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Spongiosum-combined glanuloplasty reduces glans complications after proximal hypospadias repair

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Asian Journal of Andrology 2021年第5期23卷 532-536页

作者： Yi-Qing Lyu Lin Yu Hua Xie Yi-Chen huang Xiao-Xi Li Li Sun Yan liang Fang Chen Department of Urology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

We aim to design a new glanuloplasty procedure combined with spongiosum to reduce the incidence of glans dehiscence and coronal fistula after proximal hypospadias *** who underwent urethroplasty by dorsal preputial island flap for proximal hypospadias between January 2014 and December 2016 were reviewed in this retrospective cohort *** who underwent spongiosum-combined glanuloplasty comprised the new-maneuver group,whereas those who underwent conventional glanuloplasty comprised the control *** incidence of complications was then *** the new-maneuver group,dysplastic corpus spongiosum alongside lateral Buck's fascia(0.3-0.4 cm wide)on both sides of the urethral plate was separated from the proximal normal spongy tissue,joining into the glans wings to increase tissue volume and covering the neourethra in the glans *** the control group,the neourethra was covered with superficial fascia under the coronal *** a result,the new-maneuver and control groups comprised 47 and 28 patients,*** the new-maneuver group,no glans dehiscence was detected;however,two(4.3%)patients had coronal fistula,two(4.3%)had urethral stricture,and four(8.5%)had *** the control group,two(7.1%)patients had glans dehiscence,eight(28.6%)had coronal fistula,four(14.3%)had urethral stricture,one(3.6%)had diverticulum,and one(3.6%)had penile curvature *** new-maneuver group had less incidences of coronal fistula(P<0.001),glans dehiscence(P=0.033),and urethral stricture(P=0.008)but had a higher incidence of diverticulum than the control group(P=0.040).It clearly demonstrates that spongiosum-combined glanuloplasty can significantly reduce the incidences of coronal fistula and glans dehisce.

关键词： glans dehiscence glanuloplasty hypospadias urinary fistula

Toric Intraocular Lens vs. Peripheral Corneal Relaxing Incisions to Correct Astigmatism in Eyes Undergoing Cataract Surgery

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Eye Science 2014年第4期29卷 198-203页

作者： Zhiping Liu Xiangyin Sha Xuanwei liang Zhonghao Wang Jingbo Liu Danping huang Department of Ophthalmology the Second Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Department of Ophthalmology Dyson Vision Research Institute Weill Cornell Medical College

Purpose:.To compare toric intraocular lens implantation(ToricIOL).with peripheral corneal relaxing incisions(PCRIs) for astigmatism correction in patients undergoing cataract ***: 54 patients(54 eyes) with more than 0.75 diopter(D).of preexisting corneal astigmatism were classified as group A(0.75-1.50D) or group B(1.75-2.50D). The patients were randomized to undergo Toric-IOL or PCRIs in the steep axis with spherical IOL implantation..Log MAR uncorrected visual acuity(Log MAR UCVA), Log MAR best corrected vi sual acuity.(Log MAR BCVA),.error of vector(|EV|), surgery induced refraction correction.(|SIRC |),.and correction rates(CR) were measured 1 month and 6 months ***: At 6 months postoperatively, all 54 eyes had LogMAR BCVA≤0.2. Patients who underwent PCRIs and ToricIOL with Log MAR BCVA≤0.1 showed no significant differences in group A(P=1.00) or in group B(P=0.59). Group A showed no significant differences in Log MAR UCVA(P =0.70), |EV|(P=0.13), |SIRC|(P=0.71), and CR(P=0.56)in patients underwent PCRIs and Toric-IOL. However, group B showed significant differences in Log MAR UCVA(P <0.01), |EV|(P<0.01)), |SIRC|(P<0.01), and CR(P<0.01).The Log MAR UCVA and |EV | between 1 and 6 months showed no significant differences in patients in group A. However, in group B, they are significant ***:.The efficacy and stability of Toric-IOL and PCRIs were equal in low astigmatic patients..Toric-IOL achieved an enhanced effect over PCRIs in higher astigmatic *** had the more refractive regression than Toric-IOL in 6months.

