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Progress on Sapphire Hydrogen Maser for Beidou Navigation System

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Progress on Sapphire Hydrogen Maser for Beidou Navigation Sy...

A propensity score matching comparison between GnRH agonist and GnRH antagonist protocols in patients in POSEIDON groups 3 and 4

第四届中国卫星导航学术年会

作者： Zhou Tiezhong wu qiong huang jian Gao Lianshan Beijing University of Aeronautics&Astronautics Beijing Institute of Radio Metrology & Measurement Beijing Institute of Radio Metrology&Measurement

Active hydrogen maser is one of the most important equipments for the Beidou Navigation system. The stability of active hydrogen maser does influence the synchronize accuracy of time and frequency between the satellites and the ground devices. In order to improve the stability of Sapphire Hydrogen Maser, we had done several improvements on the physical package and electrical package, which include magnetic shield improvements, developing a method to probe the hydrogen atom beam, getter pump improvement and cavity auto-turning system researching. The factor of magnetic shield has been improved to above 105 . We had researched several kinds of getter materials which can improve the lifetime of physical package. We had designed a new form of getter pump, which make the volume of physical package smaller than ever. The stability of the maser after improvement can get 3.1×10-13 @1s, 2.9×10-15 @1day.

关键词： Hydrogen maser· Magnetic shield· Improvement· Beam controlling· Frequency stability

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Chinese Medical Journal 2023年第4期136卷 482-484页

作者： Jifan Tan Luxin Liu Jiaxin Jiang Yue wu Shuchen Long qiong Wang Jia huang Reproductive Medicine Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Reproductive Medicine GuangzhouGuangdong 510080China

To the Editor:The conflicting definition of poor ovarian response has complicated the comparison of proposed *** Patient Oriented Strategies Encompassing Individualized Oocyte Number(POSEIDON)classification[1]was formulated to guide individual ovarian response management through detailed *** groups 3 and 4 were defined as patients with low anti-Müllerian hormone(AMH;<1.2 ng/mL)and/or low antral follicle count(AFC;<5).

关键词： patients EID antagonist

Blow‑Spun Si3N4‑Incorporated Nanofibrous Dressing with Antibacterial,Anti‑Inflammatory,and Angiogenic Activities for Chronic Wound Treatment

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Advanced Fiber Materials 2024年第2期6卷 543-560页

作者： Pengchao Ma Chun‑Yi Yang Chengli Li Peilun Hu Fang Yang Jiaju Lu Yin‑Yuan huang Hui wu qiong wu Yongwei Pan Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Orthopedics School of Clinical MedicineBeijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China MOE Key Laboratory of Bioinformatics Center for Synthetic and Systems BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Center for Biomaterials and Regenerative Medicine Wuzhen LaboratoryTongxiang 314500China

The effective and safe healing of chronic wounds,such as diabetic ulcers,presents a significant clinical challenge due to the adverse microenvironment in the wound that hinders essential processes of wound healing,including angiogenesis,inflammation resolution,and bacterial ***,there is an urgent demand for the development of safe and cost-effective multifunctional therapeutic *** nitride,with its distinctive antibacterial properties and bioactivities,shows great potential as a promising candidate for the treatment of chronic *** this study,a silicon nitride-incorporated collagen/chitosan nanofibrous dressing(CCS)were successfully fabricated using the solution blow spinning technique(SBS).SBS offers compelling advantages in fabricating uniform nanofibers,resulting in a three-dimensional fluffy nanofibrous scaffold that creates an optimal wound healing *** blow-spun nanofibrous dressing exhibits excellent hygroscopicity and breathability,enabling effective absorption of wound ***,the incorporated silicon nitride within the fibers triggers surface chemical reactions in the aqueous environment,leading to the release of bioactive ions that modulate the wound ***,the CCS demonstrated exceptional capabilities in absorbing wound exudate,facilitating water vapor transmission,and displaying remarkable antibacterial properties in vitro and in a rat infected wound model(up to 99.7%,4.5×10^(7)CFU/cm^(2)for Staphylococcus aureus).Furthermore,the CCS exhibited an enhanced wound closure rate,angiogenesis,and anti-inflammatory effects in a rat diabetic wound model,compared to the control group without silicon nitride incorporation.

