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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-chang Gan Xiao-Zhong Qiu Zhe-Chen Gao huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Improvement and security analysis of multi-ring discrete modulation continuous variable quantum secret sharing scheme

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Chinese Physics B 2024年第7期33卷 189-197页

作者：姜欢窈聂敏杨光孙爱晶张美玲裴昌幸 School of Communications and Information Engineering&School of Artificial Intelligence Xi'an University of Posts and TelecommunicationsXi'an 710121China State Key Laboratory of Integrated Service Networks Xidian UniversityXi'an 710071China

In order to avoid the complexity of Gaussian modulation and the problem that the traditional point-to-point communication DM-CVQKD protocol cannot meet the demand for multi-user key sharing at the same time, we propose a multi-ring discrete modulation continuous variable quantum key sharing scheme(MR-DM-CVQSS). In this paper, we primarily compare single-ring and multi-ring M-symbol amplitude and phase-shift keying modulations. We analyze their asymptotic key rates against collective attacks and consider the security key rates under finite-size effects. Leveraging the characteristics of discrete modulation, we improve the quantum secret sharing scheme. Non-dealer participants only require simple phase shifters to complete quantum secret sharing. We also provide the general design of the MR-DM-CVQSS *** conduct a comprehensive analysis of the improved protocol's performance, confirming that the enhancement through multi-ring M-PSK allows for longer-distance quantum key distribution. Additionally, it reduces the deployment complexity of the system, thereby increasing the practical value.

关键词： discrete modulation continuous variable quantum secret sharing scheme

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Standard-definition White-light,High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas:A Multicenter Randomized Controlled Trial

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Current Medical Science 2024年第3期44卷 554-560页

作者： chang-wei duan Hui-hong ZHAI Hui XIE Xian-zong MA Dong-liang YU Lang YANG Xin WANG Yu-fen TANG Jie ZHANG Hui SU Jian-qiu SHENG Jun-feng XU Peng JIN Chinese PLA General Hospital and Medical School Beijing100853China Department of Gastroenterology Xuanwu HospitalCapital Medical UniversityBeijing100053China Department of Gastroenterology The Seventh Medical Center of Chinese PLA General HospitalBeijing100700China Senior Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing100853China

Objective This study aimed to compare the performance of standard-definition white-light endoscopy(SD-WL),high-definition white-light endoscopy(HD-WL),and high-definition narrow-band imaging(HD-NBI)in detecting colorectal lesions in the Chinese *** This was a multicenter,single-blind,randomized,controlled trial with a non-inferiority *** undergoing endoscopy for physical examination,screening,and surveillance were enrolled from July 2017 to December *** primary outcome measure was the adenoma detection rate(ADR),defined as the proportion of patients with at least one adenoma *** associated factors for detecting adenomas were assessed using univariate and multivariate logistic *** Out of 653 eligible patients enrolled,data from 596 patients were *** ADRs were 34.5%in the SD-WL group,33.5%in the HD-WL group,and 37.5%in the HD-NBI group(P=0.72).The advanced neoplasm detection rates(ANDRs)in the three arms were 17.1%,15.5%,and 10.4%(P=0.17).No significant differences were found between the SD group and HD group regarding ADR or ANDR(ADR:34.5%vs.35.6%,P=0.79;ANDR:17.1%vs.13.0%,P=0.16,respectively).Similar results were observed between the HD-WL group and HD-NBI group(ADR:33.5%vs.37.7%,P=0.45;ANDR:15.5%vs.10.4%,P=0.18,respectively).In the univariate and multivariate logistic regression analyses,neither HD-WL nor HD-NBI led to a significant difference in overall adenoma detection compared to SD-WL(HD-WL:OR 0.91,P=0.69;HD-NBI:OR 1.15,P=0.80).Conclusion HD-NBI and HD-WL are comparable to SD-WL for overall adenoma detection among Chinese *** can be concluded that HD-NBI or HD-WL is not superior to SD-WL,but more effective instruction may be needed to guide the selection of different endoscopic methods in the *** study’s conclusions may aid in the efficient allocation and utilization of limited colonoscopy resources,especially advanced imaging technologies.

