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Antibacterial Thermoplastic Polyurethane Electrospun Fiber Mats Prepared by 3-Aminopropyltriethoxysilane-assisted Adsorption of Ag Nanoparticles

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Chinese Journal of Polymer Science 2017年第6期35卷 713-720页

作者： Yu-man liu 李强 huan-huan liu Hui-hui Cheng Jian Yu 郭朝霞 Key Laboratory of Advanced Materials (Ministry of Education) Department of Chemical EngineeringTsinghua University

Antibacterial thermoplastic polyurethane （TPU） electrospun fiber mats were prepared by adsorption of Ag nanoparticles （Ag NPs） onto TPU/3-aminopropyltriethoxysilane （APS） co-electrospun fiber mats from silver sol. The use of APS can functionalize TPU fibers with amino groups, facilitating the adsorption of Ag NPs. The effects of pH of silver sol and APS content on Ag NP adsorption and antibacterial activity were investigated. Ag NP adsorption was evidenced by TEM, XPS and TGA. Significant Ag NP adsorption occurred at pH = 3-5, The main driving force for Ag NP adsorption is electrostatic interaction between --NH3^＋ of the fibers and --COO- derived from the --COOH group capped on the surfaces of Ag NPs. The antibacterial activity of the Ag NP-decorated TPU/APS fiber mats was investigated using both gram-negative Escherichia coli and gram-positive Bacillus subtilis. The antibacterial rate increases with increasing APS content up to 5% where the antibacterial rates against both types of bacteria are over 99.9%.

关键词： PU Electrospinning Coupling agent Immobilization Bacteria

Facile one-pot hydrothermal method to prepare Sn(Ⅱ) and N co-doped TiO_(2) photocatalyst for water splitting under visible light irradiation

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Rare Metals 2022年第2期41卷 406-414页

作者： Xiao-huan Jiang Ying-Nan Duan Yu Tian Meng Chen Mao-Kun Li huan-huan liu Wan-Liang Yang Meng-Kui Tian School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China

In this paper,a visible light-responsive Sn^(2+)and N co-doped TiO_(2)photocatalyst was prepared by facile one-pot hydrothermal *** as-prepared samples were characterized in detail by a series of characterization *** results showed that the Sn^(2+)and N elements were co-doped into TiO_(2),while the catalyst still maintains anatase crystal structure and gets irregular little nanocluster in diameter of 9–10 nm with higher specific surface *** absorption edge of Sn^(2+)and N co-doped TiO_(2)extends to the visible light *** with Sn^(2+)-doped TiO_(2)and N-TiO_(2),the absorption edges have obvious red-shift of about 50 and 70 nm,*** synergistic effect of O 2p-N 2p and O 2p-Sn 5s hybridization to form impurity levels is the main reason for the *** hydrogen production performance of the Sn^(2+)and N co-doping TiO_(2)(n(N)/n(Ti)=1)catalyst reached the maximum value of 0.37 mmol·h^(-1)·g^(-1)under visible light,which is higher than that of N-doped TiO_(2)and SnTiO_(2)-doped TiO_(2)*** result is due to the wider visible light region-responsive ability of Sn^(2+)and N codoped into TiO_(2).Furthermore,mild hydrothermal methods will not make the Sn^(2+)oxidized to Sn^(4+),which make the catalysts still maintain high photocatalytic *** work provides a simple and mild method for the preparation of dual-element co-doped TiO_(2)with high crystallinity,excellent performance and broad application prospects.

