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SOX11 as a potential prognostic biomarker in hepatocellular carcinoma linked to immune infiltration and ferroptosis

Chinese Journal of Cancer Research 2024年第4期36卷 378-397页

作者： Hongyu Chen Qiangguo ao Yueling Wang Yue Qian Qingli Cheng Wei Zhang Department of Nephrology the Second Medical Center of PLA General HospitalNational Clinical Research Center for Geriatric DiseasesBeijing 100853China Clinical Laboratory the First Affiliated Hospital of Henan UniversityKaifeng 475000China Cell Biology Department Wuxi School of MedicineJiangnan UniversityWuxi 214122China Department of Pathogen Biology Guizhou Nursing Vocational CollegeGuiyang 550000China

Objective:SOX11 is expressed in numerous malignancies,including hepatocellular carcinomas(HCC),but its oncogenic function has not been ***,we performed a comprehensive bioinformatics analysis of the Liver Hepatocellular Carcinoma(LIHC)dataset to investigate the function of SOX11 in ***:SOX11 expression data from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)were validated by immunohistochemistry(IHC).Co-expression,differential expression,and functional analyses utilized TCGA-LIHC,Timer 2.0,Metascape,GTEx,and LinkedOmics *** with immune infiltration,ferroptosis,and immune checkpoint genes were *** changes were explored via *** regression,receiver operating characteristic curve(ROC),Kaplan-Meier analysis,and nomogram modeling evaluated associations with HCC clinicopathological ***11’s impact on proliferation and migration was studied in HepG2 and HuH7 cell ***:SOX11 was significantly elevated in HCC tumors compared to ***11-associated genes exhibited differential expression in pathways involving extracellular membrane ion *** associations were found between SOX11 levels,immune infiltration,ferroptosis,and immune checkpoint genes in HCC ***11 levels correlated with HCC stage,histologic grade,and tumor status,and independently predicted overall and disease-specific ***11 expression effectively distinguished between tumor and normal liver *** correlations highlighted a significant relationship between SOX11 and ferroptosis-associated *** SOX11 levels in HepG2 and HuH7 cells resulted in reduced proliferation and ***:SOX11 was found to represent a promising biomarker within HCC diagnosis and prognosis together with being a possible drug-target.

关键词： SOX11 biomarker HCC prognosis genetic alterations tumor-immune infiltration ferroptosis

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Study on impedance spectroscopy based on dynamic equivalent circuit of solar cell

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Optoelectronics Letters 2024年第8期20卷 449-453页

作者： XIao Wenbo LI ao WU Huaming LI Yongbo XIao Bangzhi Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063China Jiangxi Engineering Laboratory for Optoelectronics Testing Technology Nanchang 330063China College of Science and Technology Nanchang Hangkong UniversityGongqingcheng 332020China School of Engineering and Construction Nanchang UniversityNanchang 330031China

This paper investigates the impedance spectroscopy of monocrystalline silicon solar cells(MSSC)and dye-sensitized solar cells(DSSC)using solar cell dynamic equivalent resistor-capacitance(RC)and capacitor sum capacitor(CSC)***,these circuits effectively represent the dynamic behavior of MSSC and ***,the measurement method significantly impacts the accuracy of impedance measurements in the high-frequency ***,the series resistance affects the distance between the left end of the impedance spectroscopy and the origin,while the parallel resistance influences the size of the impedance *** the CSC circuit,the relative magnitudes of dielectric relaxation capacitance and chemical capacitance affect the number and position of arc in the impedance *** value of the dielectric relaxation capacitor determines the number of impedance spectroscopy *** conclusions provide guidelines for improving the accuracy of solar cell impedance measurements.

关键词： spectroscopy impedance capacitance

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Precision Control of Amphoteric Doping in Cu_(x)Bi_(2)Se_(3) Nanoplates

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Precision Chemistry 2024年第8期2卷 421-427页

作者： Huaying Ren Jingxuan Zhou ao Zhang Zixi Wu Jin Cai Xiaoyang Fu Jingyuan Zhou Zhong Wan Boxuan Zhou Yu huang Xiangfeng Duan Department of Chemistry and Biochemistry University of CaliforniaLos AngelesLos AngelesCalifornia 90095United States Department of Materials Science and Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095United States Department of Materials Science and Engineering and California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCalifornia 90095United States California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCalifornia 90095United States

Copper-doped Bi_(2)Se_(3)(Cu_(x)Bi_(2)Se_(3))is of considerable interest for tailoring its electronic properties and inducing exotic charge correlations while retaining the unique Dirac surface ***,the copper dopants in Cu_(x)Bi_(2)Se_(3) display complex electronic behaviors and may function as either electron donors or acceptors depending on their concentration and atomic sites within the Bi_(2)Se_(3) crystal ***,a precise understanding and control of the doping concentration and sites is of both fundamental and practical ***,we report a solution-based one-pot synthesis of Cu_(x)Bi_(2)Se_(3) nanoplates with systematically tunable Cu doping concentrations and doping *** studies reveal a gradual evolution from intercalative sites to substitutional sites with increasing Cu *** Cu atoms at intercalative sites function as electron donors while those at the substitutional sites function as electron acceptors,producing distinct effects on the electronic properties of the resulting *** further show that Cu_(0.18)Bi_(2)Se_(3) exhibits superconducting behavior,which is not present in Bi_(2)Se_(3),highlighting the essential role of Cu doping in tailoring exotic quantum *** study establishes an efficient methodology for precise synthesis of Cu_(x)Bi_(2)Se_(3) with tailored doping concentrations,doping sites,and electronic properties.

