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Anti-IgLON5 disease: a novel topic beyond neuroimmunology

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Neural Regeneration Research 2023年第5期18卷 1017-1022页

作者： Yi-ZongHeng Zhang You Ni Yi-Ning Gao Ding-Ding Shen Lu He Dou Yin huan-yu meng Qin-Ming Zhou Ji Hu Sheng Chen Department of Neurology&Institute of Neurology Ruijin HospitalAffiliated with Shanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghaiChina

Anti-IgLON5 disease is a recently defined autoimmune disorder of the nervous system associated with autoantibodies against IgLON5. Given its broad clinical spectrum and extremely complex pathogenesis, as well as difficulties in its early diagnosis and treatment, anti-IgLON5 disease has become the subject of considerable research attention in the field of neuroimmunology. Anti-IgLON5 disease has characteristics of both autoimmunity and neurodegeneration due to the unique activity of the antiIgLON5 antibody. Neuropathologic examination revealed the presence of a tauopathy preferentially affecting the hypothalamus and brainstem tegmentum, potentially broadening our understanding of tauopathies. In contrast to that seen with other autoimmune encephalitis-related antibodies, basic studies have demonstrated that IgLON5 antibody-induced neuronal damage and degeneration are irreversible, indicative of a potential link between autoimmunity and neurodegeneration in antiIgLON5 disease. Herein, we comprehensively review and discuss basic and clinical studies relating to anti-IgLON5 disease to better understand this complicated disorder.

关键词： anti-IgLON5 disease autoimmune encephalitis human leukocyte antigen IgG4-related diseases IgLON5 antibody IgLONs immunotherapy inflammation neurodegeneration neuroimmunology tauopathy

Extraction of gravel characteristics and spatial inversion for ecological restoration monitoring in the Northern Tibetan Plateau

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Journal of Mountain Science 2025年第2期22卷 556-574页

作者： KONG Bo yu huan QIU Xia HU Wenkai HE Bing GUAN Xudong Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China College of Geography and Planning Chengdu University of TechnologyChengdu 610059China Tibet Geological Environment Monitoring Center Lhasa 850000China School of Computer Science Chengdu University of Information TechnologyChengdu 610225China Sichuan Real Estate Registration Center(Sichuan Provincial Land and Cadastral Affairs Center) Chengdu 610072China

Previous studies have often focused on monitoring grassland growth as the primary target of remote sensing investigations on grassland ecological restoration in the northern Tibetan Plateau,overlooking the crucial role played by gravel in the ecological restoration of these *** study utilizes supervised classification and segmentation techniques based on machine learning to extract gravel morphology profiles from field-sampled plot images and calculate their characteristic *** a multivariate linear approach combined with Principal Component Analysis(PCA),a model for inferring gravel characteristic parameters is *** features,particle size characteristics,and spatial distribution patterns of gravel are *** reveal that gravel predominantly exhibit sub-rounded shapes,with 80%classified as fine *** coefficients of determination(R2)between gravel particle size and coverage,perimeter,and area are 0.444,0.724,and 0.557,respectively,indicating linear *** cumulative contribution rate of the top five remote sensing factors is 95.44%,with the first geological factor contributing 77.64%,collectively reflecting the primary information of the 20 factors *** shows that areas with larger gravel particle sizes correspond to increased perimeter and *** in the Nagqu Prefecture of northern Tibet have a particle size range of 4-8 mm,primarily comprising fine gravel which accounts for 94.61%.These findings provide a scientific basis for extracting gravel characteristic parameters and understanding their spatial distribution variations in the northern Tibetan Plateau.

关键词： Gravel characteristics parameters Northern Tibetan Plateau Gravel outline extraction Remote sensing inversion Grassland degradation

Soft Resource Slicing for Industrial Mixed Traffic in 5G Networks

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 463-465页

作者： Jingfang Ding meng Zheng Haibin yu the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Chinese Academy of Sciences the Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences the University of Chinese Academy of Sciences IEEE

Dear Editor,This letter proposes a dynamic switching soft slicing strategy for industrial mixed traffic in 5G networks. Considering two types of traffic, periodic delay-sensitive (PDS) traffic and sporadic delay-tolerant (SDT) traffic, we design a dynamic switching strategy based on a traffic-Qo S-aware soft slicing (TQASS) scheme and a resource-efficiency-aware soft slicing (REASS) scheme.