关键词： Photocatalyst Photocatalytic water splitting Visible light driven Sn^(2+)and N co-doped TiO_(2)

Recent developments in novel silica-based optical fibers

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Frontiers of Information Technology & Electronic Engineering 2019年第4期20卷 481-489页

作者： Ting-yun WANG Fu-fei PANG Su-juan huanG Jian-xiang WEN huan-huan liu Li-bo YUAN Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication Shanghai Institute for Advanced Communication and Data ScienceShanghai University Photonics Research Center Guilin University of Electronic Technology

We have summarized our recent work in the area of novel silica-based optical fibers, which can be classified into two types: silica optical fiber doped with special elements including Bi, Al, and Ce, and micro-structured multi-core fibers. For element-doped optical fiber, the Bi/Al co-doped silica fibers could exhibit a fluorescence spectrum covering the wavelength range between 1000 and 1400 nm with a full width at half maximum(FWHM) of about 150 nm, which enables its use in fiber amplifiers and laser systems. The Ce-doped fiber's center wavelengths of excitation and emission are about 340 and 430 nm, respectively. The sapphire-derived fiber(SDF) with high alumina dopant concentration in the core can form mullite through heating and cooling with arc-discharge treatment. This SDF can be further developed for an intrinsic Fabry-Perot interferometric that can withstand 1200 ℃, which allows it to be used in high-temperature sensing applications. Owing to the strong evanescent field, microstructured multi-core fiber can be used in a wide range of applications in biological fiber optic sensing, chemical measurement, and interference-related devices. Coaxial-core optical fiber is another novel kind of silica-based optical fiber that has two coaxial waveguide cores and can be used for optical trapping and micro-particle manipulation by generating a highly focused conical optical field. The recent developments of these novel fibers are discussed.

关键词： Optical fiber Fiber optic device Silica-based special fiber

Clinical efficacy of Xuebijing injection for the treatment of sepsis:A retrospective cohort study

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Journal of Integrative Medicine 2024年第6期22卷 645-651页

作者： Zhao-tang Gong Hong-xin Yang Ben-ben Zhu huan-huan liu Guleng Siri Department of Pharmacy Inner Mongolia Autonomous Region People's Hospital Department of Pharmacy Inner Mongolia Medical University Department of Pharmacy Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University Department of Pharmacy Dongfang Hospital Beijing University of Chinese Medicine Inner Mongolia Academy of Medical Sciences

Objective: The objective of this study was to investigate the clinical efficacy and safety of treating sepsis patients with Xuebijing injection(XBJI).Methods: We conducted a retrospective analysis of 418 patients who experienced severe infections and were treated with XBJI from June 2018 to June 2021. Propensity score matching was used to match the patient cases. The study population included 209 pairs of cases(418 individuals), and the analysis included data from before and after a 14-day course of treatment with carbapenem alone, or carbapenem with ***: There were no significant differences in the 14-day mortality or length of hospital stay(P > 0.05)between the two groups. The combined treatment group had more patients with C-reactive protein that returned to normal levels(compared to baseline) than the non-combined treatment group(14.4% vs 8.1%;odds ratio [OR]: 0.528; 95% confidence interval [CI]: 0.282–0.991; P = 0.026). Similarly, the combined treatment group had higher procalcitonin attainment rate(55.0% vs 39.7%; OR: 0.513; 95% CI: 0.346–0.759; P = 0.001) than the non-combined treatment group. Further, more patients in the combined treatment group achieved normal creatinine levels than in the non-combined treatment group(64.1% vs54.1%; OR: 0.659; 95% CI: 0.445–0.975; P = 0.037).Conclusion: The combination of XBJI with carbapenem did not reduce the 14-day mortality rate of patients with severe infection, but it was able to reduce the level of inflammatory factors in patients with sepsis, and had a protective effect on liver and kidney *** cite this article as: Gong ZT, Yang HX, Zhu BB, liu HH, Siri GL. Clinical efficacy of Xuebijing injection for the treatment of sepsis: A retrospective cohort study. J Integr Med. 2024; 22(6): 645–651.

