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Construction of PAMAM-based Nanocomplex Conjugated with Pt(Ⅳ)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects

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Chinese Journal of Polymer Science 2023年第6期41卷 887-896,I0007页

作者： You-Tao Xin lu-Yao Wang huan-huan Chang Fei-He Ma ming-Lei Sun Li Chen Hui Gao State Key Laboratory of Separation Membranes and Membrane Processes School of Materials Science and EngineeringTiangong UniversityTianjin 300387 China School of Chemistry and Chemical Engineering Tianjin Key Laboratory of Drug Targeting and BioimagingTianjin Enterprise Key Laboratory for Application Research of Hyaluronic AcidTianjin University of TechnologyTianjin 300384China

Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer(CRC),however,the harmful Fusobacterium nucleatum(Fn)that existed in the CRC tumor tissues leads to extreme drug resistance to oxaliplatin,which reduces the anticancer efficiency.Here we fabricated a new dendrimer-based nanocomplex with anti-tumor and antibacterial dual-functions through conjugating Pt(Ⅳ)-complex and lauric acid(LA)to the dendritic carrier PAMAM(G=3).The synthesized PAMAM-Pt-LA nanoparticle was further coated with hyaluronic acid(HA)on its surface through electrostatically interaction in order to enhance biocompatibility and tumor targeting.The biocompatibility,anti-tumor activity and antibacterial activity of PAMAM-Pt-LA@HA nanocomplex were evaluated in vitro.The results showed that the PAMAM-Pt-LA@HA nanocomplex ehxibited a good biocompatibility,high anti-colorectal cancer activity and high anti-Fn activity.This dual-functional nanocomplex provides a new method to develop anticancer nanomedicines that will be more therapeutically efficacious and less toxic than oxaliplatin for the treatment of CRC.

关键词： chemotherapy complex treatment

Fluorine Substitution Effect on the Material Properties in Transparent Aromatic Polyimides

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Chinese Journal of Polymer Science 2022年第7期40卷 781-788页

作者： Wei-Feng Peng huan-Yu Lei Xin-Xin Zhang lu-Hao Qiu ming-Jun huang South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

The recent development of flexible display technology raised additional requirements for optical and electric properties of polyimides,accelerating the structure and property tunning of transparent polyimides.The unique electronic effect and steric hindrance effect of fluorine substitutions make fluorine-containing polyimides occupy an important position in the transparent polyimide family.In this work,a series of transparent aromatic polyimides were prepared from a fixed 4,4’-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)and biphenyl diamines with different substitute groups at the 2,2’,6,6’-positions.We systematically studied the effects of pendant groups on the thermal,mechanical,optical and dielectric properties of these 6FDA-based polyimides with the aid of density function theory(DFT)calculation.In particular,we paid special attention to the simple but compact fluoro group substitution.The simple fluoro substitution brought the advantages of maintaining the linearity of the backbone and dense polymer chain packing,which would minimize the weakening of polyimides’inherent thermal,dimensional and mechanical properties.Comparing with trifluoromethyl substituted polyimides with the best optical transparency,polyimides containing fluoro substitutes exhibited slightly decreased optical transparency,but increased thermal and dimensional stability and higher mechanical strength.These results could shed light on the ultimate transparent polyimide film development toward the application in extreme working condition,e.g.,the colorless polyimide substrate film for the flexible display technology.