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Metagenomic perspectives on antibiotic resistance genes in tap water:The environmental characteristic,potential mobility and health threat

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Journal of Environmental Sciences 2025年第1期147卷 582-596页

作者： Qiyue meng Yibo Zhang Da He yu Xia Jie Fu Chenyuan Dang School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Ecological Impacts of Hydraulic Projects and Restoration of Aquatic Ecosystem of Ministry of Water Resources Institute of HydroecologyMinistry of Water Resources&Chinese Academy of SciencesWuhan 430074China School of Environmental Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen 518055China

As an emerging environmental contaminant,antibiotic resistance genes(ARGs)in tap water have attracted great *** studies have provided ARG profiles in tap water,research on their abundance levels,composition characteristics,and potential threat is still ***,9 household tap water samples were collected from the Guangdong-Hong Kong-Macao Greater Bay Area(GBA)in ***,75 sets of environmental sample data(9 types)were downloaded from the public *** was then performed to explore the differences in the abundance and composition of ARGs.221 ARG subtypes consisting of 17 types were detected in tap *** the ARG abundance in tap water was not significantly different from that found in drinking water plants and reservoirs,their composition *** tap water samples,the three most abundant classes of resistance genes were multidrug,fosfomycin and MLS(macrolide-lincosamidestreptogramin)ARGs,and their corresponding subtypes ompR,fosX and macB were also the most abundant ARG *** the potential mobility,vanS had the highest abundance on plasmids and viruses,but the absence of key genes rendered resistance to vancomycin ***,the majority of ARGs present in tap water were those that have not been assessed and are currently not listed as high-threat level ARG families based on the World Health Organization *** the current potential threat to human health posed by ARGs in tap water is limited,with persistent transfer and accumulation,especially in pathogens,the potential danger to human health posed by ARGs should not be ignored.

关键词： Antibiotic resistance genes Tap water Plasmids Viruses Health threat

High-temperature calcination dramatically promotes the activity of Cs/Co/Ce-Sn catalyst for soot oxidation

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Chinese Chemical Letters 2025年第1期36卷 534-538页

作者： meng Wang Yan Zhang yunbo yu Wenpo Shan Hong He Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesNingbo 315800China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Catalytic oxidation of soot is of great importance for emission control on diesel *** this work,a highly active Cs/Co/Ce-Sn catalyst was investigated for soot oxidation,and it was unexpectedly found that high-temperature calcination greatly improved the activity of the *** the calcination temperature was increased from 500℃ to 750℃,T_(50) decreased from 456.9℃ to 389.8℃ in a NO/O_(2)/H_(2)O/N_(2) *** results revealed that high-temperature calcination can promote the ability to transfer negative charge density from Cs to other metal cations in Cs/Co/Ce-Sn,which will facilitate the production of more oxygen defects and the generation of more surface-active oxygen *** oxygen species are beneficial to the oxidation of NO to NO_(2),leading to the high yield of NO_(2) ***,the Cs/Co/Ce-Sn catalyst calcined at 750℃ demonstrated higher activity than that calcined at 500℃.This work provides a pathway to prepare high efficiency catalysts for the removal of soot and significant insight into the effects of calcination on soot oxidation catalysts.