关键词： Xuebijing injection Sepsis Inflammatory factors Septic shock Mortality

3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota

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World Journal of Gastroenterology 2022年第46期28卷 6522-6536页

作者： Qiong-Zi He Peng Wei Jun-Zhi Zhang Tong-Tong liu Kun-Qun Shi huan-huan liu Jing-Wei Zhang Shi-Jia liu Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina College of The First Clinical Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198Jiangsu ProvinceChina

BACKGROUND 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid(BT2)is a benzothiophene carboxylate derivative that can suppress the catabolism of branched-chain amino acid(BCAA)-associated mammalian target of rapamycin complex 1(mTORC1)*** studies have demonstrated the therapeutic effects of BT2 on arthritis,liver cancer,and kidney ***,the effects of BT2 on ulcerative colitis(UC)are *** To investigate the anti-UC effects of BT2 and the underlying *** Mouse UC models were created through the administration of 3.5%dextran sodium sulfate(DSS)for 7 *** mice in the treated groups were administered salazosulfapyridine(300 mg/kg)or BT2(20 mg/kg)orally from day 1 to day *** the end of the study,all of the mice were sacrificed,and colon tissues were removed for hematoxylin and eosin staining,immunoblot analyses,and immunohistochemical *** levels were measured by flow *** contents of BCAAs including valine,leucine,and isoleucine,in mouse serum were detected by liquid chromatography-tandem mass spectrometry,and the abundance of intestinal flora was analyzed by 16S ribosomal DNA *** Our results revealed that BT2 significantly ameliorated the inflammatory symptoms and pathological damage induced by DSS in ***2 also reduced the production of the proinflammatory cytokines interleukin 6(IL-6),IL-9,and IL-2 and increased the anti-inflammatory cytokine IL-10 *** addition,BT2 notably improved BCAA catabolism and suppressed mTORC1 activation and cyclooxygenase-2 expression in the colon tissues of UC ***,highthroughput sequencing revealed that BT2 restored the gut microbial abundance and diversity in mice with *** with the DSS group,BT2 treatment increased the ratio of Firmicutes to Bacteroidetes and decreased the abundance of Enterobacteriaceae and *** Our results indicated that BT2 significantly ameliorated DSS-induced UC and that the late

关键词： 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid Ulcerative colitis Mechanistic target of rapamycin complex 1 Intestinal flora Dextran sodium sulfate Cyclooxygenase-2

Qingyi decoction attenuates intestinal epithelial cell injury via the calcineurin/nuclear factor of activated T-cells pathway

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World Journal of Gastroenterology 2022年第29期28卷 3825-3837页

作者： Guan-Yu Wang Dong Shang Gui-Xin Zhang Hui-Yi Song Nan Jiang huan-huan liu Hai-Long Chen Department of General Surgery The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Institute of Integrative Medicine of Dalian Medical University Dalian 116044Liaoning ProvinceChina Laboratory of Integrative Medicine The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Recent studies have demonstrated that dysfunction of the intestinal barrier is a significant contributing factor to the development of severe acute pancreatitis(SAP).A stable intestinal mucosa barrier functions as a major anatomic and functional barrier,owing to the balance between intestinal epithelial cell(IEC)proliferation and *** is some evidence that calcium overload may trigger IEC apoptosis and that calcineurin(CaN)/nuclear factor of activated Tcells(NFAT)signaling might play an important role in calcium-mediated *** To investigate the potential mechanisms underlying the therapeutic effect of Qingyi decoction(QYD)in *** A rat model of SAP was created via retrograde infusion of sodium *** levels of amylase,tumor necrosis factor(TNF-α),interleukin(IL)-6,D-lactic acid,and diamine oxidase(DAO);histological changes;and apoptosis of IECs were examined in rats with or without QYD *** expression of the two subunits of CaN and NFAT in intestinal tissue was measured via quantitative realtime polymerase chain reaction and western *** in vitro studies,Caco-2 cells were treated with lipopolysaccharide(LPS)and QYD serum,and then cell viability and intracellular calcium levels were *** Retrograde infusion of sodium deoxycholate increased the severity of pancreatic and intestinal pathology and the levels of serum amylase,TNF-α,and *** the indicators of intestinal mucosa damage(D-lactic acid and DAO)and the levels of IEC apoptosis were elevated in the SAP *** treatment reduced the serum levels of amylase,TNF-α,IL-6,D-lactic acid,and DAO and attenuated the histological *** apoptosis associated with SAP was ameliorated under QYD *** addition,the protein expression levels of the two subunits of CaN were remarkably elevated in the SAP group,and the NFATc3 gene was significantly upregulated at both the transcript and protein levels in the SAP group compared with th