关键词： Cu_(x)Bi_(2)Se_(3) nanoplates amphoteric doping solution-based synthesis doping sites conducting thin film superconductivity

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Fast Blood Oxygenation through Hemocompatible Asymmetric Polymer of Intrinsic Microporosity Membranes

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Research 2024年第1期2023卷 261-270页

作者： Xinxi huang Junping huang Pengcheng Su Wanbin Li Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

Membrane technology has attracted considerable attention for chemical and medical applications,among *** organs play important roles in medical science.A membrane oxygenator,also known as artificial lung,can replenish O_(2) and remove CO_(2) of blood to maintain the metabolism of patients with cardiopulmonary ***,the membrane,a key component,is subjected to inferior gas transport property,leakage propensity,and insufficient *** this study,we report efficient blood oxygenation by using an asymmetric nanoporous membrane that is fabricated using the classic nonsolvent-induced phase separation method for polymer of intrinsic *** intrinsic superhydrophobic nanopores and asymmetric configuration endow the membrane with water impermeability and gas ultrapermeability,up to 3,500 and 1,100 gas permeation units for CO_(2) and O_(2),***,the rational hydrophobic–hydrophilic nature,electronegativity,and smoothness of the surface enable the substantially restricted protein adsorption,platelet adhesion and activation,hemolysis,and thrombosis for the ***,during blood oxygenation,the asymmetric nanoporous membrane shows no thrombus formation and plasma leakage and exhibits fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 ml m^(−2) min^(−1),respectively,which are 2 to 6 times higher than those of conventional *** concepts reported here offer an alternative route to fabricate high-performance membranes and expand the possibilities of nanoporous materials for membrane-based artificial organs.

关键词： porosity asymmetric Oxygen

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Development of high-power microwave mechanical integrated continuous mining device

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3365-3377页

作者： Xia-Ting Feng Feng Lin Jiuyu Zhang Chengxiang Yang Yuntan ao Tianyang Tong Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

This article introduces a high-power microwave mechanical integrated continuous mining device,which can achieve synchronous cutting of hard rocks by microwave and *** device includes a cutting system,a rotary translation system,a loading system,a high-power microwave system,and a control and monitoring *** technology of“master-slave follow-up”disc cutter alternating side cutting of rock was proposed,which could improve the effectiveness of rock *** integrated structure of a microwave-cut system was then proposed,and synchronous motion of the microwave-cut system and adjustment of the loading system could be *** automatic adjustment technology of the microwave working distance was developed to dynamically control the optimal microwave working *** basic functions of the equipment were verified by *** comparing the two types of disk cutters,it is found that the master-slave follow-up disk cutter can improve significantly the dust removal effect and rock breaking efficiency in rock breaking process versus the conventional large disc *** tests of slate with or without microwave were conducted using a master-slave follow-up disk *** results show that the cutting patterns of slates change from intermittent chunks(without microwave irradiation)to persistent debris(with microwave irradiation),and the cutting speed is significantly improved(170%).The development of the device provides a scientific basis for changing the conventional mining technology of metal mines and realizing the mechanical continuous mining in hard metal mines.

关键词： Hard metal mine Microwave machinery Continuous mining Master-slave follow-up disc cutter

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多特征融合的驾驶员疲劳检测研究

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机械科学与技术 2018年第11期37卷 1750-1754页

作者：黄占鳌史晋芳西南科技大学制造科学与工程学院四川绵阳621010

针对驾驶疲劳检测中面部特征定位及驾驶员疲劳状态判别方法判断存在的不足,提出了利用监督下降算法同时定位驾驶员的多个面部特征。在眨眼、哈欠及点头判断的基础上,提取驾驶员眨眼频率、哈欠频率及点头频率多个特征值建立疲劳检测样本... 详细信息

针对驾驶疲劳检测中面部特征定位及驾驶员疲劳状态判别方法判断存在的不足,提出了利用监督下降算法同时定位驾驶员的多个面部特征。在眨眼、哈欠及点头判断的基础上,提取驾驶员眨眼频率、哈欠频率及点头频率多个特征值建立疲劳检测样本数据库,并构建朴素贝叶斯分类器进行疲劳判断。当驾驶员出现疲劳驾驶时及时给以警告信息,以预防交通事故发生。在实际的驾驶环境视频测试结果中,驾驶员疲劳状态的判别平均准确率达到了94.87%,具有较好的性能。