关键词： Polyimides Fluorine substitution Transparent Dielectric Colorless

Fluorinated Colorless Polyimides with High Heat-resistance and Low Birefringence

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高分子科学:英文版 2023年第10期41卷 1599-1608页

作者： Bing-Yu Zou lu-Hao Qiu huan-Yu Lei Jin-ming Liu Wei-Feng Peng Hong-Qin Zhao Feng Bao ming-Jun huang South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

The development of optical films with high transparency,high thermal resistance and low birefringence remains a challenge in the flexible display industry.In this work,we designed and synthesized a series of fluorinated colorless polyimides(CPIs)materials using 2,5-substituted m-phenylenediamine diamine monomers and 1,2,4,5-cyclohexanetetracarboxylic dianhydride(CHDA).We systematically studied the effects of fluorinated group substitutions on the thermal,mechanical,optical and dielectric properties of CPI films.The introduction of alicyclic CHDA dianhydride affords high transparency and low yellowness,while the 2,5-substituted m-phenylenediamine diamines offer the CPIs with quite low birefringence as well as high glass transition temperatures.A particular CHDA/o3FBDA film with simple chemical structure stands out,exhibiting well-balanced overall properties.

关键词： Colorless polyimide Low birefringence Fluorinated Optical flm

PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression

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Virologica Sinica 2021年第5期36卷 1154-1164页

作者： Hai-Yan Yan Hui-Qiang Wang ming Zhong Shuo Wu lu Yang Ke Li Yu-huan Li CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China NHC Key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical ScienceBeijing 100050China

Influenza A viruses(IAV)are responsible for seasonal flu epidemics,which can lead to high morbidity and mortality each year.Like other viruses,influenza virus can hijack host cellular machinery for its replication.Host cells have evolved diverse cellular defense to resist the invasion of viruses.As the main components of promyelocytic leukemia protein nuclear bodies(PML-NBs),PML can inhibit the replication of many medically important viruses including IAV.However,the mechanism of PML against IAV is unclear.In the present study,we found PML was induced in response to IAV infection and ectopic expression of PML could inhibit IAV replication,whereas knockdown of endogenous PML expression could enhance IAV replication.Further studies showed that PML increased the expression of FBXW7 by inhibiting its K48-linked ubiquitination and enhanced the interaction between FBXW7 and SHP2,which negatively regulated IAV replication during infection.Moreover,PML stabilized RIG-I to promote the production of typeⅠIFN.Collectively,these data indicated that PML inhibited IAV replication by enhancing FBXW7 expression in the antiviral immunity against influenza virus and extended the mechanism of PML in antiviral immunity.

关键词： Influenza A virus(IAV) Promyelocytic leukemia(PML) FBXW7 RIG-I

Lifting surface reconstruction of Au(100)by tellurium adsorption

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Nano Research 2023年第5期16卷 6967-6973页

作者： Erwen Zhang huan lu Wei Zhang Shuiyan Cao Yang Wang Rong Rong Ying Liu Zhuhua Zhang ming Yang Yanpeng Liu Wanlin Guo Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical StructuresInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjing 210016China College of Jincheng Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomHong KongChina

The Au(100)surface has been a subject of intense studies due to excellent catalytic activities and its model character for surface science.However,the spontaneous surface reconstruction buries active Au(100)plane and limits practical applications,how to controllably eliminate the surface reconstruction over large scale remains challenging.Here,we experimentally and theoretically demonstrate that simple decoration of the Au(100)surface by tellurium(Te)atoms can uniquely lift its reconstruction over large scale.Scanning tunneling microscopy imaging reveals that the lifting of surface reconstruction preferentially starts from the boundaries of distinct domains and then extends progressively into the domains with the reconstruction rows perpendicular to the boundaries,leaving a Au(100)-(1×1)surface behind.The Au(100)-(1×1)is saturated at~84%±2%with respect to the whole surface at a Te coverage of 0.16 monolayer.With further increasing the Te coverage to 0.25 monolayer,the Au(100)-(1×1)surface becomes reduced and overlapped by a well-ordered(2×2)-Te superstructure.No similar behavior is found for Te-decorated Au(111),Cu(111),Cu(100)surfaces,nor for the decorated Au(100)with other elements.This result may pave the way to design Au-based catalysts and,as an intermediate step,even potentially open a new route to constructing complex transition metal dichalcogenides.

