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Journal of Palaeogeography 2025年第1期14卷 172-185页

作者： Wen-Tao Yang Jia-Qi zhu Min wang Chao Liu Yong-An Qi School of Resources and Environment Henan Polytechnic University Key Laboratory of Biogenic Traces and Sedimentary Minerals of Henan Province Henan Polytechnic University State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences

We report geochemical data for carbonate rocks from the Cambrian Zhangxia Formation,southern North China Block,including trace-element contents and C,O,and Sr isotopic compositions,to determine the controls on the development of microbialites in this *** sedimentary environment of the Zhangxia Formation evolved from carbonate-slope through platform-margin-reef to ooid-shoal,and then to open-platform settings,corresponding to the development of micrites,microbialites,and oolitic *** data show that δ13C values decrease upwards through the Zhangxia Formation,from 0.99‰to-1.59‰,whereas δ18O values increase from-9.91‰to-7.10‰.Total rare earth element （REE）contents decrease upwards through the stratigraphy,and the contents of Th and Sc show a similar trend.87Sr/86Sr ratios reach a maximum of 0.710544 in the horizons of microbialite development,Member 2 of the Zhangxia Formation,above which the ratios are uniform,with a mean value of *** these geochemical data with the inferred sedimentary evolution,the Zhangxia Formation is interpreted to have formed in a depositional environment that changed from transgression to *** weathering played a crucial role in promoting the input of terrigenous materials,which in turn favored the development of microbialites during the early stage of deposition of the Zhangxia Formation.

关键词： Carbonate rocks Trace elements C and Sr isotopes Microbialites Cambrian

Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian Chunlei Shang Chaolei Zhang Xiaoye Zhou Honghui Wu Shuize wang Guilin Wu Junheng Gao Jiaming zhu Xinping Mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

Research progress in methods of acquisition, structure elucidation, and quality control of Chinese herbal polysaccharides

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Chinese Journal of Natural Medicines 2025年第2期23卷 143-157页

作者： Tingting wang Baojie zhu Jing Zhao Shaoping Li Joint Laboratory of Chinese Herbal Glycoengineering and Testing Technology University of Macau & National Glycoengineering Research Center State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macao Centre for Testing of Chinese Medicine University of Macau

The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness. However, the precise active components underlying each prescription remain incompletely understood. Polysaccharides, as a major constituent of water decoctions —the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development. The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules. This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research, focusing on methods of acquisition, structure elucidation, and quality control.

关键词： Chinese medicine Extraction and purification Polysaccharide Quality control Structural analysis

A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy

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Chinese Chemical Letters 2025年第1期36卷 397-402页

作者： Cheng-Zhe Gao Hao-Ran Jia Tian-Yu wang Xiao-Yu zhu Xiaofeng Han Fu-Gen Wu State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 211189China

Vascular disrupting agents(VDAs)can destroy tumor vasculature and lead to tumor ischemia and hypoxia,resulting in tumor ***,VDAs are easy to induce the upregulation of genes that are associated with cancer cell drug resistance and angiogenesis in tumor ***-activated chemotherapy will be an ideal supplement to VDAs therapy since it can help to fully utilize the ischemia and hypoxia induced by VDAs to realize a synergistic antitumor therapeutic ***,we design a liposome whose surface is modified with a tumor-homing peptide Cys-Arg-Glu-Lys-Ala(CREKA,which can specifically target tumor vessels and stroma)and whose aqueous cavity and lipid bilayer are loaded by a hypoxia-activatable drug banoxantrone dihydrochloride(AQ4N)and a VDA combretastatin A4(CA4),***4 can selectively target vascular endothelial cells and destroy the tumor blood vessels,which will cause the rapid inhibition of blood flow in tumor and enhance the hypoxia in the tumor *** a consequence,AQ4N can exert its boosted cytotoxicity under the enhanced hypoxic *** as-prepared liposome with a uniform particle size exhibits good stability and high cancer cell killing efficacy in *** addition,in vivo experiments confirm the excellent tumortargeting/accumulation,tumor vasculature-damaging,and tumor inhibition effects of the *** work develops a liposomal which can achieve safe and effective tumor suppression without external stimulus excitation by only single injection,and is expected to benefit the future development of effective antitumor liposomal drugs.

关键词： Tumor-homing peptide Liposome Vascular disrupting agents Chemotherapy Hypoxia-activated

A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors

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Journal of Integrative Plant Biology 2025年第1期67卷 11-14页

作者： Tongtong zhu Xuefeng Wu Guixin Yuan Dongli wang Vijai Bhadauria YouLiang Peng Junfeng Liu Xin Zhang The State Key Laboratory of Maize Bio-breeding Joint International Research Laboratory of Crop Molecular Breeding Ministry of Agriculture Key Laboratory for Crop Pest Monitoring and Green Control College of Plant Protection China Agricultural University Joint International Research Laboratory of Crop Molecular Breeding China Agricultural University Frontiers Science Center for Molecular Design Breeding China Agricultural University Sanya Institute of China Agricultural University

To defend against pathogens, plants have evolved an innate immune system, encompassing pattern-triggered immunity(PTI) and effector-triggered immunity (ETI). Nucleotide-binding leucine-rich repeat receptors (NLRs) det... 详细信息

关键词： HMA domain NLR receptors non-MAX effector resistance rice

Ni-based electrocatalysts for urea oxidation reaction: mechanism, catalyst design strategies and future perspectives

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Science China Materials 2025年第2期68卷 317-340页