关键词： Soot oxidation Calcination Surface defects Surface-active oxygen species NO_(2)

Adaptive VDI Session Placement via User Logoff Prediction

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Machine Intelligence Research 2025年第1期22卷 189-200页

作者： Wenping Fan Puhui meng yu Tian Min-Ling Zhang Yao Zhang School of Computer Science and Engineering Southeast UniversityNanjing210096China VMware Information Technology(China)Limited Beijing100190China Key Laboratory of Computer Network and Information Integration(Southeast University) Ministry of EducationNanjing210096China

After the global pandemic,DaaS(desktop as a service)has become the first choice of many companies’remote working *** the desktops are usually deployed in the public cloud when using DaaS,customers are more cost-sensitive which boosts the requirement of proactive power *** researches in this area focus on virtual desktop infrastructure(VDI)session logon behavior modeling,but for the remote desktop service host(RDSH)-shared desktop pools,logoff optimization is also *** systems place sessions by round-robin or in a pre-defined order without considering their logoff ***,these approaches usually suffer from the situation that few left sessions prevent RDSH servers from being powered-off which introduces cost *** this paper,we propose session placement via adaptive user logoff prediction(SODA),an innovative compound model towards proactive RDSH session ***,an ensemble machine learning model that can predict session logoff time is combined with a statistical session placement bucket model to place RDSH sessions with similar logoff time in a more centralized manner on RDSH ***,the infrastructure cost-saving can be improved by reducing the resource waste introduced by those RDSH hosts with very few hanging sessions left for a long *** on real RDSH pool data demonstrate the effectiveness of the proposed proactive session placement approach against existing static placement techniques.

关键词： Virtual desktop infrastructure(VDI)resource management remote desktop service logoff prediction adaptive modeling session placement

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO_(2) metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE meng XIA Huarong CHENG Anyu LIU yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Automation Chongqing University of Post and TelecommunicationsChongqing 400065China

In this paper,we present a metamaterial structure of Dirac and vanadium dioxide(VO_(2))and investigate its optical properties using the finite-difference time-domain(FDTD)*** the phase transition feature of VO_(2),the design can realize active tuning of the plasmon induced transparency(PIT)effect at terahertz frequency,thereby converting from a single PIT to a *** VO_(2) is in the insulating state,the structure is symmetric to obtain a single-band PIT *** VO_(2) is in the metallic state,the structure turns asymmetric to realize a dual-band PIT *** design provides a reference direction for the design of actively tunable ***,it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear *** addition,the structure achieves superior refractive index sensitivity in the terahertz band,surpassing 1 THz/***,the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： tunable tuning transparency

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO_(2)

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao meng Tao Chen yu Han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816JiangsuChina Advanced Membranes and Porous Materials Center Physical Sciences and Engineering DivisionKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia Institute of Sustainability for Chemicals Energy and EnvironmentA*STAR(Agency for ScienceTechnology and Research)Jurong IslandSingapore 627833Singapore College of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina

The synergy of single atoms(SAs)and nanoparticles(NPs)has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction(CO_(2)RR);however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly(ionic liquids)(PIL)precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO_(2)into *** Ni K-edge X-ray absorption near-edge structure(XANES)spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO_(2),the coexistence of Ni SAs and NPs strengthened the CO_(2)activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO_(2)→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect cO2 reduction Carbon catalyst Electrocatalysis

Bifunctional organocatalyst-catalyzed dynamic kinetic resolution of hemiketals for synthesis of chiral ketals via hydrogen bonding control

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Chinese Chemical Letters 2025年第1期36卷 248-252页

作者： meng Shan Yongmei yu mengli Sun Shuping Yang mengqi Wang Bo Zhu Junbiao Chang State Key Laboratory of Antiviral Drugs Pingyuan LaboratoryNMPA Key Laboratory for Research and Evaluation of Innovative DrugSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China

Herein,we report the dynamic kinetic resolution asymmetric acylation ofγ-hydroxy-γ-perfluoroalkyl butenolides/phthalides catalyzed by amino acid-derived bifunctional organocatalysts,and a series of ketals were obtained in high yields(up to 95%)and excellent enantioselectivities(up to 99%).In terms of synthetic utility,the reaction can be performed on a gram scale,and the product can be converted into potential biological nucleoside analog.

关键词： Bifunctional organocatalyst Dynamic kinetic resolution Hemiketal Chiral ketals Hydrogen bonding