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Olfactory Three-Needle Electroacupuncture Improved Synaptic Plasticity and Gut Microbiota of SAMP8 Mice by Stimulating Olfactory Nerve

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Chinese Journal of Integrative Medicine 2024年第8期30卷 729-741页

作者： WANG Yuan ZHENG A-ni yang huan WANG Qiang DAI Biao WANG Jia-ju WAN Yi-tong LIU Zhi-bin LIU Si-yang College of Acu-moxibustion and Massage Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China Shaanxi Key Laboratory of Acupuncture and Medicine Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China The Second Affiliated Hospital of Shaanxi University of Chinese Medicine XianyangShaanxi Province712000China Department of Traditional Chinese Medicine Baotou Medical CollegeBaotouInner Mongolia Autonomous Region014040China School of Basic Medical Sciences Xi’an Medical UniversityXi’an710021China

Objective To investigate the effects and mechanisms of olfactory three-needle(OTN)electroacupuncture(EA)stimulation of the olfactory system on cognitive dysfunction,synaptic plasticity,and the gut microbiota in senescence-accelerated mouse prone 8(SAMP8)*** Thirty-six SAMP8 mice were randomly divided into the SAMP8(P8),SAMP8+OTN(P8-OT),and SAMP8+nerve transection+OTN(P8-N-OT)groups according to a random number table(n=12 per group),and 12 accelerated senescence-resistant(SAMR1)mice were used as the control(R1)*** was performed at the Yintang(GV 29)and bilateral Yingxiang(LI 20)acupoints of SAMP8 mice for 4 *** Morris water maze test,transmission electron microscopy,terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)staining,Nissl staining,Golgi staining,Western blot,and 16S rRNA sequencing were performed,*** Compared with the P8 group,OTN improved the cognitive behavior of SAMP8 mice,inhibited neuronal apoptosis,increased neuronal activity,and attenuated hippocampal synaptic dysfunction(P<0.05 or P<0.01).Moreover,the expression levels of synaptic plasticity-related proteins N-methyl-D-aspartate receptor 1(NMDAR1),NMDAR2B,synaptophysin(SYN),and postsynaptic density protein-95(PSD95)in hippocampus were increased by OTN treatment(P<0.05 or P<0.01).Furthermore,OTN greatly enhanced the brain-derived neurotrophic factor(BDNF)/cAMP-response element binding(CREB)signaling and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling compared with the P8 group(P<0.05 or P<0.01).However,the neuroprotective effect of OTN was attenuated by olfactory nerve *** with the P8 group,OTN had a very limited effect on the fecal microbial structure and composition of SAMP8 mice,while specifically increased the genera Oscillospira and Sutterella(P<0.05).Interestingly,the P8-N-OT group showed an abnormal fecal microbiota with higher microbialα-diversity,Firmicutes/Bacter

关键词： Alzheimer's disease olfactory threeneedle electroacupuncture olfactory nerve synaptic plasticity gut microbiota Chinese medicine

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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DOMAIN DECOMPOSITION WITH NONMATCHING GRIDS FOR EXTERIOR TRANSMISSION PROBLEMS VIA FEM AND DTN MAPPING

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Journal of Computational Mathematics 2006年第3期24卷 323-342页

作者： ju-e yang De-hao Yu LSEC ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

In this paper, we are concerned with a non-overlapping domain decomposition method （DDM） for exterior transmission problems in the plane. Based on the natural boundary integral operator, we combine the DDM with a Dirichlet-to-Neumann （DtN） mapping and provide the numerical analysis with nonmatching grids. The weak continuity of the approximation solutions on the interface is imposed by a dual basis multiplier. We show that this multiplier space can generate optimal error estimate and obtain the corresponding rate of convergence. Finally, several numerical examples confirm the theoretical results.

关键词： Domain decomposition Nature boundary element Nonmatching grids Weakcontinuity D-N alternating Dual basis Projection operator Error estimate.