关键词： Chronic wound Antibacterial dressing Silicon nitride Solution blow spinning Angiogenesis

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时域电磁计算统一解决方案研究

中国科技论文在线 2010年第1期5卷 62-67页

作者：吴先良黄志祥安徽大学计算智能与信号处理教育部重点实验室合肥230039

构造了时域Maxwell方程的Hamilton函数,利用函数变分,得到了对应的Hamilton正则方程,将时域电磁问题的数值计算转化为Hamilton系统正则方程的离散求解。利用辛算法构造了时间方向上显、隐式离散方案;借助于交错差分格式、广义交错差分... 详细信息

构造了时域Maxwell方程的Hamilton函数,利用函数变分,得到了对应的Hamilton正则方程,将时域电磁问题的数值计算转化为Hamilton系统正则方程的离散求解。利用辛算法构造了时间方向上显、隐式离散方案;借助于交错差分格式、广义交错差分格式或紧差分格式实现了空间旋度的离散处理;最终提出了时域电磁计算统一的解决方案。

关键词： Hamilton函数正则方程辛算法

Glutamine metabolic microenvironment drives M2 macrophage polarization tomediate trastuzumab resistance in HER2-positive gastric cancer

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Cancer Communications 2023年第8期43卷 909-937页

作者： Xingbin Hu Zhenfeng Ma Beibei Xu Shulong Li Zhiqi Yao Bishan Liang Jiao Wang Wangjun Liao Li Lin Chunling Wang Siting Zheng Qijing wu qiong huang Le Yu Fenghua Wang Min Shi Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China School of Biomedical Engineering Southern Medical UniversityGuangzhouGuangdongP.R.China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China

Background:Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2(HER2)-positive gastric ***,the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit,and there is currently no effective reversal *** researches on the mechanism of trastuzumab resistance mainly focused on tumor cells themselves,while the understanding of the mechanisms of environment-mediated drug resistance is relatively *** study aimed to further explore the mechanisms of trastuzumab resistance to identify strategies to promote survival in these ***:Trastuzumab-sensitive and trastuzumab-resistant HER2-positive tumor tissues and cells were collected for transcriptome *** were used to analyze cell subtypes,metabolic pathways,and molecular signaling *** in microenvironmental indicators(such as macrophage,angiogenesis,and metabolism)were verified by immunofluorescence(IF)and immunohistochemical(IHC)***,a multi-scale agent-based model(ABM)was *** effects of combination treatment were further validated in nude mice to verify these effects predicted by the ***:Based on transcriptome sequencing,molecular biology,and in vivo experiments,we found that the level of glutamine metabolism in trastuzumabresistant HER2-positive cells was increased,and glutaminase 1(GLS1)was significantly ***,tumor-derived GLS1 microvesicles drove M2macrophage ***,angiogenesis promoted trastuzumab *** showed high glutamine metabolism,M2 macrophage polarization,and angiogenesis in trastuzumab-resistant HER2-positive tumor tissues from patients and ***,the cell division cycle 42(CDC42)promoted GLS1 expression in tumor cells by activating nuclear factor kappa-B(NF-κB)p65 and drove GLS1microvesicle secretion through IQmotif-containing GTPase-activating protein 1(IQGAP1).Based on the ABM and

关键词： Gastric cancer glutamine metabolism macrophage mathematical model microvesicles trastuzumab

切换正系统的渐近稳定性、L1增益及时变H∞控制

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控制理论与应用 2019年第10期36卷 1615-1621页

作者：熊建栋黄琼伍俊河南师范大学数学与信息科学学院河南新乡453007 佛山科学技术学院自动化学院广东佛山528000

本文针对带有驻留时间约束的离散时间切换线性正系统,提出了依赖驻留时间的时变分段线性余正Lyapunov函数方法,得到确保系统渐近稳定的充分条件.另外,将此方法推广到离散切换正系统的L1增益性分析中,得到系统具有未加权的γ–L1增益的... 详细信息