关键词： surface reconstruction of Au(100) tellurium facet-dependence adsorption energy anisotropy

通过四种不同的干燥方式制备β-胡萝卜素微胶囊（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第11期20卷 901-909页

作者： Xiang-yu LI Mian-bin WU Min XIAO Shu-huan lu Zhi-ming WANG Jian-ming YAO Li-rong YANG Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Hefei Institutes of Physical Science University of Science and Technology of ChinaHefei 230026China CABIO Biotech(Wuhan)Co. Ltd.Wuhan 430073China Hubei Province Nutrition Chemicals Biosynthetic Engineering Technology Research Center Wuhan 430073China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

目的:系统地比较不同的干燥方式对β-胡萝卜素微胶囊粉体性质(形态、颗粒度、水分含量、热特性和化学稳定性)的影响。创新点:全面且系统地展现了喷雾干燥、喷雾冷冻干燥、包衣和喷雾造粒等四种干燥方式对β-胡萝卜素微胶囊粉体的作用。... 详细信息

目的:系统地比较不同的干燥方式对β-胡萝卜素微胶囊粉体性质(形态、颗粒度、水分含量、热特性和化学稳定性)的影响。创新点:全面且系统地展现了喷雾干燥、喷雾冷冻干燥、包衣和喷雾造粒等四种干燥方式对β-胡萝卜素微胶囊粉体的作用。方法:β-胡萝卜素乳液通过四种不同的干燥方式得到四种胡萝卜素微胶囊粉体,通过理化指标、电子扫描显微镜拍照、差示扫描量热法(DSC)和加速稳定性实验等手段比较这四种样品的各项性质的差异。结论:通过包衣法制备的β-胡萝卜素微囊与其它方法制得的β-胡萝卜素微囊相比,具有优异的稳定性和均匀的颗粒结构。此外,DSC结果表明,微胶囊化可以提高β-胡萝卜素微胶囊的玻璃化转变温度(珀)和熔化温度(凡)值。

关键词： β-胡萝卜素微胶囊喷雾干燥喷雾冷冻干燥包衣喷雾造粒

Effects of boiling duration in processing of White Paeony Root on its overall quality evaluated by ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics analysis and high performance liquid chromatograp

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Chinese Journal of Natural Medicines 2017年第1期15卷 62-70页

作者： KONG ming XU Jun LIU huan-huan XU Jin-Di LI Xiu-Yang lu Min WANG Chun-Ru CHEN Hu-Biao LI Song-Lin Department of Pharmaceutical Analysis and Metabolomics Jiangsu Branch of China Academy of Chinese Medical Sciences and Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028 China School of Chinese Medicine Hong Kong Baptist University Hong Kong 999077 China

Boiling processing is commonly used in post-harvest handling of White Paeony Root(WPR), in order to whiten the herbal materials and preserve the bright color, since such WPR is empirically considered to possess a higher quality. The present study was designed to investigate whether and how the boiling processing affects overall quality of WPR. First, an ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry-based metabolomics approach coupled with multivariate statistical analysis was developed to compare the holistic quality of boiled and un-boiled WPR samples. Second, ten major components in WPR samples boiled for different durations were quantitatively determined using high performance liquid chromatography to further explore the effects of boiling time on the holistic quality of WPR, meanwhile the appearance of the processed herbal materials was observed. The results suggested that the boiling processing conspicuously affected the holistic quality of WPR by simultaneously and inconsistently altering the chemical compositions and that short-time boiling processing between 2 and 10 min could both make the WPR bright-colored and improve the contents of major bioactive components, which were not achieved either without boiling or with prolonged boiling. In conclusion, short-term boiling(2-10 min) is recommended for post-harvest handling of WPR.