关键词： standard-definition white-light endoscopy high-definition white-light endoscopy narrow-band imaging colonoscopy colorectal cancer screening adenoma detection rate

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秦汉彩绘陶器中“汉紫”应用及对西域的影响

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中国陶瓷 2024年第1期60卷 98-104页

作者：常艳丛欢西安外国语大学艺术遗产研究中心西安710128

“汉紫”是中国战汉时代特有的人造硅酸铜钡材料。它在彩绘陶中的使用既表现出强烈的地域性特征,又具有统一的哲学思想。基于“汉紫”在秦汉墓葬中彩绘陶的相关考古资料,梳理了它在陕西、河南、山东、江苏不同地域的应用情况和表现出的... 详细信息

“汉紫”是中国战汉时代特有的人造硅酸铜钡材料。它在彩绘陶中的使用既表现出强烈的地域性特征,又具有统一的哲学思想。基于“汉紫”在秦汉墓葬中彩绘陶的相关考古资料,梳理了它在陕西、河南、山东、江苏不同地域的应用情况和表现出的共性与个性,蠡测它集中发生于北方的多种原因及用色观念,分析它与“埃及蓝”的关系及对西域的影响。

关键词：秦汉彩绘陶汉紫汉蓝西域

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MEMS Huygens Clock Based on Synchronized Micromechanical Resonators

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Engineering 2024年第5期36卷 124-131页

作者： Xueyong Wei Mingke Xu Qiqi Yang Liu Xu a Yonghong Qi Ziming Ren Juan Ren Ronghua huan Zhuangde Jiang State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Construction Machinery Chang’an UniversityXi’an 710064China Department of Mechanics Zhejiang UniversityHangzhou 310027China

With the continuous miniaturization of electronic devices,microelectromechanical system(MEMS)oscillators that can be combined with integrated circuits have attracted increasing *** study reports a MEMS Huygens clock based on the synchronization principle,comprising two synchronized MEMS oscillators and a frequency compensation *** MEMS Huygens clock improved shorttime stability,improving the Allan deviation by a factor of 3.73 from 19.3 to 5.17 ppb at 1 s.A frequency compensation system based on the MEMS oscillator’s temperature-frequency characteristics was developed to compensate for the frequency shift of the MEMS Huygens clock by controlling the resonator *** effectively improved the long-term stability of the oscillator,with the Allan deviation improving by 1.6343105 times to 30.9 ppt at 6000 *** power consumption for compensating both oscillators simultaneously is only 2.85 mW·℃^(-1).Our comprehensive solution scheme provides a novel and precise engineering solution for achieving high-precision MEMS oscillators and extends synchronization applications in MEMS.

关键词： Frequency stability Huygens clock MEMS Oscillator Synchronization

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Stripping of aggregate from mortar in waste concrete heated by microwave:Mechanisms of differential-temperature stress and vapor expansion pressure

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 538-558页

作者： Yanping Sheng Xiao huan Peizhen Hu Liangliang Li Ahmed Abdulakeem Zhoujing Ye Linbing Wang Yanping Yin School of Materials Science and Engineering Chang'an UniversityXi'an 710064China Engineering Research Center of Transportation Materials Ministry of EducationChang'an UniversityXi'an 710064China National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China School of Environmental CivilAgricultural and Mechanical EngineeringCollege of EngineeringUniversity of GeorgiaAthensGA 30602USA

Microwave heating,which is used for pre-treatment of concrete before it is comminuted,stands as a strong candidate for selective liberation of multiphase materials like *** paper is concerned with the selective liberation of concrete's raw constituents(particularly aggregate)for recycling by considering the water content of concrete as a parameter of microwave heating for the first *** deterioration law of the concrete's performance was characterized by the variation in the splitting tensile strength and relative dynamic modulus after heating by microwave at different water ***,tests were conducted to evaluate the performance of the interface transition zone(ITZ)between aggregate and mortar as well as to investigate the reasons for the stripping behavior of aggregate-mortar,which included the interface tensile strength test,temperature measurement,and porosity *** deterioration law of splitting tensile strength and relative dynamic modulus revealed that the performance of concrete was subject to different degrees of damage depending on the water ***,experimental results showed that interface bonding strength between aggregate and mortar was dramatically impaired,and a large temperature difference was generated between the aggregate and mortar during microwave ***,the permeable pores increased considerably even when the specimens were *** the presence of water,the intactness of ITZ between aggregate and mortar was destroyed by microwave heating,and its performance was significantly lowered,which led to the occurrence of stripping behavior between aggregate and *** was reaffirmed by the microstructure presented by scanning electron ***,the newly developed microwave pretreatment improved by providing appropriate water contents for concrete corresponding to different strength grades is a promising method for recycling aggregate from waste concrete.