本文针对带有驻留时间约束的离散时间切换线性正系统,提出了依赖驻留时间的时变分段线性余正Lyapunov函数方法,得到确保系统渐近稳定的充分条件.另外,将此方法推广到离散切换正系统的L1增益性分析中,得到系统具有未加权的γ–L1增益的充分条件.进一步,对离散切换正系统设计一个时变H∞反馈控制,使闭环系统具有最小γ–L1增益.最后给出一个数值算例验证文中的结论.

关键词：渐近稳定性驻留时间余正Lyapunov函数 L1增益

Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study

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Journal of Sport and Health Science 2021年第5期10卷 560-569页

作者： Yuan Lin qiong Liu Fangchao Liu Keyong huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng huang Dongfeng Gu Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CenterShenzhen 518071China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is *** study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these ***:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified *** incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death *** ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression ***:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were *** behavior was associated with increased risk of developing cancer and deaths in a doseresponse *** multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary *** populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 *** to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of *** of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient inciden

关键词： All-cause mortality Cancer Chinese population Cohort study Sedentary behavior

Successful Pregnancy by In Vitro Fertilization after Bilateral Uterine Arterial Embolization for Cesarean Scar Pregnancy:A Case Report

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Journal of Reproduction and Contraception 2014年第3期25卷 187-191页

作者： qiong-fang wu Zhi-hui huang Yuan ZHU Nie NING Jiangxi Hospital for Women and Children

A 35-year-old woman who had one delivery by cesarean section got pregnant again. Color Doppler flow imaging and Magnetic resonance imaging （MRI） showed a cesarean scar pregnancy （CSP）. Uterine arterial embolization （UAE） and curettage was performed successfully to terminate the pregnancy. Six months after the curettage, the patient＇s menstrual flow was reduced to one non-drenched sanitary pad per day for only 1-2 d, every 30 d. The patient underwent hysterosalpingography （HSG）, which suggested the presence of a filling-defect of the left uterine cavity, with obstructed bilateral Fallopian tubes. The patient subsequently underwent lysis of adhesions by hysteroscopy plus an exploratory laparoscopy, under general anesthesia. Her men- struation gradually increased to 5-7 d every 30 d. As the patient did not become pregnant during the first year after surgery, she underwent in vitro fertilization （IVF） treatment and a repeat ultrasound showed a somewhat thin endometrial line. At last, the patient got pregnant and gave birth to a live baby by IVF.

关键词： cesarean scar pregnancy (CSP) in vitro fertilization (IVF)

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增益金纳米球壳光学特性研究

量子电子学报 2015年第5期32卷 513-518页

作者：许杰王瀚林黄志祥吴先良安徽大学电子信息工程学院安徽合肥230039 合肥师范学院电子信息工程学院安徽合肥230061

通过有限元方法研究了增益系数以及核壳比对纳米核壳结构表面等离激元共振特性的影响，对球心为增益介质、球壳为金的纳米核壳结构进行了数值模拟。计算结果表明：随着增益系数增大到临界值，散射截面增大近2×10^5倍，吸收截面变为负... 详细信息

通过有限元方法研究了增益系数以及核壳比对纳米核壳结构表面等离激元共振特性的影响，对球心为增益介质、球壳为金的纳米核壳结构进行了数值模拟。计算结果表明：随着增益系数增大到临界值，散射截面增大近2×10^5倍，吸收截面变为负值，消光截面近似为0，电场强度增强近185倍，谐振带宽从60nm缩小到1nm。同时，随着核壳比的增大，吸收及消光共振峰均发生红移现象。相关结果为增益介质在金属纳米结构中的应用提供了理论参考和技术支持。

关键词：光电子学表面等离激元共振增益介质金纳米球壳吸收截面