关键词：驾驶员疲劳检测监督下降算法多特征值融合朴素贝叶斯分类器

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Texture and Se vacancy optimization induces high thermoelectric performance in Bi_(2)Se_(3) flexible thin films

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Rare Metals 2024年第6期43卷 2796-2804页

作者： Dong-Wei ao Wei-Di Liu Yue-Xing Chen Fan Ma Yi-Jie Gu Zhuang-Hao Zheng School of Machinery and Automation Weifang UniversityWeifang 261061China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbane 4072Australia Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China

Bi_(2)Se_(3)-based flexible thin film with high thermoelectric performance is promising for the waste heat recovery *** this work,a novel post-selenization method is employed to prepare n-type Bi_(2)Se_(3)flexible thin films with highly textured *** strengthened texture and Se vacancy optimization can be simultaneously achieved by optimizing the selenization *** highly oriented texture leads to the increased carrier mobility and results in a high electric conductivity of~290.47 S·cm^(-1)at 623 ***,a high Seebeck coefficient(>110μW·K-1)is obtained due to the reduced carrier concentration,induced by optimizing vacancy ***,a high power factor of 3.49μW·cm^(-1)·K^(-2)at 623 K has been achieved in asprepared highly-bendable Bi_(2)Se_(3)flexible thin films selenized at 783 *** study introduces an effective post-selenization method to tune the texture structure and vacancies of Bi_(2)Se_(3)flexible thin films,and correspondingly achieves high thermoelectric performance.

关键词： Thermoelectric Bi_(2)Se_(3) Flexible thin film Post-selenization

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钢铁行业氢冶金技术的发展初探

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耐火材料 2021年第4期55卷 360-363页

作者：李少飞顾华志黄奥武汉科技大学省部共建耐火材料与冶金国家重点实验室湖北武汉430081

钢铁行业氢冶金是采用氢部分或完全取代碳作为铁矿石的还原剂,实现铁矿石脱氧过程的技术。它不固定存在于某一特定工艺过程中,直接还原铁工艺是氢冶金关键流程之一。从直接还原铁工艺介绍出发,结合国内外钢铁行业氢冶金项目,对氢冶金方... 详细信息

钢铁行业氢冶金是采用氢部分或完全取代碳作为铁矿石的还原剂,实现铁矿石脱氧过程的技术。它不固定存在于某一特定工艺过程中,直接还原铁工艺是氢冶金关键流程之一。从直接还原铁工艺介绍出发,结合国内外钢铁行业氢冶金项目,对氢冶金方式和氢源等相关问题进行了探讨,最后对钢铁行业推广氢冶金技术进行了展望。

关键词：钢铁行业氢冶金直接还原铁 MIDREX工艺氢源

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Sintering of phosphor-glass composites goes ultrafast

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Science China Materials 2024年第8期67卷 2711-2712页

作者： Xiaoyong huang College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China

Nowadays,with the rapid technological progress of high-quality lightings and high-end displays,high-power white light-emitting diodes(WLEDs)and high-brightness white laser diodes(WLDs)featuring with high energy density excitation,high output power and high device stability have been extensively investigated and regarded as the new-generation solid-state light sources[1–6].

关键词： diodes WLED white

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鱼雷罐底吹辅助铁水喷粉脱硫过程仿真分析

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钢铁研究学报 2010年第9期22卷 5-8页

作者：赵义黄奥肖哲栋吴斌浙江上虞东瑞高级陶瓷有限公司浙江上虞312300 武汉科技大学耐火材料与高温陶瓷国家重点实验室培育基地湖北武汉430081 中冶集团武汉冶建技术研究有限公司湖北武汉430081

根据实际鱼雷罐的脱硫操作工艺参数,采用欧拉两流体模型、多孔介质模型、耦合镁粉脱硫动力学模型,对采用底部吹气搅拌辅助鱼雷罐顶吹镁粉脱硫过程进行了仿真分析,探讨了底吹辅助工艺的影响。结果表明:底吹辅助工艺能明显提高粉剂利用率... 详细信息

根据实际鱼雷罐的脱硫操作工艺参数,采用欧拉两流体模型、多孔介质模型、耦合镁粉脱硫动力学模型,对采用底部吹气搅拌辅助鱼雷罐顶吹镁粉脱硫过程进行了仿真分析,探讨了底吹辅助工艺的影响。结果表明:底吹辅助工艺能明显提高粉剂利用率和脱硫效率;随着底吹气量的增加脱硫效果越好,30 m3/h的吹气量即能满足要求;鱼雷罐入口与边端的中部底吹对内铁水脱硫效果较好,尤其2 650 mm位置最佳;脱硫时喷粉后进行280 s内的续吹可以防止回硫和进一步降低硫含量。

关键词：鱼雷罐底吹铁水脱硫数值模拟

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