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Chemical Research in Chinese Universities 1998年第2期14卷 30-34页

作者： LI Ye-zhi GUO Chun-xiao ZHANG Li huang hua-min Department of Chemistry National Key Laboratory of ComputationalTheoretical ChemistryJilin UniversityChangchun130023

(R)-N-(β-Trichlorogermyl propionyl)thiazolidine-2-thione-4-carboxylic methyl ether(1) and its sesquioxide(2) were synthesized. The crystal structure of 1 was determined by means of X-ray diffraction analysis, which shown that the >CO and >CS groups are located in the opposite sides of C(4)—N—C(3) bond with transconfiguration. The electronic structures and optimized configurations of compounds 1 and 2 were studied with MNDO method.

关键词： (R)-N-(β-Trichlorogermyl propionyl)thiazolidine-2-thione-4-carboxylic methyl ether (R)-N-(Propionylthiazolidine-2-thione-4-methoxycarbonyl)germanium sesquioxide MNDO Electronic structure Optimized configuration

Esterification and Chemoselective Synthesis of R-Tetrahydrothiazo-2-thione-4-carboxylic Esters Catalyzed by TiCl_4

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Chemical Research in Chinese Universities 2007年第4期23卷 430-432页

作者： SHANG Yan-mei LI Jing SONG Zhi-guang LI Ye-zhi huang hua-min College of Chemistry School of Public Health Key Laboratory for Supermolecular Structure and Materials of ministry of Education Jilin University Changchun 130021 P. R. China

A series of esters of R-tetrahydrothiazo-2-thione-4-carboxylic acid [ R-TTCA ] was synthesized by direct esterifica- tion of R-TTCA with alcohols（CH3OH, C2H5OH, n-C3HTOH, i-C3HTOH, n-C4H9OH, sec-C4H9OH） in the presence of TiCl4 as the catalyst at room temperature without using any other solvent or dehydrant in high yields, 91.6%-99.1% for primary alcohols and 55%- 80% for secondary alcohols. The catalyst has a strong chemoselec-tive activity for the esterification of primary alcohols with R-TTCA in the presence of secondary alcohols. Owing to high yield, high chemoselectivity, and mild conditions used, this is an efficient method for the esterification of prima-ry alcohols with R-TTCA.

关键词： R-Tetrahydrothiazo-2-thione-4-carboxylic acid TICl4 Chemoselectivity Esterification

Synthesis and Crystal Structure of (R)-4-Hydroxymethyl-2-thioxo Thiazolidine and Its Asymmetric Catalysis

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Chemical Research in Chinese Universities 2009年第1期25卷 43-46页

作者： LI Jing SHANG Yan-mei XIAO Chuan SONG Zhi-guang LI Ye-zhi huang hua-min College of Chemistry Jilin University School of Public Health Jilin University Changchun 130021 P. R. China Key Laboratory for Supramoleeular Structure and Materials of ministry of Education Jilin University Changehun 130012 P. R. China

（R）-4-Hydroxymethyl-2-thioxo thiazolidine as a new chiral catalyst in the asymmetric addition of diethylzinc to benzaldehyde was synthesized from （R）-4-hydroxymethyl-2-thioxo thiazolidine carboxylic acid and its crystal structure was determined by X-ray diffraction method. The compound was crystallized in the orthorhombic system, space group P212121 with unit cell dimensions a=0.67253（12） nm; b=0.89164（17） nm; c=1.06146（19） nm, volume 0.6365（2） nm^3; Z=4, calculated denisity 1.557 Mg/m^3; absorption coefficient 0.733 mm^-1; F（000）=312. The X-ray crystal structure analysis reveals that the compound has a thione group.

关键词： Crystal structure Asymmetric (R)-4-Hydroxymethyl-2-thioxothiazolidine

Esterification and Selective Esterification in the Presence of TiCl_4

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Chemical Research in Chinese Universities 2007年第6期23卷 669-673页

作者： SHANG Yan-mei LI Jing ZHANG Ping SONG Zhi-guang LI Ye-zhi huang hua-min College of Chemistry Jilin University Changchun 130021 P. R. China School of Public Health Jilin University Changchun 130021 P. R. China Key Laboratory for Supermolecular Structure and Materials of ministry of Education Jilin University Changchun 130012 P. R. China

A series of carboxylic acids was esterified to the corresponding esters with TICl4 as catalyst at room temperature, in high yields. This catalyst was highly effective for the selective esterification of primary alcohols with carboxylic acids, in the presence of secondary alcohols, and for the selective esterification of saturated acid with alcohol in the presence of conjugated acid or aromatic acid. On account of the high yield, high chemoselectivity, mild condition, and being free of other dehydrants, this is an efficient method.

关键词： Esterification Chemoselectivity TiCl4

Association of (S)-Isoserine Derivatives and 2,2,4-Trimethyl-3-hydroxy-4-cyclohexenecarboxylate

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Chemical Research in Chinese Universities 2007年第1期23卷 18-21页

作者： WANG Lei ZHENG Qing-chuan SONG Zhi-guang FANG Wei-shuo LI Ye-zhi huang hua-min College of Chemistry State Key Laboratory of Theoretical and Computational Chemistry Jilin University Changchun 130021 P. R. China Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 P. R. China

Two novel compounds（4a and 4b） were obtained by the association of 2,2,4-trimethyl-3-hydroxy-5-cyclohexenecarboxylate with （S） -isoserine derivatives. The space location of the hydroxyl group of compound 1 was identified via the formation of lactone 6. Fe2 （SO4）3·xH2O was used as the catalyst for the synthesis of lactone 6. The carboxyl group was selectively protected with diazomethane. All the products were characterized via ^1H NMR and mass spectra. The Docking study showed that the associations have the potential therapeutic use of DPP-Ⅳ inhibitor.