关键词： Waste concrete Recycled aggregate Microwave heating Stripping behavior Differential-temperature stress Vapor expansion pressure

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Clinical efficacy and identification of factors confer resistance to afatinib(tyrosine kinase inhibitor)in EGFR-overexpressing esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3130-3140页

作者： Yanni Wang chang Liu huan Chen Xi Jiao Yujiao Wang Yanshuo Cao Jian Li Xiaotian Zhang Yu Sun Na Zhuo Fengxiao Dong Mengting Gao Fengyuan Wang Liyuan Dong Jifang Gong Tianqi Sun Wei Zhu Henghui Zhang Lin Shen Zhihao Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Genecast Biotechnology Co. LtdWuxiPR China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijingChina Precision Scientific(Beijing)Co. Ltd.BeijingChina Generulor Company Bio-X Lab ZhuhaiGuangdongChina Biomedical Innovation Center Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory for Therapeutic Cancer Vaccines Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival *** preclinical data showed the promising antitumor activity of afatinib in EGFR-overexpressing *** proof-of-concept,phase II trial assessed the efficacy and safety of afatinib in pretreated metastatic ESCC patients(n=41)with EGFR overexpression(NCT03940976).The study met its primary endpoint,with a confirmed objective response rate(ORR)of 39%in 38 efficacy-evaluable patients and a median overall survival of 7.8 months,with a manageable toxicity *** analysis of pretreatment tumors revealed that neurotrophic receptor tyrosine kinase 2(NTRK2)was negatively associated with afatinib sensitivity and might serve as a predictive biomarker,irrespective of EGFR ***,knocking down or inhibiting NTRK2 sensitized ESCC cells to afatinib *** study provides novel findings on the molecular factors underlying afatinib resistance and indicates that afatinib has the potential to become an important treatment for metastatic ESCC patients.

关键词： esophageal squamous expressing

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生境破碎化过程对流域生境质量的影响

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生态学报 2024年第14期44卷 6053-6066页

作者：段鹏陈文波杨欢梁翔东华理工大学测绘与空间信息工程学院南昌330013 东华理工大学江西省流域生态过程与信息重点实验室南昌330013 东华理工大学南昌市景观过程与国土空间生态修复重点实验室南昌330013

近几十年来,随着工业化、城市化的加速推进,人类活动对自然生境的干扰越来越频繁,导致生境破碎化与生境质量下降。在流域尺度上科学模拟生境破碎化过程及其对生境质量的影响,对于提升生物多样性和生态系统功能具有重要意义。以鄱阳湖流... 详细信息

近几十年来,随着工业化、城市化的加速推进,人类活动对自然生境的干扰越来越频繁,导致生境破碎化与生境质量下降。在流域尺度上科学模拟生境破碎化过程及其对生境质量的影响,对于提升生物多样性和生态系统功能具有重要意义。以鄱阳湖流域为研究区域,基于InVEST模型分析区域生境质量的演变特征;从生境面积、生境边缘和生境隔离三个特征维度模拟生境破碎化过程;采用广义加性模型和地理探测器探究不同生境破碎化过程对生境质量变化的影响与交互作用。研究结果表明:(1)鄱阳湖流域生境质量呈下降趋势,从2000年的0.7862下降到2010年的0.7807,再下降到2020年的0.7715,但总体生境质量较好。生境质量较优的区域主要分布在流域南部、东北部以及西部地区,生境质量较差的区域主要分布在各个子流域的交界处。(2)2000—2010年,鄱阳湖流域生境面积占比下降、生境边缘增加和生境隔离增加三个生境破碎化过程分别占总研究区网格数的34.70%、30.15%和4.50%;2010—2020年分别占总研究区网格数的34.80%、30.69%和4.40%;2000—2020年分别占总研究区网格数的40.82%、37.50%和5.46%。生境面积减少的网格主要集中在鄱阳湖流域的中北部地区;生境边缘增加的网格分布和生境面积减少的网格分布相似;相比之下,生境隔离增加的网格较少,主要分布在各城市的中心城区范围。(3)生境破碎化过程对生境质量具有显著影响,两者呈非线性负相关关系;三个生境破碎化过程两两之间交互作用对生境质量的影响呈现双因子增强趋势。研究结果可为鄱阳湖流域生态格局优化与生境质量提升提供科学参考。