关键词：白内障手术屈光矫正人工晶体散光角膜切口松解眼睛

Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia

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Journal of Molecular Cell Biology 2023年第12期15卷 50-64页

作者： Ting guo Chen Miao Zhonghua Liu Jingwei Duan Yanbin Ma Xiao Zhang Weiwei Yang Maoguang Xue Qiannan Deng Pengfei guo Yongmei Xi Xiaohang Yang Xun huang Wanzhong Ge Division of Human Reproduction and Developmental Genetics Women’s HospitalZhejiang University School of MedicineHangzhou 310058China Institute of Genetics Zhejiang University School of MedicineHangzhou 310058China Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women’s HospitalZhejiang University School of MedicineHangzhou 310006China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeĳing 100101China Cancer Center Zhejiang UniversityHangzhou 310058China

Mutations or dysregulated expression of NF-kappaB-activating protein(NKAP)family genes have been found in human *** NKAP family gene mutations promote tumor initiation and progression remains to be ***,we characterized dNKAP,the Drosophila homolog of NKAP,and showed that impaired dNKAP function causes genome instability and tumorigenic growth in a Drosophila epithelial tumor ***-knockdown wing imaginal discs exhibit tumorigenic characteristics,including tissue overgrowth,cell-invasive behavior,abnormal cell polarity,and cell adhesion *** knockdown causes both R-loop accumulation and DNA damage,indicating the disruption of genome *** analysis showed that dNKAP knockdown induces c-Jun N-terminal kinase(JNK)-dependent apoptosis and causes aberrant cell proliferation in distinct cell *** of the Notch and JAK/STAT signaling pathways contributes to the tumorigenic growth of dNKAP-knockdown ***,JNK signaling is essential for dNKAP depletion-mediated cell *** analysis of dNKAP-knockdown tissues confirmed the misregulation of signaling pathways involved in promoting tumorigenesis and revealed abnormal regulation of metabolic *** knockdown and oncogenic Ras,Notch,or Yki mutations show synergies in driving tumorigenesis,further supporting the tumor-suppressive role of *** summary,this study demonstrates that dNKAP plays a tumor-suppressive role by preventing genome instability in Drosophila epithelia and thus provides novel insights into the roles of human NKAP family genes in tumor initiation and progression.

关键词： Drosophila wing imaginal disc dNKAP genome instability tumorigenic growth

Light-induced tumor theranostics based on chemical-exfoliated borophene

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Light(Science & Applications) 2022年第12期11卷 2886-2899页

作者： Zhongjian Xie Yanhong Duo Taojian Fan Yao Zhu Shuai Feng Chuanbo Li Honglian guo Yanqi Ge Shakeel Ahmed Weichun huang Huiling Liu Ling Qi Rui guo Defa Li Paras N.Prasad Han Zhang Institute of Pediatrics Shenzhen Children’s HospitalShenzhenGuangdongChina Shenzhen Engineering Laboratory of phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People’s Hospitalthe First Affiliated HospitalInstitute of Microscale OptoelectronicsShenzhen University518060 ShenzhenChina Department of Microbiology Tumor and Cell Biology(MTC)Karolinska InstituteStockholmSweden Shenzhen Medical Ultrasound Engineering Center Department of UltrasonographyShenzhen People’s HospitalSecond Clinical Medical College of Jinan UniversityFirst Clinical Medical College of Southern University of Science and Technology518020 ShenzhenChina Optoelectronics Research Center School of ScienceMinzu University of China100081 BeijingPR China Nantong Key Lab of Intelligent and New Energy Materials College of Chemistry and Chemical EngineeringNantong University226019 NantongJiangsuChina Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier DevelopmentDepartment of Biomedical EngineeringJinan University510632 GuangzhouChina Department of Core Medical Laboratory the Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuanGuang Dong ProvinceChina Department of Laboratory Medicine Shenzhen Children’s HospitalShenzhenGuangdongChina Institute for Lasers Photonicsand Biophotonics and Department of ChemistryUniversity at BuffaloState University of New YorkBuffaloNYUSA

