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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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A review on different English versions of an ancient classic of Chinese medicine:huang Di Nei Jing

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Journal of Integrative Medicine 2017年第1期15卷 11-18页

作者： Xiao Ye min-hua Dong College of Humanities and Social Sciences Zhejiang Chinese Medical University Hangzhou 310053 Zhejiang Province China

huang Di Nei Jing （Nei Jing）, one of the most important classical texts of traditional Chinese medicine, is the foundation upon which today＇s Chinese medicine principles are built. This seminal ancient classic has been translated into English many times by different scholars worldwide. The authors have found thirteen English versions, each of which has its own distinctive features. By reviewing different versions and research achievements of the English translation, the authors try to summarize the translation style, purpose, content and other features of each version, and point out each translation＇s weaknesses, strengths, or significance. The emerging of so many English versions of Nei Jing, an ancient and sophisticated text, shows that scholars have disparate understanding of its language and concepts. Additionally, different educational backgrounds, professions and goals of the translators will all contribute to different perspectives and approaches in the translation. It is understandable that so many versions of translation exist for such an ancient and important classic. However, to achieve truly accurate translation of ancient classical texts of Chinese medicine, all translators should abide by certain basic requirements and translation principles.

关键词： medicine, Chinese traditional huang Di Nei Jing Su Wen Ling Shu translation ancient classics

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DWI及ADC值鉴别脑脓肿与坏死囊变脑转移瘤的价值

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第四军医大学学报 2007年第5期28卷 438-441页

作者：黄敏华郭勇林伟钱明珠张永文海军总医院磁共振室北京100037

目的:研究DWI及ADC值在鉴别脑脓肿与坏死囊变脑转移瘤中的应用价值.方法:病理及临床证实脑脓肿14例,坏死囊变脑转移瘤17例,经常规磁共振检查及弥散加权检查,在脑脓肿脑炎期、包膜期及吸收期进行弥散信号及ADC值的测量,并与坏死囊变脑转... 详细信息

目的:研究DWI及ADC值在鉴别脑脓肿与坏死囊变脑转移瘤中的应用价值.方法:病理及临床证实脑脓肿14例,坏死囊变脑转移瘤17例,经常规磁共振检查及弥散加权检查,在脑脓肿脑炎期、包膜期及吸收期进行弥散信号及ADC值的测量,并与坏死囊变脑转移瘤相比较,统计学分析采用χ2检验和t检验.结果:脑脓肿包膜期DWI为高信号,ADC值低,与坏死囊变脑转移瘤DWI及ADC值正好相反.吸收期及脑炎期脑脓肿DWI为低信号或等信号,而ADC值高信号或等信号,与坏死囊变脑转移瘤正好相类似.所有脑脓肿的平均ADC值为0.88×10-3mm2/s,坏死囊变脑转移瘤平均ADC值1.8×10-3mm2/s,两者比较有统计学差异(P<0.05).DWI信号诊断的敏感性为64.5%(20/31),特异性为100%(17/17),准确性为77%(37/48).结论:DWI及ADC值有助于鉴别包膜期脑脓肿与坏死囊变脑转移瘤,对吸收期脑脓肿与坏死囊变脑转移瘤的鉴别诊断无明显意义.

关键词：磁共振成像弥散加权成像 ADC值脑脓肿脑肿瘤/继发性

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Numerical Investigation on the Harbour Resonance Inside A Harbour with Lateral Cavities

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China Ocean Engineering 2024年第5期38卷 838-844页

作者： YU Yue-min huang Xiao-hua School of Marine Science and Engineering Hainan UniversityHaikou 570228China Key Laboratory for Sustainable Utilization of Open-Sea Fishery Ministry of Agriculture and Rural AffairsGuangzhou 510300China South China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhou 510300China

Wave-induced harbour resonance is numerically investigated inside a harbour with lateral *** theoretical solutions for the amplification parameter are compared with the simulated results under varying dimensionless wave numbers in order to verify the simulation model in a rectangular harbour at a constant *** results indicate that the numerical model can correctly calculate the natural frequency and the natural wave height.A range of calculations are performed for harbour resonance with one pair of lateral cavities,two pairs of lateral cavities and three pairs of lateral cavities,*** simulated results indicate that the amplitude of the amplification parameter decreases both at the primary natural oscillation and the secondary natural oscillation,as the number of lateral cavities *** dimensionless wave number reduces as the number of lateral cavities increases both at the primary natural oscillation and the secondary natural oscillation as well.