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Multi-camera calibration method based on minimizing the difference of reprojection error vectors

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Journal of Systems Engineering and Electronics 2018年第4期29卷 844-853页

作者： HUO ju LI Yunhui yang Ming School of Electrical Engineering Harbin Institute of Technology Control and Simulation Center Harbin Institute of Technology

In order to achieve a high precision in three-dimensional（3D） multi-camera measurement system, an efficient multi-cameracalibration method is proposed. A stitching method of large scalecalibration targets is deduced, and a fundamental of multi-cameracalibration based on the large scale calibration target is *** avoid the shortcomings of the method, the vector differencesof reprojection error with the presence of the constraint conditionof the constant rigid body transformation is modelled, and mini-mized by the Levenberg-Marquardt （LM） method. Results of thesimulation and observation data calibration experiment show thatthe accuracy of the system calibrated by the proposed methodreaches 2 mm when measuring distance section of 20 000 mmand scale section of 7 000 mm × 7 000 mm. Consequently, theproposed method of multi-camera calibration performs better thanthe fundamental in stability. This technique offers a more uniformerror distribution for measuring large scale space.

关键词： vision measurement multi-camera calibration field stitching vector error

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On the heterogeneous microstructure development in the welded joint of 12MnNiVR pressure vessel steel subjected to high heat input electrogas welding

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Journal of Materials Science & Technology 2019年第8期35卷 1747-1752页

作者： yang Shen ju Leng Cong Wang School of Metallurgy Northeastern University Shenyang 110819 China Shenyang NEU New Industrial Technology Research Institute Co. LTD Shenyang 110819 China

Microstructure features of 12 MnNiVR pressure vessel steel welded joint deposited by the high heat input electrogas welding have been systematically investigated. It is revealed that the welded joint is featured by a heterogeneous juxtaposition. The coarse grained heat-affected zone(CGHAZ) primarily consists of lath bainites and minor granular bainites. The fine grained heat-affected zone(FGHAZ) is dominated by polygonal ferrites, pearlites, and fine cementite particles. Moreover, electron backscatter diffraction results further demonstrate that the CGHAZ is populated by coarse prior austenite grains(PAGs) with high frequency(61.3%) of low angle grain boundaries(LAGBs). On the other hand, the FGHAZ is filled with fine PAGs with a lower frequency(19.6%) of LAGBs. Such microstructural differences may likely contribute to differed mechanical properties for samples tested at designed positions.

关键词： 12MnNiVR pressure vessel steel Electrogas welding High heat input Electron backscatter diffraction

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State-of-the-art of 3D printing technology of cementitious material—An emerging technique for construction

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Science China(Technological Sciences) 2018年第4期61卷 475-495页

作者： MA GuoWei WANG Li ju yang College of Architecture and Civil Engineering Beijing University of Technology School of Civil Environmental and Mining Engineering The University of Western Australia School of Mechanics and Civil Engineering China University of Mining & Technology at Beijing State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology at Beijing

In recent few years, significant improvement has been made in developing largescale 3 D printer to accommodate the need of industrial-scale 3 D printing. Cementitious materials that are compatible with 3 D printing promote rapid application of this innovative technique in the construction field with advantages of cost effective, high efficiency, design flexibility and environmental friendly. This paper firstly reviews existing 3 D printing techniques that are currently being used in commercial3 D printers. It then summarizes three latest development of largescale 3 D printing systems and identifies their relationships and limiting factors. Thereafter, critical factors that are used to evaluate the workability and printable performance of cementitious materials are specified. Easy-extrusive, easy-flowing, well-buildable, and proper setting time are significant for cementitious material to meet the critical requirements of a freeform construction process. Finally, main advantages, potential applications and the prospects of future research of 3 D printing in construction technology are suggested. The objective of this work is to review current design methodologies and operational constraints of largescale 3 D printing system and provide references for optimizing the performance of cementitious material and promote its responsible use with largescale 3 D printing technology.

关键词： 3D printing cementitious material construction automation

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Privacy Preserving Distributed Bandit Residual Feedback Online Optimization Over Time-Varying Unbalanced Graphs

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2284-2297页

作者： Zhongyuan Zhao Zhiqiang yang Luyao Jiang ju yang Quanbo Ge the School of Automation Nanjing University of Information Science and Technologyand also with Jiangsu Key Laboratory of Big Data Analysis Technology the School of Mechanical Engineering Shanghai Jiao Tong University IEEE

This paper considers the distributed online optimization(DOO) problem over time-varying unbalanced networks, where gradient information is explicitly unknown. To address this issue, a privacy-preserving distributed online one-point residual feedback(OPRF) optimization algorithm is proposed. This algorithm updates decision variables by leveraging one-point residual feedback to estimate the true gradient information. It can achieve the same performance as the two-point feedback scheme while only requiring a single function value query per iteration. Additionally, it effectively eliminates the effect of time-varying unbalanced graphs by dynamically constructing row stochastic matrices. Furthermore, compared to other distributed optimization algorithms that only consider explicitly unknown cost functions, this paper also addresses the issue of privacy information leakage of nodes. Theoretical analysis demonstrate that the method attains sublinear regret while protecting the privacy information of agents. Finally, numerical experiments on distributed collaborative localization problem and federated learning confirm the effectiveness of the algorithm.