作者： Qing Li Yingying wang Tao Pan Yuanyuan zhu huan Pang Guangling College Yangzhou UniversityYangzhou 225009China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Untreated urea-rich wastewater exerts severeadverse impacts on both the environment and human health,prompting extensive attention towards the urea oxidationreaction (UOR) as a sustainable technology to generate cleanenergy in recent years. UOR has a thermodynamic advantageover oxygen evolution reaction (OER) (1.23 V vs reversiblehydrogen electrode, RHE) and only requires 0.37 V (vs RHE),which is considered as an effective alternative to H_(2) production by water electrolysis. However, the inevitable kineticslowness and complex adsorption/desorption during the processhinder its practical application. Most traditional catalystsutilized for the UOR are comprised of precious metals, resulting in limited economic viability. Inspired by natural ureases, Ni-based catalysts have emerged as promisingalternatives owing to their rich deposits, low cost, and theregulated d orbitals of transition metal Ni, demonstratingconsiderable potential for UOR. Currently, numerous studieshave explored Ni-based hydroxides, oxides, chalcogenides, andphosphides in alkaline solutions. In this review, we will explorethe UOR reaction mechanism and summarize the catalystdesign strategies of various Ni-based catalysts recently, especially Ni-MOF, which has been rarely discussed before. Then,the broad prospects of UOR in practical applications aresummarized. Finally, based on the design strategies and performance comparisons discussed above, the challenges andprospects facing the future development of Ni-based electrocatalysts for the UOR will be presented.

关键词： urea oxidation reaction Ni-based catalysts UOR mechanism hydrogen production urea fuel cells

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi wang Junjie Yang Ganggang Zhang Chen wang Yanlian Yang Ling zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

Bright and stable quantum confined CsPbBr_(3) nanocrystals through post-synthetic chemical cutting and in-situ encapsulation

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Nano Research 2025年第2期18卷 896-904页

作者： Hao Zhang Jiang Chen Tiantian zhu Rui wang Xuemei wang Xijun Xu Jianli wang College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

Quantum-confined CsPbBr_(3) nanocrystals are promising cyan/blue-emitting materials with exceptional potential for advanced lighting and display ***,their practical application is often limited by low luminescent efficiency,undesirable color purity and instability stemming from inadequate size uniformity,and high surface defect ***,we propose a post-synthetic chemical cutting and in-situ encapsulation approach using 3-aminopropyltriethoxysilane(APTES)combined with polymethylhydrosiloxane(PMHS)to synthesize and stabilize CsPbBr_(3) nanocrystals with significant quantum *** can function as a chemical scissor efficiently cutting the green emitting CsPbBr_(3)(9.8 nm)to smaller counterparts(3.97.9 nm),while also passivating surface defects through A-site *** between APTES and PMHS prevents phase transformation during synthesis and forms a polymeric network that encapsulates and separates the quantum confined CsPbBr_(3).The resulting composites exhibit tunable emission from 517 to 461 nm,a narrow linewidth of approximately 15 nm,and quantum yields over 80%.Moreover,incorporating one CsPbBr_(3) composite into a white light-emitting diode to fill the“cyan gap”significantly enhances the color rendering index from 77.7 to *** work provides an effective strategy for developing bright and stable quantum confined CsPbBr_(3) for advanced lighting applications.

关键词： perovskite nanocrystal CsPbBr quantum confinement luminescent efficiency stability

Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor

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Chinese Chemical Letters 2025年第2期36卷 262-269页

作者： Yuanyuan Zeng Fang Liu Jun wang Bianfei Shao Tao He Zhongzheng Xiang Yan wang Shunyao zhu Tian Yang Siting Yu Changyang Gong Lei Liu Department of Radiation Oncology Cancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer Hospital Chongqing Key Laboratory of translational Research for Cancer Metastasis and individualized Treatment Chongqing University Cancer Hospital Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Pharmacy The First Affiliated Hospital of Wannan Medical CollegeYijishan Hospital of Wannan Medical College Institute of Surgery Research Daping HospitalThird Military Medical University

It is of great significance to find safe and effective radiosensitizers. A primary investigation has been made on fisetin's modification of radiation effect, but its radiosensitization and related mechanisms still need to be deeply clarified. Furthermore, fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application. In this study, we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2) signaling pathway in the tumor. Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo. On the cellular level, fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells) to radiation. In the mouse models of colon and breast cancers, fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity. Additionally, we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity. In general, this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo, but also profoundly explored its mechanisms underlying, to provide a theoretical and experimental basis for the clinical application of fisetin micelles.

关键词： Fisetin Platelet-derived growth factor receptor-β Polymetric micelles Radiosensitizer Radiotherapy

Effective stress dissipation by multi-dimensional architecture engineering for ultrafast and ultralong sodium storage

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Journal of Energy Chemistry 2025年第2期101卷 619-629页

作者： Man Zhang Jing zhu Qianqian Li Fenghua Zheng Sijiang Hu Youguo huang Hongqiang wang Xing Ou Qichang Pan Qingyu Li Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical Sciences Guangxi Normal University School of Metallurgy and Environment Central South University

Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe2-based ***,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries（SIBs）,Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage *** from the conventional sphere-like or rod-like architecture,the three-dimensional（3D） flower-like NiSe2@C composite is delicately designed and assembled with onedimensional nanorods and carbon *** importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results *** demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion ***,it can provide more Na+-storage sites and multi-directional migration pathways,leading to a fast Na+-migration channel with boosted reaction *** expected,it delivers superior rate performance(441 mA h g-1at 5.0 A g-1) and long cycling stability(563 mA h g-1at 1.0 A g-1over 1000 cycles) for *** work provides useful insights for designing high-performance conversion-based anode materials for SIBs.

关键词： Conversion-based anodes Multi-dimensional architecture Sodium-ion batteries Stress dissipation Structure engineering