关键词： (S) -Isoserine 2,2,4-Trimethyl-3-hydroxy-d-cyclohexenecarboxylate Association DPP- Ⅳ

Studies　on　Ester　Exchange　Reaction

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Chemical Research in Chinese Universities 1998年第1期14卷 38-41页

作者： Zhang, Jing-wen Zhang, Xiao-long Ma, Xiu-li Liu, Chang-cheng Mu, Ying Sun, Yun-xiu Jiang, Wen-pu huang, hua-min Li, Yao-xian Peng, Wan-ru Jilin Univ Dept Chem Changchun 130023 Peoples R China Changchun Higher Coll Med Sci Dept Pharmacol Changchun 130023 Peoples R China

ＳｔｕｄｉｅｓｏｎＥｓｔｅｒＥｘｃｈａｎｇｅＲｅａｃｔｉｏｎＺＨＡＮＧＪｉｎｇ－ｗｅｎ，ＺＨＡＮＧＸｉａｏ－ｌｏｎｇ，ＭＡＸｉｕ－ｌｉ，ＬＩＵＣｈａｎｇ－ｃｈｅｎｇ，ＭＵＹｉｎｇ，ＳＵＮＹｕｎ－ｘｉｕ，ＪＩＡＮＧＷｅ... 详细信息

ＳｔｕｄｉｅｓｏｎＥｓｔｅｒＥｘｃｈａｎｇｅＲｅａｃｔｉｏｎＺＨＡＮＧＪｉｎｇ－ｗｅｎ，ＺＨＡＮＧＸｉａｏ－ｌｏｎｇ，ＭＡＸｉｕ－ｌｉ，ＬＩＵＣｈａｎｇ－ｃｈｅｎｇ，ＭＵＹｉｎｇ，ＳＵＮＹｕｎ－ｘｉｕ，ＪＩＡＮＧＷｅｎ－ｐｕ，ＨＵＡＮＧＨｕａ－ｍｉｎ...

关键词： Reaction Studies Exchange Ester

盐酸左氧氟沙星在盆腔炎治疗中的临床疗效及安全性评估

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中国妇幼保健 2012年第7期27卷 989-990页

作者：黄华民青海红十字医院青海西宁810000

目的:探讨盐酸左氧氟沙星在盆腔炎治疗中的临床疗效及安全性评估。方法:选择以盆腔炎来院治疗的患者156例,其中急性盆腔炎患者80例,慢性盆腔炎76例。按照治疗方法不同可以分为治疗组78例(给予盐酸左氧氟沙星治疗)和观察组78例(给予氧氟... 详细信息

目的:探讨盐酸左氧氟沙星在盆腔炎治疗中的临床疗效及安全性评估。方法:选择以盆腔炎来院治疗的患者156例,其中急性盆腔炎患者80例,慢性盆腔炎76例。按照治疗方法不同可以分为治疗组78例(给予盐酸左氧氟沙星治疗)和观察组78例(给予氧氟沙星治疗)。密切观察两组患者间白细胞计数、体温变化、下腹疼痛程度变化、附件增厚程度及阴道出血情况;密切观察两组患者治疗过程中恶心呕吐、腹痛腹胀、头痛头晕、肝功能异常等不良反应的发生率。结果:治疗组总有效率为87.2%明显高于观察组(64.1%),差异具有统计学意义(P<0.05);治疗组总不良反应发生率为7.8%明显低于观察组(25.6%),差异具有统计学意义(P<0.05)。结论:盐酸左氧氟沙星注射液治疗妇科盆腔炎具有很好的疗效,且不良反应较小,值得临床推广使用。

关键词：盐酸左氧氟沙星氧氟沙星盆腔炎

经腹、经阴道与腹腔镜全子宫切除术的临床对照分析

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现代预防医学 2012年第7期39卷 1650-1651+1654页

作者：黄华民青海红十字医院

目的分析比较经腹、经阴道与腹腔镜全子宫切除3种不同方式的子宫切除术的临床效果。方法选择某院2010年1月～2011年11月行全子宫切除的72例患者作为观察对象,根据住院号随机将患者分为3组,即TAH组、TVH组、LTH组,每组各24例,对3组病例... 详细信息

目的分析比较经腹、经阴道与腹腔镜全子宫切除3种不同方式的子宫切除术的临床效果。方法选择某院2010年1月～2011年11月行全子宫切除的72例患者作为观察对象,根据住院号随机将患者分为3组,即TAH组、TVH组、LTH组,每组各24例,对3组病例的手术时间、子宫质量、术中出血量、术后镇痛率、术后排气时间、术后住院时间、术后并发症进行比较。结果 LTH组病例手术时间明显长于TAH组、TVH组;TVH组和LTH组病例术后出血量、术后阵痛率、术后排气时间、术后住院时间明显较TAH组小或低;LTH组术后出血量较TVH组大,术后排气时间较TVH组短。差异均有统计学意义(P﹤0.05)。结论相比较而言,经阴道全子宫切除术更具有优势,多数情况下可作为首选,但在临床实践中,临床医生应综合考虑,在保证医疗安全的前提下,可合理地选择手术方式。

关键词：经阴道全子宫切除术腹腔镜下全子宫切除术经腹全子宫切除术对照分析