Among 2D materials(Xenes)which are at the forefront of research activities,borophene,is an exciting new entry due to its uniquely varied optical,electronic,and chemical properties in many polymorphic forms with widely varying band gaps including the lightest 2D metallic *** this paper,we used a simple selective chemical etching to prepare borophene with a strong near IR light-induced photothermal *** photothermal efficiency is similar to plasmonic Au nanoparticles,with the added benefit of borophene being degradable due to electron deficiency of *** introduce this selective chemical etching process to obtain ultrathin and large borophene nanosheets(thickness of ~4 nm and lateral size up to ~600 nm)from the precursor of AlB_(2).We also report first-time observation of a selective Acid etching behavior showing HCl etching of Al to form a residual B lattice,while HF selectively etches B to yield an Al *** demonstrate that through surface modification with polydopamine(PDA),a biocompatible smart delivery nanoplatform of B@PDA can respond to a tumor environment,exhibiting an enhanced cellular uptake *** demonstrate that borophene can be more suitable for safe photothermal theranostic of thick tumor using deep penetrating near IR light compared to gold nanoparticles which are not degradable,thus posing longterm toxicity *** about 40 kinds of borides,we hope that our work will open door to more discoveries of this top-down selective etching approach for generating borophene structures with rich unexplored thermal,electronic,and optical properties for many other technological applications.

关键词： chemical uniquely electronic

An efficient hardware design for HDTV H.264/AVC encoder

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第6期12卷 499-506页

作者： liang WEI Institute of Information and Communication Engineering Zhejiang University Hangzhou 310027 China Zhejiang Provincial Key Laboratory of Information Network Technology Hangzhou 31002 7 China

This paper presents a hardware efficient high definition television (HDTV) encoder for H.264/AVC. We use a two-level mode decision (MD) mechanism to reduce the complexity and maintain the performance, and design a sharable architecture for normal mode fractional motion estimation (NFME), special mode fractional motion estimation (SFME), and luma motion compensation (LMC), to decrease the hardware cost. Based on these technologies, we adopt a four-stage macro-block pipeline scheme using an efficient memory management strategy for the system, which greatly reduces on-chip memory and bandwidth requirements. The proposed encoder uses about 1126k gates with an average Bjontegaard-Delta peak signal-to-noise ratio (BD-PSNR) decrease of 0.5 dB, compared with JM15.0. It can fully satisfy the real-time video encoding for 1080p@30 frames/s of H.264/AVC high profile.

关键词： H.264/AVC High-definition television (HDTV) Hardware Architecture Encoder

Directional screening and identification of potential cytotoxic components from Achnatherum inebrians by a combination of surface palsmon resonance and chromatography

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Chinese Herbal Medicines 2023年第2期15卷 329-336页

作者： Wenbin Zhou Man Wang Aiqin Zhang Danrong huang Hua guo Gangyi Shen Key Laboratory of Ethnomedicine(Minzu University of China) Ministry of EducationSchool of PharmacyMinzu University of ChinaBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Objective:To establish a method for directional screening of the cytotoxic components from the medicinal herb of Achnatherum inebrians by a combination of surface plasmon resonance(SPR)biosensor and chromatographic isolation ***:Under the guidance of bioactive assessment based on binding abilities between objects and the a-Mannosidase(a-Man)target,the active components from different solvents extracts,different polar extraction parts and fractions were screened orderly and directionally using *** with a high binding ability to a-Man can be precisely oriented in a narrower fractions range and are easy to *** human cancer cells were used to evaluate the cytotoxic activity of component with the highest affinity to ***:Eight compounds were isolated and identificated from *** for the first *** possessed the highest affinity to a-Man among ***,deoxyvasicinone showed good effects on inhibited proliferation of human hepatoma cells HepG2(IC_(50)=5.7 μmol/L),human breast cancer cells MCF7(IC_(50)=7.21 μmol/L)and human lung cancer cells HCC827(IC_(50)=0.75 μmol/L),*** particular,its inhibitory effect on HCC827 was stronger than the positive drug gefitinib(IC_(50)=1.65 μmol/L).Conclusion:A comprehensive strategy of directional screening potential cytotoxic components from herb based on biomolecular interaction and chromatography was *** as an effective anti-cancer component was initially isolated from *** is expected that this screening strategy could provide new perspectives for rapid screening and identification of active components from natural plants with the complex matrix.