关键词： Differential privacy distributed online optimization(DOO) federated learning one-point residual feedback(OPRF) time-varying unbalanced graphs

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Quick-homogeneous Corrosion of Ti-2A1-2.5Zr Alloy in High-temperature and High-pressure Water Steam

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Journal of Materials Science & Technology 2001年第1期17卷 43-44页

作者： Lin yang Zhentao YU ju DENG Northwest institute for Nonferrous Metal Research Xi’an 710016China

The corrosion behavior of Ti-2A1-2.5Zr alloy with 5 alloy contents and 5 surface states were studied in water steam at 400℃, 10.3 MPa for 72 h. The weight-increments of all samples are under 4 mg/dm2, better than Zr and Zr-alloy. or-Ti is oxidized into anatase-type TiO2 preferentially. The corrosion resistance is improved by adding Al element or pre-oxidizing treatment, the latter is more effective relatively.

关键词： corrosion resistance corrosion behavior surface states Al element

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Gene therapy for neurodegenerative disorders:advances, insights and prospects

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1347-1359页

作者： Wei Chen yang Hu Dianwen ju Department of Biological Medicines Fudan University School of Pharmacy Shanghai 201203 China Department of Ophthalmology Stanford University School of Medicine Palo Alto CA 94304 USA

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer’s disease(AD), Parkinson’s disease(PD) and Huntington’s disease(HD). Some early clinical trials have failed to achieve satisfactory therapeutic effects. Efforts to enhance effectiveness are now concentrating on three major fields: identification of new vectors,novel therapeutic targets, and reliable of delivery routes for transgenes. These approaches are being assessed closely in preclinical and clinical trials, which may ultimately provide powerful treatments for patients. Here, we discuss advances and challenges of gene therapy for neurodegenerative disorders,highlighting promising technologies, targets, and future prospects.

关键词： disorders degenerative Huntington

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Impact of hydraulic perforation on fracture initiation and propagation in shale rocks

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Science China(Technological Sciences) 2016年第5期59卷 756-762页

作者： ZHAO Xi ju yang yang Yong SU Sun GONG WenBo School of Mechanics & Civil Engineering China University of Mining & Technology Beijing 100083 China State Key Laboratory for Geo-mechanics & Deep Underground Engineering China University of Mining & Technology Xuzhou 221006 China State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology Beijing 100083 China SINOPEC Shengli Oilfield Company Geological Scientific Research Institute Dongying 257015 China

To enhance the oil and gas recovery rate, hydraulic fracturing techniques have been widely adopted for stimulation of low-permeability reservoirs. Pioneering work indicates that hydraulic perforation and layout could significantly affect fracture initiation and propagation in low-permeability reservoir rocks subjected to complex in-situ stresses. This paper reports on a novel numerical method that incorporates fracture mechanics principles and the numerical tools FRANC3D and ANSYS to investigate the three-dimensional initiation and propagation behavior of hydro-fracturing cracks in shale rock. Considering the transverse isotropic property of shale rocks, the mechanical parameters of reservoir rocks attained from laboratory tests were adopted in the simulation. The influence of perforation layouts on the 3D initiation of hydro-fracturing fractures in reservoir rocks under geo-stresses was quantitatively illuminated. The propagation and growth of fractures in three dimensions in different perforating azimuth values were illustrated. The results indicate that： 1） the optimal perforation direction should be parallel to the maximum horizontal principal stress, 2） the crack plane gradually turns toward the direction of the maximum horizontal principal stress when they are not in parallel, 3） compared with the linear and symmetric pattern, the staggered perforation is the optimal one, 4） the proper perforation density is four to six holes per meter, 5） the optimal perforation diameter in this model is 30 ram, and 6） the influence of the perforation depth on the fracture initiation pressure is low.

关键词： hydraulic fracturing perforation shale rocks in-situ stresses numerical simulation fracture mechanics

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