关键词： harbour resonance lateral cavity numerical simulation amplification parameter

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人文关怀式护理在胎膜早破孕妇中的应用效果

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当代护士（中旬刊） 2018年第4期25卷 68-69页

作者：杜爱民林春华黄敏华黄锦兰陈小香广东省阳江市人民医院阳江529500

目的探讨人文关怀式护理模式在胎膜早破孕妇中的应用效果。方法以本院产科于2016年1~12月期间收治的60例胎膜早破孕妇作为研究对象,采用随机数字表将其分为对照组与观察组,各30例,对照组给予常规护理,观察组在常规护理的基础上开展人文... 详细信息

目的探讨人文关怀式护理模式在胎膜早破孕妇中的应用效果。方法以本院产科于2016年1~12月期间收治的60例胎膜早破孕妇作为研究对象,采用随机数字表将其分为对照组与观察组,各30例,对照组给予常规护理,观察组在常规护理的基础上开展人文关怀式护理,对比2组新生儿出生后1min的阿氏(Apgar)评分以及并发症的发生情况。结果观察组Apgar评分平均为(8.06±1.09)分,其中8~10分有21例,4~7分有8例,0~3分有1例;对照组Apgar评分平均为(6.98±1.64)分,其中8~10分有15例,4~7分有9例,0~3分有6例,观察组明显高于对照组,差异有统计学意义(P<0.05)。观察组中共发生胎儿窘迫1例、早产1例、新生儿肺炎1例、宫内感染1例,并发症发生率为13.33%;对照组中共发生胎儿窘迫3例、早产3例、新生儿肺炎2例、宫内感染2例,并发症发生率为33.33%,观察组明显低于对照组,差异也具有统计学意义(P<0.05)。结论通过对胎膜早破孕妇开展人文关怀式护理,可以明显减少新生儿并发症的发生风险,同时提高新生儿的健康状况,保证母婴安全。

关键词：胎膜早破人文关怀护理 Apgar评分

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun huang Bin Jia Artem S.Pilipchuk Sibo huang Chen Shen Almas F.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Blue LED-pumped efficient NIR luminescence in Sb3+-doped lead-free metal halides

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Science China Materials 2025年

作者： Xiaoyong huang College of Physics and Optoelectronics Taiyuan University of Technology

Broadband near-infrared （NIR） light sources hold promise for some important NIR spectroscopy applications such as night vision,plant growths,optical communications,remote sensing,biomedical imaging and other noninvasive and nondestructive detections[1–4].Recently,the phosphors-converted NIR lightemitting diodes （LEDs） based on“blue LED chips+broadband NIR phosphors”are widely developed for next-generation costeffective NIR light *** this respect,the performance of NIR phosphors directly determines the overall quality of phosphors-converted NIR LEDs.

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian huang Chenxin Wang Xu Wang Xiaoyu Zhou Wei Xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

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Glomerular podocyte dysfunction in inherited renal tubular disease

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World Journal of Pediatrics 2021年第3期17卷 227-233页

作者： Li-min huang Jian-hua Mao Department of Nephrology National Clinical Research Center for Child HealthThe Children’s HospitalZhejiang University School of Medicine#57 Zhugan LaneHangzhou 310006China

Background Hereditary renal tubular disease can cause hypercalciuria,acid-base imbalance,hypokalemia,hypomagnesemia,rickets,kidney stones,*** these diseases are not diagnosed or treated in time,they can cause kidney damage and electrolyte disturbances,which can be detrimental to the maturation and development of the *** involvement in renal tubular disease patients has only been considered *** We screened 71 papers(including experimental research,clinical research,etc.)about Dent's disease,Gitelman syndrome,and cystinosis from PubMed,and made *** Glomerular disease was initially underestimated among the clinical signs of renal tubular disease or was treated merely as a consequence of the tubular *** tubular diseases affect glomerular podocytes through certain mechanisms resulting in functional damage,morphological changes,and glomerular *** This article focuses on the progress of changes in glomerular podocyte function in Dent disease,Gitelman syndrome,and cystinosis for the purposes of facilitating clinically accurate diagnosis and scientific treatment and improving prognosis.

关键词： Cystinosis Dent disease Gitelman syndrome Podocyte Renal tubule disease

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近10年中国体育产业硕博士学位论文研究热点的共词分析

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德州学院学报 2018年第4期34卷 97-100,105页

作者：黄华敏董必凯彭程彩广西民族师范学院体育学院广西崇左532200

选取中国知网(CNKI)硕博学位论文数据库体育产业学位论文为研究样本,利用Excel、SPSS20.0软件对关键词进行词频分析、聚类分析、多维尺度分析,获得中国体育产业学位论文研究的八大热点主题,旨在为后续相关研究提供参考.

关键词：体育产业学位论文共词分析

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