关键词： Severe acute pancreatitis Intestinal epithelial cell Apoptosis Calcineurin/nuclear factor of activated T-cells pathway Qingyi decoction

Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease:a meta-analysis and systematic review

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Neural Regeneration Research 2022年第11期17卷 2381-2390页

作者： Wei-Lin liu Hua-Wei Lin Miao-Ran Lin Yan Yu huan-huan liu Ya-Ling Dai Le-Wen Chen Wei-Wei Jia Xiao-Jun He Xiao-Ling Li Jing-Fang Zhu Xie-Hua Xue Jing Tao Li-Dian Chen Academy of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine FuzhouFujian ProvinceChina

Blood exosomes,which are extracellular vesicles secreted by living cells into the circulating blood,are regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease *** increasing number of blood cargo-loaded exosomes are emerging as potential biomarkers for preclinical and clinical Alzheimer's *** re,we conducted a meta-analysis and systematic review of molecular biomarkers derived from blood exosomes to comprehensively analyze their diagnostic performance in preclinical Alzheimer's disease,mild cognitive impairment,and Alzheimer's *** performed a literature search in PubMed,Web of Science,Embase,and Cochrane Library from their inception to August 15,*** research subjects mainly included Alzheimer's disease,mild cognitive impairment,and preclinical Alzheimer's *** identified 34 observational studies,of which 15 were included in the quantitative analysis(Newcastle-Ottawa Scale score 5.87 points)and 19 were used in the qualitative *** meta-analysis results showed that core biomarkers including Aβ_(1-42),P-T181-tau,P-S396-tau,and T-tau were increased in blood neuro nderived exosomes of preclinical Alzheimer's disease,mild cognitive impairment,and Alzheimer's disease patients.M olecules related to additional risk facto rs that are involved in neuroinflammation(C1q),metabolism disorder(P-S312-IRS-1),neurotrophic deficiency(HGF),vascular injury(VEGF-D),and autophagy-lysosomal system dysfunction(cathepsin D)were also *** the gene level,the differential expression of transc ription-related factors(REST)and microRNAs(miR-132)also affects RNA splicing,transport,and *** pathological changes contribute to neural loss and synaptic *** data confirm that the above-mentioned core molecules and additional ris k-related factors in blood exosomes can serve as candidate biomarkers for preclinical and clinical Alzheimer's *** findings support further development of

关键词： Alzheimer's disease amyloid-β biomarkers blood exosomes extracellular vesicles meta-analysis mild cognitive impairment systematic review tau protein

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激光测厚仪在热轧生产线上热防护的设计

仪表技术与传感器 2016年第12期 61-64,95页

作者：杨欢欢刘鸿飞北京科技大学机械工程学院北京100083

在激光测厚用于铝板带热轧生产过程中时,由于热轧生产线上温度较高且超出激光位移传感器的工作温度范围,测厚装置无法正常使用。为了保证传感器的正常工作,研究了传感器的热防护措施,并设计了相应的热防护装置,采用风冷、半导体制冷、... 详细信息

在激光测厚用于铝板带热轧生产过程中时,由于热轧生产线上温度较高且超出激光位移传感器的工作温度范围,测厚装置无法正常使用。为了保证传感器的正常工作,研究了传感器的热防护措施,并设计了相应的热防护装置,采用风冷、半导体制冷、水冷和绝热的组合措施。经过测试,传感器环境温度可以控制在(25.6±0.1)℃(设定温度25℃),起到了热防护的作用,并有效地减小了传感器的温度漂移,达到了设计要求。

关键词：热防护制冷片 DS18B20 PID 风冷气凝胶毡

Evaluation of the aromaticity of Corannulene molecule by NICS index and current density

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Evaluation of the aromaticity of Corannulene molecule by NIC...