关键词：生境破碎化生境质量 InVEST模型广义加性模型地理探测器

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Equation of state for boron nitride along the principal Hugoniot to 16 Mbar

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Matter and Radiation at Extremes 2024年第5期9卷 77-86页

作者： huan Zhang Yutong Yang Weimin Yang Zanyang Guan Xiaoxi duan Mengsheng Yang Yonggang Liu Jingxiang Shen Katarzyna Batani Diluka Singappuli Ke Lan Yongsheng Li Wenyi Huo Hao Liu Yulong Li Dong Yang Sanwei Li Zhebin Wang Jiamin Yang Zongqing Zhao Weiyan Zhang Liang Sun Wei Kang Dimitri Batani National Key Laboratory of Plasma Physics Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China HEDPS Center for Applied Physics and Technologyand College of PhysicsPeking UniversityBeijing 100871China HEDPS Center for Applied Physics and Technologyand School of EngineeringPeking UniversityBeijing 100871China Institute of Plasma Physics and Laser Microfusion Hery 2301-497 WarszawaPoland Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Institute of Applied Physics and Computational Mathematics Beijing 100094China

The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood owing to the challenges of performing experiments and realizing ab initio ***,we report the first shock Hugoniot data on hexagonal boron nitride at pressures of 5–16 Mbar,using hohlraum-driven shock waves at the SGIII-p laser facility in *** density functional theory molecular dynamics calculations closely match experimental data,validating the equations of state for modeling the shock response of boron nitride and filling a crucial gap in the knowledge of boron nitride properties in the region of multi-Mbar pressures and eV *** results presented here provide fundamental insights into boron nitride under the extreme conditions relevant to inertial confinement fusion,hydrogen–boron fusion,and high-energy-density physics.

关键词： boron Hugoniot extreme

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命令式动态规划类算法程序推导及机械化验证

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软件学报 2024年第9期35卷 4218-4241页

作者：左正康孙欢王昌晶游珍黄箐王唱唱江西师范大学数字产业学院江西上饶334006 江西师范大学计算机信息工程学院江西南昌330022 网络化支撑软件国家国际科技合作基地(江西师范大学) 江西南昌330022

动态规划是一种递归求解问题最优解的方法,主要通过求解子问题的解并组合这些解来求解原问题.由于其子问题之间存在大量依赖关系和约束条件,所以验证过程繁琐,尤其对命令式动态规划类算法程序正确性验证是一个难点.基于动态规划类算法Is... 详细信息

动态规划是一种递归求解问题最优解的方法,主要通过求解子问题的解并组合这些解来求解原问题.由于其子问题之间存在大量依赖关系和约束条件,所以验证过程繁琐,尤其对命令式动态规划类算法程序正确性验证是一个难点.基于动态规划类算法Isabelle/HOL函数式建模与验证,通过证明命令式动态规划类算法程序与其的等价性,避免证明正确性时处理复杂的依赖关系和约束条件,提出命令式动态规划类算法程序设计框架及其机械化验证.首先,根据动态规划类算法的优化方法(备忘录方法)和性质(最优子结构性质和子问题重叠性质)描述问题规约、归纳递推关系式和形式化构造出循环不变式,并且基于递推关系式生成IMP(minimalistic imperative programming language)代码;其次,将问题规约、循环不变式和生成的IMP代码输入VCG(verification condition generator),自动生成正确性的验证条件;然后,在Isabelle/HOL定理证明器中对验证条件进行机械化验证.算法首先设计为命令式动态规划类算法的一般形式,并进一步实例化得到具体算法.最后,例证所提框架的有效性,为动态规划类算法的自动化推导和验证提供参考价值.

关键词： Isabelle/HOL 机械化验证动态规划命令式 VCG

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