关键词：白 Paeony 根沸腾处理全面质量主要 bioactive 部件 Metabolomics

Activation of Cannabinoid Receptor 1 in GABAergic Neurons in the Rostral Anterior Insular Cortex Contributes to the Analgesia Following Common Peroneal Nerve Ligation

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Neuroscience Bulletin 2023年第9期39卷 1348-1362页

作者： ming Zhang Cong Li Qian Xue Chang-Bo lu huan Zhao Fan-Cheng Meng Ying Zhang Sheng-Xi Wu Yan Zhang Hui Xu Department of Neurobiology and Collaborative Innovation Center for Brain Science School of Basic MedicineThe Fourth Military Medical UniversityXi’an710032China Department of Anesthesiology Heze Municipal HospitalHeze274031China Department of Cardiovascular Surgery Xi’an International Medical Center HospitalXi’an710100China Department of Basic Medical Laboratory The General Hospital of Western Theater CommandChengdu610083China

The rostral agranular insular cortex(RAIC)has been associated with pain modulation.Although the endogenous cannabinoid system(eCB)has been shown to regulate chronic pain,the roles of eCBs in the RAIC remain elusive under the neuropathic pain state.Neuropathic pain was induced in C57BL/6 mice by common peroneal nerve(CPN)ligation.The roles of the eCB were tested in the RAIC of ligated CPN C57BL/6J mice,glutamatergic,or GABAergic neuron cannabinoid receptor 1(CB1R)knockdown mice with the whole-cell patch-clamp and pain behavioral methods.The E/I ratio(amplitude ratio between mEPSCs and mIPSCs)was significantly increased in layer V pyramidal neurons of the RAIC in CPN-ligated mice.Depolarization-induced suppression of inhibition but not depolarization-induced suppression of excitation in RAIC layer V pyramidal neurons were significantly increased in CPN-ligated mice.The analgesic effect of ACEA(a CB1R agonist)was alleviated along with bilateral dorsolateral funiculus lesions,with the administration of AM251(a CB1R antagonist),and in CB1R knockdown mice in GABAergic neurons,but not glutamatergic neurons of the RAIC.Our results suggest that CB1R activation reinforces the function of the descending pain inhibitory pathway via reducing the inhibition of glutamatergic layer V neurons by GABAergic neurons in the RAIC to induce an analgesic effect in neuropathic pain.

关键词： Rostral agranular insular cortex:Cannabinoid receptor 1-Neuropathic pain Dorsolateral fasciculus:GABAergic neuron

Anti-IgLON5 disease: a novel topic beyond neuroimmunology

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Neural Regeneration Research 2023年第5期18卷 1017-1022页

作者： Yi-ZongHeng Zhang You Ni Yi-Ning Gao Ding-Ding Shen lu He Dou Yin huan-Yu Meng Qin-ming Zhou Ji Hu Sheng Chen Department of Neurology&Institute of Neurology Ruijin HospitalAffiliated with Shanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghaiChina

Anti-IgLON5 disease is a recently defined autoimmune disorder of the nervous system associated with autoantibodies against IgLON5. Given its broad clinical spectrum and extremely complex pathogenesis, as well as difficulties in its early diagnosis and treatment, anti-IgLON5 disease has become the subject of considerable research attention in the field of neuroimmunology. Anti-IgLON5 disease has characteristics of both autoimmunity and neurodegeneration due to the unique activity of the antiIgLON5 antibody. Neuropathologic examination revealed the presence of a tauopathy preferentially affecting the hypothalamus and brainstem tegmentum, potentially broadening our understanding of tauopathies. In contrast to that seen with other autoimmune encephalitis-related antibodies, basic studies have demonstrated that IgLON5 antibody-induced neuronal damage and degeneration are irreversible, indicative of a potential link between autoimmunity and neurodegeneration in antiIgLON5 disease. Herein, we comprehensively review and discuss basic and clinical studies relating to anti-IgLON5 disease to better understand this complicated disorder.

关键词： anti-IgLON5 disease autoimmune encephalitis human leukocyte antigen IgG4-related diseases IgLON5 antibody IgLONs immunotherapy inflammation neurodegeneration neuroimmunology tauopathy