Xingxi huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

SYNTHESIS AND CRYSTAL STRUCTURE OF THE CLUSTER COMPOUND MoS_4Cu_2Ag(Ph_3P)_3Br.H_2O

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Chinese Chemical Letters 1995年第3期6卷 263-264页

作者： Long, DL Xin, XQ huang, XY Cai, jh Kang, BS Nanjing Univ State Key Lab Coordinat Chem Nanjing 210093 Peoples R China Chinese Acad Sci Fujian Inst Res Struct Matter State Key Lab Struct Chem Fuzhou 350002 Peoples R China

MoS4Cu2Ag(Ph3P)3Br.H2O, fw = 1344, triclinic, space group P1 : a= 13.246(4),b = 20.314(6), c = 11 .995(4)A, α= 93.25(3)° β= 115.99(2)° γ = 74.44(3)° V= 2788.(2)A 3.Z= 2, Dc = 1 .60g cm-3, F(000)= 1340, μc=22.87cm-1, R = 0.060, Rw = 0.067. This is the first example or tetranuclear M-Mo-S cluster containing Cu and Ag together and the structure is a completed cubane that the Br atom bonds to Cu and Ag.

关键词： MoS4Cu2Ag COMPOUND CLUSTER Br Ph3P Cu

SYNTHESIS AND STRUCTURE OF A NOVEL“BUTTERFLY”CLUSTER“MoOS_3Cu_2(Py)_2(PPh_3)_2”

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Chinese Chemical Letters 1995年第1期6卷 91-92页

作者： Hou, HW Xin, HQ huang, XX Cai, jh Kang, BS Nanjing Univ Dept Chem State Key Lab Coordinat Chem Nanjing 210093 Peoples R China Chinese Acad Sci Fujian Inst Res Struct Matter State Key Lab Struct Chem Fuzhou 350002 Peoples R China

Reactions or [NH1]2MoO2S2, CuI and PPh3 in Py produced mixed-metal cluster [MoOS3Cu2(Py)2(PPh3)2], which crystallizes in the monoclinic, space group P21 / a with a= 18. 149(4), b = 10.044(3), c = 25. 171(7)A, β = 107.45(2)°,V = 4377(2)A3,Z= 4, Dx. = 1.54, R = 0.040, Rw= 0.049. The results of structure determination show that the central unit of the cluster compound is composed of three metal and three sulfur atoms.

关键词：魫蜢