关键词： Achnatherum inebrians(Hance)Keng chromatography cytotoxic components deoxyvasicinone surface plasmon resonance α-Mannosidase

LARGE MAGNETIC ENTROPY CHANGE IN La0.67-xGdxCa0.33MnO3

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南京大学学报(自然科学) 1998年第4期 124-126页

作者： huang He guo Zaibing Wang Dunhui Du Youwei

Ｒｅｃｅｎｔｌｙ，ｍｏｒｅａｎｄｍｏｒｅｐｅｏｐｌｅｆｏｃｕｓｔｈｅｉｒａｔｅｎｔｉｏｎｏｎｔｈｅｍａｇｎｅｔｉｃｒｅｆｒｉｇｅｒａｔｉｏｎｂｅｃａｕｓｅｉｔｈａｓｌｏｔｓｏｆａｄｖａｎｔａｇｅｓｏｖｅｒｔｈｅｇａｓ... 详细信息

Ｒｅｃｅｎｔｌｙ，ｍｏｒｅａｎｄｍｏｒｅｐｅｏｐｌｅｆｏｃｕｓｔｈｅｉｒａｔｅｎｔｉｏｎｏｎｔｈｅｍａｇｎｅｔｉｃｒｅｆｒｉｇｅｒａｔｉｏｎｂｅｃａｕｓｅｉｔｈａｓｌｏｔｓｏｆａｄｖａｎｔａｇｅｓｏｖｅｒｔｈｅｇａｓｒｅｆｒｉｇｅｒａｔｉｏｎ．Ｉｎｔ...

关键词： refrigeration magnetic entropy perovskite

On mapping degrees between 1-connected 5-manifolds

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Science China Mathematics 2006年第12期49卷 1855-1863页

作者： TAN liang LMAM Department of MathematicsPeking UniversityBeijing 100871China

We study the set of the mapping degrees between simply connected closed manifolds in this paper.

关键词： mapping degree simply connected manifolds Moore space Eilenberg-Maclane space.

Mitigating ROP Attacks via ARM-Specific In-Place Instruction Randomization

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China Communications 2016年第9期13卷 208-226页

作者： Yu liang Key Laboratory of Aerospace Information Security and Trust Computing of Ministry of Education Wuhan 430079China Computer School of Wuhan University Wuhan 430079China

Defending against return-oriented programing(ROP) attacks is extremely challenging for modern operating *** the most popular mobile OS running on ARM,Android is even more vulnerable to ROP attacks due to its weak implementation of ASLR and the absence of effective control-flow integrity *** this paper,leveraging specific ARM features,an instruction randomization strategy to mitigate ROP attacks in Android even with the threat of single pointer leakage vulnerabilities is *** popping out more registers in functions' epilogue instructions and reallocating registers in function scopes,branch targets in all(direct and indirect) branch instructions potential to be ROP gadgets are changed *** the knowledge of binaries' runtime instructions layout,adversary's repeated control flow transfer in ROP exploits will be ***,this instruction randomization idea has been implemented in both Android Dalvik runtime and *** evaluations proved it is capable to introduce enough randomness for more than 99% discovered functions and thwart about 95% ROP gadgets in application's shared libraries and oat file compiled from Dalvik ***,evaluations on real-world exploits also confirmed its effectiveness on mitigating ROP attacks within acceptable performance overhead.

关键词： software security ROP mitigation instruction randomization ARM architecture